AiPD: Autoinhibited Protein Database

Q9Y6E0

Gene name	STK24 (MST3, STK3)
Protein name	Serine/threonine-protein kinase 24
Names	Mammalian STE20-like protein kinase 3, MST-3, STE20-like kinase MST3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8428
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-61 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

173-196 (Activation loop from InterPro)

Target domain	36-286 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

41 structures for Q9Y6E0

Entry ID	Method	Resolution	Chain	Position	Source
3A7F	X-ray	155 A	A	27-315	PDB
3A7G	X-ray	200 A	A/B	27-315	PDB
3A7H	X-ray	196 A	A/B	27-315	PDB
3A7I	X-ray	145 A	A	27-315	PDB
3A7J	X-ray	150 A	A	27-315	PDB
3CKW	X-ray	196 A	A	31-323	PDB
3CKX	X-ray	270 A	A	31-323	PDB
3ZHP	X-ray	290 A	C/D	31-301	PDB
4O27	X-ray	319 A	B	30-309	PDB
4QML	X-ray	188 A	A	24-315	PDB
4QMM	X-ray	185 A	A	24-315	PDB
4QMN	X-ray	209 A	A	27-315	PDB
4QMO	X-ray	190 A	A	24-315	PDB
4QMP	X-ray	200 A	A	24-315	PDB
4QMQ	X-ray	177 A	A	24-315	PDB
4QMS	X-ray	188 A	A	24-315	PDB
4QMT	X-ray	150 A	A	24-315	PDB
4QMU	X-ray	155 A	A	24-315	PDB
4QMV	X-ray	240 A	A	24-315	PDB
4QMW	X-ray	160 A	A	24-315	PDB
4QMX	X-ray	188 A	A	24-315	PDB
4QMY	X-ray	188 A	A	24-315	PDB
4QMZ	X-ray	188 A	A	24-315	PDB
4QNA	X-ray	185 A	A	27-315	PDB
4QO9	X-ray	220 A	A/B	24-315	PDB
4U8Z	X-ray	163 A	A	24-310	PDB
4W8D	X-ray	177 A	A	24-310	PDB
4W8E	X-ray	179 A	A	24-311	PDB
7B30	X-ray	210 A	A	4-301	PDB
7B31	X-ray	180 A	A	4-301	PDB
7B32	X-ray	175 A	A	4-301	PDB
7B33	X-ray	190 A	A	4-301	PDB
7B34	X-ray	210 A	A	4-301	PDB
7B35	X-ray	240 A	A/B	4-301	PDB
8BZI	X-ray	172 A	A	4-301	PDB
8BZJ	X-ray	252 A	A/B	4-301	PDB
8QLQ	X-ray	164 A	A	4-301	PDB
8QLR	X-ray	185 A	A/B	4-301	PDB
8QLS	X-ray	161 A	A	4-301	PDB
8QLT	X-ray	147 A	A	4-301	PDB
AF-Q9Y6E0-F1	Predicted				AlphaFoldDB

