AiPD: Autoinhibited Protein Database

Q9Y613

Gene name	FHOD1 (FHOS, FHOS1)
Protein name	FH1/FH2 domain-containing protein 1
Names	Formin homolog overexpressed in spleen 1, FHOS, Formin homology 2 domain-containing protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:29109
EC number
Protein Class	FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I (PTHR45920)

Descriptions

Formin-family proteins, in the active state, form actin-based structures such as stress fibers. Formin homology domain protein 1 (FHOD1) is a major endothelial formin and is normally autoinhibited by intramolecular interaction between the N-terminal GBD domain and C-terminal DAD domain. The release of DAD allows the FH2 domain to then nucleate and elongate non-branched actin filaments.

Autoinhibitory domains (AIDs)

Target domain	616-1013 (FH2 domains)
Relief mechanism	PTM
Assay	Mutagenesis experiment, Deletion assay, Split protein assay

AID

1081-1145 (DAD domain)

Target domain

616-1013 (FH2 domains)

Relief mechanism

PTM (ROCK-catalyzed phosphorylation of Ser1131, Ser1137, or Thr1141)

Assay

Mutagenesis experiment, Deletion assay, Split protein assay

Accessory elements

No accessory elements

References

Takeya R et al. (2008) "The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells", The EMBO journal, 27, 618-28

Autoinhibited structure

Activated structure

4 structures for Q9Y613

Entry ID	Method	Resolution	Chain	Position	Source
3DAD	X-ray	230 A	A/B	1-339	PDB
6XF1	X-ray	280 A	B/D	14-334	PDB
6XF2	X-ray	711 A	B/D	14-334	PDB
AF-Q9Y613-F1	Predicted				AlphaFoldDB

