AiPD: Autoinhibited Protein Database

Q9Y6D6

Gene name	ARFGEF1 (ARFGEP1, BIG1)
Protein name	Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Names	Brefeldin A-inhibited GEP 1, ADP-ribosylation factor guanine nucleotide-exchange factor 1, p200 ARF guanine nucleotide exchange factor, p200 ARF-GEP1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10565
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

12-94 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

12-94 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q9Y6D6

Entry ID	Method	Resolution	Chain	Position	Source
3LTL	X-ray	220 A	A/B	691-889	PDB
5EE5	X-ray	228 A	A	1-229	PDB
5J5C	X-ray	340 A	B	1-224	PDB
AF-Q9Y6D6-F1	Predicted				AlphaFoldDB

896 variants for Q9Y6D6

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV001290727 RCV002276682 rs1805830692	336	M>missing	Global developmental delay DEVELOPMENTAL DELAY, IMPAIRED SPEECH, BEHAVIORAL ABNORMALITIES, AND SEIZURES [ClinVar]	Yes	ClinVar dbSNP
rs1804841321 RCV002276683 RCV001290728	648	Q>*	Global developmental delay Developmental delay, impaired speech, and behavioral abnormalities, with or without seizures [ClinVar]	Yes	ClinVar dbSNP
VAR_087629	648	Q>del	DEDISB; decreased protein abundance [UniProt]	Yes	UniProt
rs1840585492 RCV001290724	720	L>missing	Global developmental delay [ClinVar]	Yes	ClinVar dbSNP
RCV002276680 rs1840520188 VAR_087630 RCV001290721	798	D>N	Global developmental delay Developmental delay, impaired speech, and behavioral abnormalities, with or without seizures DEDISB; decreased protein abundance [ClinVar, UniProt]	Yes	ClinVar UniProt dbSNP
CA371214120 rs1563869264 RCV001290726	799	R>*	Global developmental delay Variant assessed as Somatic; impact. [ClinVar, NCI-TCGA]	Yes	ClinGen ClinVar Ensembl NCI-TCGA dbSNP
RCV002276679 rs1840507738 RCV001290121	842	Q>*	DEVELOPMENTAL DELAY, IMPAIRED SPEECH, BEHAVIORAL ABNORMALITIES, AND SEIZURES [ClinVar]	Yes	ClinVar dbSNP
VAR_087631	842	Q>del	DEDISB [UniProt]	Yes	UniProt
rs1839888192 RCV001290725	976	C>missing	Global developmental delay [ClinVar]	Yes	ClinVar dbSNP
RCV001290729 CA371199990 rs1308211020	1233	Q>*	Global developmental delay [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
rs146133956 COSM1101211 CA371196313 RCV001290730	1345	R>*	Global developmental delay Variant assessed as Somatic; impact. endometrium stomach [ClinVar, NCI-TCGA, Cosmic]	Yes	ClinGen cosmic curated ClinVar ESP NCI-TCGA TOPMed dbSNP gnomAD
VAR_087632	1455	C>del	DEDISB [UniProt]	Yes	UniProt
rs1838287933 RCV002276681 RCV001780236 RCV001290722	1774	R>*	Global developmental delay Developmental delay, impaired speech, and behavioral abnormalities, with or without seizures [ClinVar]	Yes	ClinVar dbSNP
VAR_087633	1774	R>del	DEDISB [UniProt]	Yes	UniProt
rs369779833 CA4772610	2	Y>C		No	ClinGen ESP ExAC gnomAD
CA371253712 rs1326853723	2	Y>D		No	ClinGen gnomAD
rs762648819 CA4772607	4	G>E		No	ClinGen ExAC gnomAD
rs765893935 CA4772608	4	G>R		No	ClinGen ExAC gnomAD
CA371253623 rs1472016796	5	K>N		No	ClinGen gnomAD
CA4772606 rs773513092	5	K>R		No	ClinGen ExAC TOPMed gnomAD
CA371253583 rs1563926936	8	K>R		No	ClinGen Ensembl
CA371253503 rs1453859318	11	F>L		No	ClinGen gnomAD
rs575822599 CA178327432	11	F>S		No	ClinGen Ensembl
CA4772604 rs765553102	14	R>W		No	ClinGen ExAC TOPMed gnomAD
CA371253452 rs1347297540	15	A>G		No	ClinGen TOPMed
TCGA novel	15	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371253449 rs1347297540	15	A>V		No	ClinGen TOPMed
CA4772601 rs768754442	20	L>V		No	ClinGen ExAC TOPMed gnomAD
CA178327423 rs878891010	20	L>W		No	ClinGen Ensembl
CA4772600 rs746993809	21	A>D		No	ClinGen ExAC gnomAD
CA371253339 COSM3834948 rs1350102787	21	A>T	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
TCGA novel	22	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371253308 rs1302340992	23	K>R		No	ClinGen gnomAD
TCGA novel	24	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371253234 rs1477016231	28	A>G		No	ClinGen TOPMed gnomAD
rs1477016231 CA371253233	28	A>V		No	ClinGen TOPMed gnomAD
CA4772591 rs751084276	31	S>C		No	ClinGen ExAC gnomAD
rs754553351 CA4772592	31	S>T		No	ClinGen ExAC gnomAD
CA371253193 rs751084276	31	S>Y		No	ClinGen ExAC gnomAD
CA178327393 rs909771404	35	K>T		No	ClinGen Ensembl
CA371253128 rs1479253199	36	A>V		No	ClinGen gnomAD
CA371253097 rs1378735697	38	E>G		No	ClinGen gnomAD
CA178301650 rs1038077353	42	E>G		No	ClinGen TOPMed
rs144563065 CA4772563	44	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs753201303 CA4772562	44	I>T		No	ClinGen ExAC gnomAD
rs767528474 CA4772561	46	A>V		No	ClinGen ExAC TOPMed gnomAD
rs774730853 CA4772559	47	E>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	49	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371259393 rs1409793632	50	K>E		No	ClinGen gnomAD
CA371259387 rs1417634804	50	K>N		No	ClinGen TOPMed gnomAD
CA178300541 rs144506580	53	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs144506580 CA4772535	53	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA178300558 rs938635856	53	P>S		No	ClinGen Ensembl
rs972627593 CA178300534	54	P>L		No	ClinGen TOPMed
rs1214124211 CA371259352	54	P>S		No	ClinGen gnomAD
CA4772533 rs760449947	55	H>D		No	ClinGen ExAC gnomAD
rs745773603 CA4772529	60	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4772528 rs773900413	60	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA371259304 rs1442160635	62	S>P		No	ClinGen gnomAD
rs1324212767 CA371259269	67	P>Q		No	ClinGen gnomAD
rs1563901020 CA371259250	70	S>A		No	ClinGen Ensembl
TCGA novel	71	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371259237 rs1158477924	72	T>A		No	ClinGen gnomAD
CA4772524 rs756451699	72	T>I		No	ClinGen ExAC TOPMed gnomAD
CA4772523 rs143012582	76	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA371259192 rs1193998653	78	D>V		No	ClinGen gnomAD
rs1453645148 CA371259166	81	F>L		No	ClinGen gnomAD
rs1213060906 CA371259109	89	Q>H		No	ClinGen TOPMed gnomAD
CA371259112 rs1461198864	89	Q>P		No	ClinGen gnomAD
CA178300451 rs538740809	90	S>Y		No	ClinGen 1000Genomes
CA178300449 rs910132709	91	K>R		No	ClinGen TOPMed gnomAD
rs766586260 CA4772518	92	C>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	92	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1327421874 CA371259080	94	R>C		No	ClinGen TOPMed
COSM1101236 CA371259079 rs369515490	94	R>H	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP NCI-TCGA TOPMed gnomAD
CA178300443 rs369515490	94	R>L		No	ClinGen ESP TOPMed gnomAD
rs1301714952 CA371259067	96	V>A		No	ClinGen gnomAD
CA4772517 rs758509264	96	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1437459663 CA371259060	97	S>N		No	ClinGen gnomAD
CA4772494 rs753957502	107	I>T		No	ClinGen ExAC TOPMed gnomAD
rs766359315 CA4772490	113	T>I		No	ClinGen ExAC gnomAD
CA4772489 rs762869514	114	G>D		No	ClinGen ExAC gnomAD
CA4772488 rs368559554	115	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1337264407 CA371258913	117	P>L		No	ClinGen gnomAD
rs1376165205 CA371258916	117	P>S		No	ClinGen TOPMed
rs1293933334 CA371258908	118	D>G		No	ClinGen gnomAD
rs1232802022 CA371258903	119	S>G		No	ClinGen TOPMed gnomAD
rs1160057263 CA371258886	120	T>R		No	ClinGen TOPMed
CA371258881 rs1353450636	121	T>A		No	ClinGen gnomAD
CA371258883 rs1353450636	121	T>P		No	ClinGen gnomAD
CA371258857 rs769168664	123	G>A		No	ClinGen ExAC TOPMed gnomAD
rs769168664 CA4772487	123	G>D		No	ClinGen ExAC TOPMed gnomAD
CA371258808 rs1391745660	127	I>T		No	ClinGen gnomAD
rs1395428517 CA371258797	128	D>G		No	ClinGen gnomAD
rs1035393239 CA178298788	128	D>Y		No	ClinGen TOPMed
rs1391308115 CA371258777	130	I>L		No	ClinGen TOPMed
CA371258734 rs1386041962	133	T>I		No	ClinGen TOPMed
CA4772484 rs769150403 COSM3779314	134	I>M	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA4772485 rs776110527	134	I>T		No	ClinGen ExAC gnomAD
rs1459081461 CA371258727	134	I>V		No	ClinGen gnomAD
rs1182040428 CA371258700	136	G>D		No	ClinGen gnomAD
rs1184530742 CA371258620	143	T>A		No	ClinGen TOPMed gnomAD
CA4772483 rs747321357	146	G>R		No	ClinGen ExAC gnomAD
