Q9YI66

PR
Gene name
tyro3 (dtk)
Protein name
Tyrosine-protein kinase receptor TYRO3
Names
Tyrosine-protein kinase DTK
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

407-510 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9YI66

Entry ID Method Resolution Chain Position Source
AF-Q9YI66-F1 Predicted AlphaFoldDB

No variants for Q9YI66

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9YI66

No associated diseases with Q9YI66

14 regional properties for Q9YI66

Type Name Position InterPro Accession
domain Protein kinase domain 497 - 768 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 497 - 765 IPR001245
domain Immunoglobulin subtype 2 33 - 102 IPR003598-1
domain Immunoglobulin subtype 2 129 - 188 IPR003598-2
domain Immunoglobulin subtype 27 - 114 IPR003599-1
domain Immunoglobulin subtype 123 - 200 IPR003599-2
domain Fibronectin type III 202 - 297 IPR003961-1
domain Fibronectin type III 299 - 403 IPR003961-2
domain Immunoglobulin-like domain 21 - 112 IPR007110-1
domain Immunoglobulin-like domain 117 - 192 IPR007110-2
active_site Tyrosine-protein kinase, active site 630 - 642 IPR008266
domain Immunoglobulin I-set 22 - 98 IPR013098
binding_site Protein kinase, ATP binding site 503 - 529 IPR017441
domain Tyrosine-protein kinase, catalytic domain 497 - 765 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

8 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
glomerular filtration The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
phagocytosis A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
podocyte development The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells.
positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q98949 TYRO3 Tyrosine-protein kinase receptor TYRO3 Gallus gallus (Chicken) PR
Q06418 TYRO3 Tyrosine-protein kinase receptor TYRO3 Homo sapiens (Human) SS
P55144 Tyro3 Tyrosine-protein kinase receptor TYRO3 Mus musculus (Mouse) SS
Q7X8C5 WAKL2 Wall-associated receptor kinase-like 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9S9M2 WAKL4 Wall-associated receptor kinase-like 4 Arabidopsis thaliana (Mouse-ear cress) PR
O73878 ephb4b Ephrin type-B receptor 4b Danio rerio (Zebrafish) (Brachydanio rerio) SS
O13147 ephb3 Ephrin type-B receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
F1QVU0 ltk Tyrosine-protein kinase receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
O13146 epha3 Ephrin type-A receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
E7F3X9 ddr1 receptor protein-tyrosine kinase Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5MD89 flt4 Vascular endothelial growth factor receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8AXB3 kdrl Vascular endothelial growth factor receptor kdr-like Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5GIT4 kdr Vascular endothelial growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90Z00 fgfr1a Fibroblast growth factor receptor 1-A Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90413 fgfr4 Fibroblast growth factor receptor 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
O73791 tek Angiopoietin-1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8JFR5 kita Mast/stem cell growth factor receptor kita Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9I8N6 csf1r Macrophage colony-stimulating factor 1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9DE49 pdgfra Platelet-derived growth factor receptor alpha Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8JG38 fgfr2 Fibroblast growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9I8X3 fgfr3 Fibroblast growth factor receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEVSLCILLF LLHFNEGIHG VRFTQKPFHQ TVTQGNMVRL GCAFEGLSEP EIIWMKDGEK
70 80 90 100 110 120
LFSTDQMYIT LDPYHWETFH SVKSVQQQDA GKYWCEVEYH GAIISSEPAW ITVAGVPHFG
130 140 150 160 170 180
VEPEDVAAFA GESFNLTCAA SGPPEPVEVL WWLGGEQNGD FTPSPSVLFV KGVNESIKFH
190 200 210 220 230 240
CEPRNARGIS VSRTGTVHIK ARPDSLGRTG HHVSDFNITL TWSPGFTGHS QLSTCTIQLS
250 260 270 280 290 300
RGPGEVKLPD VVVEVPPFQH VFEGLRSYSN YSVRVRCDNE VGSSPFSPWV DFHTPQAAPS
310 320 330 340 350 360
AAPKNFTFDL SEQQLTLSWA TLEQEELRGR LQEELRGRLL AYKLQWNQGG ESQDPLLFKE
370 380 390 400 410 420
NVAHLSGAGR FFNATFQVAA CTMAGCGPWS QPVLVMPVSA MQAQTQRGHM WVGLLFGLLV
430 440 450 460 470 480
ATMVGLLLIV LIRNRGKETQ FGSAFAAQGA EVPVSFTAAR SFNRQFPELP ESTLDSLGIN
490 500 510 520 530 540
SDLKAKLQDV LIFERLLTLG RMLGKGEFGS VREAFLKSEN NSGQKVAVKV LKTDINSSSD
550 560 570 580 590 600
IEQCLKEAAY MKDFHHPNVI QLIGVSLHRR AQQRLPIPMV ILPFMKHGDL HTFLLMSRLG
610 620 630 640 650 660
DEPFTVSQQI LIQFMLDIAR GMEYLSNKNI IHRDLAARNC MLNENMSVCV ADFGLSKKIY
670 680 690 700 710 720
SGDYYRQGSV SKLPVKWIAL ESLADNVYTT QSDVWAFGVT MWEIMTRGQT PYPGVENSEI
730 740 750 760 770 780
YEYLIKGERL KQPPDCPADI YEIMHSCWSP VPKCRPSFQH LIDQLELLWA KLNPAPVKEP
790 800 810 820 830 840
LLYVNLEEED GEQANSGTRS SEEPSWGVPW QCAGIEEDEK DWLMVSSGAA LAIGGDYRYI
850 860 870
IGPSVSAIDE ESRHSEDGLS EDIREEEEDV IINV