1032 variants for Q9Y613

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA396314464 rs1213350921	2	A>P		No	ClinGen gnomAD
CA282322989 rs202198443	2	A>V		No	ClinGen TOPMed gnomAD
rs1225828340 CA396314422	3	G>V		No	ClinGen TOPMed gnomAD
rs1307433020 CA396314402	4	G>W		No	ClinGen gnomAD
CA396314366 rs1214633722	6	D>N		No	ClinGen gnomAD
rs766867560 CA8106624	7	R>G		No	ClinGen ExAC gnomAD
rs371173821 CA8106623	8	G>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1265666981 CA396314254	10	G>A		No	ClinGen gnomAD
CA8106620 rs539343247	12	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs539343247 CA8106619	12	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA282322943 rs557437499	12	P>S		No	ClinGen 1000Genomes TOPMed
rs557437499 CA396314177	12	P>T		No	ClinGen 1000Genomes TOPMed
CA396314157 rs1171120616	13	V>L		No	ClinGen gnomAD
CA396314101 rs1475037099	15	V>A		No	ClinGen TOPMed
rs1430355671 CA396314108	15	V>M		No	ClinGen TOPMed gnomAD
CA396314095 rs1393404584	16	V>M		No	ClinGen gnomAD
CA8106618 rs768513270	17	T>A		No	ClinGen ExAC gnomAD
rs749236488 CA8106617	17	T>I		No	ClinGen ExAC gnomAD
rs1255213937 CA396314026	18	V>G		No	ClinGen gnomAD
rs769604004 CA8106615	21	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs867246971 CA282322931	22	Y>H		No	ClinGen gnomAD
rs867246971 CA396313954	22	Y>N		No	ClinGen gnomAD
rs571828284 CA8106613	23	L>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs745712930 CA8106614	23	L>V		No	ClinGen ExAC TOPMed gnomAD
CA396313820 rs1233054976	27	D>N		No	ClinGen gnomAD
rs779142609 CA8106610	30	A>S		No	ClinGen ExAC TOPMed gnomAD
rs779142609 CA396313738	30	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8106609 rs755488635	31	C>S		No	ClinGen ExAC TOPMed gnomAD
rs1395561984 CA396313703	31	C>Y		No	ClinGen TOPMed gnomAD
CA8106607 rs199924523	35	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396313585 rs1435509255	36	E>D		No	ClinGen gnomAD
rs1173097174 CA396313609	36	E>K		No	ClinGen gnomAD
CA396313550 rs1397104508	38	R>C		No	ClinGen gnomAD
CA8106606 rs750850328	38	R>H		No	ClinGen ExAC gnomAD
CA8106605 rs750850328	38	R>L		No	ClinGen ExAC gnomAD
rs1418829065 CA396313536	39	R>W		No	ClinGen gnomAD
rs767070782 CA396313515	40	A>P		No	ClinGen ExAC gnomAD
CA8106604 rs767070782	40	A>S		No	ClinGen ExAC gnomAD
CA282322892 rs767070782	40	A>T		No	ClinGen ExAC gnomAD
rs992063266 CA282322885	41	P>A		No	ClinGen TOPMed gnomAD
CA396313468 rs1597336947	41	P>L		No	ClinGen Ensembl
rs1484994701 CA396313460	42	T>I		No	ClinGen gnomAD
rs1209541498 CA396313455	43	C>S		No	ClinGen gnomAD
rs761530842 CA8106603	44	S>I		No	ClinGen ExAC TOPMed gnomAD
rs773676466 CA396313403	44	S>R		No	ClinGen ExAC TOPMed gnomAD
rs761530842 CA396313412	44	S>T		No	ClinGen ExAC TOPMed gnomAD
CA282322874 rs567469416	45	L>P		No	ClinGen 1000Genomes
rs763615681 CA8106601	46	D>E		No	ClinGen ExAC gnomAD
rs957962312 CA282322869	46	D>N		No	ClinGen TOPMed gnomAD
rs1307485450 CA396313349	47	G>W		No	ClinGen gnomAD
rs762833884 CA8106600	48	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1220658110 CA396313318	48	A>V		No	ClinGen TOPMed
rs775373777 CA8106599	50	P>L		No	ClinGen ExAC TOPMed gnomAD
CA396313212 rs1567399870	53	A>E		No	ClinGen Ensembl
rs1453348290 CA396313159	54	Q>H		No	ClinGen TOPMed gnomAD
CA396313138 rs1206679925	55	I>T		No	ClinGen TOPMed
rs1370102722 CA396313113	56	P>L		No	ClinGen gnomAD
CA396313123 rs1364697882	56	P>T		No	ClinGen TOPMed gnomAD
rs769770868 CA8106598	57	A>T		No	ClinGen ExAC TOPMed gnomAD
rs371163067 CA8106597	57	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA282322838 rs967892821	63	G>R		No	ClinGen Ensembl
CA396312831 rs1465290345	64	A>G		No	ClinGen gnomAD
rs1465290345 CA396312830	64	A>V		No	ClinGen gnomAD
CA396312817 rs1229990575	65	P>S		No	ClinGen gnomAD
rs779087433 CA8106593	66	L>F		No	ClinGen ExAC gnomAD
CA396309727 rs1252073588	68	L>V		No	ClinGen TOPMed gnomAD
rs201110066 CA8106577	69	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA396309698 rs1453167148	70	D>N		No	ClinGen TOPMed gnomAD
rs149529136 CA8106575	72	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs149529136 CA8106574	72	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA396309588 rs1597328066	73	L>P		No	ClinGen Ensembl
rs1442166694 CA396309530	74	Q>H		No	ClinGen TOPMed
rs769052388 CA8106573	74	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs868071545 CA282316804	75	V>L		No	ClinGen Ensembl
rs540354299 CA282316798	77	P>A		No	ClinGen Ensembl
rs1299959982 CA396309471	77	P>L		No	ClinGen gnomAD
CA396309425 rs150611515	79	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8106571 rs150611515	79	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA396309354 rs1439049011	80	Y>*		No	ClinGen gnomAD
rs770139198 CA8106570	80	Y>H		No	ClinGen ExAC gnomAD
CA396309328 rs1239514684	81	Y>*		No	ClinGen TOPMed gnomAD
CA282316789 rs769945366	81	Y>C		No	ClinGen TOPMed
CA396309342 rs1334396409	81	Y>D		No	ClinGen gnomAD
CA396309306 rs1328746309	82	L>P		No	ClinGen gnomAD
rs866922991 CA282316782	83	D>G		No	ClinGen Ensembl
rs983132447 CA282316788	83	D>N		No	ClinGen Ensembl
CA282316779 rs751768375	84	T>A		No	ClinGen TOPMed gnomAD
CA396309249 rs1370591121	84	T>I		No	ClinGen gnomAD