rs1228609152 CA371258564	148	Q>K		No	ClinGen TOPMed
TCGA novel	150	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4772482 rs181099627	152	I>L		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	156	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768482778 CA4772460	158	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1348258522 CA371258277	158	A>V		No	ClinGen gnomAD
rs776037456 CA4772458	159	V>A		No	ClinGen ExAC
rs760401084 CA4772459	159	V>I		No	ClinGen ExAC TOPMed gnomAD
CA371258252 rs748428891	163	H>N		No	ClinGen ExAC TOPMed gnomAD
CA371258246 rs1318381561	163	H>Q		No	ClinGen gnomAD
rs748428891 CA4772456	163	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA4772455 rs562671176	164	I>L		No	ClinGen ExAC TOPMed gnomAD
CA4772454 rs562671176	164	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	169	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749383940 CA4772453	170	T>I		No	ClinGen ExAC gnomAD
rs1157441742 CA371258198	171	V>I		No	ClinGen TOPMed gnomAD
CA4772452 rs147785456	173	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4772450 rs748343992	174	A>V		No	ClinGen ExAC gnomAD
TCGA novel	176	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140713901 CA178296552	180	N>S		No	ClinGen ESP TOPMed
rs1446560773 CA371258102	185	S>N		No	ClinGen gnomAD
rs758092043 CA4772448	186	K>R		No	ClinGen ExAC TOPMed gnomAD
CA371258070 rs1047822027	189	I>M		No	ClinGen TOPMed
CA371258057 rs1348542717	191	Q>R		No	ClinGen TOPMed gnomAD
CA4772446 rs765029714	193	T>A		No	ClinGen ExAC gnomAD
rs1231875440 CA371258032	195	K>R		No	ClinGen TOPMed gnomAD
CA371258033 rs1231875440	195	K>T		No	ClinGen TOPMed gnomAD
rs757207098 CA4772445	197	T>A		No	ClinGen ExAC gnomAD
rs1270478481 CA371258016	198	L>V		No	ClinGen gnomAD
CA178296527 rs375579913	199	T>N		No	ClinGen ESP
TCGA novel	203	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371357899 CA178296510	205	I>T		No	ClinGen ESP
CA4772444 rs753467284	205	I>V		No	ClinGen ExAC
rs1314181915 CA371257952	207	A>V		No	ClinGen gnomAD
rs763667176 CA4772443	208	R>C		No	ClinGen ExAC gnomAD
rs1587249291 CA371257949	208	R>H		No	ClinGen Ensembl
rs775243712 CA4772441	209	M>I		No	ClinGen ExAC gnomAD
rs760454209 CA4772442	209	M>V		No	ClinGen ExAC gnomAD
TCGA novel	213	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1031287802 CA178296482	213	A>V		No	ClinGen Ensembl
rs745710547 CA4772428	215	Q>R		No	ClinGen ExAC gnomAD
CA371256884 rs1319679156	218	K>T		No	ClinGen TOPMed
CA4772426 rs757183150	220	M>V		No	ClinGen ExAC gnomAD
CA4772425 rs753804375	224	R>G		No	ClinGen ExAC gnomAD
rs1330010304 CA371256792	224	R>M		No	ClinGen gnomAD
CA371256785 rs1409556340	224	R>S		No	ClinGen gnomAD
rs1563894275 CA371256757	226	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs763728256 CA4772424	226	R>W		No	ClinGen ExAC gnomAD
CA4772423 rs752409370	227	Q>H		No	ClinGen ExAC gnomAD
CA371256737 rs1475615865	228	H>D		No	ClinGen gnomAD
rs200834597 CA4772421	228	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1179984638 CA371256714	229	H>L		No	ClinGen gnomAD
rs1179984638 CA371256715	229	H>R		No	ClinGen gnomAD
rs1344388478 CA371256703	230	H>R		No	ClinGen TOPMed
CA4772420 rs144569761	230	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA371256636 rs766739388	235	P>A		No	ClinGen ExAC TOPMed gnomAD
rs766739388 CA4772418	235	P>T		No	ClinGen ExAC TOPMed gnomAD
rs763468863 CA4772417	236	V>I		No	ClinGen ExAC gnomAD
CA178292193 rs905474246	237	S>N		No	ClinGen TOPMed gnomAD
CA4772415 rs370787018	238	H>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs776681380 CA4772413	240	E>K		No	ClinGen ExAC gnomAD
rs768829279 CA4772412	243	S>L		No	ClinGen ExAC TOPMed gnomAD
rs747224293 CA4772411	244	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1477395623 CA371256478	247	R>G		No	ClinGen TOPMed
rs770710364 CA4772409	250	P>A		No	ClinGen ExAC TOPMed gnomAD
rs375469959 CA4772407	251	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA371256393 rs1406939161 CA371256395	252	Q>H		No	ClinGen TOPMed
rs756105532 CA4772406	253	T>S		No	ClinGen ExAC gnomAD
CA4772405 rs370772971	254	V>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	255	D>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371256349 rs1292146078	256	H>D		No	ClinGen gnomAD
rs780719537 CA4772404	256	H>R		No	ClinGen ExAC gnomAD
rs1587238852 CA371256335	257	I>V		No	ClinGen Ensembl
rs1587238832 CA371256299	259	Q>H		No	ClinGen Ensembl
CA4772401 rs766681415	262	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	263	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs955021939 CA178292077	265	L>P		No	ClinGen Ensembl
RCV000955187 CA4772399 rs61753695	266	D>Y		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA371256188 rs1319219148	267	L>R		No	ClinGen gnomAD
CA371256175 rs1285658290	268	H>R		No	ClinGen gnomAD
CA371256179 rs1294209872	268	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA4772397 rs762305898	270	N>D		No	ClinGen ExAC TOPMed gnomAD
rs1289752973 CA371256116	272	V>G		No	ClinGen TOPMed
rs4321984 VAR_028749 CA178292046	273	D>Y		No	ClinGen UniProt Ensembl dbSNP
CA371256061 rs1306088929	276	L>F		No	ClinGen TOPMed gnomAD
CA371256063 rs1306088929	276	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1370559410 CA371256005	280	T>A		No	ClinGen gnomAD
CA4772395 rs768761106	280	T>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	281	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4772393 rs775713594	282	P>H		No	ClinGen ExAC gnomAD
rs1364117236 CA371255920	286	S>C		No	ClinGen gnomAD
CA4772390 rs527981069	287	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4772391 rs749151632	287	D>G		No	ClinGen ExAC gnomAD
CA178292007 rs368008426	287	D>H		No	ClinGen Ensembl
CA4772389 rs149899042	288	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA178291998 rs1002606879	289	S>A		No	ClinGen Ensembl
CA371255824 rs1453404737	293	N>S		No	ClinGen gnomAD
rs4641048 CA178291988	295	Q>H		No	ClinGen Ensembl
CA4772386 rs61758692	296	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA371255786 rs1301394858	296	T>S		No	ClinGen TOPMed gnomAD
rs61758692 CA4772387	296	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	298	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs551759273 CA4772384	300	Q>K		No	ClinGen 1000Genomes ExAC gnomAD
CA4772383 rs531843869	301	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA4772382 rs750857646	303	A>T		No	ClinGen ExAC TOPMed gnomAD
rs765557150 CA4772381	304	A>V		No	ClinGen ExAC gnomAD
CA371255657 rs1460770955	306	T>P		No	ClinGen gnomAD
rs745499442 CA4772361	309	K>E		No	ClinGen ExAC gnomAD
CA371254475 rs1254640307	309	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA178288630 rs888218708	310	N>K		No	ClinGen TOPMed gnomAD
CA371254428 rs1587228454	312	V>A		No	ClinGen Ensembl
CA371254424 rs1277623235	313	L>I		No	ClinGen gnomAD
CA4772358 rs76811394 COSM150498	314	Y>C	stomach [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA4772359 rs76811394	314	Y>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs996930481 CA178288626	314	Y>H		No	ClinGen Ensembl
VAR_036155	316	G>E	a colorectal cancer sample; somatic mutation [UniProt]	No	UniProt
CA4772357 rs764719716 COSM1101234	316	G>R	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1250575552 CA371254371	317	E>G		No	ClinGen gnomAD
TCGA novel	317	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA178288590 rs756572458	319	H>L		No	ClinGen ExAC TOPMed gnomAD
CA4772356 rs756572458	319	H>R		No	ClinGen ExAC TOPMed gnomAD
CA4772355 rs752860157	321	C>F		No	ClinGen ExAC gnomAD
CA371254331 rs1299695735	322	E>D		No	ClinGen TOPMed gnomAD
rs1309195144 CA371254304	326	Q>R		No	ClinGen TOPMed gnomAD
CA371254288 rs1167874617	328	I>T		No	ClinGen gnomAD
rs895868722 CA178288572	332	I>V		No	ClinGen TOPMed gnomAD
CA4772349 rs776280671	335	E>K		No	ClinGen ExAC gnomAD
CA371254229 rs1563890913	336	M>I		No	ClinGen Ensembl
CA4772348 rs768708118	336	M>V		No	ClinGen ExAC gnomAD
CA4772347 rs746893285	337	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1447770575 CA371254228	337	V>M		No	ClinGen Ensembl
