AiPD: Autoinhibited Protein Database

Q9Y6F1

Gene name	PARP3
Protein name	Protein mono-ADP-ribosyltransferase PARP3
Names	ADP-ribosyltransferase diphtheria toxin-like 3, ARTD3, DNA ADP-ribosyltransferase PARP3, IRT1, NAD(+) ADP-ribosyltransferase 3, ADPRT-3, Poly [ADP-ribose] polymerase 3, PARP-3, hPARP-3, Poly[ADP-ribose] synthase 3, pADPRT-3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10039
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-76 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

17 structures for Q9Y6F1

Entry ID	Method	Resolution	Chain	Position	Source
2EOC	NMR	-	A	41-157	PDB
3C49	X-ray	280 A	A	178-532	PDB
3C4H	X-ray	210 A	A	178-532	PDB
3CE0	X-ray	280 A	A	178-532	PDB
3FHB	X-ray	230 A	A	178-532	PDB
4GV0	X-ray	190 A	A	178-532	PDB
4GV2	X-ray	180 A	A	178-532	PDB
4GV4	X-ray	180 A	A	178-532	PDB
4L6Z	X-ray	200 A	A	178-532	PDB
4L70	X-ray	200 A	A	178-532	PDB
4L7L	X-ray	210 A	A	178-532	PDB
4L7N	X-ray	180 A	A	178-532	PDB
4L7O	X-ray	200 A	A	178-532	PDB
4L7P	X-ray	230 A	A	178-532	PDB
4L7R	X-ray	220 A	A	178-532	PDB
4L7U	X-ray	280 A	A	178-532	PDB
AF-Q9Y6F1-F1	Predicted				AlphaFoldDB