258 variants for Q9Y6E0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA255286368 rs377710984	2	D>N		No	ClinGen ESP
rs1430960692 CA388578761	4	R>G		No	ClinGen gnomAD
rs1555308608 CA388578751	5	A>V		No	ClinGen Ensembl
rs765832622 CA388578741	6	Q>H		No	ClinGen ExAC gnomAD
CA388578724 rs1252937951	9	G>R		No	ClinGen gnomAD
CA388578713 rs199704221	11	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7027600 rs199704221	11	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7027599 rs767224704	11	A>V		No	ClinGen ExAC gnomAD
CA388578682 rs1325820347	15	R>S		No	ClinGen gnomAD
rs1407881061 CA388578660	19	L>V		No	ClinGen gnomAD
rs200734397 CA7027595	20	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1444111813 CA388578649	21	H>Y		No	ClinGen TOPMed gnomAD
CA388578638 rs1594636724	22	P>L		No	ClinGen Ensembl
CA388578641 rs1357065848	22	P>S		No	ClinGen gnomAD
rs1333157923 CA388578631	24	G>R		No	ClinGen gnomAD
CA7027593 rs775447860	26	T>M		No	ClinGen ExAC gnomAD
CA388578588 rs1362092187	29	K>Q		No	ClinGen gnomAD
rs138709503 CA7027566	30	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA388578558 rs1566382040	33	E>A		No	ClinGen Ensembl
rs147174875 CA7027565	35	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA7027564 rs749765531	37	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1566382016 CA388578530	37	T>S		No	ClinGen Ensembl
CA388578519 rs1388533028	39	L>V		No	ClinGen TOPMed gnomAD
CA388578488 rs1287481247	43	G>E		No	ClinGen TOPMed
CA7027563 rs780709997	44	K>N		No	ClinGen ExAC gnomAD
rs1384618269 CA388578475	45	G>D		No	ClinGen TOPMed
CA7027562 rs756705949	50	V>M		No	ClinGen ExAC gnomAD
TCGA novel	51	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388578416 rs1594634169	54	I>V		No	ClinGen Ensembl
rs777417489 CA7027560	56	N>D		No	ClinGen ExAC TOPMed gnomAD
CA7027559 rs757979383	56	N>S		No	ClinGen ExAC gnomAD
CA388578401 rs777417489	56	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs147189846 CA7027556	57	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA7027558 rs753081866	57	R>W		No	ClinGen ExAC TOPMed gnomAD
CA388578366 rs1282305524	61	V>G		No	ClinGen TOPMed
rs1317133404 CA388578352	64	I>V		No	ClinGen TOPMed
CA388578330 rs1361391433	67	I>V		No	ClinGen gnomAD
rs753782555 CA7027555	68	D>H		No	ClinGen ExAC gnomAD
CA7027551 rs773422324	85	V>L		No	ClinGen ExAC gnomAD
rs113816588 CA255285648	87	S>G		No	ClinGen Ensembl
TCGA novel	96	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388578121 rs1349618771	96	K>R		No	ClinGen TOPMed
rs1462644419 CA388578097	99	G>V		No	ClinGen gnomAD
rs533468847 CA255285639	101	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs533468847 CA7027547	101	Y>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA388578082 rs1270923974	102	L>M		No	ClinGen TOPMed
CA7027508 rs754673991	104	D>V		No	ClinGen ExAC gnomAD
CA7027507 rs749153621	111	M>T		No	ClinGen ExAC gnomAD
rs1386340650 CA388577973	115	G>C		No	ClinGen gnomAD
rs756164380 CA7027505	118	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA388577951 rs367740523	119	A>P		No	ClinGen ESP TOPMed
rs367740523 COSM199080 CA255267892	119	A>T	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP NCI-TCGA TOPMed
CA388602550 rs1226403908	125	P>T		No	ClinGen gnomAD
CA7027477 rs758658760	129	D>G		No	ClinGen ExAC gnomAD
CA7027476 rs752874860	130	E>G		No	ClinGen ExAC gnomAD
rs1404076548 CA388602506	131	T>I		No	ClinGen TOPMed gnomAD
rs748384716 CA255311009	132	Q>*		No	ClinGen Ensembl
CA7027474 rs759755166	132	Q>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs200051143 CA255311007	132	Q>R		No	ClinGen 1000Genomes
rs187296189 CA388602494	133	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766854170 CA388602490	134	A>D		No	ClinGen ExAC gnomAD
CA7027472 rs766854170	134	A>G		No	ClinGen ExAC gnomAD
rs761222508 CA7027471	138	R>G		No	ClinGen ExAC gnomAD
rs774049427 CA7027470	138	R>K		No	ClinGen ExAC TOPMed gnomAD
rs781173575 CA255310958	144	L>F		No	ClinGen Ensembl