CA396309237 rs1567393918	85	E>K		No	ClinGen Ensembl
rs1202882602 CA396309131	89	E>K		No	ClinGen TOPMed
CA8106567 rs757610175	92	R>Q		No	ClinGen ExAC gnomAD
CA396308916 rs1483224603	94	M>I		No	ClinGen TOPMed
rs1187049425 CA396308905	95	L>P		No	ClinGen TOPMed
CA396308901 rs1483345839	96	E>K		No	ClinGen gnomAD
rs1276797977 CA396308867	97	G>C		No	ClinGen TOPMed gnomAD
rs751968775 CA8106566	97	G>D		No	ClinGen ExAC gnomAD
CA396308870 rs1276797977	97	G>S		No	ClinGen TOPMed gnomAD
rs1347331147 CA396308814	99	Y>C		No	ClinGen TOPMed gnomAD
CA8106565 rs201953720	101	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs138319092 CA8106563	102	I>T		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs758111434 CA8106562	103	S>G		No	ClinGen ExAC gnomAD
rs1291940124 CA396308571	104	K>N		No	ClinGen TOPMed gnomAD
CA282316455 rs967146400	106	R>Q		No	ClinGen TOPMed gnomAD
CA282316458 rs940031284	106	R>W		No	ClinGen TOPMed gnomAD
CA396308429 rs1347930201	109	T>M		No	ClinGen Ensembl
rs1022198584 CA282316454	113	R>W		No	ClinGen gnomAD
rs1435471216 CA396308314	114	T>A		No	ClinGen TOPMed
CA8106542 rs754484700	117	S>F		No	ClinGen ExAC TOPMed gnomAD
rs753341714 CA8106541	121	N>S		No	ClinGen ExAC gnomAD
rs1413971720 CA396308037 COSM2994560	122	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA396308013 rs1160854447	123	I>V		No	ClinGen TOPMed
rs1267728082 CA396307628	127	L>P		No	ClinGen gnomAD
CA396307425 rs1305208794	132	G>D		No	ClinGen gnomAD
CA396307357 rs1441351495	134	E>Q		No	ClinGen gnomAD
rs748552667 CA8106526	135	L>F		No	ClinGen ExAC TOPMed gnomAD
rs145840650 CA8106525	136	R>C		No	ClinGen ESP ExAC gnomAD
CA8106524 rs754648916	136	R>H		No	ClinGen ExAC TOPMed gnomAD
rs748830125 CA8106523	137	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8106522 rs779437165	137	R>H		No	ClinGen ExAC TOPMed gnomAD
CA396307222 rs779437165	137	R>L		No	ClinGen ExAC TOPMed gnomAD
rs748830125 CA282315995	137	R>S		No	ClinGen ExAC TOPMed gnomAD
rs910461067 CA282315979	138	S>Y		No	ClinGen Ensembl
rs756065183 CA8106521	139	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1169304513 CA396307181	140	F>L		No	ClinGen gnomAD
CA282315962 rs954629708	141	S>L		No	ClinGen Ensembl
CA396306992 rs1193290163	145	I>M		No	ClinGen gnomAD
CA396307025 rs1406533762	145	I>N		No	ClinGen Ensembl
rs1269942068 CA396306963	146	F>L		No	ClinGen gnomAD
CA8106518 rs757096015	147	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1254800316 CA396306812	148	E>Q		No	ClinGen gnomAD
CA8106499 rs751300179	149	D>G		No	ClinGen ExAC gnomAD
rs1257478931 CA396306698	152	L>M		No	ClinGen gnomAD
rs777441924 CA8106498	155	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA8106496 rs754039931	157	V>E		No	ClinGen ExAC gnomAD
CA8106495 rs372756034	159	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1269523734 CA396306442	161	G>R		No	ClinGen TOPMed
rs1269523734 CA396306431	161	G>W		No	ClinGen TOPMed
rs1175703306 CA396306393	163	S>G		No	ClinGen Ensembl
rs1327971983 CA723040579	164	C>*		No	ClinGen Ensembl
rs1297458426 CA396306346	164	C>S		No	ClinGen gnomAD
CA396306331 rs750563807	165	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs750563807 CA8106493	165	L>R		No	ClinGen ExAC TOPMed gnomAD
CA8106492 rs768012015	167	R>C		No	ClinGen ExAC TOPMed gnomAD
rs762232923 CA8106491	167	R>H		No	ClinGen ExAC TOPMed gnomAD
CA396306254 rs762232923	167	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8106490 rs373603283	172	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA396306089 rs1474528498	173	D>G		No	ClinGen gnomAD
CA8106488 rs763412691	173	D>N		No	ClinGen ExAC gnomAD
CA396306058 rs1423944782	174	H>Q		No	ClinGen gnomAD
rs1186238834 CA396306068	174	H>R		No	ClinGen gnomAD
rs775256264 CA8106487	174	H>Y		No	ClinGen ExAC gnomAD
rs1366811401 CA396306032	175	N>S		No	ClinGen TOPMed
CA396305979 rs1409590434	177	Q>H		No	ClinGen TOPMed
rs140668109 CA8106485	178	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1351919438 CA396305900	180	I>L		No	ClinGen TOPMed
rs1268566681 CA396305871	181	L>V		No	ClinGen gnomAD
rs770933496 CA8106483	183	A>T		No	ClinGen ExAC gnomAD
CA396304366 rs1167301204	183	A>V		No	ClinGen TOPMed
CA8106467 rs769504134	185	G>D		No	ClinGen ExAC TOPMed gnomAD
rs148338011 CA8106468	185	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA396304220 rs1227863684	186	Q>*		No	ClinGen gnomAD
CA282315667 rs919184189	188	M>I		No	ClinGen Ensembl
CA396304115 rs1433101647	189	L>F		No	ClinGen Ensembl
rs1300167969 CA396303979	192	D>V		No	ClinGen gnomAD
CA396303919 rs1355875849	193	G>*		No	ClinGen gnomAD
CA396303878 rs1597326327	194	M>I		No	ClinGen Ensembl
rs770380576 CA8106464	196	G>E		No	ClinGen ExAC gnomAD
CA8106462 rs773001414	197	V>G		No	ClinGen ExAC gnomAD
rs1597326278 CA396303755	198	V>G		No	ClinGen Ensembl
rs1597326290 CA396303770	198	V>M		No	ClinGen Ensembl
CA396303717 rs1315185282	199	A>T		No	ClinGen TOPMed
rs772106179 CA8106460	204	I>V		No	ClinGen ExAC gnomAD
rs747894579 CA8106459	205	Q>H		No	ClinGen ExAC
rs1390401508 CA396303486	205	Q>R		No	ClinGen gnomAD
rs1341069399 CA396303277	211	C>Y		No	ClinGen gnomAD
rs587777904 CA248418 RCV000190292	212	A>V		No	ClinGen ClinVar Ensembl dbSNP