490 variants for Q9Y6F1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA74681261 rs866112543	2	A>D		No	ClinGen Ensembl
rs918761252 CA353042434	2	A>P		No	ClinGen TOPMed gnomAD
CA74681259 rs918761252	2	A>T		No	ClinGen TOPMed gnomAD
RCV000896799 rs61729070 CA2426629	5	P>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs61729070 CA2426630	5	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2426628 rs751167668	5	P>S		No	ClinGen ExAC gnomAD
rs745627499 CA2426631	7	P>S		No	ClinGen ExAC TOPMed gnomAD
rs756022423 CA2426632	8	W>*		No	ClinGen ExAC TOPMed gnomAD
rs1363493692 CA353042524	10	Q>L		No	ClinGen gnomAD
CA353042550 rs780025809	12	E>D		No	ClinGen ExAC gnomAD
CA353042557 rs1577655831	13	G>V		No	ClinGen Ensembl
rs768712096 CA2426635	14	P>S		No	ClinGen ExAC TOPMed gnomAD
rs778869919 CA2426638	15	E>V		No	ClinGen ExAC gnomAD
CA2426640 rs189015907	16	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1246056358 CA353042627	19	G>D		No	ClinGen gnomAD
CA2426641 rs773475379	19	G>S		No	ClinGen ExAC TOPMed gnomAD
CA2426643 rs559905723	20	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2426644 rs777130796	20	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs559905723 CA2426642	20	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1424103029 CA353042644	22	A>T		No	ClinGen TOPMed gnomAD
rs1368283028 CA353042653	23	G>E		No	ClinGen TOPMed
rs1043360310 CA353042658	24	R>K		No	ClinGen TOPMed gnomAD
CA74681376 rs1043360310	24	R>T		No	ClinGen TOPMed gnomAD
CA2426649 rs767255898	26	E>G		No	ClinGen ExAC gnomAD
rs1387637076 CA353042670	26	E>K		No	ClinGen TOPMed
CA353042679 rs1275794552	27	D>A		No	ClinGen gnomAD
CA2426650 rs750156231	27	D>H		No	ClinGen ExAC TOPMed gnomAD
rs1298521980 CA353042687	28	P>H		No	ClinGen TOPMed gnomAD
CA2426651 rs755967363	29	F>I		No	ClinGen ExAC gnomAD
CA353042695 rs1404408798	29	F>L		No	ClinGen TOPMed
CA2426652 rs779715407	30	R>C		No	ClinGen ExAC gnomAD
CA2426653 rs377163298	30	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs377163298 CA353042700	30	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2426655 rs754890031	32	T>I		No	ClinGen ExAC gnomAD
rs370350966 CA2426658	33	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA2426657 rs748207351	33	A>S		No	ClinGen ExAC TOPMed gnomAD
CA74681458 rs748207351	33	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2426662 rs1553715940 CA353042720	34	E>D		No	ClinGen Ensembl
rs777971460 CA353042715	34	E>K		No	ClinGen ExAC gnomAD
rs777971460 CA2426660	34	E>Q		No	ClinGen ExAC gnomAD
CA74681524 rs368760022	37	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA2426665 rs368760022	37	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA353042735 rs1156310266	37	K>R		No	ClinGen TOPMed gnomAD
CA74681536 rs896284708	38	A>T		No	ClinGen TOPMed gnomAD
rs1577656040 CA353042743	38	A>V		No	ClinGen Ensembl
CA2426666 rs371068434	40	P>L		No	ClinGen ESP ExAC gnomAD
CA353042751 rs1407550102	40	P>S		No	ClinGen gnomAD
CA2426668 rs77898224 RCV000972704	41	A>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2426669 rs77898224	41	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353042760 rs998111620	42	E>K		No	ClinGen TOPMed gnomAD
CA74681556 rs998111620	42	E>Q		No	ClinGen TOPMed gnomAD
rs1030523241 CA74681574	42	E>V		No	ClinGen TOPMed gnomAD
rs1227928596 CA353042773	43	K>N		No	ClinGen gnomAD
rs368341120 CA2426670	44	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA74681590 rs1007682490	44	R>H		No	ClinGen TOPMed gnomAD
CA353042775 rs1007682490	44	R>P		No	ClinGen TOPMed gnomAD
rs368341120 CA74681582	44	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1340942562 CA353042785	46	I>V		No	ClinGen TOPMed
CA2426672 rs750029311	47	R>C		No	ClinGen ExAC TOPMed gnomAD
CA2426673 rs781073336	47	R>H		No	ClinGen ExAC TOPMed gnomAD
rs781073336 CA74681617	47	R>L		No	ClinGen ExAC TOPMed gnomAD
rs375373643 CA2426675	48	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1179448538 CA353042838	51	T>I		No	ClinGen gnomAD
CA353042831 rs1482514759	51	T>P		No	ClinGen gnomAD
CA353042842 rs1472816252	52	C>R		No	ClinGen TOPMed gnomAD
CA2426677 rs778812042	52	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA74681628 rs919190481	56	S>N		No	ClinGen gnomAD
CA353042919 rs1187863259	58	P>R		No	ClinGen TOPMed
CA74681651 rs994226115	59	G>E		No	ClinGen TOPMed gnomAD
CA2426682 rs757453925	59	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2426684 rs746194544	61	Q>*		No	ClinGen ExAC gnomAD
CA2426685 rs367991633	61	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA74682011 rs933680407	63	Y>F		No	ClinGen Ensembl
rs1345270594 CA353043322	64	E>*		No	ClinGen gnomAD
rs1345270594 CA353043308	64	E>K		No	ClinGen gnomAD
rs751564378 CA2426698	68	C>R		No	ClinGen ExAC gnomAD
CA353043407 rs1275859385	68	C>Y		No	ClinGen gnomAD
CA353043443 rs1211152599	71	N>H		No	ClinGen gnomAD
rs746166733 CA2426701	72	Q>H		No	ClinGen ExAC gnomAD
rs781255408 CA2426700	72	Q>R		No	ClinGen ExAC gnomAD
CA353043524 rs1025059167	75	I>F		No	ClinGen TOPMed gnomAD
CA353043529 rs1471197112	75	I>T		No	ClinGen TOPMed