CA4772346 rs775031644	338	N>H		No	ClinGen ExAC gnomAD
rs1346287784 CA371254216	339	I>L		No	ClinGen gnomAD
rs1331740711 CA371254206	340	V>A		No	ClinGen TOPMed
CA371254209 rs1415717120	340	V>I		No	ClinGen TOPMed
CA178281943 rs553294668	344	M>T		No	ClinGen gnomAD
rs565313375 CA4772321	344	M>V		No	ClinGen ExAC TOPMed gnomAD
CA371253938 rs1388396483	345	G>A		No	ClinGen TOPMed
rs1371346419 CA371253930	346	E>K		No	ClinGen TOPMed gnomAD
rs770012022 CA4772319	347	G>E		No	ClinGen ExAC gnomAD
CA4772320 rs778218475	347	G>W		No	ClinGen ExAC gnomAD
rs748665917 CA4772318	348	T>A		No	ClinGen ExAC TOPMed gnomAD
rs755532297 CA4772316	353	S>N		No	ClinGen ExAC
rs781739609 CA4772317	353	S>R		No	ClinGen ExAC gnomAD
CA371253818 rs1413282587	354	A>T		No	ClinGen TOPMed
CA371253784 rs140569992	356	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs140569992 CA4772315	356	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1196161647 CA371253764	357	N>K		No	ClinGen gnomAD
CA178281883 rs1030938397	357	N>S		No	ClinGen TOPMed
rs199816572 CA4772313	358	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs367687566 CA4772314	358	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs750563533 CA4772312	361	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1449993806 CA371253678	362	E>D		No	ClinGen gnomAD
CA371253617 rs1263959407	365	S>N		No	ClinGen gnomAD
rs1487938175 CA371253565	367	S>R		No	ClinGen gnomAD
rs1458972092 CA371253539	368	E>K		No	ClinGen gnomAD
CA371253480 rs1283598200	370	I>T		No	ClinGen gnomAD
rs113233246 CA178281860	371	Q>R		No	ClinGen Ensembl
CA4772310 rs760320186	373	N>S		No	ClinGen ExAC gnomAD
CA371253347 rs1273945379	376	P>L		No	ClinGen gnomAD
CA178281842 rs1031013620	380	I>V		No	ClinGen gnomAD
rs1318444253 CA371253281	381	S>F		No	ClinGen gnomAD
CA178281841 rs749253154	385	T>I		No	ClinGen TOPMed
rs1261157740 CA371253225	386	P>S		No	ClinGen gnomAD
rs1563883147 CA371253182	389	P>L		No	ClinGen Ensembl
TCGA novel	391	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	392	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4772306 rs773900199	392	R>S		No	ClinGen ExAC gnomAD
CA4772305 rs770296871	394	S>L		No	ClinGen ExAC TOPMed gnomAD
rs75111017 CA4772304	398	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA178281819 rs75111017	398	N>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA371252996 rs1587196848	400	T>A		No	ClinGen Ensembl
rs1274007000 CA371219609	410	S>L		No	ClinGen TOPMed
CA4772287 rs765914390	411	P>H		No	ClinGen ExAC TOPMed gnomAD
CA178239905 rs765914390	411	P>R		No	ClinGen ExAC TOPMed gnomAD
CA371219606 rs1292389787	411	P>S		No	ClinGen Ensembl
CA371219598 rs1439160507	413	A>T		No	ClinGen gnomAD
rs1404424004 CA371219593	413	A>V		No	ClinGen TOPMed gnomAD
TCGA novel	414	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA178239902 rs1040035704	414	K>N		No	ClinGen Ensembl
rs1273351016 CA371219589	414	K>T		No	ClinGen gnomAD
CA178239898 rs78884955	415	F>V		No	ClinGen Ensembl
rs537950704 CA4772286	416	S>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4772285 rs537950704	416	S>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761529850 CA178239868	419	L>F		No	ClinGen ExAC TOPMed gnomAD
CA371219549 rs777189480	420	Q>L		No	ClinGen ExAC gnomAD
CA4772282 rs777189480	420	Q>P		No	ClinGen ExAC gnomAD
rs769097390 CA4772281	423	A>D		No	ClinGen ExAC gnomAD
rs769097390 CA371219527	423	A>G		No	ClinGen ExAC gnomAD
rs772208540 CA4772278	427	F>V		No	ClinGen ExAC gnomAD
rs1010934782 CA178239847	430	L>F		No	ClinGen TOPMed gnomAD
rs1167222689 CA371219450	435	M>T		No	ClinGen gnomAD
CA4772276 rs779019298	435	M>V	Variant assessed as Somatic; 4.626e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA371219440 rs1405862929	436	K>I		No	ClinGen gnomAD
CA4772275 rs757522766	446	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	448	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4772254 rs756313238	451	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA371218971 rs1354802061	452	S>C		No	ClinGen TOPMed
rs901104524 CA178237875	453	K>R		No	ClinGen TOPMed gnomAD
CA371218962 rs1219961611	454	I>F		No	ClinGen TOPMed gnomAD
CA371218960 rs1219961611	454	I>V		No	ClinGen TOPMed gnomAD
rs779870449 CA4772252	456	S>P		No	ClinGen ExAC gnomAD
TCGA novel	459	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371218879 rs1216397684	465	Q>H		No	ClinGen gnomAD
CA4772250 rs750330408	474	N>S		No	ClinGen ExAC TOPMed gnomAD
rs778601035 CA4772249	475	E>G		No	ClinGen ExAC gnomAD
rs1350123170 CA371218762	475	E>K		No	ClinGen gnomAD
rs756761381 CA4772248	477	F>L		No	ClinGen ExAC TOPMed gnomAD
rs753559272 CA371218712	478	I>L		No	ClinGen ExAC TOPMed gnomAD
rs753559272 CA4772247	478	I>V		No	ClinGen ExAC TOPMed gnomAD
CA4772245 rs760372196	481	I>V		No	ClinGen ExAC gnomAD
TCGA novel	485	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	485	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA178237835 rs1014512662	498	P>S		No	ClinGen Ensembl
TCGA novel	502	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4772242 rs759991178	502	E>D		No	ClinGen ExAC gnomAD
rs1026472926 CA178237826	507	I>T		No	ClinGen Ensembl
rs1187817028 CA371218311	507	I>V		No	ClinGen gnomAD
rs771009386 CA4772240	509	L>F		No	ClinGen ExAC gnomAD
CA371218240 rs1403695984	514	N>D		No	ClinGen TOPMed
CA371218216 rs1211033244	517	T>A		No	ClinGen gnomAD
TCGA novel	520	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	521	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371217150 rs1423653976	526	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	530	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746053755 CA371217103	532	L>F		No	ClinGen gnomAD
rs373169129 CA4772211	533	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	536	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778848500 CA4772210	538	S>C		No	ClinGen ExAC gnomAD
CA4772209 rs369952425	539	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1344007085 CA371217039	542	F>S		No	ClinGen TOPMed
rs1196877628 CA371217002	547	M>V		No	ClinGen gnomAD
CA371216988 rs1428032536	548	V>G		No	ClinGen TOPMed
rs749187709 CA4772208	553	T>M		No	ClinGen ExAC gnomAD
CA371216951 rs1367795283	554	R>S		No	ClinGen TOPMed
CA371216936 rs1319628995	556	C>W		No	ClinGen gnomAD
rs149585401 CA4772206	556	C>Y		No	ClinGen ESP ExAC gnomAD
rs1360305790 CA371216886	562	V>I		No	ClinGen gnomAD
rs1360305790 CA371216884	562	V>L		No	ClinGen gnomAD
rs886141882 CA178235621	576	A>V		No	ClinGen TOPMed gnomAD
rs749240943 CA4772191	578	I>V		No	ClinGen ExAC gnomAD
TCGA novel	580	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	585	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769604519 CA4772189	585	D>V		No	ClinGen ExAC gnomAD
CA371216577 rs1265332006	594	G>D		No	ClinGen TOPMed gnomAD
CA4772188 rs747756594	594	G>S		No	ClinGen ExAC TOPMed gnomAD
rs138242444 CA178235598	596	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA371216533 rs1487805509	597	E>*		No	ClinGen gnomAD
CA178235582 rs923094119	597	E>A		No	ClinGen TOPMed gnomAD
CA371216530 rs923094119	597	E>G		No	ClinGen TOPMed gnomAD
CA371216497 rs1201770117	599	G>V		No	ClinGen gnomAD
TCGA novel	601	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371216438 rs1348395111	603	V>I		No	ClinGen TOPMed
rs1268754282 CA371216360	607	S>R		No	ClinGen gnomAD
CA4772167 rs746672155	608	L>P		No	ClinGen ExAC gnomAD
TCGA novel	612	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371216317 rs1450728541	614	E>Q		No	ClinGen gnomAD
CA371216313 rs1402489937	614	E>V		No	ClinGen gnomAD
rs779586937 CA178235534	616	L>S		No	ClinGen Ensembl
rs376779610 CA4772166	618	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA178235528 rs113878715	636	S>P		No	ClinGen Ensembl
CA371216141 rs1472971986	638	T>A		No	ClinGen gnomAD
CA4772163 rs779117076	639	T>A		No	ClinGen ExAC gnomAD
CA371216136 rs779117076	639	T>P		No	ClinGen ExAC gnomAD
CA4772161 rs754252311	640	L>F		No	ClinGen ExAC gnomAD
CA371216050 rs1280727022	642	Q>*		No	ClinGen gnomAD