rs201074597 CA8106447	216	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8106448 rs201074597	216	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA8106446 rs766104962	216	R>H		No	ClinGen ExAC gnomAD
rs1208201473 CA396302808	219	V>A		No	ClinGen gnomAD
rs151310312 CA8106442	220	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396302726 rs1422267033	221	T>I		No	ClinGen TOPMed gnomAD
rs1410859310 COSM972366 CA396302708	222	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed
rs774086008 CA8106440	223	L>P		No	ClinGen ExAC TOPMed
rs774086008 CA396302663	223	L>R		No	ClinGen ExAC TOPMed
rs184602535 CA8106438	227	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs781253183 CA8106437	230	V>E		No	ClinGen ExAC gnomAD
rs1358203039 CA396302373	232	Y>N		No	ClinGen gnomAD
CA396302269 rs1334476867	234	E>K		No	ClinGen gnomAD
CA396302174 rs1385545175	235	N>K		No	ClinGen TOPMed
rs1386214466 CA396302144	237	A>T		No	ClinGen gnomAD
CA396302084 rs1386105935	238	P>L		No	ClinGen TOPMed
CA8106435 rs746993596	239	L>P		No	ClinGen ExAC TOPMed gnomAD
rs1414202318 CA396302001	241	I>V		No	ClinGen gnomAD
CA8106434 rs777922035	242	R>C		No	ClinGen ExAC gnomAD
CA8106433 rs149208562	242	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs753286217 CA8106432	243	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1328803832 CA396301848	245	N>D		No	ClinGen TOPMed
rs1463784973 CA396301790	246	S>T		No	ClinGen gnomAD
rs1267925358 CA396301666	248	A>G		No	ClinGen gnomAD
CA396301570 rs1351516779	251	T>S		No	ClinGen TOPMed
rs755374138 CA8106429	252	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1389777352 CA396301282	253	A>G		No	ClinGen gnomAD
CA396301285 rs928387683	253	A>P		No	ClinGen TOPMed gnomAD
CA282315227 rs928387683	253	A>T		No	ClinGen TOPMed gnomAD
rs763948852 CA8106404	256	W>*		No	ClinGen ExAC
CA396301163 rs1597325674	256	W>R		No	ClinGen Ensembl
rs1451691622 CA396301124	257	A>T		No	ClinGen gnomAD
rs1597325656 CA396301086	258	N>S		No	ClinGen Ensembl
CA8106403 rs569469386	260	V>L		No	ClinGen ExAC gnomAD
CA8106402 rs775096284	261	S>T		No	ClinGen ExAC gnomAD
CA396300840 rs1489102072	265	E>K		No	ClinGen gnomAD
rs769662396 CA8106400	268	G>D		No	ClinGen ExAC gnomAD
rs369404876 CA8106399	269	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs533228055 CA8106398	269	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1422725668 CA396300548	270	D>A		No	ClinGen TOPMed
rs1228715854 CA396300525	271	P>A		No	ClinGen TOPMed gnomAD
CA396300491 rs1216765074	271	P>R		No	ClinGen gnomAD
CA8106396 rs748236698	273	L>F		No	ClinGen ExAC gnomAD
rs779140496 CA8106395	275	V>M		No	ClinGen ExAC gnomAD
CA8106394 rs376479272	277	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA282315176 rs376479272	277	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs372012238 CA8106391	279	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA8106390 rs372012238	279	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1170949707 CA396299673	284	T>M		No	ClinGen TOPMed
rs1465700159 CA396299637	286	A>P		No	ClinGen TOPMed
rs757902430 COSM1378878 CA8106366	286	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs557703439 CA8106364	287	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs367638121 CA8106363	287	A>V		No	ClinGen ESP ExAC gnomAD
rs1264803028 CA396299544	288	L>F		No	ClinGen TOPMed gnomAD
CA8106362 rs753630901	288	L>P		No	ClinGen ExAC gnomAD
rs1264803028 CA396299595	288	L>V		No	ClinGen TOPMed gnomAD
CA8106359 rs774687823	289	P>R		No	ClinGen ExAC gnomAD
CA8106360 rs762089938	289	P>S		No	ClinGen ExAC gnomAD
CA8106358 rs764462854	291	Q>E		No	ClinGen ExAC gnomAD
CA396299331 rs1216658951	293	S>F		No	ClinGen TOPMed
CA8106356 rs373831988	295	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA8106355 rs775432050	296	D>N		No	ClinGen ExAC gnomAD
CA8106354 rs770275000	298	T>M		No	ClinGen ExAC gnomAD
CA396299071 rs1160839344	302	E>K		No	ClinGen gnomAD
rs776939350 CA8106352	303	Q>*		No	ClinGen ExAC gnomAD
CA8106351 rs771252784	305	G>D		No	ClinGen ExAC gnomAD
rs747423653 CA8106350	307	E>Q		No	ClinGen ExAC gnomAD
rs1444868183 CA396298911	308	A>T		No	ClinGen gnomAD
rs368067896 CA8106349	309	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs897849332 CA282314845	311	Q>R		No	ClinGen TOPMed gnomAD
rs758053370 CA8106348	313	H>Y		No	ClinGen ExAC gnomAD
CA8106345 rs754899118	315	G>C		No	ClinGen ExAC gnomAD
CA8106343 rs370846681	316	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1434780234 CA396298650	317	A>V		No	ClinGen gnomAD
rs1424150810 CA396298603	319	T>N		No	ClinGen TOPMed
rs547533260 CA282314826	320	D>H		No	ClinGen TOPMed
rs1470337692 CA396298539	322	D>N		No	ClinGen TOPMed
CA396298478 rs1377101439	324	R>C		No	ClinGen Ensembl
COSM972364 CA396298466 rs1385624610	324	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA8106339 rs764305887	325	T>A		No	ClinGen ExAC gnomAD
rs1162115126 COSM3421089 CA396298436	325	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1036789063 CA282314807	327	L>F		No	ClinGen Ensembl
rs1424821234 CA396298393	327	L>P		No	ClinGen TOPMed gnomAD
rs1567391280 CA396298366	329	L>F		No	ClinGen Ensembl
