Q9Z2U4
PR
Gene name |
Elf4 |
Protein name |
ETS-related transcription factor Elf-4 |
Names |
E74-like factor 4, Myeloid Elf-1-like factor |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56501 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z2U4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z2U4-F1 | Predicted | AlphaFoldDB |
56 variants for Q9Z2U4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389558613 | 13 | E>D | No | EVA | |
| rs3389525107 | 16 | S>N | No | EVA | |
| rs3389559203 | 19 | M>L | No | EVA | |
| rs3389537416 | 25 | L>P | No | EVA | |
| rs3389573236 | 32 | P>S | No | EVA | |
| rs3389559175 | 33 | A>S | No | EVA | |
| rs233106718 | 43 | E>D | No | EVA | |
| rs3407970258 | 58 | N>S | No | EVA | |
| rs3410115619 | 74 | L>V | No | EVA | |
| rs3389559188 | 87 | T>I | No | EVA | |
| rs3389551337 | 90 | N>D | No | EVA | |
| rs3389573271 | 91 | V>M | No | EVA | |
| rs3389562944 | 114 | S>N | No | EVA | |
| rs3389537445 | 137 | T>N | No | EVA | |
| rs3389559134 | 140 | P>S | No | EVA | |
| rs3389562938 | 143 | L>M | No | EVA | |
| rs3389507038 | 145 | K>R | No | EVA | |
| rs3410317942 | 194 | M>I | No | EVA | |
| rs3410735395 | 196 | I>L | No | EVA | |
| rs3410259698 | 196 | I>M | No | EVA | |
| rs3409349817 | 204 | K>I | No | EVA | |
| rs3410259671 | 234 | E>V | No | EVA | |
| rs3410483463 | 237 | I>F | No | EVA | |
| rs3408977870 | 237 | I>S | No | EVA | |
| rs3410483502 | 258 | D>Y | No | EVA | |
| rs3389562978 | 261 | Y>H | No | EVA | |
| rs3389515599 | 296 | L>M | No | EVA | |
| rs3389557923 | 325 | T>I | No | EVA | |
| rs3408897101 | 343 | D>V | No | EVA | |
| rs13483739 | 344 | N>I | No | EVA | |
| rs13483739 | 344 | N>S | No | EVA | |
| rs3389537464 | 371 | E>G | No | EVA | |
| rs3389551340 | 378 | T>S | No | EVA | |
| rs3389573286 | 382 | S>G | No | EVA | |
| rs3410109779 | 382 | S>T | No | EVA | |
| rs241851623 | 385 | Q>K | No | EVA | |
| rs3409349958 | 410 | V>E | No | EVA | |
| rs3410109721 | 410 | V>L | No | EVA | |
| rs3389507165 | 415 | T>S | No | EVA | |
| rs3389568620 | 439 | T>S | No | EVA | |
| rs3410317987 | 452 | F>L | No | EVA | |
| rs3389558598 | 459 | Q>H | No | EVA | |
| rs3410115602 | 459 | Q>R | No | EVA | |
| rs3409733832 | 464 | L>P | No | EVA | |
| rs3410115554 | 478 | A>G | No | EVA | |
| rs3410115585 | 478 | A>T | No | EVA | |
| rs3408897086 | 481 | I>M | No | EVA | |
| rs3410109727 | 481 | I>S | No | EVA | |
| rs3410230119 | 482 | L>I | No | EVA | |
| rs246259915 | 490 | A>T | No | EVA | |
| rs223708074 | 499 | A>G | No | EVA | |
| rs3389568621 | 570 | R>K | No | EVA | |
| rs230807571 | 584 | S>P | No | EVA | |
| rs3389507101 | 588 | H>Y | No | EVA | |
| rs3389562960 | 598 | L>I | No | EVA | |
| rs255316367 | 625 | V>I | No | EVA |
No associated diseases with Q9Z2U4
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear body | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| PML body | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| natural killer cell proliferation | The expansion of a natural killer cell population by cell division. |
| NK T cell proliferation | The expansion of a NK T cell population by cell division. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q58DT0 | ELF5 | ETS-related transcription factor Elf-5 | Bos taurus (Bovine) | SS |