TCGA novel	642	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771132598 CA4772139	644	K>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	646	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371215912 rs1356109154	650	M>T		No	ClinGen gnomAD
CA4772138 rs749813829	654	K>R		No	ClinGen ExAC gnomAD
rs1371229274 CA371215812	656	P>A		No	ClinGen gnomAD
rs537079988 CA4772136	658	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs781395241 CA4772134	659	I>R		No	ClinGen ExAC gnomAD
rs752860752 CA4772135	659	I>V		No	ClinGen ExAC gnomAD
CA4772133 rs368332929	661	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA4772130 rs761460203	671	T>A		No	ClinGen ExAC gnomAD
CA371215537 rs1436787771	673	S>A		No	ClinGen gnomAD
rs1268876505 CA371215399	679	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1288952096 CA371215380	680	S>C		No	ClinGen TOPMed
rs1197909586 CA371215377	680	S>N		No	ClinGen TOPMed gnomAD
CA178235200 rs145173986	682	Q>H		No	ClinGen ESP
rs775031548 CA4772126	683	M>L		No	ClinGen ExAC gnomAD
TCGA novel	685	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771522851 CA4772125	690	E>D		No	ClinGen ExAC gnomAD
CA371215090 rs1366799626	697	Q>H		No	ClinGen gnomAD
rs1281236178 CA371215062	700	E>D		No	ClinGen gnomAD
rs1587167428 CA371215034	702	I>T		No	ClinGen Ensembl
rs1277220113 CA371214988	706	I>L		No	ClinGen TOPMed
CA178235177 rs915954092	707	D>H		No	ClinGen TOPMed
rs1332855060 CA371214745	710	N>Y		No	ClinGen gnomAD
CA371214732 TCGA novel rs1222260912	711	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen TOPMed
CA4772106 rs773904011	712	K>R		No	ClinGen ExAC gnomAD
rs765983514 CA4772105	714	K>E		No	ClinGen ExAC gnomAD
CA4772104 rs762644535	715	R>T		No	ClinGen ExAC TOPMed gnomAD
rs868812236 CA178231693	716	G>*		No	ClinGen Ensembl
TCGA novel	716	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4772103 rs773733329	716	G>V		No	ClinGen ExAC gnomAD
CA4772102 rs770242580	717	I>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	717	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371214701 rs770242580	717	I>V		No	ClinGen ExAC TOPMed gnomAD
CA4772100 rs777222331	728	T>A		No	ClinGen ExAC gnomAD
CA178231676 rs201705584	729	T>A		No	ClinGen Ensembl
rs1248897282 CA371214611	730	P>A		No	ClinGen TOPMed
rs769194487 CA4772099	730	P>L		No	ClinGen ExAC TOPMed gnomAD
rs898643631 CA178231653	733	I>T		No	ClinGen gnomAD
CA371214582 rs1369869723	734	A>D		No	ClinGen TOPMed
rs1187751821 CA371214585	734	A>T		No	ClinGen TOPMed
rs1006949529 CA178231633	736	F>L		No	ClinGen TOPMed gnomAD
CA178231631 rs368734230	738	H>L		No	ClinGen ESP TOPMed
rs1017796535 CA178231632	738	H>Y		No	ClinGen TOPMed
TCGA novel	739	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371214547 rs1323247630	739	Q>P		No	ClinGen gnomAD
rs1395794307 CA371214525	742	R>K		No	ClinGen TOPMed
rs1336362179 CA371214500	745	S>F		No	ClinGen TOPMed
CA371214486 rs1196793314	746	T>A		No	ClinGen TOPMed
CA4772065 rs370609948	746	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA4772064 rs370609948	746	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs781014133 CA4772062	747	Q>E		No	ClinGen ExAC gnomAD
rs1304117949 CA371214455	751	F>L		No	ClinGen gnomAD
CA4772060 rs751473980	756	D>N		No	ClinGen ExAC gnomAD
TCGA novel	757	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4772059 rs779433086	759	N>I		No	ClinGen ExAC TOPMed gnomAD
CA4772058 rs757921940	760	K>E		No	ClinGen ExAC gnomAD
CA4772057 rs201306369	760	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs765051169 CA4772056	765	A>T		No	ClinGen ExAC gnomAD
rs754203571 CA4772054	766	Y>F		No	ClinGen ExAC gnomAD
CA371214338 rs1367498986	767	V>A		No	ClinGen TOPMed
CA178230019 rs373557895	773	S>A		No	ClinGen ESP gnomAD
CA178229985 rs1053795900	776	D>Y		No	ClinGen Ensembl
CA4772052 rs761120816	780	A>G		No	ClinGen ExAC gnomAD
rs1336520096 CA371214229	783	M>T		No	ClinGen TOPMed
CA4772051 rs192394900	789	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1357962390 CA371214108	801	M>V		No	ClinGen TOPMed
TCGA novel	804	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772261055 CA178229959	807	R>G		No	ClinGen Ensembl
CA371214053 rs1404916182	808	Y>F		No	ClinGen gnomAD
TCGA novel	810	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA178229923 rs748544685	814	G>R		No	ClinGen Ensembl
rs1336220096 CA371213952	815	Q>R		No	ClinGen gnomAD
CA371213937 rs1468139759	816	T>I		No	ClinGen gnomAD
CA371213932 rs1168268343	817	L>F		No	ClinGen gnomAD
rs376677831 CA4772029	820	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs773423820 CA4772028	821	A>G		No	ClinGen ExAC
rs773423820 CA178229592	821	A>V		No	ClinGen ExAC
rs1241949806 CA371213558	831	I>V		No	ClinGen gnomAD
CA371213545 rs1191036972	833	M>L		No	ClinGen TOPMed
TCGA novel	834	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371213325 rs1244097264	845	N>S		No	ClinGen gnomAD
rs1222890188 CA371213282	848	T>A		No	ClinGen gnomAD
CA178226230 rs919102903	849	K>R		No	ClinGen TOPMed
rs1377303552 CA371213251	850	E>G		No	ClinGen gnomAD
CA4772000 rs745807755	851	Q>R		No	ClinGen ExAC gnomAD
rs1408896716 CA371213209	853	I>V		No	ClinGen TOPMed
rs1357085508 CA371213144	857	R>K		No	ClinGen TOPMed
TCGA novel	858	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4771999 rs201654906	860	N>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	864	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	868	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371212983 rs1311204931	870	L>I		No	ClinGen TOPMed gnomAD
CA371212953 COSM1101227 rs1176167354	872	A>D	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1408047976 CA371212959	872	A>S		No	ClinGen gnomAD
TCGA novel	873	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4771995 rs755810202	874	Y>C		No	ClinGen ExAC gnomAD
CA371212800 RCV000850381 rs1490604083	884	M>V		No	ClinGen ClinVar TOPMed dbSNP gnomAD
CA178226184 rs951483189	887	T>A		No	ClinGen gnomAD
TCGA novel	888	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4771994 rs747712444	890	L>V		No	ClinGen ExAC gnomAD
CA4771993 rs781541220	892	I>V		No	ClinGen ExAC gnomAD
rs1025716820 CA178226150	894	T>A		No	ClinGen Ensembl
rs1017568863 CA178226142	897	S>N		No	ClinGen TOPMed
TCGA novel	901	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1158609538 CA371211847	904	E>V		No	ClinGen gnomAD
TCGA novel	921	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA178224472 COSM1245309 rs988981305	921	T>I	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed
TCGA novel	928	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371211646 rs1446120711	932	V>F		No	ClinGen TOPMed
TCGA novel	936	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371211542 rs1430594041	947	P>S		No	ClinGen gnomAD
TCGA novel	948	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1308583743 CA371209523	952	A>S		No	ClinGen gnomAD
CA4771949 rs746403844	954	T>M		No	ClinGen ExAC gnomAD
TCGA novel	957	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1358530735 CA371209442	958	A>G		No	ClinGen TOPMed gnomAD
CA4771947 rs757781689	960	F>C		No	ClinGen ExAC gnomAD
rs1164407678 CA371209381	963	G>C		No	ClinGen TOPMed gnomAD
rs1164407678 CA371209379	963	G>S		No	ClinGen TOPMed gnomAD
CA371209362 rs1587114144	965	Q>K		No	ClinGen Ensembl
rs1383425247 CA371209346 COSM194709	966	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs756434225 CA4771944	967	C>S		No	ClinGen ExAC gnomAD
TCGA novel	970	T>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371209273 rs1171217848	970	T>I		No	ClinGen TOPMed
CA371209256 rs766205926	971	E>D		No	ClinGen ExAC TOPMed gnomAD
rs750228227 CA4771940 CA4771941	972	V>L		No	ClinGen ExAC TOPMed gnomAD
rs765125851 CA4771939	974	S>C		No	ClinGen ExAC TOPMed gnomAD
rs765125851 CA371209224	974	S>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	975	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1398070538 CA371209156	980	I>V		No	ClinGen TOPMed
rs201419316 CA4771938	982	C>R		No	ClinGen 1000Genomes ExAC gnomAD
rs763556817 CA4771936	984	I>M		No	ClinGen ExAC gnomAD