rs144258782 CA8106337	330	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA396298309 rs144258782	330	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs763095522 CA8106338	330	Y>F		No	ClinGen ExAC gnomAD
CA396298308 rs1367261754	331	E>K		No	ClinGen TOPMed
CA396298307 rs1367261754	331	E>Q		No	ClinGen TOPMed
CA8106318 rs752830654	333	A>T		No	ClinGen ExAC gnomAD
rs1408756042 CA396298016	339	G>E		No	ClinGen gnomAD
rs928377874 CA282314645	341	I>V		No	ClinGen Ensembl
CA396297922 rs1330516913	343	E>G		No	ClinGen gnomAD
rs139581188 CA8106317	344	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1401257936 CA396297881	346	G>D		No	ClinGen gnomAD
CA396297873 rs1177021256	347	A>T		No	ClinGen gnomAD
CA396297844 rs371700085	349	G>A		No	ClinGen ESP TOPMed gnomAD
CA282314632 rs371700085	349	G>E		No	ClinGen ESP TOPMed gnomAD
CA396297829 rs1470577109	350	R>Q		No	ClinGen gnomAD
rs766805526 CA8106313	351	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8106314 rs150975190	351	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA8106312 rs773578700	353	R>*		No	ClinGen ExAC gnomAD
CA8106310 rs772357080	353	R>L		No	ClinGen ExAC TOPMed gnomAD
CA396297792 rs772357080	353	R>P		No	ClinGen ExAC TOPMed gnomAD
CA396297738 rs1379952925	357	S>A		No	ClinGen TOPMed gnomAD
CA396297742 rs1379952925	357	S>P		No	ClinGen TOPMed gnomAD
rs1268126911 CA396297728	358	S>A		No	ClinGen TOPMed gnomAD
CA396297725 rs1222672555	358	S>Y		No	ClinGen TOPMed gnomAD
rs748737467 CA8106305	359	E>G		No	ClinGen ExAC TOPMed gnomAD
rs374375025 CA8106303	360	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs779720663 CA8106304	360	E>G		No	ClinGen ExAC gnomAD
rs745829895 CA396297648	361	G>D		No	ClinGen ExAC TOPMed gnomAD
CA8106302 rs745829895	361	G>V		No	ClinGen ExAC TOPMed gnomAD
CA396297632 rs1355976618	363	R>G		No	ClinGen TOPMed
rs1386323948 CA396297605	364	S>G		No	ClinGen gnomAD
CA282314591 rs1032635811	364	S>T		No	ClinGen gnomAD
CA396297571 rs1401310652	365	R>P		No	ClinGen gnomAD
rs1410298332 CA396297547	366	R>C		No	ClinGen gnomAD
CA8106301 rs781228896	366	R>H		No	ClinGen ExAC gnomAD
rs1244042315 CA396297500	367	S>F		No	ClinGen gnomAD
CA396297483 rs1463851556	369	E>K		No	ClinGen gnomAD
rs1217158444 CA396297424	371	G>R		No	ClinGen gnomAD
rs1459156698 CA396297408	371	G>V		No	ClinGen gnomAD
rs1316942614 CA396297392	372	G>D		No	ClinGen gnomAD
rs1226200266 CA396297367	373	C>F		No	ClinGen gnomAD
CA396297372 rs1226200266	373	C>Y		No	ClinGen gnomAD
CA396297341 rs1315387715	374	P>L		No	ClinGen gnomAD
rs753857928 CA8106296	375	A>P		No	ClinGen ExAC TOPMed gnomAD
rs753857928 CA8106295	375	A>S		No	ClinGen ExAC TOPMed gnomAD
rs753857928 CA282314545	375	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8106294 rs766471183	375	A>V		No	ClinGen ExAC
rs1030401479 CA282314528	376	R>H		No	ClinGen TOPMed gnomAD
rs756575045 CA8106293	378	P>R		No	ClinGen ExAC gnomAD
CA396297266 rs1404911569	379	E>G		No	ClinGen gnomAD
CA282314515 rs199860700	379	E>K		No	ClinGen 1000Genomes
CA8106291 rs768121587	381	G>S		No	ClinGen ExAC gnomAD
rs756168034 CA8106270	382	P>T		No	ClinGen ExAC TOPMed gnomAD
rs767909484 CA8106268	384	G>D		No	ClinGen ExAC TOPMed gnomAD
rs751818400 CA8106266	385	P>H		No	ClinGen ExAC TOPMed gnomAD
CA396297015 rs1471348741	387	S>L		No	ClinGen TOPMed gnomAD
CA396296996 rs1367147641	388	P>L		No	ClinGen TOPMed
rs764581326 CA8106265	389	V>I		No	ClinGen ExAC TOPMed gnomAD
CA8106264 rs763448887	390	G>R		No	ClinGen ExAC gnomAD
rs1597324123 CA396296937	392	T>P		No	ClinGen Ensembl
rs1202888605 CA396296911	394	S>P		No	ClinGen gnomAD
rs1324167486 CA396296893	395	T>N		No	ClinGen gnomAD
rs1226615994 CA396296879	396	G>A		No	ClinGen gnomAD
COSM972363 CA8106263 rs775259952	396	G>S	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs765039105 CA8106262	397	P>S		No	ClinGen ExAC TOPMed gnomAD
CA396296850 rs1377357629	398	A>V		No	ClinGen gnomAD
rs758964283 CA8106261	400	L>R		No	ClinGen ExAC gnomAD
CA8106260 rs776209936	401	T>A		No	ClinGen ExAC TOPMed gnomAD
rs770716017 CA8106259	402	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1450940515 CA396296767	403	P>L		No	ClinGen gnomAD
rs1159287570 CA396296766	404	A>T		No	ClinGen TOPMed gnomAD
rs772953255 CA8106256	406	S>N		No	ClinGen ExAC TOPMed
rs772953255 CA396296694	406	S>T		No	ClinGen ExAC TOPMed
CA396296649 rs1182744774	407	P>L		No	ClinGen gnomAD
rs898890195 CA282314116	408	V>E		No	ClinGen TOPMed gnomAD
CA396296642 rs200846612	408	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8106255 rs200846612	408	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396296609 rs1349963338	410	P>L		No	ClinGen TOPMed gnomAD
rs1241350719 CA396296591	411	P>L		No	ClinGen gnomAD
rs780244054 COSM972362 CA8106253	413	G>S	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA396296539 rs1197217813	414	L>P		No	ClinGen TOPMed
rs201882646 CA8106251	416	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781350701 CA8106250	416	A>V		No	ClinGen ExAC gnomAD
CA282314071 rs371370894	417	S>*		No	ClinGen ESP TOPMed gnomAD
rs752072735 CA8106249	418	V>L		No	ClinGen ExAC gnomAD
CA8106248 rs752072735	418	V>M		No	ClinGen ExAC gnomAD
CA8106245 rs753177881	419	N>K		No	ClinGen ExAC TOPMed gnomAD
rs778470352 CA8106247	419	N>Y		No	ClinGen ExAC gnomAD