CA74682074 rs1025059167	75	I>V		No	ClinGen TOPMed gnomAD
CA2426703 rs756366078	76	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs780577794 CA2426705	78	N>S		No	ClinGen ExAC gnomAD
CA353043625 rs1559746986	79	N>S		No	ClinGen Ensembl
rs1255157273 CA353043650	80	N>S		No	ClinGen TOPMed
rs552254917 CA2426706	81	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs769313993 CA2426707	83	Y>C		No	ClinGen ExAC gnomAD
rs1468324474 CA353043711	83	Y>H		No	ClinGen TOPMed
rs910827312 CA353043756	85	I>M		No	ClinGen TOPMed gnomAD
CA2426708 rs775035411	87	L>P		No	ClinGen ExAC gnomAD
CA2426709 VAR_056643 rs34224216	91	S>N		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1303112420 CA353043870	92	N>K		No	ClinGen gnomAD
CA2426710 rs770544626	93	R>C		No	ClinGen ExAC TOPMed gnomAD
CA2426712 rs745485603	93	R>H		No	ClinGen ExAC TOPMed
rs745485603 CA2426713	93	R>L		No	ClinGen ExAC TOPMed
CA2426714 rs759244368	94	F>L		No	ClinGen ExAC
CA2426716 rs764966907	96	T>A		No	ClinGen ExAC gnomAD
rs1272668841 CA353043920	96	T>I		No	ClinGen gnomAD
CA2426715 rs764966907	96	T>S		No	ClinGen ExAC gnomAD
CA2426718 rs763997868	97	C>F		No	ClinGen ExAC gnomAD
CA353043952 rs1269394296	99	N>H		No	ClinGen gnomAD
CA2426719 rs751570746	100	R>C		No	ClinGen ExAC TOPMed gnomAD
VAR_054622 rs28547534 CA74682171	100	R>H		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA353043976 rs28547534	100	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353043984 rs1452507037	101	W>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353043977 rs1269869991	101	W>R		No	ClinGen gnomAD
rs1466029720 CA353043999	102	G>D		No	ClinGen TOPMed gnomAD
rs1322449143 CA353043994	102	G>S		No	ClinGen TOPMed
CA2426721 rs372767757	103	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2426722 rs372767757	103	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA74682189 rs1047814977	103	R>H		No	ClinGen TOPMed gnomAD
CA74682212 rs556624982	104	V>A		No	ClinGen gnomAD
rs756424008 CA2426723	104	V>M		No	ClinGen ExAC gnomAD
CA2426741 rs190579855	107	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353044107 rs190579855	107	V>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770324920 CA2426744	108	G>S		No	ClinGen ExAC TOPMed gnomAD
rs541784687 CA353044177	112	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1577657312 CA353044168	112	I>V		No	ClinGen Ensembl
CA353044237 rs1315438963	116	T>I		No	ClinGen gnomAD
CA353044265 rs1245767035	118	L>P		No	ClinGen gnomAD
rs1234254456 CA353044275	119	E>G		No	ClinGen TOPMed
rs1559747197	123	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353044331 rs1436997381	123	K>E		No	ClinGen TOPMed
CA74682339 rs943565070	125	F>L		No	ClinGen TOPMed gnomAD
CA2426748 rs754168916	125	F>S		No	ClinGen ExAC gnomAD
rs553698927 CA2426751	127	K>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1423151040 CA353044408	127	K>N		No	ClinGen gnomAD
CA2426752 rs753100599	129	F>L		No	ClinGen ExAC gnomAD
CA353044460 rs778185003	130	R>P		No	ClinGen ExAC TOPMed gnomAD
CA2426754 rs778185003	130	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM1046776 rs146036726 CA2426753	130	R>W	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA2426756 rs139794805	134	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353044552 rs1380583136	135	N>K		No	ClinGen gnomAD
rs1281474780 CA353044568	136	N>I		No	ClinGen TOPMed
rs768381965 CA2426759	137	W>C		No	ClinGen ExAC gnomAD
CA2426758 rs200132301	137	W>L		No	ClinGen ExAC TOPMed gnomAD
CA353044577 rs1346236394	137	W>R		No	ClinGen Ensembl
CA353044629 rs761611493	140	R>P		No	ClinGen ExAC TOPMed gnomAD
rs761611493 CA2426761	140	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2426760 rs201155006	140	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2426762 rs772010324	141	D>H		No	ClinGen ExAC gnomAD
CA2426764 rs760822264	142	H>R		No	ClinGen ExAC gnomAD
CA2426763 rs773069122	142	H>Y		No	ClinGen ExAC gnomAD
CA2426765 rs368155703	144	V>M		No	ClinGen ESP ExAC gnomAD
CA353044762 rs1201709393	145	S>C		No	ClinGen TOPMed gnomAD
TCGA novel	145	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2426769 rs765482748	146	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA2426767 rs200304190	146	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758739863 CA2426770	147	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1434515174 CA353044800	148	G>D		No	ClinGen gnomAD
rs1177399444 CA353044836	149	K>N		No	ClinGen TOPMed
CA2426775 rs142065339	153	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs755552511 CA2426773	153	I>N		No	ClinGen ExAC TOPMed gnomAD
COSM1538120 CA353044905 rs755552511	153	I>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1230843513 CA353044896	153	I>V		No	ClinGen TOPMed
rs556975187 CA2426776	154	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA2426777 rs778466941	155	V>I		No	ClinGen ExAC gnomAD
rs1391466373 CA353045005	159	D>N		No	ClinGen gnomAD
rs1436357016 CA353045033	160	E>G		No	ClinGen gnomAD
CA2426778 rs747949223	166	V>M		No	ClinGen ExAC gnomAD
rs767985528 CA2426811	168	V>L		No	ClinGen ExAC gnomAD