CA4771937 rs776142271	984	I>V		No	ClinGen ExAC gnomAD
CA4771934 rs142188640	989	I>V		No	ClinGen ESP ExAC gnomAD
TCGA novel	991	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752871160 CA178211116	995	E>V		No	ClinGen Ensembl
CA178211085 rs372985099	1000	V>I		No	ClinGen ESP TOPMed gnomAD
CA4771913 rs774607442	1014	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1587111244 CA371207722	1015	I>V		No	ClinGen Ensembl
CA371207514 rs1440617892	1024	D>G		No	ClinGen TOPMed
CA4771911 rs749822900	1030	I>T		No	ClinGen ExAC gnomAD
TCGA novel	1031	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs113798396 CA178211042	1032	V>A		No	ClinGen Ensembl
rs1370452083 CA371207394	1034	H>N		No	ClinGen Ensembl
rs145286962 CA371207365	1036	D>H		No	ClinGen ESP ExAC gnomAD
CA4771909 rs145286962	1036	D>N		No	ClinGen ESP ExAC gnomAD
CA4771908 rs375079762	1039	Y>C		No	ClinGen ESP ExAC gnomAD
CA4771888 rs768714441	1057	A>T		No	ClinGen ExAC gnomAD
CA4771886 rs780313573	1059	L>F		No	ClinGen ExAC gnomAD
rs749124100 CA4771884	1060	I>M		No	ClinGen ExAC gnomAD
rs1183176292 CA371206660	1066	P>A		No	ClinGen gnomAD
CA371206649 rs1437573073	1067	R>*		No	ClinGen gnomAD
rs1250094954 CA371206647 COSM1101219	1067	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA4771882 rs756032037	1068	Y>C		No	ClinGen ExAC gnomAD
CA371206588 rs752610322	1070	S>P		No	ClinGen ExAC TOPMed gnomAD
CA4771881 rs752610322	1070	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1376978967 CA371206562	1071	G>E		No	ClinGen TOPMed
rs1008886908 CA178210610	1075	G>C		No	ClinGen TOPMed
CA4771880 rs780576264	1077	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1432971720 CA371206270	1085	D>H		No	ClinGen TOPMed
rs139223571 CA178210560	1086	Q>H		No	ClinGen ESP TOPMed
CA4771879 rs754572236	1087	A>P		No	ClinGen ExAC TOPMed gnomAD
CA371206189 rs1352936766	1087	A>V		No	ClinGen gnomAD
rs751107137 CA4771878	1088	P>S		No	ClinGen ExAC TOPMed gnomAD
rs751107137 CA371206188	1088	P>T		No	ClinGen ExAC TOPMed gnomAD
CA371206150 rs996116653	1090	E>D		No	ClinGen TOPMed gnomAD
rs1279159476 CA371204107	1097	V>A		No	ClinGen TOPMed
CA371203978 rs1342621540	1102	D>G		No	ClinGen TOPMed
rs111784419 CA178205590	1104	K>R		No	ClinGen Ensembl
rs1189670760 CA371203785	1111	E>G		No	ClinGen gnomAD
CA4771857 rs754839021	1113	I>T		No	ClinGen ExAC gnomAD
rs1188069454 CA371203701	1117	S>G		No	ClinGen gnomAD
rs375461478 CA4771838	1131	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs779714564 CA4771837	1133	T>A		No	ClinGen ExAC gnomAD
rs1168145356 CA371201755	1138	N>D		No	ClinGen gnomAD
CA178202109 rs924441420	1138	N>S		No	ClinGen TOPMed
CA4771812 rs778208022	1145	R>C		No	ClinGen ExAC TOPMed gnomAD
rs756525677 CA4771810	1145	R>H		No	ClinGen ExAC gnomAD
rs778208022 CA4771811	1145	R>S		No	ClinGen ExAC TOPMed gnomAD
CA4771808 rs781692371	1152	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA178201910 rs955116586	1153	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	1154	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4771806 rs751681115	1157	S>C		No	ClinGen ExAC gnomAD
rs1288100333 CA371201462	1158	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA371201457 rs1219606941	1159	T>A		No	ClinGen TOPMed
rs1347785695 CA371201455	1159	T>I		No	ClinGen gnomAD
rs763241729 CA4771804	1160	H>N		No	ClinGen ExAC gnomAD
rs1386468724 CA371201442	1161	P>R		No	ClinGen gnomAD
rs1387736660 CA371201385	1169	I>V		No	ClinGen gnomAD
CA178201871 rs868146086	1177	M>I		No	ClinGen Ensembl
rs1261256523 CA371201205	1182	L>I		No	ClinGen TOPMed gnomAD
TCGA novel	1184	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4771801 rs760613968	1188	W>S		No	ClinGen ExAC gnomAD
rs867694198 CA178201469	1202	P>S		No	ClinGen TOPMed
CA371200541 rs1587085799	1206	V>I		No	ClinGen Ensembl
CA371200513 rs1381218522	1208	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	1209	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA178201441 rs998787281	1211	V>I		No	ClinGen TOPMed gnomAD
rs1295551174 CA371200258	1219	M>I		No	ClinGen gnomAD
rs1587085716 CA371200271	1219	M>V		No	ClinGen Ensembl
rs1454509000 CA371200254	1220	K>Q		No	ClinGen gnomAD
rs747757030 CA4771774 COSM3951807	1225	G>R	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	1236	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1240	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4771771 rs747385663	1242	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4771769 rs758907802	1243	I>T		No	ClinGen ExAC gnomAD
CA371199780 rs1206103055	1246	R>Q		No	ClinGen TOPMed gnomAD
CA371199782 rs1253162847	1246	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA4771744 rs751331329	1249	S>C		No	ClinGen ExAC gnomAD
rs1257063541 CA371199688	1251	T>I		No	ClinGen TOPMed
CA4771743 rs553520474	1253	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4771742 rs758271830	1258	R>Q		No	ClinGen ExAC gnomAD
rs1242748363 CA371199646	1258	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA178201162 rs988555627	1261	A>G		No	ClinGen Ensembl
rs750301034 CA4771741	1263	M>T		No	ClinGen ExAC gnomAD
CA4771739 rs761379423	1268	A>V		No	ClinGen ExAC gnomAD
rs1321093475 CA371199543	1270	N>D		No	ClinGen gnomAD
rs1460485840 CA371199456	1275	W>R		No	ClinGen TOPMed
CA371199399 rs1404084178	1276	K>N		No	ClinGen gnomAD
rs1160560536 CA371199346	1278	I>N		No	ClinGen gnomAD
rs1391397839 CA371199347	1278	I>V		No	ClinGen gnomAD
rs955757386 CA178201133	1280	S>A		No	ClinGen TOPMed
CA371199156 rs1410248694	1284	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs760327271 CA4771736	1286	A>S		No	ClinGen ExAC gnomAD
rs760327271 CA371199091	1286	A>T		No	ClinGen ExAC gnomAD
TCGA novel	1286	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1478503998 CA371199058	1287	S>F		No	ClinGen gnomAD
CA371199047 rs1246186593	1288	D>H		No	ClinGen gnomAD
rs1196773781 CA371199016	1289	Q>P		No	ClinGen gnomAD
CA371198987 rs1421230696	1290	D>G		No	ClinGen TOPMed
CA4771735 rs775750702	1290	D>N		No	ClinGen ExAC gnomAD
rs367664307 CA178201081	1293	I>V		No	ClinGen ESP TOPMed gnomAD
CA178201075 rs978430189	1297	A>E		No	ClinGen Ensembl
CA371198773 rs1563849840	1298	F>L		No	ClinGen Ensembl
rs760137402 CA4771733	1300	T>I		No	ClinGen ExAC gnomAD
TCGA novel	1302	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4771731 rs374793420	1302	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA371198667 rs1340496124	1303	H>N		No	ClinGen gnomAD
CA4771727 rs748333460	1304	I>N		No	ClinGen ExAC gnomAD
CA4771728 rs769938373	1304	I>V		No	ClinGen ExAC gnomAD
rs549571655 CA4771707	1306	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA371197170 rs1489949999	1309	F>C		No	ClinGen gnomAD
rs1390858728 CA371197163	1310	E>Q		No	ClinGen gnomAD
rs1168106065 CA371197145	1311	K>*		No	ClinGen gnomAD
TCGA novel	1312	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1312	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1312	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4771706 CA371197108 rs773167167	1313	F>L		No	ClinGen ExAC TOPMed gnomAD
CA4771705 rs769851880	1314	P>A		No	ClinGen ExAC gnomAD
TCGA novel	1315	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4771704 rs142115845	1315	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1482780011 CA371197069	1317	I>V		No	ClinGen gnomAD
TCGA novel CA4771702 rs768834501	1318	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC gnomAD NCI-TCGA
rs745712094 CA4771701	1319	S>C		No	ClinGen ExAC TOPMed gnomAD
rs200846406 CA4771699	1320	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA371196967 rs1184994996	1323	A>E		No	ClinGen TOPMed
CA4771698 rs201732515	1323	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA371196799 rs1282861285	1330	F>I		No	ClinGen gnomAD
rs767341513 CA4771694	1331	A>V		No	ClinGen ExAC TOPMed gnomAD
CA4771692 rs751980171	1332	C>W		No	ClinGen ExAC TOPMed gnomAD
CA4771691 rs766814154	1333	N>H		No	ClinGen ExAC gnomAD
rs1216229672 CA371196731	1333	N>S		No	ClinGen gnomAD
CA4771690 rs763579019	1335	A>D		No	ClinGen ExAC gnomAD