rs1444990736 CA396296369	422	P>L		No	ClinGen TOPMed
CA396296361 rs1162591040	423	T>A		No	ClinGen gnomAD
CA8106242 rs753239382	423	T>I		No	ClinGen ExAC TOPMed gnomAD
CA8106243 rs753239382	423	T>N		No	ClinGen ExAC TOPMed gnomAD
rs1597323898 CA396296331	424	I>N		No	ClinGen Ensembl
rs765946969 CA8106241 COSM194368	424	I>V	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA282314050 rs766460976	425	S>C		No	ClinGen Ensembl
CA396296288 rs1190864120	426	V>A		No	ClinGen TOPMed gnomAD
rs1460613314 CA396296303	426	V>M		No	ClinGen TOPMed
rs1239139232 CA396296285	427	A>T		No	ClinGen gnomAD
rs935687758 CA282314045	429	S>L		No	ClinGen TOPMed gnomAD
rs934284052 CA282314041	430	A>D		No	ClinGen TOPMed
rs868061468 CA282314035	431	D>Y		No	ClinGen Ensembl
CA8106239 rs773113128	432	T>P		No	ClinGen ExAC TOPMed gnomAD
CA396296162 rs773113128	432	T>S		No	ClinGen ExAC TOPMed gnomAD
CA282314030 rs112918660	433	S>F		No	ClinGen ExAC gnomAD
CA8106238 rs112918660	433	S>Y		No	ClinGen ExAC gnomAD
CA8106237 rs761595877 COSM3712063	434	S>R	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs774140986 CA8106236	435	E>K		No	ClinGen ExAC TOPMed gnomAD
CA396295998 rs1306153599	438	I>T		No	ClinGen TOPMed
rs749674590 CA8106201	441	A>T		No	ClinGen ExAC gnomAD
CA396293674 rs904601743	442	R>G		No	ClinGen gnomAD
CA8106200 rs779755764	442	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs904601743 CA282312897	442	R>W		No	ClinGen gnomAD
CA8106199 rs755729329	443	F>S		No	ClinGen ExAC gnomAD
CA396293499 rs371069606	446	N>K		No	ClinGen ESP ExAC gnomAD
rs1189975071 CA396293487	447	V>E		No	ClinGen TOPMed
CA396293470 rs751453077	448	A>E		No	ClinGen ExAC TOPMed gnomAD
CA8106196 rs756795171	448	A>T		No	ClinGen ExAC gnomAD
CA8106195 rs751453077	448	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1350943383 CA396293427	449	A>P		No	ClinGen gnomAD
CA282312871 rs1041457164	451	E>A		No	ClinGen Ensembl
rs199754555 CA8106193	453	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8106192 rs775216754	454	K>Q		No	ClinGen ExAC gnomAD
rs766612246 CA8106191	455	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA396293255 rs1597321403	456	V>G		No	ClinGen Ensembl
CA8106190 COSM972359 rs761027309	457	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8106187 rs748259381	459	A>V		No	ClinGen ExAC gnomAD
rs774862376 CA8106186	460	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA396293191 rs1161926255	460	Q>K		No	ClinGen gnomAD
rs576712879 CA8106185	461	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA8106183 rs148095513	462	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs749656540 CA8106184	462	R>W		No	ClinGen ExAC TOPMed gnomAD
CA396293131 rs1214426042	463	A>E		No	ClinGen gnomAD
rs1242116105 CA396293139 COSM4141839	463	A>T	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
rs755736544 CA8106182	464	E>D		No	ClinGen ExAC gnomAD
rs568216912 CA8106180	466	L>F		No	ClinGen 1000Genomes ExAC gnomAD
CA8106177 rs150240690	468	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs553913184 CA282312777	469	A>T		No	ClinGen 1000Genomes gnomAD
CA396292988 rs1269572814	469	A>V		No	ClinGen gnomAD
CA396292978 rs1285298373	470	M>L		No	ClinGen TOPMed
rs1049360138 CA282312774	471	P>S		No	ClinGen TOPMed gnomAD
rs142023201 CA8106176	472	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1469270049 CA396292902	473	E>D		No	ClinGen TOPMed
rs752514725 CA396292890	474	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1424273451 CA396292895	474	A>S		No	ClinGen gnomAD
CA8106174 rs752514725	474	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1427155192 CA396292886	475	G>S		No	ClinGen TOPMed gnomAD
rs373548373 CA8106171 COSM1378873	476	G>E	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA396292855 rs1475434302	477	H>R		No	ClinGen gnomAD
rs992241696 CA282312735	478	P>S		No	ClinGen Ensembl
CA396292750 rs1261228089	480	A>V		No	ClinGen gnomAD
CA396292747 rs199614307	481	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs754761714 CA8106154	481	R>Q		No	ClinGen ExAC gnomAD
rs199614307 CA8106155	481	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA396292682 rs1597320986	485	D>A		No	ClinGen Ensembl
rs753689172 CA8106153	485	D>Y		No	ClinGen ExAC gnomAD
rs2271291 CA8106152	486	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396292628 rs1489243436	488	E>G		No	ClinGen gnomAD
rs1477247004 CA396292636	488	E>K		No	ClinGen TOPMed
rs1299088267 CA396292585	490	A>V		No	ClinGen gnomAD
rs1449555008 CA396292531	493	A>V		No	ClinGen gnomAD
CA8106151 rs551923090	495	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396292447 rs1597320926	497	Q>*		No	ClinGen Ensembl
CA396292428 rs1468795212	497	Q>H		No	ClinGen gnomAD
rs77281081 CA396292338	500	A>D		No	ClinGen gnomAD
CA282312657 rs77281081	500	A>G		No	ClinGen gnomAD
CA396292337 rs77281081	500	A>V		No	ClinGen gnomAD
CA282312649 rs764116221	501	P>H		No	ClinGen ExAC TOPMed gnomAD
CA8106149 rs764116221	501	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1177540851 CA396292304	502	C>R		No	ClinGen gnomAD
rs1567387481 CA396292260	503	V>L		No	ClinGen Ensembl