CA7027467 rs775223138	146	Y>H		No	ClinGen ExAC gnomAD
TCGA novel	148	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769632212 CA7027466	149	S>L		No	ClinGen ExAC TOPMed gnomAD
rs769632212 CA388602391	149	S>W		No	ClinGen ExAC TOPMed gnomAD
rs1343019624 CA388602362	153	I>T		No	ClinGen gnomAD
CA388602351 rs1282764405	155	R>G		No	ClinGen gnomAD
rs756445268 CA7027431	159	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1594588859 CA388602300	160	A>G		No	ClinGen Ensembl
rs768202626 CA7027429	161	N>S		No	ClinGen ExAC gnomAD
CA255310588 rs999053866	162	V>F		No	ClinGen TOPMed
TCGA novel	169	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	169	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1380116652 CA388602231	171	K>T		No	ClinGen gnomAD
rs1313996531 CA388602226	172	L>M		No	ClinGen gnomAD
rs1452699686 CA388602216	173	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA7027423 rs766098532	177	V>M		No	ClinGen ExAC gnomAD
rs1469824644 CA388602161	182	T>S		No	ClinGen TOPMed
CA255310547 rs1030365872	192	V>M		No	ClinGen TOPMed
CA388602075 rs1474493473	194	T>I		No	ClinGen TOPMed
TCGA novel	201	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA255310543 rs998156740 COSM949156	201	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs772979932 CA7027421	204	K>E		No	ClinGen ExAC gnomAD
CA388602001 rs1401687070	205	Q>*		No	ClinGen TOPMed
rs1566355038 CA388601992	206	S>L		No	ClinGen Ensembl
rs748047643 CA7027419	207	A>T		No	ClinGen ExAC TOPMed gnomAD
rs774330452 CA7027418	208	Y>C		No	ClinGen ExAC gnomAD
CA7027417 rs200214942	210	S>L		No	ClinGen ExAC TOPMed gnomAD
rs780259578 CA7027415	211	K>M		No	ClinGen ExAC gnomAD
TCGA novel	212	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765775549 CA7027386	213	D>G		No	ClinGen ExAC gnomAD
CA7027385 rs755795754	214	I>M		No	ClinGen ExAC TOPMed gnomAD
CA255306586 rs373472101	222	I>T		No	ClinGen ESP
CA388601178 rs1247945260	222	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	223	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1226124868 CA388601157	225	A>E		No	ClinGen gnomAD
rs750032550 CA7027384	225	A>S		No	ClinGen ExAC gnomAD
CA388601151 rs1480769725	226	R>T		No	ClinGen gnomAD
TCGA novel	227	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7027383 rs767318445	229	P>Q		No	ClinGen ExAC gnomAD
rs533812307 CA255306556 COSM949155	233	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA7027381 rs751311043	234	L>P		No	ClinGen ExAC gnomAD
CA255306528 rs3198689	236	P>S		No	ClinGen Ensembl
CA388601002 rs1306775623	243	I>L		No	ClinGen gnomAD
rs762775670 CA7027379	245	K>E		No	ClinGen ExAC gnomAD
rs369487519 CA7027378	247	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1334783577 CA388600932	248	P>A		No	ClinGen gnomAD
rs1349512233 CA388600917	249	P>L		No	ClinGen TOPMed gnomAD
CA7027376 rs549040576	250	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA7027375 rs183029623	250	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1361801511 CA388600875	254	N>S		No	ClinGen gnomAD
CA388600843 rs1180844062	258	P>L		No	ClinGen gnomAD
rs777978360 CA388600812	262	F>L		No	ClinGen ExAC gnomAD
CA388600806 rs1388007185	263	V>A		No	ClinGen gnomAD
CA388600808 rs1181195707	263	V>L		No	ClinGen gnomAD
rs1460523185 CA388600802	264	E>*		No	ClinGen gnomAD
CA388600766 rs1264264289	269	K>E		No	ClinGen gnomAD
rs772676191 CA7027371	271	P>A		No	ClinGen ExAC TOPMed gnomAD
CA388600747 rs1400122531	271	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1240294419 CA388600741	272	S>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA388600153 rs1382540624	276	T>I		No	ClinGen gnomAD
CA7027348 rs780654939	277	A>P		No	ClinGen ExAC gnomAD
rs777642903 CA7027345	284	K>R		No	ClinGen ExAC TOPMed gnomAD
rs752685410 CA7027343	286	I>V		No	ClinGen ExAC gnomAD
CA388600077 rs1456560217	287	L>V		No	ClinGen TOPMed gnomAD
rs1194470118 CA388600071	288	R>C		No	ClinGen gnomAD
rs1194470118 CA388600072	288	R>G		No	ClinGen gnomAD
CA7027342 rs369035053	288	R>H		No	ClinGen ESP ExAC
CA388600064 rs1267138184	289	N>S		No	ClinGen gnomAD
TCGA novel	289	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388600055 rs1566347686	290	A>V		No	ClinGen Ensembl
CA7027340 rs754013530	292	K>R		No	ClinGen ExAC gnomAD
CA388600038 rs1339127769	293	T>A		No	ClinGen TOPMed
rs1384486584 CA388600024	293	T>I		No	ClinGen TOPMed
rs1292366983 CA388600017	294	S>P		No	ClinGen TOPMed gnomAD
rs1194131780 CA388600001	295	Y>C		No	ClinGen gnomAD
rs1566347658 CA388599962	297	T>N		No	ClinGen Ensembl
rs899785309 CA255304739	299	L>P		No	ClinGen TOPMed gnomAD
rs773250947 CA388599866	301	D>E		No	ClinGen ExAC gnomAD
rs200886883 CA7027336	301	D>N		No	ClinGen Ensembl
CA7027334 rs767933244	302	R>S		No	ClinGen ExAC TOPMed gnomAD
CA7027332 rs575613052	306	W>C		No	ClinGen 1000Genomes ExAC gnomAD
rs762155142 CA7027333	306	W>R		No	ClinGen ExAC gnomAD
CA388599703 rs1325160867	307	K>R		No	ClinGen gnomAD
rs376658386 CA7027330	309	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA7027329 rs150258777	311	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150258777 CA388599589	311	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA255304648 rs773948435	314	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs755112984 CA388599522	315	S>L		No	ClinGen TOPMed gnomAD
CA388599526 rs1199137075	315	S>P		No	ClinGen TOPMed gnomAD
CA255304647 rs755112984	315	S>W		No	ClinGen TOPMed gnomAD
rs1566347505 CA388599514	316	S>R		No	ClinGen Ensembl
rs748012213 CA7027324	318	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA388599493 rs1437489800	319	D>E		No	ClinGen gnomAD
CA388599473 rs761940289	321	D>E		No	ClinGen ExAC TOPMed gnomAD
rs753779424 CA388599464	322	A>S		No	ClinGen ExAC TOPMed gnomAD
rs753779424 CA7027321	322	A>T		No	ClinGen ExAC TOPMed gnomAD
rs201143273 CA7027320	322	A>V		No	ClinGen ExAC TOPMed gnomAD
CA255302924 rs774742226	323	E>Q		No	ClinGen gnomAD
CA388598759 rs1203965225	325	D>G		No	ClinGen TOPMed
rs760065540 CA7027293	325	D>N		No	ClinGen ExAC gnomAD
TCGA novel	326	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388598738 rs772629882	327	Q>E		No	ClinGen ExAC gnomAD
CA7027292 rs772629882	327	Q>K		No	ClinGen ExAC gnomAD
rs771659220 CA7027291	329	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA388598700 rs1213353621	330	G>A		No	ClinGen gnomAD
rs1446258560 CA388598698	331	G>S		No	ClinGen gnomAD
rs758627015	332	S>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA388598671 rs1241810596	334	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	336	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388598624 rs1464712061	341	I>L		No	ClinGen TOPMed gnomAD
rs199722205 CA388598617	342	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199722205 CA7027287	342	R>Q	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA7027286 rs749155828	346	P>A		No	ClinGen ExAC
rs779880742 CA7027285	346	P>H		No	ClinGen ExAC TOPMed gnomAD
rs1156681744 CA388598586	347	K>E		No	ClinGen TOPMed
TCGA novel	347	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388598583 rs1381955197	347	K>R		No	ClinGen gnomAD
CA388598575 rs1384189963	348	N>S		No	ClinGen TOPMed
CA7027283 rs531575904	350	E>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA255302878 rs368976799	350	E>K		No	ClinGen ESP TOPMed gnomAD
rs1566345928 CA388598541	353	A>D		No	ClinGen Ensembl
rs781150359 CA7027282	355	Q>R		No	ClinGen ExAC gnomAD
COSM949152 rs376391138 CA7027279	357	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA388598519 rs1384915644	357	S>P		No	ClinGen gnomAD
CA7027280 rs376391138	357	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA7027277 rs753051598	358	D>E		No	ClinGen ExAC gnomAD
CA388598488 rs187486106	360	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7027276 rs765604738	360	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	361	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7027273 rs767141558	362	N>S		No	ClinGen ExAC gnomAD
