Q9Z268
PR
Gene name |
Rasal1 |
Protein name |
RasGAP-activating-like protein 1 |
Names |
RAS protein activator like 1, Ras GTPase-activating-like protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:19415 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z268
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z268-F1 | Predicted | AlphaFoldDB |
47 variants for Q9Z268
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388781826 | 2 | A>V | No | EVA | |
| rs3388783014 | 5 | G>S | No | EVA | |
| rs3396165698 | 17 | L>V | No | EVA | |
| rs3396265181 | 18 | P>L | No | EVA | |
| rs3395966074 | 19 | A>V | No | EVA | |
| rs3388782978 | 28 | P>S | No | EVA | |
| rs3388768952 | 32 | V>M | No | EVA | |
| rs3388772397 | 65 | F>L | No | EVA | |
| rs3388772373 | 77 | T>P | No | EVA | |
| rs3388758205 | 79 | G>E | No | EVA | |
| rs3388792875 | 96 | A>V | No | EVA | |
| rs864296688 | 110 | V>L | No | EVA | |
| rs3388788296 | 111 | D>E | No | EVA | |
| rs3388791375 | 127 | L>M | No | EVA | |
| rs3388792873 | 177 | F>S | No | EVA | |
| rs3388768989 | 185 | E>G | No | EVA | |
| rs3388787937 | 211 | F>V | No | EVA | |
| rs3395884266 | 211 | F>Y | No | EVA | |
| rs220113346 | 221 | T>I | No | EVA | |
| rs3388792825 | 225 | K>T | No | EVA | |
| rs3388758161 | 227 | P>S | No | EVA | |
| rs3388758175 | 248 | A>V | No | EVA | |
| rs3388781849 | 265 | Y>D | No | EVA | |
| rs263673468 | 334 | N>K | No | EVA | |
| rs3396097862 | 398 | K>R | No | EVA | |
| rs3388772414 | 430 | G>W | No | EVA | |
| rs3388788273 | 431 | R>H | No | EVA | |
| rs3388779291 | 446 | C>R | No | EVA | |
| rs3388791453 | 469 | F>L | No | EVA | |
| rs3388781072 | 508 | I>F | No | EVA | |
| rs3396119939 | 512 | G>A | No | EVA | |
| rs3396032576 | 514 | Q>L | No | EVA | |
| rs3395884306 | 516 | G>A | No | EVA | |
| rs3388788002 | 534 | I>T | No | EVA | |
| rs222958881 | 554 | G>R | No | EVA | |
| rs864281878 | 586 | F>L | No | EVA | |
| rs3388785182 | 598 | R>Q | No | EVA | |
| rs3388781103 | 622 | V>M | No | EVA | |
| rs32173509 | 626 | D>E | No | EVA | |
| rs3388783052 | 657 | V>M | No | EVA | |
| rs3388781862 | 658 | N>K | No | EVA | |
| rs3388788483 | 676 | G>C | No | EVA | |
| rs32173511 | 679 | V>A | No | EVA | |
| rs224651728 | 679 | V>I | No | EVA | |
| rs3388788218 | 719 | P>Q | No | EVA | |
| rs228767465 | 752 | T>P | No | EVA | |
| rs3388788416 | 767 | C>Y | No | EVA |
No associated diseases with Q9Z268
5 regional properties for Q9Z268
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | 593 - 872 | IPR000403 |
| domain | Phosphoinositide 3-kinase, accessory (PIK) domain | 293 - 535 | IPR001263 |
| domain | C2 phosphatidylinositol 3-kinase-type domain | 14 - 188 | IPR002420 |
| conserved_site | Phosphatidylinositol 3/4-kinase, conserved site | 623 - 637 | IPR018936-1 |
| conserved_site | Phosphatidylinositol 3/4-kinase, conserved site | 716 - 736 | IPR018936-2 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| metal ion binding | Binding to a metal ion. |
| phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cellular response to calcium ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| negative regulation of Ras protein signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction. |
| positive regulation of dendrite extension | Any process that activates or increases the frequency, rate or extent of dendrite extension. |
| regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKSGSLSIR | VVEGRALPAK | DVSGSSDPYC | LVKVDDQVVA | RTATIWRSLS | PFWGEEYTVH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LPLDFHHLAF | YVLDEDTVGH | DDIIGKISLS | KEAITADPRG | IDSWINLSRV | DPDAEVQGEV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CLDVKLLEDA | RGRCLRCHVR | QARDLAPRDI | SGTSDPFARV | FWGNHSLETS | TIKKTRFPHW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DEVLELREAP | GTTSPLRVEL | WDWDMVGKND | FLGMVEFTPQ | TLQQKPPNGW | FRLLPFPRAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DSGGSLGALR | LKVRLTEDRV | LPSQYYQPLM | ELLLESVQGP | AEEDTTSPLA | LLEELASGDC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RQDLATKLVK | LFLGRGLAGP | FLDYLTRREV | ARTNDPNTLF | RSNSLASKSM | EQFMKLVGMR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YLHEVLRPVI | SRVFEEKKYM | ELDPCKMDLN | RSRRISFKGT | PTEEQVRETS | LGLLTGYLGS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VVDAIVSSTG | RCPLALRLAF | KQLQRCVEKR | FSGIEHQDVK | YLAISGFLFL | RFFAPAILTP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KLFDLRDQHA | DPQTSRSLLL | LAKAVQSIGN | LGQQLGQGKE | QWLAPLHPFL | LQSISRVRDF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LDQLVDVDED | EEAGGPACAL | VQPSTIVREG | FLLKRKEEPG | GLATRFAFKK | RYFRLSGRDL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SYSKTPEWQV | HTSIPLSCIR | AVEHVDEGAF | QLPHVMQVVT | QDGAGTSHTT | YLQCKNVNDL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NQWLSALRKA | SAPNPGKLVA | CHPGAFRSGR | WTCCLQAERS | AAGCSRTHSA | ITLGDWSDPL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DPDAEAQAVY | RQLLLGRDQL | RLKLLEDSSL | DTEVDPGRDS | SATDGPCAEV | LAQQRAATTH |
| 790 | |||||
| LLQVLEDLEQ | AHEEFQKRG |