CA282312614 rs74771707	506	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs74771707 CA396292141	506	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs74771707 CA8106144	506	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8106145 rs564483976	506	R>W		No	ClinGen ExAC TOPMed gnomAD
rs770549814 CA8106142	507	A>D		No	ClinGen ExAC TOPMed gnomAD
CA8106143 rs770549814	507	A>G		No	ClinGen ExAC TOPMed gnomAD
rs947794746 CA282312609	507	A>S		No	ClinGen TOPMed gnomAD
CA396292113 rs770549814	507	A>V		No	ClinGen ExAC TOPMed gnomAD
CA396292080 rs1308037833	508	Q>H		No	ClinGen gnomAD
rs917660510 CA282312602	508	Q>P		No	ClinGen Ensembl
COSM1378871 CA8106140 rs369969027	509	R>*	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA8106141 rs369969027	509	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA8106139 rs771435032	509	R>Q		No	ClinGen ExAC gnomAD
CA396292032 rs1567387385	510	S>G		No	ClinGen Ensembl
rs373647547 CA8106138	513	P>Q		No	ClinGen ESP ExAC TOPMed
rs1487661400 CA396291845	515	P>L		No	ClinGen TOPMed
CA396291846 rs1336571223	515	P>S		No	ClinGen gnomAD
CA396291850 rs1336571223	515	P>T		No	ClinGen gnomAD
rs201535041 CA396291743	516	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8106137 rs201535041	516	K>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs147764255 CA8106136	517	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1451042224 CA396291665	518	P>R		No	ClinGen gnomAD
rs1055473456 CA282312592	519	L>R		No	ClinGen TOPMed
CA8106135 rs753670739	520	I>T		No	ClinGen ExAC TOPMed gnomAD
rs977646364 CA396291538	521	P>L		No	ClinGen Ensembl
rs977646364 CA282312581	521	P>Q		No	ClinGen Ensembl
rs202036259 CA8106134	521	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs202036259 CA8106133	521	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA282312575 rs968974323	522	A>G		No	ClinGen Ensembl
rs751687594 CA8106132	523	S>R		No	ClinGen ExAC gnomAD
rs764393738 CA8106131	525	K>R		No	ClinGen ExAC gnomAD
rs2271290 CA282312547	527	E>G		No	ClinGen Ensembl
rs1445156498 CA396291321	527	E>K		No	ClinGen gnomAD
CA396291267 rs1258260730	528	P>L		No	ClinGen gnomAD
rs1203436423 CA396291245	529	I>N		No	ClinGen gnomAD
CA8106130 rs762878368	531	E>*		No	ClinGen ExAC gnomAD
CA396291113 rs1219077804	532	L>I		No	ClinGen gnomAD
rs77958237 CA8106126	533	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs77958237 CA8106127	533	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1247250727 CA396291058	534	T>P		No	ClinGen gnomAD
rs1342746927 CA396291008	535	R>C		No	ClinGen TOPMed gnomAD
rs550457905 CA8106125	535	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs550457905 CA396291004	535	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772681218 CA8106123	538	R>S		No	ClinGen ExAC TOPMed gnomAD
CA8106122 rs771758797	541	I>T		No	ClinGen ExAC TOPMed gnomAD
CA282312531 rs1008214080	541	I>V		No	ClinGen TOPMed gnomAD
rs1198047093 CA396290727	542	G>R		No	ClinGen TOPMed
CA8106121 rs747604950	543	D>Y		No	ClinGen ExAC
rs774059853 CA8106120	548	D>H		No	ClinGen ExAC gnomAD
rs774059853 CA396290464	548	D>N		No	ClinGen ExAC gnomAD
CA396289003 rs1458258190	554	D>H		No	ClinGen gnomAD
CA8106118 rs749275536	555	Q>H		No	ClinGen ExAC gnomAD
rs768690449 CA8106119	555	Q>K		No	ClinGen ExAC gnomAD
CA396288953 rs1427926351	556	D>N		No	ClinGen TOPMed gnomAD
CA282312521 rs1025618348	557	M>I		No	ClinGen Ensembl
CA8106117 rs780166979	560	V>I		No	ClinGen ExAC gnomAD
rs755811201 CA8106116	561	E>K		No	ClinGen ExAC TOPMed gnomAD
rs755811201 CA396288811	561	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1291365175 CA396288802	561	E>V		No	ClinGen TOPMed gnomAD
rs745684341 CA8106115	563	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8106114 rs777856944	564	E>V		No	ClinGen ExAC gnomAD
CA282312490 rs752754049	565	A>S		No	ClinGen ExAC TOPMed gnomAD
CA8106112 rs752754049	565	A>T		No	ClinGen ExAC TOPMed gnomAD
CA396288703 rs1325297530	565	A>V		No	ClinGen gnomAD
CA396288659 rs1387227302	567	K>R		No	ClinGen TOPMed
CA396288600 rs1343221621	569	I>N		No	ClinGen TOPMed gnomAD
CA396288596 rs1343221621	569	I>S		No	ClinGen TOPMed gnomAD
CA8106110 rs201097392	571	A>P		No	ClinGen 1000Genomes ExAC gnomAD
CA396288541 rs1392619512	571	A>V		No	ClinGen gnomAD
rs911975133 CA282312480	573	S>*		No	ClinGen TOPMed
CA8106108 rs766923124	574	P>A		No	ClinGen ExAC gnomAD
rs773691517 CA8106106	575	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA8106107 rs760881083	575	P>S		No	ClinGen ExAC TOPMed gnomAD
CA396288437 rs760881083	575	P>T		No	ClinGen ExAC TOPMed gnomAD
rs767062511 CA8106105	578	L>P		No	ClinGen ExAC gnomAD
rs761605463 CA8106104	579	L>P		No	ClinGen ExAC gnomAD
rs768237571 CA8106103	580	S>*		No	ClinGen ExAC TOPMed gnomAD
rs768237571 CA8106102	580	S>L		No	ClinGen ExAC TOPMed gnomAD
CA8106100 rs527827835	581	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1350744760 CA396288267	582	V>G		No	ClinGen TOPMed
rs769839495 CA8106099	583	P>S		No	ClinGen ExAC gnomAD
rs769839495 CA396288256	583	P>T		No	ClinGen ExAC gnomAD
CA396288218 rs1332519767	584	P>L		No	ClinGen gnomAD
CA8106098 rs745640879	584	P>S		No	ClinGen ExAC gnomAD
rs748329982 CA396288199	585	P>H		No	ClinGen ExAC TOPMed gnomAD
CA8106095 rs748329982	585	P>L		No	ClinGen ExAC TOPMed gnomAD
CA396288189 rs748329982	585	P>R		No	ClinGen ExAC TOPMed gnomAD
