X5M8U1

PR
Gene name
gcy-17
Protein name
Receptor-type guanylate cyclase gcy-17
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_W03F11.2
EC number
4.6.1.2: Phosphorus-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

478-569 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for X5M8U1

Entry ID Method Resolution Chain Position Source
AF-X5M8U1-F1 Predicted AlphaFoldDB

No variants for X5M8U1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for X5M8U1

No associated diseases with X5M8U1

6 regional properties for X5M8U1

Type Name Position InterPro Accession
domain Protein kinase domain 535 - 824 IPR000719
domain Adenylyl cyclase class-3/4/guanylyl cyclase 846 - 1059 IPR001054
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 591 - 806 IPR001245
domain Receptor, ligand binding region 48 - 419 IPR001828
domain Haem NO binding associated 831 - 867 IPR011645
conserved_site Adenylyl cyclase class-4/guanylyl cyclase, conserved site 989 - 1012 IPR018297

Functions

Description
EC Number 4.6.1.2 Phosphorus-oxygen lyases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTP binding Binding to GTP, guanosine triphosphate.
guanylate cyclase activity Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
peptide receptor activity Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

8 GO annotations of biological process

Name Definition
cGMP biosynthetic process The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
chemosensory behavior Behavior that is dependent upon the sensation of chemicals.
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.
receptor guanylyl cyclase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
response to metal ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P46197 NPR2 Atrial natriuretic peptide receptor 2 Bos taurus (Bovine) PR
O02740 GUCY2F Retinal guanylyl cyclase 2 Bos taurus (Bovine) PR
P51841 GUCY2F Retinal guanylyl cyclase 2 Homo sapiens (Human) PR
Q02846 GUCY2D Retinal guanylyl cyclase 1 Homo sapiens (Human) PR
P20594 NPR2 Atrial natriuretic peptide receptor 2 Homo sapiens (Human) PR
P52785 Gucy2e Retinal guanylyl cyclase 1 Mus musculus (Mouse) PR
Q6VVW5 Npr2 Atrial natriuretic peptide receptor 2 Mus musculus (Mouse) PR
Q5SDA5 Gucy2f Retinal guanylyl cyclase 2 Mus musculus (Mouse) PR
P51840 Gucy2e Retinal guanylyl cyclase 1 Rattus norvegicus (Rat) PR
P18910 Npr1 Atrial natriuretic peptide receptor 1 Rattus norvegicus (Rat) PR
P16067 Npr2 Atrial natriuretic peptide receptor 2 Rattus norvegicus (Rat) PR
P51842 Gucy2f Retinal guanylyl cyclase 2 Rattus norvegicus (Rat) PR
O16544 gcy-19 Receptor-type guanylate cyclase gcy-19 Caenorhabditis elegans PR
Q09435 gcy-1 Receptor-type guanylate cyclase gcy-1 Caenorhabditis elegans PR
Q10029 gcy-2 Receptor-type guanylate cyclase gcy-2 Caenorhabditis elegans PR
Q18331 gcy-11 Receptor-type guanylate cyclase gcy-11 Caenorhabditis elegans PR
Q23682 gcy-5 Receptor-type guanylate cyclase gcy-5 Caenorhabditis elegans PR
10 20 30 40 50 60
MLFLRLFIFT PFLILANCQA RRTIKVGLLF VQNVSSLQVG IGYRTSAAAV LVTKNKIRED
70 80 90 100 110 120
HVLDGFDFEF LWDFDECNEI LGAGKTVDLL EVKKVDVIFG PTCSRPALIS SALATYYNIP
130 140 150 160 170 180
IFEWGLTSTR QLTDVKRFPT TLPFSVNSYS LAMAILGTLK QFQWTEFVFL YCNDGDDEKC
190 200 210 220 230 240
ESLKDDVQTV ASAHEELSLA YTFRIQSKKL EDMRAAIVEI KKRGRIIVAC VASGNGSKRT
250 260 270 280 290 300
LMQAVALENA NNSEYVYIMA ETNSRGFVVE EVGGKWHYLW EGKFDDSDTF STEDSRTSMA
310 320 330 340 350 360
NLLFLVDNMG MNNVVTPQYL NFSKNVIEMM KDEPFNCVED CVGEEYSSVA KYAGQLADAF
370 380 390 400 410 420
YAYAVAVNRL LTANPQAEIR NGTMILRNIG MTFEGVGGGD LTVDPDSART SEIIMIGLNS
430 440 450 460 470 480
SRLPETYGKL IINNQSVHFE QLYSDEVMDV WNGRQRPKAK PTCGFTGTQC PPDFVRDYLV
490 500 510 520 530 540
IVIIIVMFLI FAVSAAVGAV FYAIRQKRKE IERQDELWHV EASHLKPISK KSKSEASQRS
550 560 570 580 590 600
FASGPSTSTK LTVESRTETT RFIFYIYQVR NNEVVAANKH DFRPQLTDVE RSELRQMRSL
610 620 630 640 650 660
DHDNLNKFIG LCLNSQQLLS IWRYCSRGSL ADVISRSSMQ MDSFFMLSLI RDIANGLGFI
670 680 690 700 710 720
HTSMLHFHGY LSSRSCLIDD RWQVKISDFG LNEVRGMDKL STENMLWWAP EVLRGLEQRS
730 740 750 760 770 780
KEADIYSFGI ICSEVITRSS AFDLENRKEK PEEIIYQLKK GGFNAIRPSL LTDEALEINP
790 800 810 820 830 840
ALVHLIRDCW TEKPSERPPI DQVRSLLRGM NDGKKGNLMD HVFNMLETYA STLEEEVNER
850 860 870 880 890 900
TKELVEEQKK SDVLLYRMLP KTVAEKLKAG ISIEPETFEL VTIFFSDVVQ FTTLASKCTP
910 920 930 940 950 960
LQVVQLLNDL YTIFDSIIEQ NDVYKVETIG DGYLCVSGLP HRNGHDHIKH IARMSLAFLS
970 980 990 1000 1010 1020
SLAEFRVAHM PSERINLRIG INCGSVVAGV VGLTMPRYCL FGDAVNTASR MESNGKPGRI
1030 1040 1050 1060 1070 1080
HVSSEANHLL THVVGGFRTE ERGEVIIKGK GVMNTYWLLG ENDSVPVKSN MRKRENTPSM
ARSITPEI