Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9ZVM9

Entry ID Method Resolution Chain Position Source
AF-Q9ZVM9-F1 Predicted AlphaFoldDB

26 variants for Q9ZVM9

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH13570771 9 A>T No 1000Genomes
ENSVATH04962277 28 G>E No 1000Genomes
tmp_1_20396796_C_A 36 S>I No 1000Genomes
tmp_1_20396742_T_A 54 E>V No 1000Genomes
tmp_1_20396704_C_T 67 G>R No 1000Genomes
ENSVATH04962275 81 N>Y No 1000Genomes
tmp_1_20396631_A_C 91 V>G No 1000Genomes
tmp_1_20396613_G_A 97 S>F No 1000Genomes
tmp_1_20396297_C_T 170 R>Q No 1000Genomes
ENSVATH13570763 231 E>A No 1000Genomes
ENSVATH14316498 265 T>M No 1000Genomes
tmp_1_20395515_T_G 362 R>S No 1000Genomes
tmp_1_20395511_T_C 364 I>V No 1000Genomes
ENSVATH04962260 366 E>D No 1000Genomes
ENSVATH04962258 376 L>F No 1000Genomes
tmp_1_20395418_C_T 395 A>T No 1000Genomes
ENSVATH13570762 399 S>R No 1000Genomes
tmp_1_20395294_G_T 403 T>K No 1000Genomes
tmp_1_20395254_C_G 416 K>N No 1000Genomes
tmp_1_20394683_C_T 441 A>T No 1000Genomes
tmp_1_20394628_A_C 459 L>R No 1000Genomes
tmp_1_20394141_A_T 514 F>I No 1000Genomes
ENSVATH04962199 519 M>T No 1000Genomes
ENSVATH04962198 520 V>L No 1000Genomes
tmp_1_20394013_C_A 556 K>N No 1000Genomes
ENSVATH14316451 569 A>T No 1000Genomes

No associated diseases with Q9ZVM9

3 regional properties for Q9ZVM9

Type Name Position InterPro Accession
domain Protein kinase domain 118 - 402 IPR000719
active_site Serine/threonine-protein kinase, active site 238 - 250 IPR008271
binding_site Protein kinase, ATP binding site 124 - 147 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

3 GO annotations of biological process

Name Definition
phosphorylation of RNA polymerase II C-terminal domain The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
positive regulation of transcription elongation by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
protein phosphorylation The process of introducing a phosphate group on to a protein.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q03957 CTK1 CTD kinase subunit alpha Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q5EAB2 CDK9 Cyclin-dependent kinase 9 Bos taurus (Bovine) PR
Q5ZKN1 CDK9 Cyclin-dependent kinase 9 Gallus gallus (Chicken) PR
P50750 CDK9 Cyclin-dependent kinase 9 Homo sapiens (Human) PR
Q99J95 Cdk9 Cyclin-dependent kinase 9 Mus musculus (Mouse) PR
Q641Z4 Cdk9 Cyclin-dependent kinase 9 Rattus norvegicus (Rat) PR
P46551 cdk-12 Cyclin-dependent kinase 12 Caenorhabditis elegans PR
F4I114 At1g09600 Probable serine/threonine-protein kinase At1g09600 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FGW5 CDKG1 Cyclin-dependent kinase G1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C9U2 CDKD-1 Cyclin-dependent kinase D-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMT0 CDKD-3 Cyclin-dependent kinase D-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q6GLD8 cdk9 Cyclin-dependent kinase 9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MGCVFGREAA TTTTAEAKQA KSSKASSGVV VVGESSVTKS NGVIADDVEK KKNEEANGDK
70 80 90 100 110 120
ERKSSKGDRR RSTKPNPRLS NPSKHWRGEQ VAAGWPSWLS DACGEALNGW VPRKADTFEK
130 140 150 160 170 180
IDKIGQGTYS NVYKAKDMLT GKIVALKKVR FDNLEPESVK FMAREILVLR RLDHPNVVKL
190 200 210 220 230 240
EGLVTSRMSC SLYLVFQYMD HDLAGLASSP VVKFSESEVK CLMRQLISGL EHCHSRGVLH
250 260 270 280 290 300
RDIKGSNLLI DDGGVLKIAD FGLATIFDPN HKRPMTSRVV TLWYRAPELL LGATDYGVGI
310 320 330 340 350 360
DLWSAGCILA ELLAGRPIMP GRTEVEQLHK IYKLCGSPSE DYWKKGKFTH GAIYKPREPY
370 380 390 400 410 420
KRSIRETFKD FPPSSLPLID ALLSIEPEDR QTASAALKSE FFTSEPYACE PADLPKYPPS
430 440 450 460 470 480
KEIDAKRRDE ETRRQRAASK AQGDGARKNR HRDRSNRALP APEANAELQS NVDRRRLITH
490 500 510 520 530 540
ANAKSKSEKF PPPHQDGGAM GVPLGASQHI DPTFIPRDMV PSFTSSSFNF SKDEPPTQVQ
550 560 570
TWSGPLGHPI TGVSRKKKDN TKSSKGKRAV VA