rs1563849152 CA371196656	1335	A>S		No	ClinGen Ensembl
CA371196612 rs1411354649	1337	P>A		No	ClinGen gnomAD
TCGA novel	1340	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371196497 rs1460460227	1340	S>N		No	ClinGen TOPMed
rs1406844180 CA371196308	1345	R>Q		No	ClinGen TOPMed
CA371196246 rs1472796528	1347	I>T		No	ClinGen gnomAD
CA178199894 rs370394131	1348	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
COSM1101210 rs1250558374 CA371196206	1348	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs773820080 CA4771689	1350	C>R		No	ClinGen ExAC gnomAD
CA4771688 rs765632256	1353	Y>H		No	ClinGen ExAC gnomAD
CA4771685 rs199775958	1356	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1347846005 CA371195891	1356	D>H		No	ClinGen TOPMed gnomAD
TCGA novel	1362	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1322434117 CA371195349	1364	Y>C		No	ClinGen gnomAD
CA4771668 rs764116931	1366	S>N		No	ClinGen ExAC TOPMed gnomAD
COSM3432512 rs775735472 CA4771666	1367	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs773726515 CA4771665	1369	M>T		No	ClinGen ExAC TOPMed gnomAD
CA178198914 rs961858754	1371	V>I		No	ClinGen gnomAD
CA371195118 rs1249402722	1372	A>V		No	ClinGen gnomAD
rs1246422272 CA371194996	1377	V>L		No	ClinGen gnomAD
TCGA novel	1378	W>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA178198878 rs78319917	1383	F>V		No	ClinGen Ensembl
rs780874117 CA4771659	1384	P>A		No	ClinGen ExAC gnomAD
rs377506272 CA4771658	1385	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA371194801 rs1368615255	1386	L>V		No	ClinGen Ensembl
rs1256757226 CA371194766	1387	F>C		No	ClinGen gnomAD
CA4771657 rs746489087	1389	L>I		No	ClinGen ExAC gnomAD
CA4771656 rs779920834	1390	S>F		No	ClinGen ExAC
CA371194666 rs1299997718	1392	I>V		No	ClinGen TOPMed gnomAD
rs750813318 CA4771654	1394	N>S		No	ClinGen ExAC TOPMed gnomAD
CA371194581 rs1316136340	1395	R>K		No	ClinGen gnomAD
CA371194419 rs1301876508	1401	R>T		No	ClinGen gnomAD
rs1013775742 CA178194167	1412	M>T		No	ClinGen TOPMed
rs1254196396 CA371192385	1415	Y>C		No	ClinGen gnomAD
CA371192306 rs1271022707	1417	H>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4771639 rs779653335	1418	T>A		No	ClinGen ExAC gnomAD
CA178194141 rs775589893	1421	K>T		No	ClinGen Ensembl
TCGA novel	1425	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1427	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1214812941 CA371191855 COSM605944	1429	R>I	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA4771636 rs779355989	1432	F>S		No	ClinGen ExAC gnomAD
CA371191488 rs1288559470	1441	P>R		No	ClinGen gnomAD
rs1217832756 CA371191447	1443	Q>R		No	ClinGen TOPMed
rs1307431671 CA371190506	1453	T>I		No	ClinGen TOPMed
CA371190305 rs1320471329	1460	Y>F		No	ClinGen TOPMed
CA4771607 rs766569116	1461	A>S		No	ClinGen ExAC gnomAD
rs1478371319 CA371190281	1462	I>V		No	ClinGen TOPMed gnomAD
CA4771605 rs753691197	1464	D>V		No	ClinGen ExAC gnomAD
CA178192875 rs914514650	1471	E>K		No	ClinGen Ensembl
TCGA novel	1474	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371189953 rs1179940786	1474	S>R		No	ClinGen TOPMed
CA371189911 rs1445097490	1475	D>G		No	ClinGen gnomAD
rs1230870028 CA371189865	1476	V>A		No	ClinGen TOPMed
rs1280240081 CA371189892	1476	V>I		No	ClinGen gnomAD
CA4771602 rs775335992	1481	I>V		No	ClinGen ExAC gnomAD
rs142342517 CA4771601	1483	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs759031840 CA4771600	1486	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	1488	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1321816950 CA371189523	1489	V>L		No	ClinGen gnomAD
CA178192620 rs772338295	1499	S>P		No	ClinGen Ensembl
CA4771571 rs772327347	1503	C>Y		No	ClinGen ExAC gnomAD
CA4771570 rs745909815	1507	V>I		No	ClinGen ExAC gnomAD
CA178192555 rs984450556	1509	I>V		No	ClinGen Ensembl
CA178192554 rs951697257	1511	N>S		No	ClinGen TOPMed
CA371188687 rs1478731972	1513	E>K		No	ClinGen TOPMed
CA371188643 rs1204421626	1515	F>S		No	ClinGen gnomAD
CA4771566 rs562598310	1517	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA4771567 rs752446276	1517	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1521	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200528352 CA4771564	1522	K>R		No	ClinGen ExAC TOPMed gnomAD
CA371188494 rs1414609273	1524	C>F		No	ClinGen TOPMed
rs1038538095 CA178192517	1525	N>D		No	ClinGen Ensembl
CA4771562 rs762520131	1525	N>K		No	ClinGen ExAC gnomAD
CA4771563 rs766277577	1525	N>S		No	ClinGen ExAC gnomAD
CA4771561 rs749924378	1529	D>H		No	ClinGen ExAC
rs111800527 CA178192507	1531	F>L		No	ClinGen Ensembl
rs761463781 CA371188370	1532	K>E		No	ClinGen ExAC gnomAD
rs761463781 CA4771559	1532	K>Q		No	ClinGen ExAC gnomAD
CA371188318 rs1351481157	1535	I>V		No	ClinGen gnomAD
rs1158418686 CA371188297	1536	P>L		No	ClinGen gnomAD
CA371188285 rs1440764608	1538	A>T		No	ClinGen TOPMed gnomAD
rs1045151994 COSM1457932 CA178192501	1538	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1368306069 CA371187888	1539	L>M		No	ClinGen TOPMed
TCGA novel	1542	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749942462 CA371187771	1543	R>*		No	ClinGen ExAC TOPMed gnomAD
rs764686681 CA4771540	1543	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs761394814 CA178191725	1545	N>I		No	ClinGen ExAC TOPMed gnomAD
CA4771539 rs761394814	1545	N>S		No	ClinGen ExAC TOPMed gnomAD
rs753576102 CA4771538	1547	G>R		No	ClinGen ExAC gnomAD
rs1004723225 CA178191695	1548	E>G		No	ClinGen Ensembl
CA178191691 rs886278417	1549	T>A		No	ClinGen TOPMed
CA371187687 rs886278417	1549	T>P		No	ClinGen TOPMed
CA4771537 rs763622698	1550	A>V		No	ClinGen ExAC TOPMed gnomAD
CA4771536 rs761167080	1551	P>H		No	ClinGen ExAC
rs528881590 CA178191673	1551	P>S		No	ClinGen 1000Genomes gnomAD
rs142098461 CA371187651	1552	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4771532 rs142098461	1552	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs142098461 CA4771533	1552	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs772716482 CA4771534	1552	P>S		No	ClinGen ExAC gnomAD
rs1158560535 CA371187641	1553	P>L		No	ClinGen TOPMed
CA4771530 rs374667605	1553	P>S		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs774148781	1553	P>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA4771529 rs749301225	1556	P>L		No	ClinGen ExAC TOPMed gnomAD
CA4771528 rs773554490	1558	S>N		No	ClinGen ExAC gnomAD
CA371187528 rs1461552161	1561	P>S		No	ClinGen TOPMed
rs748331865 CA4771505	1563	D>V		No	ClinGen ExAC
CA178188523 rs143577156	1563	D>Y		No	ClinGen ESP gnomAD
CA4771503 rs771904962	1564	T>I		No	ClinGen ExAC gnomAD
CA371186431 rs1338593829	1565	I>V		No	ClinGen gnomAD
rs778974444 CA4771501	1566	S>P		No	ClinGen ExAC TOPMed gnomAD
rs778974444 CA371186407	1566	S>T		No	ClinGen ExAC TOPMed gnomAD
CA178188508 rs538530120	1567	Q>H		No	ClinGen gnomAD
rs947225314 CA178188507	1568	K>T		No	ClinGen Ensembl
rs757127977 CA4771500	1569	S>F		No	ClinGen ExAC gnomAD
rs1292257643 CA371186341	1570	V>I		No	ClinGen gnomAD
rs368780304 CA4771498	1572	I>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA4771497 rs368780304	1572	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs748842649 COSM77284 CA4771499	1572	I>V	ovary [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1384835038 CA371186279	1573	H>L		No	ClinGen TOPMed
CA371186265 rs1563839149	1573	H>Q		No	ClinGen Ensembl
CA178188466 rs914079132	1574	D>G		No	ClinGen TOPMed
rs991217984 CA178188450	1578	P>R		No	ClinGen Ensembl
rs1308125389 CA371186185	1578	P>S		No	ClinGen TOPMed
rs755463973 CA4771494	1579	R>G		No	ClinGen ExAC gnomAD
rs751961605 CA4771493	1581	V>A		No	ClinGen ExAC gnomAD
CA178188414 rs371657272	1582	D>N		No	ClinGen ESP TOPMed
rs1164327469 CA371186095	1583	N>S		No	ClinGen Ensembl
CA371186085 rs766927159	1584	R>K		No	ClinGen ExAC TOPMed gnomAD
CA178188393 rs185041603	1584	R>S		No	ClinGen 1000Genomes
CA4771492 rs766927159	1584	R>T		No	ClinGen ExAC TOPMed gnomAD
rs1474387977 CA371186068	1585	P>L		No	ClinGen gnomAD
rs1164463476 CA371186075	1585	P>T		No	ClinGen gnomAD
CA371185956 rs1182543725	1590	V>F		No	ClinGen gnomAD
