AiPD: Autoinhibited Protein Database

Gene name	At1g54610 (T22H22.5)
Protein name	Probable serine/threonine-protein kinase At1g54610
Names
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G54610
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-136 (Predicted disordered autoinhibitory region) PR

1-136 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9ZVM9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH13570771	9	A>T	No	1000Genomes
ENSVATH04962277	28	G>E	No	1000Genomes
tmp_1_20396796_C_A	36	S>I	No	1000Genomes
tmp_1_20396742_T_A	54	E>V	No	1000Genomes
tmp_1_20396704_C_T	67	G>R	No	1000Genomes
ENSVATH04962275	81	N>Y	No	1000Genomes
tmp_1_20396631_A_C	91	V>G	No	1000Genomes
tmp_1_20396613_G_A	97	S>F	No	1000Genomes
tmp_1_20396297_C_T	170	R>Q	No	1000Genomes
ENSVATH13570763	231	E>A	No	1000Genomes
ENSVATH14316498	265	T>M	No	1000Genomes
tmp_1_20395515_T_G	362	R>S	No	1000Genomes
tmp_1_20395511_T_C	364	I>V	No	1000Genomes
ENSVATH04962260	366	E>D	No	1000Genomes
ENSVATH04962258	376	L>F	No	1000Genomes
tmp_1_20395418_C_T	395	A>T	No	1000Genomes
ENSVATH13570762	399	S>R	No	1000Genomes
tmp_1_20395294_G_T	403	T>K	No	1000Genomes
tmp_1_20395254_C_G	416	K>N	No	1000Genomes
tmp_1_20394683_C_T	441	A>T	No	1000Genomes
tmp_1_20394628_A_C	459	L>R	No	1000Genomes
tmp_1_20394141_A_T	514	F>I	No	1000Genomes
ENSVATH04962199	519	M>T	No	1000Genomes
ENSVATH04962198	520	V>L	No	1000Genomes
tmp_1_20394013_C_A	556	K>N	No	1000Genomes
ENSVATH14316451	569	A>T	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	118 - 402	IPR000719
active_site	Serine/threonine-protein kinase, active site	238 - 250	IPR008271
binding_site	Protein kinase, ATP binding site	124 - 147	IPR017441

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity	Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

Name	Definition
phosphorylation of RNA polymerase II C-terminal domain	The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
positive regulation of transcription elongation by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
protein phosphorylation	The process of introducing a phosphate group on to a protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q03957	CTK1	CTD kinase subunit alpha	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q5EAB2	CDK9	Cyclin-dependent kinase 9	Bos taurus (Bovine)	PR
Q5ZKN1	CDK9	Cyclin-dependent kinase 9	Gallus gallus (Chicken)	PR
P50750	CDK9	Cyclin-dependent kinase 9	Homo sapiens (Human)	PR
Q99J95	Cdk9	Cyclin-dependent kinase 9	Mus musculus (Mouse)	PR
Q641Z4	Cdk9	Cyclin-dependent kinase 9	Rattus norvegicus (Rat)	PR
P46551	cdk-12	Cyclin-dependent kinase 12	Caenorhabditis elegans	PR
F4I114	At1g09600	Probable serine/threonine-protein kinase At1g09600	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FGW5	CDKG1	Cyclin-dependent kinase G1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9C9U2	CDKD-1	Cyclin-dependent kinase D-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LMT0	CDKD-3	Cyclin-dependent kinase D-3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6GLD8	cdk9	Cyclin-dependent kinase 9	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR