Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z2H1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z2H1-F1 | Predicted | AlphaFoldDB |
No variants for Q9Z2H1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9Z2H1 | |||||
No associated diseases with Q9Z2H1
5 regional properties for Q9Z2H1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 456 - 580 | IPR000595 |
| domain | Ion transport domain | 144 - 383 | IPR005821 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 483 - 499 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 521 - 544 | IPR018488-2 |
| domain | Cyclic nucleotide-gated channel, C-terminal leucine zipper domain | 572 - 640 | IPR032406 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite terminus | A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| G-protein beta-subunit binding | Binding to a G-protein beta subunit. |
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| negative regulation of signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| regulation of G protein-coupled receptor signaling pathway | Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O46471 | RGS16 | Regulator of G-protein signaling 16 | Bos taurus (Bovine) | PR |
| Q3T0T8 | RGS5 | Regulator of G-protein signaling 5 | Bos taurus (Bovine) | PR |
| P49802 | RGS7 | Regulator of G-protein signaling 7 | Homo sapiens (Human) | PR |
| O15539 | RGS5 | Regulator of G-protein signaling 5 | Homo sapiens (Human) | PR |
| Q0QWG9 | Grid2ip | Delphilin | Mus musculus (Mouse) | PR |
| O54829 | Rgs7 | Regulator of G-protein signaling 7 | Mus musculus (Mouse) | PR |
| Q18312 | rgs-3 | Regulator of G-protein signaling rgs-3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERVVVSMQD | PDQGVKMRSQ | RLLITVIPHA | VAGRDLVEWL | VQKFCILEDE | ALHLGTLLAQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HGYIYPLRES | RDLTLRPDET | PYRFQTPYFW | TSTMWPAAEL | DYAIYLAKKN | IQKQGALVDY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EKEHYALLHK | KINHAWDLVL | MQAREQLRAA | KQRRKGDRMV | ISCQEQTYWL | VNKPPPGAPN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ILEQGPERGS | YNPSHMQMSS | DFYKCEIECF | RKALGRNRVK | SSACLEAYLK | FSSQHGPHDP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IMSGCLPSNP | WITDDVTYWA | MNAPNVAAPT | KLRVERWSFS | FRELLDDPVG | RAHFMDFLQK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EFSAENLSFW | EACEELRFGG | QAQVPTLVDS | VYQQFLAPGA | ARWINIDSRT | MERTLEGLRQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PHRYVLDAAQ | LHIYMLMKKD | SYPRFLKSDI | YKGLLEEAVI | PLETKRWPFP | FLRKPLHSSP |
| 430 | 440 | ||||
| SPALQSTPRE | PAATSSPEGA | DGE |