Q9ZQR3

PR
Gene name
At2g14510 (T13P21.11)
Protein name
Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G14510
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

505-582 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

704-711 (Activation loop from InterPro)

Target domain

563-835 (Protein kinase domain)

Relief mechanism

Assay

722-729 (Activation loop from InterPro)

Target domain

563-835 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9ZQR3

Entry ID Method Resolution Chain Position Source
AF-Q9ZQR3-F1 Predicted AlphaFoldDB

215 variants for Q9ZQR3

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH13090661 2 E>K No 1000Genomes
ENSVATH05460840 5 N>S No 1000Genomes
ENSVATH01786960 7 F>L No 1000Genomes
tmp_2_6175030_A_G 8 M>T No 1000Genomes
ENSVATH05460839 16 S>A No 1000Genomes
ENSVATH05460838 18 M>L No 1000Genomes
tmp_2_6174997_G_T 19 S>Y No 1000Genomes
ENSVATH01786958 26 Q>L No 1000Genomes
ENSVATH01786957 27 Q>E No 1000Genomes
ENSVATH01786945 39 K>N No 1000Genomes
ENSVATH13090624 40 E>K No 1000Genomes
tmp_2_6174821_G_A 41 S>F No 1000Genomes
ENSVATH01786943 43 I>T No 1000Genomes
ENSVATH01786942 46 S>A No 1000Genomes
tmp_2_6174806_G_A 46 S>L No 1000Genomes
ENSVATH01786941 47 S>N No 1000Genomes
ENSVATH01786941 47 S>T No 1000Genomes
tmp_2_6174801_T_A 48 N>Y No 1000Genomes
ENSVATH01786939 49 L>I No 1000Genomes
ENSVATH07863183 51 F>Y No 1000Genomes
tmp_2_6174776_T_C 56 N>S No 1000Genomes
ENSVATH05460828 57 F>L No 1000Genomes
ENSVATH01786936 67 Q>E No 1000Genomes
ENSVATH01786935 75 I>L No 1000Genomes
tmp_2_6174719_A_C 75 I>S No 1000Genomes
tmp_2_6174698_A_C 82 L>W No 1000Genomes
ENSVATH00228631 89 I>S No 1000Genomes
ENSVATH13090623 90 R>* No 1000Genomes
ENSVATH13090622 90 R>K No 1000Genomes
ENSVATH13090621 92 C>R No 1000Genomes
ENSVATH07863180 96 S>N No 1000Genomes
tmp_2_6174655_A_T 96 S>R No 1000Genomes
ENSVATH01786930 98 K>E No 1000Genomes
ENSVATH01786929 100 G>S No 1000Genomes
ENSVATH01786928 103 Y>F No 1000Genomes
ENSVATH05460827 105 I>M No 1000Genomes
ENSVATH05460826 110 Y>F No 1000Genomes
ENSVATH14447636 117 L>V No 1000Genomes
ENSVATH13090620 118 N>D No 1000Genomes
ENSVATH00228630 119 T>I No 1000Genomes
tmp_2_6174565_A_C 126 F>L No 1000Genomes
ENSVATH01786923 133 T>K No 1000Genomes
ENSVATH05460825 134 S>I No 1000Genomes
ENSVATH14447635 136 D>N No 1000Genomes
ENSVATH07863177 139 I>K No 1000Genomes
ENSVATH01786922 141 D>G No 1000Genomes
ENSVATH07863176 142 V>G No 1000Genomes
ENSVATH01786920 151 V>I No 1000Genomes
ENSVATH13090617 169 S>T No 1000Genomes
ENSVATH01786915 176 I>V No 1000Genomes
ENSVATH05460823 188 A>T No 1000Genomes
ENSVATH07863175 189 R>Q No 1000Genomes
tmp_2_6174362_T_C 194 K>R No 1000Genomes
ENSVATH09456760 195 S>N No 1000Genomes
ENSVATH09456760 195 S>T No 1000Genomes
ENSVATH09456759 196 M>I No 1000Genomes
tmp_2_6174357_T_G 196 M>L No 1000Genomes
ENSVATH13090616 197 A>E No 1000Genomes
ENSVATH13090616 197 A>V No 1000Genomes
ENSVATH01786911 198 H>L No 1000Genomes
ENSVATH01786911 198 H>R No 1000Genomes
tmp_2_6174347_A_C 199 F>C No 1000Genomes