rs771627826 CA178188372	1591	S>F		No	ClinGen gnomAD
rs771627826 CA371185944	1591	S>Y		No	ClinGen gnomAD
CA4771490 rs200067038	1592	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs148891437 CA4771489	1592	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1231068075 CA371185913	1594	A>T		No	ClinGen gnomAD
rs192893582 CA4771486	1596	N>K		No	ClinGen 1000Genomes ExAC gnomAD
rs759384353 CA4771485	1597	E>G		No	ClinGen ExAC gnomAD
rs1181758314 CA371185848	1599	V>A		No	ClinGen TOPMed
CA371185774 rs1563839023	1605	T>A		No	ClinGen Ensembl
rs1327415815 CA371185771	1605	T>R		No	ClinGen gnomAD
CA4771467 rs753899026	1608	F>L		No	ClinGen ExAC gnomAD
rs760819223 CA4771465	1610	E>A		No	ClinGen ExAC gnomAD
rs774229384 CA4771464	1616	A>V	Variant assessed as Somatic; 4.636e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs770578752 CA4771463	1621	C>R		No	ClinGen ExAC gnomAD
rs1438619127 CA371210203	1629	Q>H		No	ClinGen TOPMed
rs1321046312 CA371210199	1630	T>A		No	ClinGen gnomAD
CA371210191 rs1192023379	1631	I>V		No	ClinGen gnomAD
rs773060622 CA4771461	1632	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4771460 rs201164020	1633	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1346565578 CA371210155	1634	I>F		No	ClinGen gnomAD
rs1346565578 CA371210156	1634	I>V		No	ClinGen gnomAD
rs1280207113 CA371210150	1635	V>I		No	ClinGen gnomAD
TCGA novel	1636	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4771459 rs747676449	1637	F>S		No	ClinGen ExAC gnomAD
rs1364504901 CA371210109	1639	A>T		No	ClinGen gnomAD
TCGA novel	1644	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1164047191 CA371210006	1653	Q>R		No	ClinGen TOPMed
rs202145371 CA4771437	1655	D>G		No	ClinGen ExAC TOPMed gnomAD
rs746498172 CA4771438	1655	D>N		No	ClinGen ExAC gnomAD
rs771740489 CA4771436	1656	A>E		No	ClinGen ExAC TOPMed gnomAD
CA371209973 rs771740489	1656	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs779182355 CA4771434	1661	V>A		No	ClinGen ExAC gnomAD
rs146795624 CA4771433	1662	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747174516 CA4771432	1662	R>H		No	ClinGen ExAC gnomAD
rs756186000 CA371209933	1663	V>I		No	ClinGen ExAC TOPMed gnomAD
CA4771430 rs756186000	1663	V>L		No	ClinGen ExAC TOPMed gnomAD
CA371209927 rs1475879568	1664	D>H		No	ClinGen gnomAD
CA371209920 rs1420868062	1665	T>P		No	ClinGen gnomAD
rs752814909 CA4771429	1667	D>N		No	ClinGen ExAC gnomAD
CA371209905 rs752814909	1667	D>Y		No	ClinGen ExAC gnomAD
rs1310875470 CA371209866	1672	R>C		No	ClinGen TOPMed gnomAD
rs200392828 CA4771428	1672	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA178225765 rs753932107	1673	F>L		No	ClinGen Ensembl
CA4771427 rs755163996	1673	F>Y		No	ClinGen ExAC gnomAD
TCGA novel	1674	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1676	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765248096 CA4771425	1687	L>S		No	ClinGen ExAC gnomAD
rs1460740152 CA371209751	1689	S>A		No	ClinGen gnomAD
rs776749836 CA4771423	1691	R>*		No	ClinGen ExAC gnomAD
CA371209708 rs140098688	1695	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs140098688 COSM194695 CA4771421	1695	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs745494130 CA4771418	1700	N>S		No	ClinGen ExAC gnomAD
CA371209669 rs771330319	1701	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs771330319 CA4771416	1701	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA371209643 rs1195608205	1704	T>S		No	ClinGen TOPMed
CA371209641 rs1317577733	1705	A>T		No	ClinGen TOPMed gnomAD
CA371209631 rs1265932859	1706	L>R		No	ClinGen gnomAD
CA371209618 rs1223715004	1708	K>T		No	ClinGen gnomAD
TCGA novel	1709	A>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1710	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4771396 rs770563842	1715	S>F		No	ClinGen ExAC TOPMed gnomAD
CA371208905 rs770563842	1715	S>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1718	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1718	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763363183 CA4771395	1718	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs773562348 CA4771394	1720	L>V		No	ClinGen ExAC gnomAD
TCGA novel	1725	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1174799553 CA371208838	1725	S>T		No	ClinGen gnomAD
CA4771392 rs748644009	1729	C>S		No	ClinGen ExAC gnomAD
CA4771391 rs781533455	1730	G>R		No	ClinGen ExAC gnomAD
CA371208777 rs1563832518	1732	R>C		No	ClinGen Ensembl
TCGA novel	1733	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1261248319 CA371208730	1736	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4771390 rs112331011	1736	R>W		No	ClinGen ExAC gnomAD
rs1295752067 CA371208698	1739	M>T		No	ClinGen gnomAD
CA4771389 rs376386254	1739	M>V		No	ClinGen ESP ExAC gnomAD
CA371208664 rs1211586520	1742	S>G		No	ClinGen TOPMed
CA371208659 rs1258403438	1742	S>N		No	ClinGen gnomAD
rs200667386 CA178224596	1742	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA4771387 rs758636963	1743	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4771386 rs753689074	1743	R>H		No	ClinGen ExAC TOPMed gnomAD
rs372291665 CA4771384	1744	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1587023221 CA371208634	1745	S>G		No	ClinGen Ensembl
CA4771383 rs148841369	1745	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA371208622 rs1169338020	1746	A>S		No	ClinGen gnomAD
rs141949495 CA4771382	1749	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs909120619 CA178224565	1755	L>S		No	ClinGen TOPMed gnomAD
rs1352195908 CA371208437	1758	C>S		No	ClinGen gnomAD
CA4771352 rs775732841	1771	E>D		No	ClinGen ExAC gnomAD
TCGA novel	1772	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371208311 rs1455115002	1773	H>R		No	ClinGen TOPMed
CA371208305 rs1232838320	1774	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs745904733 CA4771350	1775	E>K		No	ClinGen ExAC gnomAD
CA371208295 rs1372245205	1776	A>P		No	ClinGen gnomAD
CA371207881 rs1159159227	1784	F>L		No	ClinGen gnomAD
rs554847027 CA178223813	1787	K>N		No	ClinGen Ensembl
TCGA novel	1789	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774697108 CA4771349	1791	I>M		No	ClinGen ExAC gnomAD
rs771042710 CA4771348	1792	S>R		No	ClinGen ExAC TOPMed gnomAD
CA371207747 rs1195463388	1792	S>T		No	ClinGen gnomAD
CA371207696 rs780928406	1795	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1282973032 CA371206599	1796	F>L		No	ClinGen TOPMed
CA4771285 rs770883946	1803	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	1803	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4771284 rs748819686	1804	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	1805	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772781521 CA4771283	1807	L>V		No	ClinGen ExAC gnomAD
rs1488246912 CA371206408	1808	C>Y		No	ClinGen gnomAD
CA4771281 rs747854182	1811	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1249315086 CA371206272	1815	L>F		No	ClinGen TOPMed
rs1051426438 CA178222536	1815	L>M		No	ClinGen TOPMed gnomAD
CA4771279 rs755365542	1817	P>A		No	ClinGen ExAC gnomAD
CA371206200 rs1301632153	1820	R>H		No	ClinGen gnomAD
CA371206190 rs1386019458	1821	A>V		No	ClinGen gnomAD
CA4771278 rs780443181	1822	V>I		No	ClinGen ExAC gnomAD
CA4771277 rs780443181	1822	V>L		No	ClinGen ExAC gnomAD
rs879166392 CA178222530	1823	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA371206167 rs1189313598	1824	R>G		No	ClinGen TOPMed
TCGA novel	1829	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM274020 rs750537195 CA4771274	1831	G>R	kidney Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs765254352 CA4771273	1832	V>I		No	ClinGen ExAC gnomAD
rs1177181414 CA371205934	1835	Q>H		No	ClinGen gnomAD
CA4771272 rs757302258	1836	I>L		No	ClinGen ExAC gnomAD
CA4771271 rs754044082	1837	S>P		No	ClinGen ExAC gnomAD
rs754044082 CA371205917	1837	S>T		No	ClinGen ExAC gnomAD
rs921667617 CA178222510	1842	Q>R		No	ClinGen TOPMed
CA371205779 rs1214544003	1843	E>A		No	ClinGen gnomAD
CA178222508 rs991959376	1844	L>F		No	ClinGen gnomAD
rs764369258 CA4771270	1849	Q>*		No	ClinGen ExAC gnomAD

No associated diseases with Q9Y6D6

2 regional properties for Q9Y6D6

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	120 - 380	IPR000719
active_site	Serine/threonine-protein kinase, active site	239 - 251	IPR008271

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Cytoplasm, perinuclear region Golgi apparatus Golgi apparatus, trans-Golgi network membrane Nucleus Nucleus, nucleolus Nucleus matrix	Translocates from cytoplasm to membranes and nucleus upon cAMP treatment
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
nuclear matrix	The dense fibrillar network lying on the inner side of the nuclear membrane.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
small nuclear ribonucleoprotein complex	A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs.
trans-Golgi network	The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

3 GO annotations of molecular function

Name	Definition
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
myosin binding	Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
protein kinase A regulatory subunit binding	Binding to one or both of the regulatory subunits of protein kinase A.

10 GO annotations of biological process

Name	Definition
endomembrane system organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
exocytosis	A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
Golgi organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
negative regulation of actin filament polymerization	Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
negative regulation of GTPase activity	Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
positive regulation of wound healing	Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
protein glycosylation	A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of ARF protein signal transduction	Any process that modulates the frequency, rate or extent of ARF protein signal transduction.
regulation of establishment of cell polarity	Any process that modulates the frequency, rate or extent of establishment of cell polarity.

14 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O46382	ARFGEF1	Brefeldin A-inhibited guanine nucleotide-exchange protein 1	Bos taurus (Bovine)	PR
Q9Y6D5	ARFGEF2	Brefeldin A-inhibited guanine nucleotide-exchange protein 2	Homo sapiens (Human)	PR
Q9UIA0	CYTH4	Cytohesin-4	Homo sapiens (Human)	SS
Q5JU85	IQSEC2	IQ motif and SEC7 domain-containing protein 2	Homo sapiens (Human)	EV
Q9UPP2	IQSEC3	IQ motif and SEC7 domain-containing protein 3	Homo sapiens (Human)	SS
Q6DN90	IQSEC1	IQ motif and SEC7 domain-containing protein 1	Homo sapiens (Human)	EV
Q99418	CYTH2	Cytohesin-2	Homo sapiens (Human)	SS
O43739	CYTH3	Cytohesin-3	Homo sapiens (Human)	EV
Q15438	CYTH1	Cytohesin-1	Homo sapiens (Human)	SS
Q92538	GBF1	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	Homo sapiens (Human)	PR
A2A5R2	Arfgef2	Brefeldin A-inhibited guanine nucleotide-exchange protein 2	Mus musculus (Mouse)	PR
G3X9K3	Arfgef1	Brefeldin A-inhibited guanine nucleotide-exchange protein 1	Mus musculus (Mouse)	PR
D4A631	Arfgef1	Brefeldin A-inhibited guanine nucleotide-exchange protein 1	Rattus norvegicus (Rat)	PR
Q7TSU1	Arfgef2	Brefeldin A-inhibited guanine nucleotide-exchange protein 2	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MYEGKKTKNM	FLTRALEKIL	ADKEVKKAHH	SQLRKACEVA	LEEIKAETEK	QSPPHGEAKA
70	80	90	100	110	120
GSSTLPPVKS	KTNFIEADKY	FLPFELACQS	KCPRIVSTSL	DCLQKLIAYG	HLTGNAPDST
130	140	150	160	170	180
TPGKKLIDRI	IETICGCFQG	PQTDEGVQLQ	IIKALLTAVT	SQHIEIHEGT	VLQAVRTCYN
190	200	210	220	230	240
IYLASKNLIN	QTTAKATLTQ	MLNVIFARME	NQALQEAKQM	EKERHRQHHH	LLQSPVSHHE
250	260	270	280	290	300
PESPQLRYLP	PQTVDHISQE	HEGDLDLHTN	DVDKSLQDDT	EPENGSDISS	AENEQTEADQ
310	320	330	340	350	360
ATAAETLSKN	EVLYDGENHD	CEEKPQDIVQ	NIVEEMVNIV	VGDMGEGTTI	NASADGNIGT
370	380	390	400	410	420
IEDGSDSENI	QANGIPGTPI	SVAYTPSLPD	DRLSVSSNDT	QESGNSSGPS	PGAKFSHILQ
430	440	450	460	470	480
KDAFLVFRSL	CKLSMKPLSD	GPPDPKSHEL	RSKILSLQLL	LSILQNAGPI	FRTNEMFINA
490	500	510	520	530	540
IKQYLCVALS	KNGVSSVPEV	FELSLSIFLT	LLSNFKTHLK	MQIEVFFKEI	FLYILETSTS
550	560	570	580	590	600
SFDHKWMVIQ	TLTRICADAQ	SVVDIYVNYD	CDLNAANIFE	RLVNDLSKIA	QGRGSQELGM
610	620	630	640	650	660
SNVQELSLRK	KGLECLVSIL	KCMVEWSKDQ	YVNPNSQTTL	GQEKPSEQEM	SEIKHPETIN
670	680	690	700	710	720
RYGSLNSLES	TSSSGIGSYS	TQMSGTDNPE	QFEVLKQQKE	IIEQGIDLFN	KKPKRGIQYL
730	740	750	760	770	780
QEQGMLGTTP	EDIAQFLHQE	ERLDSTQVGE	FLGDNDKFNK	EVMYAYVDQH	DFSGKDFVSA
790	800	810	820	830	840
LRMFLEGFRL	PGEAQKIDRL	MEKFAARYLE	CNQGQTLFAS	ADTAYVLAYS	IIMLTTDLHS
850	860	870	880	890	900
PQVKNKMTKE	QYIKMNRGIN	DSKDLPEEYL	SAIYNEIAGK	KISMKETKEL	TIPTKSSKQN
910	920	930	940	950	960
VASEKQRRLL	YNLEMEQMAK	TAKALMEAVS	HVQAPFTSAT	HLEHVRPMFK	LAWTPFLAAF
970	980	990	1000	1010	1020
SVGLQDCDDT	EVASLCLEGI	RCAIRIACIF	SIQLERDAYV	QALARFTLLT	VSSGITEMKQ
1030	1040	1050	1060	1070	1080
KNIDTIKTLI	TVAHTDGNYL	GNSWHEILKC	ISQLELAQLI	GTGVKPRYIS	GTVRGREGSL
1090	1100	1110	1120	1130	1140
TGTKDQAPDE	FVGLGLVGGN	VDWKQIASIQ	ESIGETSSQS	VVVAVDRIFT	GSTRLDGNAI
1150	1160	1170	1180	1190	1200
VDFVRWLCAV	SMDELLSTTH	PRMFSLQKIV	EISYYNMGRI	RLQWSRIWEV	IGDHFNKVGC
1210	1220	1230	1240	1250	1260
NPNEDVAIFA	VDSLRQLSMK	FLEKGELANF	RFQKDFLRPF	EHIMKRNRSP	TIRDMVVRCI
1270	1280	1290	1300	1310	1320
AQMVNSQAAN	IRSGWKNIFS	VFHLAASDQD	ESIVELAFQT	TGHIVTLVFE	KHFPATIDSF
1330	1340	1350	1360	1370	1380
QDAVKCLSEF	ACNAAFPDTS	MEAIRLIRHC	AKYVSDRPQA	FKEYTSDDMN	VAPEDRVWVR
1390	1400	1410	1420	1430	1440
GWFPILFELS	CIINRCKLDV	RTRGLTVMFE	IMKTYGHTYE	KHWWQDLFRI	VFRIFDNMKL
1450	1460	1470	1480	1490	1500
PEQQTEKAEW	MTTTCNHALY	AICDVFTQYL	EVLSDVLLDD	IFAQLYWCVQ	QDNEQLARSG
1510	1520	1530	1540	1550	1560
TNCLENVVIL	NGEKFTLEIW	DKTCNCTLDI	FKTTIPHALL	TWRPNSGETA	PPPPSPVSEK
1570	1580	1590	1600	1610	1620
PLDTISQKSV	DIHDSIQPRS	VDNRPQAPLV	SASAVNEEVS	KIKSTAKFPE	QKLFAALLIK
1630	1640	1650	1660	1670	1680
CVVQLELIQT	IDNIVFFPAT	SKKEDAENLA	AAQRDAVDFD	VRVDTQDQGM	YRFLTSQQLF
1690	1700	1710	1720	1730	1740
KLLDCLLESH	RFAKAFNSNN	EQRTALWKAG	FKGKSKPNLL	KQETSSLACG	LRILFRMYMD
1750	1760	1770	1780	1790	1800
ESRVSAWEEV	QQRLLNVCSE	ALSYFLTLTS	ESHREAWTNL	LLLFLTKVLK	ISDNRFKAHA
1810	1820	1830	1840
SFYYPLLCEI	MQFDLIPELR	AVLRRFFLRI	GVVFQISQPP	EQELGINKQ