TCGA novel	169	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750983836 CA2426812	170	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1351198757 CA353045476	171	G>D		No	ClinGen gnomAD
rs764655833 CA2426814	172	P>T		No	ClinGen ExAC TOPMed gnomAD
rs752348794 CA2426816	173	V>L		No	ClinGen ExAC gnomAD
rs752348794 CA2426815	173	V>M		No	ClinGen ExAC gnomAD
rs1228725541 CA353045533	174	R>G		No	ClinGen gnomAD
CA2426817 rs777612680	175	T>A		No	ClinGen ExAC gnomAD
CA353045600 rs1559747444	177	T>I		No	ClinGen Ensembl
CA2426818 rs751381329	178	K>E		No	ClinGen ExAC TOPMed gnomAD
CA2426820 rs557304982	179	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs371449435 CA2426819 COSM3696176	179	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA353045693 rs1231731736	182	P>L		No	ClinGen gnomAD
rs1467826738 CA353045688	182	P>S		No	ClinGen TOPMed gnomAD
rs769855939 CA2426822	184	S>T		No	ClinGen ExAC TOPMed gnomAD
CA353045748 rs1385031033	185	L>R		No	ClinGen gnomAD
rs749485749 CA2426824	186	D>V		No	ClinGen ExAC gnomAD
CA74682826 rs868070734	188	A>D		No	ClinGen Ensembl
CA353045803 rs868070734	188	A>V		No	ClinGen Ensembl
rs774600519 CA2426826	190	Q>E		No	ClinGen ExAC gnomAD
rs1326913758 CA353045833	190	Q>R		No	ClinGen gnomAD
rs1255736845 CA353045843	191	K>E		No	ClinGen TOPMed
CA2426827 rs762148437	192	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1252295316 CA353045913	196	I>T		No	ClinGen TOPMed
CA353045908 rs1448706323	196	I>V		No	ClinGen gnomAD
rs936686024 CA74682859	198	S>G		No	ClinGen TOPMed
CA2426828 rs772488674	198	S>N		No	ClinGen ExAC gnomAD
CA353045996 rs1316539453	201	M>I		No	ClinGen TOPMed
CA2426833 rs762577128	206	M>I		No	ClinGen ExAC gnomAD
CA2426832 rs752121357	206	M>T		No	ClinGen ExAC gnomAD
CA2426831 rs200955531	206	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA353046069 rs1280086813	207	A>T		No	ClinGen gnomAD
CA353046099 rs1243002033	209	M>K		No	ClinGen TOPMed gnomAD
CA353046101 rs1243002033	209	M>T		No	ClinGen TOPMed gnomAD
CA2426835 rs751324062	209	M>V		No	ClinGen ExAC gnomAD
CA2426836 rs757047542	210	D>G		No	ClinGen ExAC gnomAD
CA74682876 rs867995336	211	L>M		No	ClinGen gnomAD
CA353046125 rs867995336	211	L>V		No	ClinGen gnomAD
rs773482557 CA2426848	213	V>M		No	ClinGen ExAC gnomAD
rs1421062246 CA353046214	215	K>E		No	ClinGen TOPMed
CA2426850 rs761144798	216	M>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	217	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2426851 rs771324673	217	P>T		No	ClinGen ExAC gnomAD
CA353046276 rs1559747597	219	G>E		No	ClinGen Ensembl
CA2426855 rs763703635	220	K>N		No	ClinGen ExAC TOPMed gnomAD
CA74683007 rs1051490353	222	S>N		No	ClinGen Ensembl
rs761582982 CA353046311 CA2426857	222	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1345737446 CA353046312	223	K>Q		No	ClinGen gnomAD
CA353046333 rs1280777501	224	Q>*		No	ClinGen gnomAD
rs1335922542 CA353046343	224	Q>H		No	ClinGen TOPMed
rs750153146 CA2426859	225	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs750153146 CA353046347	225	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA2426862 rs766208894	225	Q>H		No	ClinGen ExAC gnomAD
rs755984921 CA2426860	225	Q>L		No	ClinGen ExAC TOPMed
rs753879087 CA2426863	226	I>L		No	ClinGen ExAC TOPMed gnomAD
rs149821166 CA2426866	228	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs564192189 CA2426864	228	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2426868 rs200544465	231	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs200544465 CA2426869	231	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA353046447 rs1490568612	232	A>V		No	ClinGen gnomAD
rs199681575 CA2426872	235	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774027071 CA2426875	236	L>V		No	ClinGen ExAC TOPMed gnomAD
rs761446569 CA2426876	240	L>P		No	ClinGen ExAC TOPMed gnomAD
rs995264319 CA74683148	241	K>N		No	ClinGen Ensembl
CA353046553 rs1423643511	242	G>D		No	ClinGen TOPMed gnomAD
rs1025275811 CA74683150	242	G>S		No	ClinGen Ensembl
rs1423643511 CA353046556	242	G>V		No	ClinGen TOPMed gnomAD
rs375713100 CA2426878	244	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs760383165 CA2426879	244	T>M		No	ClinGen ExAC TOPMed gnomAD
rs760383165 CA2426880	244	T>R		No	ClinGen ExAC TOPMed gnomAD
rs758563354 CA2426885	251	E>K		No	ClinGen ExAC gnomAD
rs1329214709 CA353046713	254	S>P		No	ClinGen TOPMed
rs747264733 CA2426888	255	S>A		No	ClinGen ExAC gnomAD
CA2426889 rs371960861	256	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA353046747 rs1292800378	256	H>Y		No	ClinGen gnomAD
rs781639763 CA2426890	257	F>L		No	ClinGen ExAC gnomAD
CA353046824 rs1385834154	259	T>I		No	ClinGen TOPMed
CA353046812 rs1577658459	259	T>P		No	ClinGen Ensembl
CA2426892 rs369155045	260	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs778334099 CA2426894	261	I>M		No	ClinGen ExAC TOPMed gnomAD
CA353046851 rs1189488920	261	I>T		No	ClinGen TOPMed gnomAD
CA2426895 rs79176238	262	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA74683307 rs762278473	262	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1376425597 CA353046912	264	N>K		No	ClinGen TOPMed