ENSVATH00228629 199 F>L No 1000Genomes
ENSVATH01786905 214 V>I No 1000Genomes
ENSVATH13090598 220 M>I No 1000Genomes
ENSVATH13090596 230 I>M No 1000Genomes
ENSVATH01786903 233 T>S No 1000Genomes
tmp_2_6174127_A_T 241 D>E No 1000Genomes
ENSVATH00228628 244 N>K No 1000Genomes
ENSVATH05460813 245 P>L No 1000Genomes
ENSVATH05460812 255 I>V No 1000Genomes
ENSVATH01786901 259 G>V No 1000Genomes
tmp_2_6174069_C_T 261 E>K No 1000Genomes
tmp_2_6174062_A_C 263 L>W No 1000Genomes
ENSVATH05460809 268 N>I No 1000Genomes
tmp_2_6174046_A_C 268 N>K No 1000Genomes
tmp_2_6174036_A_C 272 S>A No 1000Genomes
ENSVATH14447532 280 L>I No 1000Genomes
ENSVATH01786900 281 F>Y No 1000Genomes
ENSVATH05460808 284 E>Q No 1000Genomes
ENSVATH05460806 286 Q>K No 1000Genomes
ENSVATH01786899 287 Q>K No 1000Genomes
ENSVATH01786898 290 V>A No 1000Genomes
ENSVATH13090583 291 N>H No 1000Genomes
ENSVATH07863172 295 E>Q No 1000Genomes
ENSVATH07863170 299 L>V No 1000Genomes
ENSVATH14447531 302 G>D No 1000Genomes
ENSVATH14447531 302 G>V No 1000Genomes
ENSVATH05460804 303 V>D No 1000Genomes
ENSVATH09456744 303 V>I No 1000Genomes
ENSVATH01786897 309 T>I No 1000Genomes
tmp_2_6173918_C_A 311 W>L No 1000Genomes
ENSVATH13090582 313 F>L No 1000Genomes
ENSVATH05460803 315 A>S No 1000Genomes
ENSVATH01786896 316 R>G No 1000Genomes
ENSVATH01786895 316 R>K No 1000Genomes
tmp_2_6173894_G_A 319 S>F No 1000Genomes
ENSVATH05460802 322 A>G No 1000Genomes
ENSVATH01786893 327 E>G No 1000Genomes
ENSVATH05460801 339 P>L No 1000Genomes
ENSVATH07863167 339 P>S No 1000Genomes
ENSVATH13090580 351 E>D No 1000Genomes
ENSVATH05460798 353 F>V No 1000Genomes
ENSVATH13090579 356 I>V No 1000Genomes
ENSVATH01786887 359 P>R No 1000Genomes
ENSVATH07863166 362 D>E No 1000Genomes
ENSVATH01786886 365 T>M No 1000Genomes
ENSVATH01786886 365 T>R No 1000Genomes
tmp_2_6173749_T_A 367 E>D No 1000Genomes
ENSVATH13090558 371 I>V No 1000Genomes
ENSVATH01786862 373 K>N No 1000Genomes
ENSVATH14447528 379 Q>P No 1000Genomes
tmp_2_6173516_T_G 381 S>R No 1000Genomes
tmp_2_6173506_C_T 384 S>N No 1000Genomes
tmp_2_6173486_C_G 391 V>L No 1000Genomes
ENSVATH01786857 396 S>T No 1000Genomes
ENSVATH13090557 406 D>Y No 1000Genomes
ENSVATH13090555 412 R>G No 1000Genomes
ENSVATH05460782 415 S>A No 1000Genomes
ENSVATH01786850 420 L>S No 1000Genomes
tmp_2_6173321_C_A 421 S>I No 1000Genomes
ENSVATH01786849 424 T>I No 1000Genomes
ENSVATH01786847 428 S>* No 1000Genomes
ENSVATH01786848 428 S>P No 1000Genomes
ENSVATH01786848 428 S>T No 1000Genomes
ENSVATH13090529 429 P>A No 1000Genomes
ENSVATH07863159 431 I>L No 1000Genomes
tmp_2_6173289_G_T 432 Q>K No 1000Genomes
ENSVATH07863158 438 R>Q No 1000Genomes
ENSVATH07863157 439 E>K No 1000Genomes
tmp_2_6173176_G_C 443 S>* No 1000Genomes
tmp_2_6173137_G_T 456 A>D No 1000Genomes
ENSVATH01786828 457 T>N No 1000Genomes
ENSVATH01786825 460 P>S No 1000Genomes
ENSVATH01786817 465 H>N No 1000Genomes
ENSVATH13090503 478 A>T No 1000Genomes
ENSVATH01786811 480 Q>H No 1000Genomes
ENSVATH01786810 483 E>K No 1000Genomes
ENSVATH01786809 483 E>V No 1000Genomes