rs539699022 CA7027240	367	I>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs539699022 CA7027239	367	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA255301323 rs745775571	368	P>A		No	ClinGen Ensembl
CA388598124 rs1239494682	368	P>Q		No	ClinGen gnomAD
CA388598122 rs1239494682	368	P>R		No	ClinGen gnomAD
CA388598081 rs780538522	370	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1256890472 CA388598071	371	P>R		No	ClinGen gnomAD
CA388598016 rs1306622781	374	Q>H		No	ClinGen gnomAD
rs763707852 CA7027234	374	Q>R		No	ClinGen ExAC gnomAD
CA7027232 rs752141997	381	S>C		No	ClinGen ExAC TOPMed gnomAD
CA7027231 rs764995635	383	L>V		No	ClinGen ExAC gnomAD
CA388597894 rs1401490050	385	A>G		No	ClinGen TOPMed gnomAD
rs1401490050 CA388597892	385	A>V		No	ClinGen TOPMed gnomAD
rs201281398 CA255298227	388	K>R		No	ClinGen Ensembl
CA388596669 rs1455622356	390	K>E		No	ClinGen TOPMed
CA7027206 rs754690599	392	Q>R		No	ClinGen ExAC gnomAD
CA7027205 rs753439445	393	A>T		No	ClinGen ExAC
rs368487579 CA7027204	393	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA388596614 rs1283432288	394	C>Y		No	ClinGen TOPMed
CA7027201 rs376180284	395	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1246833021 CA388596605	396	G>R		No	ClinGen gnomAD
rs1456693015 CA388596586	398	L>F		No	ClinGen TOPMed gnomAD
CA388596579 rs1277770576	399	G>V		No	ClinGen TOPMed
CA7027198 rs768573549	401	I>T		No	ClinGen ExAC gnomAD
CA7027199 rs774523403	401	I>V		No	ClinGen ExAC gnomAD
CA388596545 rs1218438785	405	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs200464604 CA388596544	405	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7027196 rs200464604 COSM1716398	405	R>Q	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA7027195 rs770132294	406	G>E		No	ClinGen ExAC
CA388596533 rs17855964	407	A>G		No	ClinGen gnomAD
rs17855964 CA255298189	407	A>V		No	ClinGen gnomAD
rs1164498258 CA388596531	408	I>V		No	ClinGen gnomAD
rs771507258 CA7027192	409	Y>C		No	ClinGen ExAC gnomAD
CA7027193 rs370882237	409	Y>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA388596523 rs771507258	409	Y>S		No	ClinGen ExAC gnomAD
rs141193021 CA7027190	411	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs779740713 CA7027188	413	E>A		No	ClinGen ExAC TOPMed gnomAD
rs779740713 CA7027187	413	E>G		No	ClinGen ExAC TOPMed gnomAD
COSM48791 rs55953606 VAR_041148 CA7027186	414	A>V	lung [Cosmic]	No	ClinGen cosmic curated UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1257403145 CA388596457	420	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1218981858 CA388596423	424	A>V		No	ClinGen gnomAD
CA388596420 rs1342098291	425	Q>*		No	ClinGen gnomAD
CA255298140 rs55897869 VAR_041149	426	L>I		No	ClinGen UniProt TOPMed dbSNP
rs202009189 CA388596408	427	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs202009189 CA7027181	427	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA388596389 rs1229173893	428	Q>H		No	ClinGen gnomAD
CA388596394 rs1374058419	428	Q>R		No	ClinGen TOPMed
rs1242214552 CA388596380	429	R>Q		No	ClinGen TOPMed
CA388596357 rs763189179	431	Q>*		No	ClinGen ExAC gnomAD
CA7027180 rs763189179	431	Q>E		No	ClinGen ExAC gnomAD
CA388596354 rs1594568857	431	Q>P		No	ClinGen Ensembl
CA7027130 rs767823502	435	L>V		No	ClinGen ExAC gnomAD
rs1594563504 CA388594853	436	S>N		No	ClinGen Ensembl
rs762324256 CA7027128	438	G>R		No	ClinGen ExAC gnomAD
TCGA novel	439	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388594768 rs774776414	440	T>I		No	ClinGen ExAC
rs774776414 CA7027126	440	T>S		No	ClinGen ExAC
CA388594759 rs552813433	441	S>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs552813433 CA7027125	441	S>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7027124 rs759021740	442	S>A		No	ClinGen ExAC gnomAD
rs1566338829 CA388594737	442	S>F		No	ClinGen Ensembl
CA388594714 rs1209209764	443	H>Q		No	ClinGen TOPMed
rs1477443832 CA611914176	444	H>C		No	ClinGen gnomAD