CA2426898 rs770580933	266	G>S		No	ClinGen ExAC TOPMed gnomAD
CA353046954 rs1559747758	267	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
VAR_056644 rs323870 CA2426899	269	Q>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2426900 rs759376439	270	P>T		No	ClinGen ExAC gnomAD
COSM1424317 rs752698881 CA2426902	271	P>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs765147770 CA2426901	271	P>S		No	ClinGen ExAC gnomAD
CA2426904 rs764250768	274	N>S		No	ClinGen ExAC TOPMed gnomAD
rs751685874 CA2426905	276	P>S		No	ClinGen ExAC gnomAD
CA353047072 rs1479672420	277	E>K		No	ClinGen gnomAD
CA2426906 rs373954134	280	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA74683353 rs912447475	280	Q>R		No	ClinGen TOPMed gnomAD
CA353047097 rs1460756249	281	A>T		No	ClinGen gnomAD
CA353047112 rs1577658602	283	K>E		No	ClinGen Ensembl
rs1428714096 CA353047118	283	K>N		No	ClinGen gnomAD
rs780698146 CA2426910	284	D>Y		No	ClinGen ExAC gnomAD
rs1039524045 CA74683373	285	M>T		No	ClinGen TOPMed
CA353047141 rs1398246598	287	L>Q		No	ClinGen TOPMed
rs1246069994 CA353047155	288	V>L		No	ClinGen TOPMed
CA2426932 rs147106158	290	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370705194 CA353047176	291	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA353047174 rs1559747998	291	D>V		No	ClinGen Ensembl
rs780756887 CA353047182	292	I>M		No	ClinGen ExAC TOPMed gnomAD
CA74683629 rs912573993	292	I>S		No	ClinGen Ensembl
CA2426936 rs185963971	293	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2426937 rs185963971	293	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1236983775 CA353047198	295	A>D		No	ClinGen TOPMed
rs1292383963 CA353047208	297	A>T		No	ClinGen Ensembl
rs1410800673 CA353047221	299	Q>*		No	ClinGen gnomAD
rs367711623 CA74683657	302	S>C		No	ClinGen ESP
CA353047252 rs1368847177	304	Q>K		No	ClinGen TOPMed
rs1401706763 CA353047256	304	Q>R		No	ClinGen gnomAD
CA2426940 rs768613911	306	K>R		No	ClinGen ExAC gnomAD
CA2426941 rs774210062 COSM3696177	307	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA2426943 rs573971821	308	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773510395 CA2426944	309	E>G		No	ClinGen ExAC gnomAD
CA353047287 rs1298401829	309	E>Q		No	ClinGen TOPMed
CA2426945 rs760998871	310	E>K		No	ClinGen ExAC gnomAD
CA353047296 rs1418679590	310	E>V		No	ClinGen TOPMed
CA353047302 rs1577659038	311	V>G		No	ClinGen Ensembl
CA353047307 rs1267960887	312	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA74683682 rs74982310	313	H>D		No	ClinGen Ensembl
CA353047313 rs1577659057	313	H>P		No	ClinGen Ensembl
CA2426946 rs201530765	313	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA74683702 rs938457848	314	P>S		No	ClinGen Ensembl
CA353047331 rs1175221429	316	D>G		No	ClinGen TOPMed
CA2426947 rs754198499	317	R>*	Variant assessed as Somatic; 4.638e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA353047335 rs754198499	317	R>G		No	ClinGen ExAC TOPMed gnomAD
CA2426948 rs368640893	317	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA353047341 rs1189457117	318	D>V		No	ClinGen TOPMed
CA2426949 rs765770991	319	Y>C		No	ClinGen ExAC gnomAD
CA353047355 rs1487531619	320	Q>*		No	ClinGen TOPMed
CA2426950 rs753149799	320	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs780707738 CA2426952	321	L>F		No	ClinGen ExAC gnomAD
rs1217477619 CA353047372	323	K>E		No	ClinGen TOPMed
rs1470779320 CA353047401	327	Q>*		No	ClinGen gnomAD
CA353047409 rs1177092600	328	L>V		No	ClinGen gnomAD
CA2426954 rs562757156	329	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353047420 rs1213463635	330	D>G		No	ClinGen TOPMed
CA353047428 rs1164456330	331	S>C		No	ClinGen TOPMed gnomAD
rs1164456330 CA353047429	331	S>F		No	ClinGen TOPMed gnomAD
rs1045321907 CA74683724	331	S>P		No	ClinGen gnomAD
TCGA novel	332	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1559748129 CA353047430	332	G>R		No	ClinGen Ensembl
rs201870307 CA2426955	335	E>A		No	ClinGen 1000Genomes ExAC gnomAD
CA353047460 rs1330940981	336	Y>*		No	ClinGen gnomAD
rs749094633 CA2426956	336	Y>C		No	ClinGen ExAC gnomAD
CA353047482 rs760877290	338	V>L		No	ClinGen ExAC TOPMed gnomAD
rs760877290 CA2426962	338	V>M		No	ClinGen ExAC TOPMed gnomAD
rs199581414 CA2426963	340	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1408197306 CA353048092	340	Q>H		No	ClinGen gnomAD
rs1577659359 CA353048139	344	E>*		No	ClinGen Ensembl
CA353048186 rs1421632188	347	G>D		No	ClinGen TOPMed
rs1189745860 CA353048192	348	S>G		No	ClinGen TOPMed
CA353048203 rs1577659370	348	S>R		No	ClinGen Ensembl
rs761707566 CA2426964	349	N>D		No	ClinGen ExAC gnomAD
rs1335798903 CA353048216	349	N>K		No	ClinGen gnomAD
CA353048239 rs1258342395	351	R>K		No	ClinGen gnomAD
CA74683835 rs759386901	351	R>W		No	ClinGen Ensembl
rs1577659392 CA353048252	352	C>G		No	ClinGen Ensembl
CA353048248 rs1577659392	352	C>S		No	ClinGen Ensembl
CA2426965 rs759879310	352	C>Y		No	ClinGen ExAC gnomAD
CA2426967 rs753203252	353	P>R		No	ClinGen ExAC TOPMed gnomAD