ENSVATH05460770 484 K>N No 1000Genomes
ENSVATH01786808 486 D>E No 1000Genomes
ENSVATH01786807 490 L>I No 1000Genomes
ENSVATH01786806 491 F>Y No 1000Genomes
ENSVATH14447472 492 V>I No 1000Genomes
ENSVATH05460762 497 T>K No 1000Genomes
ENSVATH05460761 498 R>P No 1000Genomes
ENSVATH05460761 498 R>Q No 1000Genomes
ENSVATH00228625 499 R>H No 1000Genomes
ENSVATH05460759 500 G>E No 1000Genomes
tmp_2_6172846_C_T 500 G>R No 1000Genomes
ENSVATH05460758 501 K>Q No 1000Genomes
tmp_2_6172842_T_G 501 K>T No 1000Genomes
tmp_2_6172837_G_T 503 Q>K No 1000Genomes
ENSVATH05460756 503 Q>R No 1000Genomes
ENSVATH07863149 505 K>R No 1000Genomes
tmp_2_6172788_G_A 519 A>V No 1000Genomes
ENSVATH01786793 520 V>A No 1000Genomes
tmp_2_6172783_T_A 521 T>S No 1000Genomes
ENSVATH14447470 524 V>M No 1000Genomes
ENSVATH07863144 530 I>V No 1000Genomes
ENSVATH01786759 555 Y>F No 1000Genomes
tmp_2_6172394_A_G 581 F>S No 1000Genomes
tmp_2_6172338_A_T 600 Y>N No 1000Genomes
tmp_2_6172227_C_T 608 E>K No 1000Genomes
ENSVATH13090450 612 R>K No 1000Genomes
ENSVATH00228624 629 I>N No 1000Genomes
ENSVATH01786744 634 I>V No 1000Genomes
ENSVATH01786742 645 E>D No 1000Genomes
ENSVATH13090448 651 R>H No 1000Genomes
ENSVATH13090447 653 G>C No 1000Genomes
tmp_2_6171993_A_G 654 S>P No 1000Genomes
ENSVATH01786728 659 S>P No 1000Genomes
ENSVATH05460723 660 S>G No 1000Genomes
ENSVATH14447262 660 S>N No 1000Genomes
ENSVATH01786727 662 L>F No 1000Genomes
ENSVATH01786727 662 L>I No 1000Genomes
ENSVATH01786726 663 K>E No 1000Genomes
ENSVATH13090446 663 K>N No 1000Genomes
ENSVATH01786724 669 A>G No 1000Genomes
tmp_2_6171805_C_T 678 G>R No 1000Genomes
ENSVATH01786709 680 Q>K No 1000Genomes
ENSVATH01786708 680 Q>P No 1000Genomes
ENSVATH00228623 683 M>I No 1000Genomes
tmp_2_6171751_C_T 696 G>S No 1000Genomes
tmp_2_6171689_A_C 716 S>R No 1000Genomes
ENSVATH01786700 718 A>G No 1000Genomes
ENSVATH01786701 718 A>T No 1000Genomes
ENSVATH05460713 723 N>T No 1000Genomes
tmp_2_6171661_C_T 726 G>R No 1000Genomes
ENSVATH07863109 737 L>Q No 1000Genomes
ENSVATH01786681 753 V>L No 1000Genomes
ENSVATH01786679 757 S>I No 1000Genomes
tmp_2_6171464_G_A 759 T>I No 1000Genomes
ENSVATH13090401 764 I>M No 1000Genomes
tmp_2_6171449_A_C 764 I>S No 1000Genomes
ENSVATH13090400 769 D>N No 1000Genomes
ENSVATH13090399 771 S>C No 1000Genomes
ENSVATH13090398 772 Y>F No 1000Genomes
ENSVATH13090396 783 N>H No 1000Genomes
tmp_2_6171345_C_T 799 D>N No 1000Genomes
ENSVATH01786670 800 S>A No 1000Genomes
ENSVATH01786670 800 S>T No 1000Genomes
ENSVATH13090384 820 Q>H No 1000Genomes
tmp_2_6171281_T_C,A 820 Q>L No 1000Genomes
tmp_2_6171281_T_C,A 820 Q>R No 1000Genomes
ENSVATH05460705 839 N>K No 1000Genomes
ENSVATH07863100 843 I>K No 1000Genomes
ENSVATH05460704 846 Q>H No 1000Genomes
ENSVATH05460703 848 Q>P No 1000Genomes
ENSVATH01786664 849 N>I No 1000Genomes
ENSVATH07863099 854 L>S No 1000Genomes
tmp_2_6171174_G_C 856 H>D No 1000Genomes
ENSVATH09456692 858 V>L No 1000Genomes
tmp_2_6171159_T_C 861 I>V No 1000Genomes
ENSVATH13090382 868 R>H No 1000Genomes

