Q9Z1W9
PR
Gene name |
Stk39 (Spak) |
Protein name |
STE20/SPS1-related proline-alanine-rich protein kinase |
Names |
Ste-20-related kinase, Serine/threonine-protein kinase 39 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:53416 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
221-249 (Activation loop from InterPro)
Target domain |
75-349 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
3 structures for Q9Z1W9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5D9H | X-ray | 310 A | A/B | 63-403 | PDB |
| 5DBX | X-ray | 250 A | A/B | 63-390 | PDB |
| AF-Q9Z1W9-F1 | Predicted | AlphaFoldDB |
18 variants for Q9Z1W9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs234909396 | 14 | S>P | No | EVA | |
| rs3388555100 | 52 | A>S | No | EVA | |
| rs3388553155 | 87 | A>T | No | EVA | |
| rs3388557319 | 113 | T>M | No | EVA | |
| rs3388553448 | 118 | L>I | No | EVA | |
| rs3388548245 | 214 | E>D | No | EVA | |
| rs3388553458 | 228 | F>L | No | EVA | |
| rs3388555017 | 299 | Q>P | No | EVA | |
| rs3388557900 | 348 | F>L | No | EVA | |
| rs3388557857 | 375 | K>Q | No | EVA | |
| rs3388559826 | 383 | S>I | No | EVA | |
| rs3388559773 | 397 | S>C | No | EVA | |
| rs3388555775 | 401 | M>I | No | EVA | |
| rs3388558933 | 406 | E>K | No | EVA | |
| rs3388557858 | 449 | Q>L | No | EVA | |
| rs3388555695 | 463 | V>L | No | EVA | |
| rs3388551401 | 543 | D>E | No | EVA | |
| rs3388559836 | 552 | Q>R | No | EVA |
No associated diseases with Q9Z1W9
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cell body | The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extrinsic component of membrane | The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
29 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular chloride ion homeostasis | Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell. |
| cellular hypotonic response | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. |
| cellular response to chemokine | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus. |
| cellular response to potassium ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. |
| chemokine (C-X-C motif) ligand 12 signaling pathway | The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| ion homeostasis | Any process involved in the maintenance of an internal steady state of ions within an organism or cell. |
| macrophage activation | A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. |
| maintenance of lens transparency | A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina. |
| negative regulation of creatine transmembrane transporter activity | Any process that stops, prevents or reduces the frequency, rate or extent of creatine transmembrane transporter activity. |
| negative regulation of pancreatic juice secretion | Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. |
| negative regulation of potassium ion transmembrane transport | Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport. |
| negative regulation of potassium ion transmembrane transporter activity | Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity. |
| negative regulation of sodium ion transmembrane transporter activity | Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| peptidyl-threonine phosphorylation | The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
| positive regulation of ion transmembrane transporter activity | Any process that activates or increases the activity of an ion transporter. |
| positive regulation of p38MAPK cascade | Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. |
| positive regulation of potassium ion transport | Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| positive regulation of T cell chemotaxis | Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of blood pressure | Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. |
| regulation of inflammatory response | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. |
| response to aldosterone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus. |
| response to dietary excess | The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9C0K7 | STRADB | STE20-related kinase adapter protein beta | Homo sapiens (Human) | PR |
| Q7RTN6 | STRADA | STE20-related kinase adapter protein alpha | Homo sapiens (Human) | PR |
| O95747 | OXSR1 | Serine/threonine-protein kinase OSR1 | Homo sapiens (Human) | PR |
| Q9UEW8 | STK39 | STE20/SPS1-related proline-alanine-rich protein kinase | Homo sapiens (Human) | PR |
| Q8K4T3 | Stradb | STE20-related kinase adapter protein beta | Mus musculus (Mouse) | PR |
| Q3UUJ4 | Strada | STE20-related kinase adapter protein alpha | Mus musculus (Mouse) | PR |
| Q6P9R2 | Oxsr1 | Serine/threonine-protein kinase OSR1 | Mus musculus (Mouse) | PR |
| O54988 | Slk | STE20-like serine/threonine-protein kinase | Mus musculus (Mouse) | PR |
| O55098 | Stk10 | Serine/threonine-protein kinase 10 | Mus musculus (Mouse) | PR |
| P70218 | Map4k1 | Mitogen-activated protein kinase kinase kinase kinase 1 | Mus musculus (Mouse) | PR |
| Q61161 | Map4k2 | Mitogen-activated protein kinase kinase kinase kinase 2 | Mus musculus (Mouse) | SS |
| Q99JP0 | Map4k3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Mus musculus (Mouse) | SS |
| Q99JT2 | Stk26 | Serine/threonine-protein kinase 26 | Mus musculus (Mouse) | PR |
| Q99KH8 | Stk24 | Serine/threonine-protein kinase 24 | Mus musculus (Mouse) | PR |
| Q9Z2W1 | Stk25 | Serine/threonine-protein kinase 25 | Mus musculus (Mouse) | PR |
| Q8BPM2 | Map4k5 | Mitogen-activated protein kinase kinase kinase kinase 5 | Mus musculus (Mouse) | PR |
| Q863I2 | OXSR1 | Serine/threonine-protein kinase OSR1 | Sus scrofa (Pig) | PR |
| Q7TNZ6 | Strada | STE20-related kinase adapter protein alpha | Rattus norvegicus (Rat) | PR |
| O88506 | Stk39 | STE20/SPS1-related proline-alanine-rich protein kinase | Rattus norvegicus (Rat) | PR |
| O23304 | BLUS1 | Serine/threonine-protein kinase BLUS1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEPSGSPVH | VQLSQQAAPV | TAAAATAPAA | ATSAPAPAPA | PAPAASAAPA | PAPAAAPAPA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PAAQAVGWPI | CRDAYELQEV | IGSGATAVVQ | AALCKPRQER | VAIKRINLEK | CQTSMDELLK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EIQAMSQCSH | PNVVTYYTSF | VVKDELWLVM | KLLSGGSMLD | IIKYIVNRGE | HKNGVLEEAI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IATILKEVLE | GLDYLHRNGQ | IHRDLKAGNI | LLGEDGSVQI | ADFGVSAFLA | TGGDVTRNKV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RKTFVGTPCW | MAPEVMEQVR | GYDFKADMWS | FGITAIELAT | GAAPYHKYPP | MKVLMLTLQN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DPPTLETGVE | DKEMMKKYGK | SFRKLLSLCL | QKDPSKRPTA | AELLKCKFFQ | KAKNREYLIE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KLLTRTPDIA | QRAKKVRRVP | GSSGHLHKTE | DGDWEWSDDE | MDEKSEEGKA | AASQEKSRRV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KEENSEISVN | AGGIPEQIQS | LSVHDSQAQP | NANEDYREGP | CAVNLVLRLR | NSRKELNDIR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FEFTPGRDTA | DGVSQELFSA | GLVDGHDVVI | VAANLQKIVD | DPKALKTLTF | KLASGCDGSE |
| 550 | |||||
| IPDEVKLIGF | AQLSVS |