rs765533970 CA2426966	353	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1442718289 CA353048306	357	H>D		No	ClinGen Ensembl
rs764627892 CA2426969 COSM1663321	357	H>Q	kidney [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA353048325 rs1459426393	358	I>T		No	ClinGen TOPMed
rs755676813 CA2426972	359	W>*		No	ClinGen ExAC gnomAD
CA2426971 rs755676813	359	W>C		No	ClinGen ExAC gnomAD
CA2426973 rs753433682	360	K>E		No	ClinGen ExAC gnomAD
CA2426974 rs754741701	361	V>A		No	ClinGen ExAC TOPMed gnomAD
CA2426975 rs778594031	362	N>K		No	ClinGen ExAC gnomAD
TCGA novel	363	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2426976 rs748058853	363	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1242913307 CA353048420	364	E>D		No	ClinGen gnomAD
CA353048416 rs1179854368	364	E>G		No	ClinGen TOPMed gnomAD
rs1168599112 CA353048440	366	E>*		No	ClinGen TOPMed gnomAD
rs772102477 CA2426977	366	E>V		No	ClinGen ExAC gnomAD
CA353048499 rs1577659754	367	E>K		No	ClinGen Ensembl
rs544556176 CA2426996	371	Q>*		No	ClinGen 1000Genomes ExAC gnomAD
rs746957285 CA2426997	374	S>A		No	ClinGen ExAC
rs770994413 CA2426998	375	K>Q		No	ClinGen ExAC gnomAD
TCGA novel	376	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781165090 CA2427000	378	N>S		No	ClinGen ExAC gnomAD
rs746004739 CA2427001	379	R>G		No	ClinGen ExAC gnomAD
rs111921408 COSM1260940 CA2427003	379	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA2427002 rs746004739	379	R>W		No	ClinGen ExAC gnomAD
CA74684163 rs1027753378	381	L>V		No	ClinGen TOPMed gnomAD
CA2427004 rs576950398	383	W>C		No	ClinGen 1000Genomes ExAC gnomAD
rs952223369 CA74684169	384	H>R		No	ClinGen TOPMed gnomAD
rs774778258 CA2427006	385	G>D		No	ClinGen ExAC gnomAD
CA2427005 RCV000949691 rs76343500	385	G>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1577659844 CA353048738	386	T>P		No	ClinGen Ensembl
rs370827208 CA2427007	388	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs373811748 CA2427008	389	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA353048811 rs1577659869	390	V>G		No	ClinGen Ensembl
CA2427010 rs376472160	390	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs569487633 CA2427011	392	A>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2427012 rs569487633	392	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2427014 rs764003034	393	A>T		No	ClinGen ExAC TOPMed gnomAD
rs751503675 CA2427015	394	I>V		No	ClinGen ExAC gnomAD
CA2427016 rs199520803	395	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	395	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	396	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781243530 CA2427017	396	T>S		No	ClinGen ExAC gnomAD
rs1259916749 CA353048888	398	G>W		No	ClinGen TOPMed
CA2427018 rs201317730	400	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1303676002 CA2427019	400	R>H		No	ClinGen TOPMed
CA353048935 rs1481625477	401	I>N		No	ClinGen gnomAD
CA2427021 rs199671052	401	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA353048940 rs374472117	402	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs374472117 CA2427022	402	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1249729572 CA353048967	403	P>S		No	ClinGen gnomAD
CA353048975 rs1456321786	404	H>N		No	ClinGen gnomAD
TCGA novel	405	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA74684230 rs868804586	406	G>S		No	ClinGen Ensembl
rs749523867 CA2427023	407	G>W		No	ClinGen ExAC gnomAD
rs368862832 CA2427024 COSM1424319	408	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs774725267 CA2427025	408	R>H		No	ClinGen ExAC TOPMed gnomAD
CA2427027 rs774725267	408	R>L		No	ClinGen ExAC TOPMed gnomAD
rs774725267 CA2427026	408	R>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	409	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353049066 rs1422338506	409	V>I		No	ClinGen TOPMed
rs371906755 CA2427029	412	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs371906755 CA353049148	412	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1461989223 CA353049147	412	G>S		No	ClinGen gnomAD
rs775235337 CA2427031	414	Y>H		No	ClinGen ExAC gnomAD
CA2427033 rs531222167	418	E>G		No	ClinGen 1000Genomes ExAC gnomAD
rs751381242 CA2427034	419	N>D		No	ClinGen ExAC gnomAD
rs1310765927 CA353049350	420	S>N		No	ClinGen gnomAD
CA2427035 rs757135609	421	K>R		No	ClinGen ExAC gnomAD
CA2427036 rs767354956	422	S>L		No	ClinGen ExAC gnomAD
CA353049392 rs1228232535	422	S>T		No	ClinGen gnomAD
rs187375113 CA74684289	424	G>R		No	ClinGen 1000Genomes
rs1343349194 CA353049762	427	I>T		No	ClinGen TOPMed
CA353049750 rs1429845114	427	I>V		No	ClinGen TOPMed
rs750960039 CA353049773	428	G>D		No	ClinGen Ensembl
CA74685079 rs750960039	428	G>V		No	ClinGen Ensembl
CA2427055 CA353049802 rs368727238	429	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs767354688 CA2427053	429	M>L		No	ClinGen ExAC TOPMed gnomAD
CA2427054 rs767354688	429	M>V		No	ClinGen ExAC TOPMed gnomAD
CA353049810 rs1430033459	430	K>T		No	ClinGen TOPMed
CA353049826 rs1202311231	431	C>F		No	ClinGen TOPMed gnomAD
CA353049820 rs1175830831	431	C>R		No	ClinGen TOPMed