No associated diseases with Q9Y6E0

2 regional properties for Q9Y6E0

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	36 - 286	IPR000719
binding_site	Protein kinase, ATP binding site	42 - 65	IPR017441

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Nucleus Membrane	The truncated form (MST3/N) translocates to the nucleus Colocalizes with STK38L in the membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
metal ion binding	Binding to a metal ion.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

10 GO annotations of biological process

Name	Definition
cellular response to starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
execution phase of apoptosis	A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
intrinsic apoptotic signaling pathway in response to oxidative stress	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
negative regulation of cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
positive regulation of axon regeneration	Any process that activates, maintains or increases the rate of axon regeneration.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of axon regeneration	Any process that modulates the frequency, rate or extent of axon regeneration.
response to hydrogen peroxide	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

27 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3SWY6	STK25	Serine/threonine-protein kinase 25	Bos taurus (Bovine)	PR
Q5E9L6	STK4	Serine/threonine-protein kinase 4	Bos taurus (Bovine)	SS
P41279	MAP3K8	Mitogen-activated protein kinase kinase kinase 8	Homo sapiens (Human)	EV
Q9H2G2	SLK	STE20-like serine/threonine-protein kinase	Homo sapiens (Human)	PR
O94804	STK10	Serine/threonine-protein kinase 10	Homo sapiens (Human)	PR
O95747	OXSR1	Serine/threonine-protein kinase OSR1	Homo sapiens (Human)	PR
Q9UEW8	STK39	STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (Human)	PR
Q9Y4K4	MAP4K5	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (Human)	PR
Q92918	MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (Human)	EV
Q12851	MAP4K2	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (Human)	EV
Q8IVH8	MAP4K3	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (Human)	SS
Q9P289	STK26	Serine/threonine-protein kinase 26	Homo sapiens (Human)	PR
O00506	STK25	Serine/threonine-protein kinase 25	Homo sapiens (Human)	PR
Q13188	STK3	Serine/threonine-protein kinase 3	Homo sapiens (Human)	SS
Q13043	STK4	Serine/threonine-protein kinase 4	Homo sapiens (Human)	EV
Q07174	Map3k8	Mitogen-activated protein kinase kinase kinase 8	Mus musculus (Mouse)	SS
Q99JT2	Stk26	Serine/threonine-protein kinase 26	Mus musculus (Mouse)	PR
Q9Z2W1	Stk25	Serine/threonine-protein kinase 25	Mus musculus (Mouse)	PR
Q99KH8	Stk24	Serine/threonine-protein kinase 24	Mus musculus (Mouse)	PR
Q9JI10	Stk3	Serine/threonine-protein kinase 3	Mus musculus (Mouse)	SS
Q9JI11	Stk4	Serine/threonine-protein kinase 4	Mus musculus (Mouse)	PR
Q63562	Map3k8	Mitogen-activated protein kinase kinase kinase 8	Rattus norvegicus (Rat)	SS
B0LT89	Stk24	Serine/threonine-protein kinase 24	Rattus norvegicus (Rat)	PR
H2L099	gck-1	Germinal center kinase 1	Caenorhabditis elegans	PR
Q9NB31	cst-1	Serine/threonine-protein kinase cst-1	Caenorhabditis elegans	PR
Q6P3Q4	stk4	Serine/threonine-protein kinase 4	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	SS
Q7ZUQ3	stk3	Serine/threonine-protein kinase 3	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MDSRAQLWGL	ALNKRRATLP	HPGGSTNLKA	DPEELFTKLE	KIGKGSFGEV	FKGIDNRTQK
70	80	90	100	110	120
VVAIKIIDLE	EAEDEIEDIQ	QEITVLSQCD	SPYVTKYYGS	YLKDTKLWII	MEYLGGGSAL
130	140	150	160	170	180
DLLEPGPLDE	TQIATILREI	LKGLDYLHSE	KKIHRDIKAA	NVLLSEHGEV	KLADFGVAGQ
190	200	210	220	230	240
LTDTQIKRNT	FVGTPFWMAP	EVIKQSAYDS	KADIWSLGIT	AIELARGEPP	HSELHPMKVL
250	260	270	280	290	300
FLIPKNNPPT	LEGNYSKPLK	EFVEACLNKE	PSFRPTAKEL	LKHKFILRNA	KKTSYLTELI
310	320	330	340	350	360
DRYKRWKAEQ	SHDDSSSEDS	DAETDGQASG	GSDSGDWIFT	IREKDPKNLE	NGALQPSDLD
370	380	390	400	410	420
RNKMKDIPKR	PFSQCLSTII	SPLFAELKEK	SQACGGNLGS	IEELRGAIYL	AEEACPGISD
430	440
TMVAQLVQRL	QRYSLSGGGT	SSH