| Q0VC65 | ETV6 | Transcription factor ETV6 | Bos taurus (Bovine) | SS |
| P32519 | ELF1 | ETS-related transcription factor Elf-1 | Homo sapiens (Human) | PR |
| Q9UKW6 | ELF5 | ETS-related transcription factor Elf-5 | Homo sapiens (Human) | EV |
| Q9Y603 | ETV7 | Transcription factor ETV7 | Homo sapiens (Human) | SS |
| P78545 | ELF3 | ETS-related transcription factor Elf-3 | Homo sapiens (Human) | SS |
| P41212 | ETV6 | Transcription factor ETV6 | Homo sapiens (Human) | SS |
| Q99607 | ELF4 | ETS-related transcription factor Elf-4 | Homo sapiens (Human) | PR |
| P97360 | Etv6 | Transcription factor ETV6 | Mus musculus (Mouse) | EV |
| Q60775 | Elf1 | ETS-related transcription factor Elf-1 | Mus musculus (Mouse) | PR |
| Q8VDK3 | Elf5 | ETS-related transcription factor Elf-5 | Mus musculus (Mouse) | SS |
| Q9JHC9 | Elf2 | ETS-related transcription factor Elf-2 | Mus musculus (Mouse) | PR |
| Q00422 | Gabpa | GA-binding protein alpha chain | Mus musculus (Mouse) | EV |
| Q9WTP3 | Spdef | SAM pointed domain-containing Ets transcription factor | Mus musculus (Mouse) | PR |
| P70459 | Erf | ETS domain-containing transcription factor ERF | Mus musculus (Mouse) | PR |
| P81270 | Erg | Transcriptional regulator ERG | Mus musculus (Mouse) | SS |
| P28322 | Etv4 | ETS translocation variant 4 | Mus musculus (Mouse) | SS |
| Q9CXC9 | Etv5 | ETS translocation variant 5 | Mus musculus (Mouse) | SS |
| P41164 | Etv1 | ETS translocation variant 1 | Mus musculus (Mouse) | SS |
| P41971 | Elk3 | ETS domain-containing protein Elk-3 | Mus musculus (Mouse) | EV |
| P41158 | Elk4 | ETS domain-containing protein Elk-4 | Mus musculus (Mouse) | PR |
| P41969 | Elk1 | ETS domain-containing protein Elk-1 | Mus musculus (Mouse) | PR |
| P15037 | Ets2 | Protein C-ets-2 | Mus musculus (Mouse) | SS |
| P27577 | Ets1 | Protein C-ets-1 | Mus musculus (Mouse) | EV |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAIALQPSDL | VFEFASNGMD | DIHQLEDPSV | FPAVIVEQVP | YPELVHLCSG | LDLDEVHNGI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IRDRTLCMTQ | DQILEGSILL | TDDDVSTSNN | VSSTEVLFNV | ATPSDVLDEK | QIFSSPEVLS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DSNSVQAINL | PNFLLSTPEP | DDLKKTSDAG | DQKEHSEEEK | VSREENLRKM | GKARKRNRKT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KNNRSTSPVT | DPSMPIRKKS | KDGKGSTIYL | WEFLLALLQD | RNTCPKYIKW | TQREKGIFKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VDSKAVSKLW | GKQKNKPDMN | YETMGRALRY | YYQRGILAKV | EGQRLVYQFK | EMPKDLVVID |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DEEESPETPE | DSSQASTSST | PSTSTIRRAS | SRVGTRASPE | DKDNPPWEKP | KVQHTGLQPS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ASLELGLSVD | EEVPTTSTML | ASPLQSQARL | TKTVSSSPAP | SNIHLGVAPV | GPGSTVTLQT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IPLTTVLTNG | PPASTTAPTQ | LVLQSVPQVS | TFKDTFTLQT | SFPLNTNLQE | NQVATQGAPL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ILSGLPQLLA | GANPQSNPAP | SQVIGAGSAG | PSSQPPGTVI | AAFIRTSSGT | SVPVVKEGPL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RSSSYVQGVV | TGAPVEGLLV | PEETLRELLR | DQGHLQPLPS | QVLSRGSHNL | SLVGNQTLSP |
| 610 | 620 | 630 | 640 | 650 | |
| PSHPTVGLTP | VAELELSSGS | GPLFVTEPSV | TRSPTQAPFS | PFNPTSLIKM | EPQDI |