Q9Z139
PR
Gene name |
Ror1 (Ntrkr1) |
Protein name |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 |
Names |
mROR1, Neurotrophic tyrosine kinase, receptor-related 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:26563 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
632-657 (Activation loop from InterPro)
Target domain |
473-746 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9Z139
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z139-F1 | Predicted | AlphaFoldDB |
40 variants for Q9Z139
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388683521 | 36 | V>I | No | EVA | |
| rs3388691636 | 53 | D>V | No | EVA | |
| rs28214987 | 55 | G>D | No | EVA | |
| rs28214986 | 69 | T>M | No | EVA | |
| rs3388697069 | 75 | A>T | No | EVA | |
| rs28214985 | 86 | P>S | No | EVA | |
| rs3388697077 | 99 | V>G | No | EVA | |
| rs3388693161 | 104 | R>I | No | EVA | |
| rs3388697547 | 106 | S>T | No | EVA | |
| rs3394663739 | 141 | S>T | No | EVA | |
| rs3388690579 | 197 | E>G | No | EVA | |
| rs3388685041 | 198 | I>K | No | EVA | |
| rs3388700340 | 201 | Q>L | No | EVA | |
| rs3388697853 | 211 | T>I | No | EVA | |
| rs3388690604 | 217 | D>G | No | EVA | |
| rs3388696669 | 218 | K>E | No | EVA | |
| rs3388697555 | 257 | N>S | No | EVA | |
| rs3388696662 | 258 | V>I | No | EVA | |
| rs3388693129 | 261 | Q>H | No | EVA | |
| rs3388697880 | 417 | A>T | No | EVA | |
| rs3388697856 | 432 | Q>P | No | EVA | |
| rs3388691668 | 457 | N>I | No | EVA | |
| rs3388696702 | 563 | F>S | No | EVA | |
| rs3388690633 | 567 | R>* | No | EVA | |
| rs3388700310 | 637 | S>T | No | EVA | |
| rs3394601655 | 658 | W>R | No | EVA | |
| rs3388691629 | 661 | P>L | No | EVA | |
| rs3388691716 | 668 | K>R | No | EVA | |
| rs3388697872 | 705 | V>G | No | EVA | |
| rs3388688055 | 750 | E>K | No | EVA | |
| rs3394443352 | 765 | N>K | No | EVA | |
| rs3394558658 | 765 | N>S | No | EVA | |
| rs3388691696 | 793 | S>R | No | EVA | |
| rs225199996 | 809 | A>G | No | EVA | |
| rs3394726192 | 809 | A>M | No | EVA | |
| rs3388675294 | 845 | I>V | No | EVA | |
| rs3394327461 | 868 | V>M | No | EVA | |
| rs3394726174 | 871 | L>W | No | EVA | |
| rs3388697528 | 872 | P>S | No | EVA | |
| rs3388701207 | 877 | N>K | No | EVA |
No associated diseases with Q9Z139
10 regional properties for Q9Z139
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Kringle | 310 - 393 | IPR000001 |
| domain | Protein kinase domain | 473 - 746 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 474 - 746 | IPR001245 |
| domain | Immunoglobulin subtype 2 | 70 - 138 | IPR003598 |
| domain | Immunoglobulin subtype | 64 - 149 | IPR003599 |
| domain | Immunoglobulin-like domain | 42 - 141 | IPR007110 |
| active_site | Tyrosine-protein kinase, active site | 611 - 623 | IPR008266 |
| domain | Immunoglobulin I-set | 61 - 143 | IPR013098 |
| conserved_site | Kringle, conserved site | 361 - 374 | IPR018056 |
| domain | Frizzled domain | 165 - 299 | IPR020067 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon terminus | Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
| stress fiber | A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
| Wnt receptor activity | Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| Wnt-protein binding | Binding to a Wnt-protein, a secreted growth factor involved in signaling. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| astrocyte development | The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. |
| inner ear development | The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure. |
| positive regulation of I-kappaB kinase/NF-kappaB signaling | Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. |
| positive regulation of kinase activity | Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| positive regulation of NF-kappaB transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
| positive regulation of phosphatidylinositol 3-kinase signaling | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. |
| sensory perception of sound | The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. |
78 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q91044 | NTRK3 | NT-3 growth factor receptor | Gallus gallus (Chicken) | SS |
| Q91987 | NTRK2 | BDNF/NT-3 growth factors receptor | Gallus gallus (Chicken) | SS |
| Q91009 | NTRK1 | High affinity nerve growth factor receptor | Gallus gallus (Chicken) | SS |
| Q8AXY6 | MUSK | Muscle, skeletal receptor tyrosine protein kinase | Gallus gallus (Chicken) | SS |
| Q5IS37 | NTRK3 | NT-3 growth factor receptor | Pan troglodytes (Chimpanzee) | SS |
| Q24488 | Ror | Tyrosine-protein kinase transmembrane receptor Ror | Drosophila melanogaster (Fruit fly) | SS |
