Q9Z1M4
Gene name |
Rps6kb2 |
Protein name |
Ribosomal protein S6 kinase beta-2 |
Names |
S6K-beta-2 , S6K2 , EC 2.7.11.1 , 70 kDa ribosomal protein S6 kinase 2 , p70 ribosomal S6 kinase beta , p70 S6 kinase beta , p70 S6K-beta , p70 S6KB |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:58988 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
67-328 (Protein kinase domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
211-234 (Activation loop from InterPro)
Target domain |
67-328 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
211-234 (Activation loop from InterPro)
Target domain |
67-328 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Lai KO et al. (2015) "Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis", The Journal of biological chemistry, 290, 14637-46
- Dennis PB et al. (1998) "Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation", The Journal of biological chemistry, 273, 14845-52
- Mahalingam M et al. (1996) "Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains", Molecular and cellular biology, 16, 405-13
Autoinhibited structure
Activated structure
1 structures for Q9Z1M4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z1M4-F1 | Predicted | AlphaFoldDB |
19 variants for Q9Z1M4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389495339 | 58 | G>D | No | EVA | |
| rs3389514840 | 60 | E>K | No | EVA | |
| rs3389509699 | 93 | G>E | No | EVA | |
| rs3389424866 | 113 | T>I | No | EVA | |
| rs3408885841 | 119 | E>V | No | EVA | |
| rs3389515858 | 174 | Y>* | No | EVA | |
| rs3389519574 | 218 | E>V | No | EVA | |
| rs3389525033 | 260 | Y>N | No | EVA | |
| rs3389424878 | 293 | T>S | No | EVA | |
| rs3408837500 | 299 | L>P | No | EVA | |
| rs3389515874 | 306 | R>P | No | EVA | |
| rs3389514799 | 335 | D>A | No | EVA | |
| rs3409079367 | 357 | Q>R | No | EVA | |
| rs3389507732 | 379 | S>N | No | EVA | |
| rs3389463977 | 421 | P>L | No | EVA | |
| rs3389481261 | 437 | P>H | No | EVA | |
| rs3389515855 | 465 | L>F | No | EVA | |
| rs3389515912 | 474 | K>M | No | EVA | |
| rs3389481258 | 476 | S>F | No | EVA |
No associated diseases with Q9Z1M4
5 regional properties for Q9Z1M4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 67 - 328 | IPR000719 |
| domain | AGC-kinase, C-terminal | 329 - 399 | IPR000961 |
| active_site | Serine/threonine-protein kinase, active site | 190 - 202 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 73 - 99 | IPR017441 |
| domain | Protein kinase, C-terminal | 349 - 389 | IPR017892 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| peptide binding | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
| ribosomal protein S6 kinase activity | Catalysis of the reaction |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of insulin receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of translational initiation | Any process that activates or increases the frequency, rate or extent of translational initiation. |
| TOR signaling | The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6TJY3 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Bos taurus (Bovine) | SS |
| P23443 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens (Human) | EV SS |
| Q9HBY8 | SGK2 | Serine/threonine-protein kinase Sgk2 | Homo sapiens (Human) | SS |
| O00141 | SGK1 | Serine/threonine-protein kinase Sgk1 | Homo sapiens (Human) | PR |
| Q96BR1 | SGK3 | Serine/threonine-protein kinase Sgk3 | Homo sapiens (Human) | SS |
| Q9UBS0 | RPS6KB2 | Ribosomal protein S6 kinase beta-2 | Homo sapiens (Human) | PR |
| Q8QZV4 | Stk32c | Serine/threonine-protein kinase 32C | Mus musculus (Mouse) | PR |
| Q9ERE3 | Sgk3 | Serine/threonine-protein kinase Sgk3 | Mus musculus (Mouse) | PR |
| Q9WUT3 | Rps6ka2 | Ribosomal protein S6 kinase alpha-2 | Mus musculus (Mouse) | SS |
| P18653 | Rps6ka1 | Ribosomal protein S6 kinase alpha-1 | Mus musculus (Mouse) | SS |
| P18654 | Rps6ka3 | Ribosomal protein S6 kinase alpha-3 | Mus musculus (Mouse) | SS |
| Q9Z2B9 | Rps6ka4 | Ribosomal protein S6 kinase alpha-4 | Mus musculus (Mouse) | SS |
| Q8C050 | Rps6ka5 | Ribosomal protein S6 kinase alpha-5 | Mus musculus (Mouse) | PR |
| Q8BSK8 | Rps6kb1 | Ribosomal protein S6 kinase beta-1 | Mus musculus (Mouse) | SS |
| P67999 | Rps6kb1 | Ribosomal protein S6 kinase beta-1 | Rattus norvegicus (Rat) | EV SS |
| Q5BKK4 | sgk1 | Serine/threonine-protein kinase Sgk1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAVFDLDLE | TEEGSEGEGE | PEFSPADVCP | LGELRAAGLE | TVGHYEEVEL | TESSVNLGPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RIGPHCFELL | SVLGKGGYGK | VFQVRKVQGT | NLGKIYAMKV | LRKAKIVCSA | KDTAHTRAER |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NILESVKHPF | IVELAYAFQT | GGKLYLILEC | LSGGELFTHL | EREGIFLEDT | ACFYLAEITL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ALGHLHSHGI | IYRDLKPENI | MLSSQGHIKL | TDFGLCKESI | HEGAITHTFC | GTIEYMAPEI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LVRTGHNRAV | DWWSLGALMY | DMLTGSPPFT | AENRKKTMDK | IIKGKLVLPP | YLTPDARDLA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KKFLKRNPTQ | RIGGGLGDAA | DVQRHPFFRH | INWDDLLARR | VDPPFRPSLQ | SEEDVSQFDA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RFTRQTPVDS | PDDTALSESA | NQAFLGFTYV | APSVLDSIKE | GFSFQPKLRS | PRRLNSSPRT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PISPLKFSPF | EGFRPSPGPP | EPMEPSLPPL | LPSPPSPPPT | STAPLPIRPP | SGTKKSKKGR |
| GRSGR |