rs1202311231 CA353049825	431	C>S		No	ClinGen TOPMed gnomAD
CA353049822 rs1202311231	431	C>Y		No	ClinGen TOPMed gnomAD
rs766341004 CA2427056	432	G>V		No	ClinGen ExAC gnomAD
CA353049858 rs1187468953	433	A>D		No	ClinGen TOPMed
rs1559749010 CA353049855	433	A>T		No	ClinGen Ensembl
CA353049872 rs1485779348	434	H>R		No	ClinGen TOPMed
rs374483120 CA2427058	435	H>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1221157761 CA353049929	437	G>A		No	ClinGen TOPMed
CA2427061 rs752978578	437	G>S		No	ClinGen ExAC TOPMed gnomAD
CA74685086 rs1057400584	439	M>V		No	ClinGen TOPMed gnomAD
rs1295919099 CA353050031	443	E>V		No	ClinGen TOPMed
TCGA novel	449	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353050133 rs1406837294	450	H>D		No	ClinGen gnomAD
CA353050140 rs1303628737	450	H>Q		No	ClinGen TOPMed gnomAD
rs778232806 CA2427063	451	H>P		No	ClinGen ExAC TOPMed gnomAD
rs199676447 CA2427064	454	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199676447 CA2427065	454	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1336091151 CA353050197	456	N>H		No	ClinGen TOPMed
TCGA novel	458	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2427067 rs748807218	458	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1215450198 CA353050226	458	S>T		No	ClinGen gnomAD
rs768290433 CA2427068	459	L>*		No	ClinGen ExAC gnomAD
rs1171456408 CA353050259	461	S>N		No	ClinGen TOPMed
rs773813635 CA2427069	461	S>R		No	ClinGen ExAC gnomAD
rs1428258902 CA353050267	462	P>A		No	ClinGen TOPMed
rs369716461 CA2427070	462	P>L		No	ClinGen ESP ExAC gnomAD
TCGA novel	462	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2427071 rs771721568	465	G>S		No	ClinGen ExAC gnomAD
CA74685131 rs370384763	465	G>V		No	ClinGen Ensembl
CA2427073 rs760510733	467	D>N		No	ClinGen ExAC TOPMed gnomAD
CA2427074 rs760510733	467	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs532572190 CA2427075	468	S>G		No	ClinGen 1000Genomes ExAC gnomAD
CA74685156 rs1015387529	468	S>N		No	ClinGen TOPMed
CA353050342 rs1426682896	469	V>F		No	ClinGen gnomAD
rs373129708 CA2427076	470	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA2427078 rs377219878	471	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2427079 rs201544821	472	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2427080 rs201544821	472	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2427081 rs200954849	472	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353050364 rs1381945841	473	G>V		No	ClinGen TOPMed
CA2427082 rs376234079	476	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1246202610 CA353050388	477	P>S		No	ClinGen gnomAD
CA2427099 rs751839575	479	P>L		No	ClinGen ExAC TOPMed gnomAD
rs751839575 CA2427098	479	P>R		No	ClinGen ExAC TOPMed gnomAD
CA2427101 rs750916489	480	T>N		No	ClinGen ExAC gnomAD
CA2427102 rs78218556	481	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2427103 rs780471800	485	L>V		No	ClinGen ExAC gnomAD
CA353050935 rs1577661823	486	E>Q		No	ClinGen Ensembl
rs1424371805 CA353050975	488	D>G		No	ClinGen gnomAD
rs757910277 CA2427105	492	V>A		No	ClinGen ExAC gnomAD
rs747679406 CA2427104	492	V>M		No	ClinGen ExAC gnomAD
rs374239491 CA2427107 COSM1650160	493	V>M	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
COSM1424327 rs1333166723 CA353051067	495	P>L	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA353051065 rs1333166723	495	P>R		No	ClinGen TOPMed gnomAD
CA2427108 rs770674176	497	G>A		No	ClinGen ExAC TOPMed gnomAD
CA353051091 rs770674176	497	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1432337372 CA353051104	498	Q>R		No	ClinGen gnomAD
CA353051117 rs1270303859	499	P>L		No	ClinGen gnomAD
CA2427109 rs201864296	501	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA353051152 rs1216265477	502	C>Y		No	ClinGen gnomAD
rs1256644326 CA353051172	503	P>L		No	ClinGen TOPMed gnomAD
rs1221792345 CA353051164	503	P>S		No	ClinGen Ensembl
CA2427111 rs368229941	504	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA353051204 rs1278234582	506	S>G		No	ClinGen gnomAD
CA74685566 rs992986134	509	T>I		No	ClinGen TOPMed
CA2427114 rs371768759	510	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2427113 rs371768759	510	F>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	514	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762153689 CA2427116	514	E>K		No	ClinGen ExAC TOPMed gnomAD
rs767887974 CA2427117	515	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA353051337 rs1577661941	515	Y>H		No	ClinGen Ensembl
rs767887974 CA353051340	515	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA2427119 rs756490602	516	L>F		No	ClinGen ExAC gnomAD
CA353051408 rs1451238748	520	E>K		No	ClinGen TOPMed
CA2427121 rs766904544	524	R>C		No	ClinGen ExAC TOPMed gnomAD
CA2427122 rs199619306	524	R>H		No	ClinGen ExAC TOPMed gnomAD
rs201923901 CA2427124	526	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs746563726 CA2427125	526	R>H		No	ClinGen ExAC TOPMed gnomAD
rs201923901 CA353051488	526	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1577661984 CA353051561	531	V>G		No	ClinGen Ensembl