| Q9V6K3 | Nrk | Tyrosine-protein kinase transmembrane receptor Ror2 | Drosophila melanogaster (Fruit fly) | SS |
| O15146 | MUSK | Muscle, skeletal receptor tyrosine-protein kinase | Homo sapiens (Human) | EV |
| P04629 | NTRK1 | High affinity nerve growth factor receptor | Homo sapiens (Human) | EV |
| Q16288 | NTRK3 | NT-3 growth factor receptor | Homo sapiens (Human) | SS |
| Q16620 | NTRK2 | BDNF/NT-3 growth factors receptor | Homo sapiens (Human) | EV |
| Q01974 | ROR2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Homo sapiens (Human) | EV |
| Q01973 | ROR1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Homo sapiens (Human) | PR |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P97793 | Alk | ALK tyrosine kinase receptor | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q62371 | Ddr2 | Discoidin domain-containing receptor 2 | Mus musculus (Mouse) | SS |
| Q03146 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| P70424 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Mus musculus (Mouse) | SS |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| Q01887 | Ryk | Tyrosine-protein kinase RYK | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P24786 | NTRK3 | NT-3 growth factor receptor | Sus scrofa (Pig) | SS |
| Q62838 | Musk | Muscle, skeletal receptor tyrosine protein kinase | Rattus norvegicus (Rat) | SS |
| P35739 | Ntrk1 | High affinity nerve growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q03351 | Ntrk3 | NT-3 growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q63604 | Ntrk2 | BDNF/NT-3 growth factors receptor | Rattus norvegicus (Rat) | SS |
| G5EGK5 | cam-1 | Tyrosine-protein kinase receptor cam-1 | Caenorhabditis elegans | SS |
| Q9SXB5 | At1g11303 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64783 | At1g61370 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64770 | At1g61490 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SYA0 | At1g61500 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81833 | SD11 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64778 | At1g61420 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64776 | At1g61440 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64780 | At1g61400 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SY95 | At1g61550 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64782 | SD129 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64774 | At1g61460 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SXB8 | At1g11330 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11330 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64793 | At1g67520 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64784 | At1g61360 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39203 | SD22 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHRPRRRGTR | PPPLALLAAL | LLAARGADAQ | ETELSVSAEL | VPTSSWNTSS | EIDKGSYLTL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DEPMNNITTS | LGQTAELHCK | VSGNPPPSIR | WFKNDAPVVQ | EPRRISFRAT | NYGSRLRIRN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDTTDTGYFQ | CVATNGKKVV | STTGVLFVKF | GPPPTASPGS | SDEYEEDGFC | QPYRGIACAR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FIGNRTVYME | SLHMQGEIEN | QITAAFTMIG | TSSHLSDKCS | QFAIPSLCHY | AFPYCDETSS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VPKPRDLCRD | ECEVLENVLC | QTEYIFARSN | PMILMRLKLP | NCEDLPQPES | PEAANCIRIG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IPMADPINKN | HKCYNSTGVD | YRGTVSVTKS | GRQCQPWNSQ | YPHTHSFTAL | RFPELNGGHS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YCRNPGNQKE | APWCFTLDEN | FKSDLCDIPA | CDSKDSKEKN | KMEILYILVP | SVAIPLAIAF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LFFFICVCRN | NQKSSSPPVQ | RQPKPVRGQN | VEMSMLNAYK | PKSKAKELPL | SAVRFMEELG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ECTFGKIYKG | HLYLPGMDHA | QLVAIKTLKD | YNNPQQWTEF | QQEASLMAEL | HHPNIVCLLG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AVTQEQPVCM | LFEYMNQGDL | HEFLIMRSPH | SDVGCSSDED | GTVKSSLDHG | DFLHIAIQIA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AGMEYLSSHF | FVHKDLAARN | ILIGEQLHVK | ISDLGLSREI | YSADYYRVQS | KSSLPIRWMP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PEAIMYGKFS | SDSDIWSFGV | VLWEIFSFGL | QPYYGFSNQE | VIEMVRKRQL | LPCSEDCPPR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MYSLMTECWN | EIPSRRPRFK | DIHVRLRSWE | GLSSHTSSTT | PSGGNATTQT | TSLSASPVSN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LSNPRFPNYM | FPSQGITPQG | QIAGFIGPAI | PQNQRFIPIN | GYPIPPGYAA | FPAAHYQPAG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PPRVIQHCPP | PKSRSPSSAS | GSTSTGHVAS | LPSSGSNQEA | NVPLLPHMSI | PNHPGGMGIT |
| 910 | 920 | 930 | |||
| VFGNKSQKPY | KIDSKQSSLL | GDSHIHGHTE | SMISAEV |