Q9Z2W1
Gene name |
Stk25 (Sok1) |
Protein name |
Serine/threonine-protein kinase 25 |
Names |
Ste20-like kinase, Sterile 20/oxidant stress-response kinase 1, SOK-1, Ste20/oxidant stress response kinase 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:59041 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
157-180 (Activation loop from InterPro)
Target domain |
20-270 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9Z2W1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z2W1-F1 | Predicted | AlphaFoldDB |
28 variants for Q9Z2W1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs231391391 | 13 | R>C | No | EVA | |
| rs3388491545 | 17 | E>* | No | EVA | |
| rs3388492087 | 28 | K>T | No | EVA | |
| rs3388491656 | 100 | G>C | No | EVA | |
| rs3388490994 | 150 | E>G | No | EVA | |
| rs3388489886 | 159 | F>L | No | EVA | |
| rs3388492002 | 165 | L>F | No | EVA | |
| rs3388489949 | 177 | G>V | No | EVA | |
| rs3388489960 | 182 | M>I | No | EVA | |
| rs3388492951 | 184 | P>S | No | EVA | |
| rs3388492804 | 186 | V>A | No | EVA | |
| rs3388492770 | 212 | E>G | No | EVA | |
| rs3388491516 | 220 | P>H | No | EVA | |
| rs3390342495 | 222 | R>Q | No | EVA | |
| rs3388489586 | 225 | F>Y | No | EVA | |
| rs3388489883 | 229 | K>M | No | EVA | |
| rs3388489808 | 232 | P>Q | No | EVA | |
| rs3388489047 | 260 | T>I | No | EVA | |
| rs3388489047 | 260 | T>S | No | EVA | |
| rs3390187087 | 262 | K>R | No | EVA | |
| rs3388489658 | 289 | R>S | No | EVA | |
| rs3388492913 | 354 | R>K | No | EVA | |
| rs3388489042 | 375 | Q>* | No | EVA | |
| rs3388491918 | 379 | S>G | No | EVA | |
| rs3388492814 | 388 | N>K | No | EVA | |
| rs3388492033 | 393 | A>T | No | EVA | |
| rs3388489379 | 405 | M>K | No | EVA | |
| rs3388492769 | 421 | H>N | No | EVA |
No associated diseases with Q9Z2W1
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| axonogenesis | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. |
| establishment of Golgi localization | The directed movement of the Golgi to a specific location. |
| establishment or maintenance of cell polarity | Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. |
| Golgi localization | Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. |
| Golgi reassembly | The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance. |
| intrinsic apoptotic signaling pathway in response to hydrogen peroxide | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2). |
| positive regulation of axonogenesis | Any process that activates or increases the frequency, rate or extent of axonogenesis. |
| positive regulation of stress-activated MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| response to hydrogen peroxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWY6 | STK25 | Serine/threonine-protein kinase 25 | Bos taurus (Bovine) | PR |
| Q5E9L6 | STK4 | Serine/threonine-protein kinase 4 | Bos taurus (Bovine) | SS |
| P41279 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Homo sapiens (Human) | EV |
| Q9P289 | STK26 | Serine/threonine-protein kinase 26 | Homo sapiens (Human) | PR |
| Q9Y6E0 | STK24 | Serine/threonine-protein kinase 24 | Homo sapiens (Human) | PR |
| O00506 | STK25 | Serine/threonine-protein kinase 25 | Homo sapiens (Human) | PR |
| Q13188 | STK3 | Serine/threonine-protein kinase 3 | Homo sapiens (Human) | SS |
| Q13043 | STK4 | Serine/threonine-protein kinase 4 | Homo sapiens (Human) | EV |
| Q07174 | Map3k8 | Mitogen-activated protein kinase kinase kinase 8 | Mus musculus (Mouse) | SS |
| Q99JT2 | Stk26 | Serine/threonine-protein kinase 26 | Mus musculus (Mouse) | PR |
| Q99KH8 | Stk24 | Serine/threonine-protein kinase 24 | Mus musculus (Mouse) | PR |
| O54988 | Slk | STE20-like serine/threonine-protein kinase | Mus musculus (Mouse) | PR |
| O55098 | Stk10 | Serine/threonine-protein kinase 10 | Mus musculus (Mouse) | PR |
| Q6P9R2 | Oxsr1 | Serine/threonine-protein kinase OSR1 | Mus musculus (Mouse) | PR |
| Q9Z1W9 | Stk39 | STE20/SPS1-related proline-alanine-rich protein kinase | Mus musculus (Mouse) | PR |
| P70218 | Map4k1 | Mitogen-activated protein kinase kinase kinase kinase 1 | Mus musculus (Mouse) | PR |
| Q61161 | Map4k2 | Mitogen-activated protein kinase kinase kinase kinase 2 | Mus musculus (Mouse) | SS |
| Q99JP0 | Map4k3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Mus musculus (Mouse) | SS |
| Q9JI10 | Stk3 | Serine/threonine-protein kinase 3 | Mus musculus (Mouse) | SS |
| Q9JI11 | Stk4 | Serine/threonine-protein kinase 4 | Mus musculus (Mouse) | PR |
| Q8BPM2 | Map4k5 | Mitogen-activated protein kinase kinase kinase kinase 5 | Mus musculus (Mouse) | PR |
| Q63562 | Map3k8 | Mitogen-activated protein kinase kinase kinase 8 | Rattus norvegicus (Rat) | SS |
| B0LT89 | Stk24 | Serine/threonine-protein kinase 24 | Rattus norvegicus (Rat) | PR |
| H2L099 | gck-1 | Germinal center kinase 1 | Caenorhabditis elegans | PR |
| Q9NB31 | cst-1 | Serine/threonine-protein kinase cst-1 | Caenorhabditis elegans | PR |
| Q6P3Q4 | stk4 | Serine/threonine-protein kinase 4 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q7ZUQ3 | stk3 | Serine/threonine-protein kinase 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAHLRGFAHQ | HSRVDPEELF | TKLDRIGKGS | FGEVYKGIDN | HTKEVVAIKI | IDLEEAEDEI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EDIQQEITVL | SQCDSPYITR | YFGSYLKSTK | LWIIMEYLGG | GSALDLLKPG | PLEETYIATI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LREILKGLDY | LHSERKIHRD | IKAANVLLSE | QGDVKLADFG | VAGQLTDTQI | KRNTFVGTPF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WMAPEVIKQS | AYDFKADIWS | LGITAIELAK | GEPPNSDLHP | MRVLFLIPKN | NPPTLEGHHS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KPFKEFVEAC | LNKDPRFRPT | AKELLKHKFI | TRYTKKTSFL | TELIDRYKRW | KSEGHGEESS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SEDSDIDGEA | EDGEQGPIWT | FPPTIRPSPH | SKLHKGTALH | SSQKPAEPIK | RQPRSQCLST |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LVRPVFGELK | EKHKQSGGSV | GALEELENAF | SLAEESCPGI | SDKLMVHLVE | RVQRFSHSRN |
| HLTSTR |