No associated diseases with Q9Y6F1

3 regional properties for Q9Y6F1

Type	Name	Position	InterPro Accession
domain	Poly(ADP-ribose) polymerase, regulatory domain	182 - 319	IPR004102
domain	WGR domain	59 - 150	IPR008893
domain	Poly(ADP-ribose) polymerase, catalytic domain	313 - 533	IPR012317

Functions

		Description
EC Number
Subcellular Localization	Nucleus Chromosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole	Almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected (PubMed:16924674) In response to DNA damage, localizes to sites of double-strand break (PubMed:21270334, PubMed:28447610) Also localizes to single-strand breaks (PubMed:27530147) Preferentially localized to the daughter centriole (PubMed:10329013)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
centriole	A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intercellular bridge	A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
site of double-strand break	A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

7 GO annotations of molecular function

Name	Definition
catalytic activity	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
NAD DNA ADP-ribosyltransferase activity	Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA.
NAD+ ADP-ribosyltransferase activity	Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
NAD+- protein-aspartate ADP-ribosyltransferase activity	Catalysis of the reaction: L-aspartyl- + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-
NAD+- protein-lysine ADP-ribosyltransferase activity	Catalysis of the reaction: L-lysyl- + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-
NAD+-protein ADP-ribosyltransferase activity	Catalysis of the reaction: amino acyl- + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-
NAD+-protein-glutamate ADP-ribosyltransferase activity	Catalysis of the reaction: L-glutamyl- + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-

14 GO annotations of biological process

Name	Definition
DNA ADP-ribosylation	The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA.
DNA repair	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
double-strand break repair	The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
negative regulation of isotype switching	Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.
negative regulation of telomerase RNA reverse transcriptase activity	Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA reverse transcriptase activity.
positive regulation of DNA ligation	Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.
positive regulation of double-strand break repair via nonhomologous end joining	Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
protein ADP-ribosylation	The transfer, from NAD, of ADP-ribose to protein amino acids.
protein auto-ADP-ribosylation	The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.
protein localization to site of double-strand break	Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred.
protein mono-ADP-ribosylation	The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids.
protein poly-ADP-ribosylation	The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain.
regulation of mitotic spindle organization	Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
telomere maintenance	Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

14 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P18493	PARP1	Poly [ADP-ribose] polymerase 1	Bos taurus (Bovine)	SS
P26446	PARP1	Poly [ADP-ribose] polymerase 1	Gallus gallus (Chicken)	SS
P35875	Parp	Poly [ADP-ribose] polymerase	Drosophila melanogaster (Fruit fly)	SS
P09874	PARP1	Poly [ADP-ribose] polymerase 1	Homo sapiens (Human)	SS
Q9UGN5	PARP2	Poly [ADP-ribose] polymerase 2	Homo sapiens (Human)	EV
O50017	PARP2	Poly [ADP-ribose] polymerase 2	Zea mays (Maize)	SS
P11103	Parp1	Poly [ADP-ribose] polymerase 1	Mus musculus (Mouse)	SS
O88554	Parp2	Poly [ADP-ribose] polymerase 2	Mus musculus (Mouse)	SS
P27008	Parp1	Poly [ADP-ribose] polymerase 1	Rattus norvegicus (Rat)	SS
Q0JMY1	PARP2-B	Poly [ADP-ribose] polymerase 2-B	Oryza sativa subsp. japonica (Rice)	SS
Q5Z8Q9	PARP2-A	Poly [ADP-ribose] polymerase 2-A	Oryza sativa subsp. japonica (Rice)	SS
Q11207	PARP2	Poly [ADP-ribose] polymerase 2	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9ZP54	PARP1	Poly [ADP-ribose] polymerase 1	Arabidopsis thaliana (Mouse-ear cress)	SS
Q5RHR0	parp1	Poly [ADP-ribose] polymerase 1	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MAPKPKPWVQ	TEGPEKKKGR	QAGREEDPFR	STAEALKAIP	AEKRIIRVDP	TCPLSSNPGT
70	80	90	100	110	120
QVYEDYNCTL	NQTNIENNNN	KFYIIQLLQD	SNRFFTCWNR	WGRVGEVGQS	KINHFTRLED
130	140	150	160	170	180
AKKDFEKKFR	EKTKNNWAER	DHFVSHPGKY	TLIEVQAEDE	AQEAVVKVDR	GPVRTVTKRV
190	200	210	220	230	240
QPCSLDPATQ	KLITNIFSKE	MFKNTMALMD	LDVKKMPLGK	LSKQQIARGF	EALEALEEAL
250	260	270	280	290	300
KGPTDGGQSL	EELSSHFYTV	IPHNFGHSQP	PPINSPELLQ	AKKDMLLVLA	DIELAQALQA
310	320	330	340	350	360
VSEQEKTVEE	VPHPLDRDYQ	LLKCQLQLLD	SGAPEYKVIQ	TYLEQTGSNH	RCPTLQHIWK
370	380	390	400	410	420
VNQEGEEDRF	QAHSKLGNRK	LLWHGTNMAV	VAAILTSGLR	IMPHSGGRVG	KGIYFASENS
430	440	450	460	470	480
KSAGYVIGMK	CGAHHVGYMF	LGEVALGREH	HINTDNPSLK	SPPPGFDSVI	ARGHTEPDPT
490	500	510	520	530
QDTELELDGQ	QVVVPQGQPV	PCPEFSSSTF	SQSEYLIYQE	SQCRLRYLLE	VHL