No associated diseases with Q9ZQR3

No regional properties for Q9ZQR3

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9ZQR3

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

36 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q91044 NTRK3 NT-3 growth factor receptor Gallus gallus (Chicken) SS
Q91987 NTRK2 BDNF/NT-3 growth factors receptor Gallus gallus (Chicken) SS
Q91009 NTRK1 High affinity nerve growth factor receptor Gallus gallus (Chicken) SS
P0C0K6 EPHB6 Ephrin type-B receptor 6 Pan troglodytes (Chimpanzee) SS
P20594 NPR2 Atrial natriuretic peptide receptor 2 Homo sapiens (Human) PR
Q03145 Epha2 Ephrin type-A receptor 2 Mus musculus (Mouse) PR
Q60750 Epha1 Ephrin type-A receptor 1 Mus musculus (Mouse) SS
P24786 NTRK3 NT-3 growth factor receptor Sus scrofa (Pig) SS
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
Q19238 F09A5.2 Putative tyrosine-protein kinase F09A5.2 Caenorhabditis elegans SS
P43293 PBL11 Probable serine/threonine-protein kinase PBL11 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E8W4 ANX2 Receptor-like protein kinase ANXUR2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGG3 At1g51820 Probable LRR receptor-like serine/threonine-protein kinase At1g51820 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGW2 PAM74 Probable LRR receptor-like serine/threonine-protein kinase PAM74 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN93 At5g59680 Probable LRR receptor-like serine/threonine-protein kinase At5g59680 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN94 At5g59670 Receptor-like protein kinase At5g59670 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LIG2 At3g21340 Receptor-like protein kinase At3g21340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SNA3 At3g46340 Putative receptor-like protein kinase At3g46340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LPZ9 SD113 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 Arabidopsis thaliana (Mouse-ear cress) SS
P43298 TMK1 Receptor protein kinase TMK1 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGI2 At1g67720 Probable LRR receptor-like serine/threonine-protein kinase At1g67720 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWW0 ALE2 Receptor-like serine/threonine-protein kinase ALE2 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M2S4 LECRKS4 L-type lectin-domain containing receptor kinase S.4 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWZ5 SD25 G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 Arabidopsis thaliana (Mouse-ear cress) PR
O64556 At2g19230 Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXB4 At1g11300 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JQ4 PRK2 Pollen receptor-like kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZS4 NIK3 Protein NSP-INTERACTING KINASE 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AG2 SERK1 Somatic embryogenesis receptor kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
O64477 At2g19130 G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 Arabidopsis thaliana (Mouse-ear cress) SS
Q9XIC7 SERK2 Somatic embryogenesis receptor kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
METRNKFMLL ACATFSIMSL VKSQNQQGFI SLDCGLPSKE SYIEPSSNLT FISDVNFIRG
70 80 90 100 110 120
GKTGNIQNNS RTNFIFKPFK VLRYFPDGIR NCYSLSVKQG TKYLIRTLFY YGNYDGLNTS
130 140 150 160 170 180
PRFDLFLGPN IWTSVDVLIA DVGDGVVEEI VHVTRSNILD ICLVKTGTST PMISAIELRP
190 200 210 220 230 240
LRYDTYTART GSLKSMAHFY FTNSDEAIRY PEDVYDRVWM PYSQPEWTQI NTTRNVSGFS
250 260 270 280 290 300
DGYNPPQGVI QTASIPTNGS EPLTFTWNLE SSDDETYAYL FFAEIQQLKV NETREFKILA
310 320 330 340 350 360
NGVDYIDYTP WKFEARTLSN PAPLKCEGGV CRVQLSKTPK STLPPLMNAI EIFSVIQFPQ
370 380 390 400 410 420
SDTNTDEVIA IKKIQSTYQL SRISWQGDPC VPKQFSWMGV SCNVIDISTP PRIISLDLSL
430 440 450 460 470 480
SGLTGVISPS IQNLTMLREL DLSNNNLTGE VPEFLATIKP LLVIHLRGNN LRGSVPQALQ
490 500 510 520 530 540
DREKNDGLKL FVDPNITRRG KHQPKSWLVA IVASISCVAV TIIVLVLIFI FRRRKSSTRK
550 560 570 580 590 600
VIRPSLEMKN RRFKYSEVKE MTNNFEVVLG KGGFGVVYHG FLNNEQVAVK VLSQSSTQGY
610 620 630 640 650 660
KEFKTEVELL LRVHHVNLVS LVGYCDEGID LALIYEFMEN GNLKEHLSGK RGGSVLNWSS
670 680 690 700 710 720
RLKIAIESAL GIEYLHIGCQ PPMVHRDVKS TNILLGLRFE AKLADFGLSR SFLVGSQAHV
730 740 750 760 770 780
STNVAGTLGY LDPEYYLKNW LTEKSDVYSF GIVLLESITG QPVIEQSRDK SYIVEWAKSM
790 800 810 820 830 840
LANGDIESIM DPNLHQDYDS SSSWKALELA MLCINPSSTQ RPNMTRVAHE LNECLEIYNL
850 860
TKIRSQDQNS SKSLGHTVTF ISDIPSAR