rs758519818 CA8106096	585	P>T		No	ClinGen ExAC TOPMed gnomAD
CA282312436 rs202100815	586	P>S		No	ClinGen 1000Genomes
rs1479123697 CA396288042	587	P>R		No	ClinGen gnomAD
CA396288053 rs1173323109	587	P>T		No	ClinGen gnomAD
rs779130412 CA8106085	588	L>F		No	ClinGen ExAC
rs754992774 CA8106082	590	P>L		No	ClinGen ExAC
rs1362347590 CA396287868	591	P>L		No	ClinGen gnomAD
CA396287822 rs1240518516	592	P>Q		No	ClinGen gnomAD
CA396287821 rs1240518516	592	P>R		No	ClinGen gnomAD
rs766789787 CA8106080	592	P>S		No	ClinGen ExAC gnomAD
CA8106078 rs750728195	596	G>S		No	ClinGen ExAC gnomAD
rs370608943 CA396287666	597	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs370608943 CA8106076	597	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA396287651 rs1436365704	598	F>L		No	ClinGen TOPMed gnomAD
CA396287605 rs1346641439	599	P>T		No	ClinGen gnomAD
CA8106075 rs762296356	603	P>S		No	ClinGen ExAC
CA396287413 rs1567386784	604	L>Q		No	ClinGen Ensembl
rs762552120 CA8106072	605	P>S		No	ClinGen ExAC TOPMed gnomAD
CA396287354 rs1333210430	606	L>R		No	ClinGen gnomAD
rs775126250 CA8106071	607	A>V		No	ClinGen ExAC gnomAD
rs1243619674 CA396287300	608	A>S		No	ClinGen TOPMed
CA396287317 rs1243619674	608	A>T		No	ClinGen TOPMed
CA8106069 rs759559297	609	P>L		No	ClinGen ExAC gnomAD
rs759559297 CA8106070	609	P>R		No	ClinGen ExAC gnomAD
rs780261895 CA282312353	609	P>S		No	ClinGen gnomAD
rs376217621 CA8106068	610	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA396287144 rs1440628827	611	P>L		No	ClinGen TOPMed gnomAD
CA396287152 rs1440628827	611	P>R		No	ClinGen TOPMed gnomAD
rs1567386701 CA396287101	613	S>P		No	ClinGen Ensembl
rs1382566437 CA396287077	614	V>M		No	ClinGen gnomAD
rs1444556764 CA396287046	615	P>S		No	ClinGen TOPMed gnomAD
rs746821300 CA8106066	616	D>V		No	ClinGen ExAC TOPMed gnomAD
CA282312335 rs979187926	617	S>R		No	ClinGen TOPMed
CA396286949 rs1251011211	618	S>A		No	ClinGen TOPMed
rs1210176725 CA396286900	619	A>P		No	ClinGen TOPMed gnomAD
CA396286780 rs1281645618	624	R>G		No	ClinGen gnomAD
CA396286578 rs1354082668	631	W>*		No	ClinGen gnomAD
CA8106065 rs779039184	631	W>R		No	ClinGen ExAC gnomAD
CA8106064 rs574787945	632	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs139223474 CA8106063	632	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs139223474 CA396286546	632	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA396286520 rs1423480466	633	E>G		No	ClinGen TOPMed
rs1460949007 CA396286509	634	L>V		No	ClinGen TOPMed
rs1284760151 CA396286424	637	A>T		No	ClinGen TOPMed gnomAD
rs1450242086 CA396286408	637	A>V		No	ClinGen gnomAD
rs1395080745 CA396286406	638	G>R		No	ClinGen TOPMed
CA282312303 rs1056641182	640	H>R		No	ClinGen Ensembl
CA282312308 rs866203183	640	H>Y		No	ClinGen TOPMed
rs1424477137 CA396286262	644	A>E		No	ClinGen gnomAD
rs750899390 CA8106060	644	A>T		No	ClinGen ExAC gnomAD
CA282312280 rs992581861	646	R>C		No	ClinGen TOPMed
rs756274113 CA8106059	646	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1473457113 CA396286191	647	F>L		No	ClinGen gnomAD
CA396286181 rs1277044423	647	F>S		No	ClinGen TOPMed
CA396286099 rs1239878776	650	C>F		No	ClinGen TOPMed gnomAD
CA396286108 rs1239878776	650	C>Y		No	ClinGen TOPMed gnomAD
rs143431266 CA8106057	651	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1216217779 CA396286068	652	T>S		No	ClinGen gnomAD
rs763827204 CA8106056	655	A>V		No	ClinGen ExAC gnomAD
rs1200085030 CA396285910	658	D>H		No	ClinGen TOPMed
rs752119367 CA8106054	660	V>F		No	ClinGen ExAC gnomAD
rs752119367 CA282312266	660	V>I		No	ClinGen ExAC gnomAD
rs200811858 CA396285760	663	D>H		No	ClinGen TOPMed gnomAD
rs200811858 CA282312261	663	D>N		No	ClinGen TOPMed gnomAD
CA8106052 rs758990957	664	T>A		No	ClinGen ExAC gnomAD
rs139535724 CA8106051	664	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8106048 rs773047427	665	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1404674367 CA396285583	666	R>*		No	ClinGen TOPMed gnomAD
rs768842590 CA8106047	666	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA396285525 rs1262669020	668	E>Q		No	ClinGen gnomAD
rs780168242 CA8106045	674	R>C		No	ClinGen ExAC TOPMed gnomAD
rs769858079 CA8106044	674	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8106043 rs745945448	676	K>R		No	ClinGen ExAC gnomAD
CA8106042 rs146291728	677	E>D		No	ClinGen ESP ExAC gnomAD
rs1597319535 CA396285156	678	V>G		No	ClinGen Ensembl
rs757901504 CA8106041	678	V>L		No	ClinGen ExAC TOPMed gnomAD
rs751953340 CA8106040	679	L>P		No	ClinGen ExAC gnomAD
CA396285144 rs1383836137	680	P>T		No	ClinGen TOPMed
CA396284409 rs1359329177	687	G>D		No	ClinGen gnomAD
rs753364765 CA8106016	688	R>C		No	ClinGen ExAC TOPMed gnomAD
rs765913254 CA8106015	688	R>H		No	ClinGen ExAC TOPMed gnomAD
rs374165476 CA282311242	689	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs370261438 CA282311241	689	R>Q		No	ClinGen ESP TOPMed gnomAD
rs374165476 CA8106014	689	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA8106012 rs767451584	690	T>P		No	ClinGen ExAC gnomAD
rs1325682741 CA396284313	691	M>T		No	ClinGen TOPMed
CA396284328 rs1436206199	691	M>V		No	ClinGen TOPMed
CA396284264 rs1368245887	692	T>I		No	ClinGen TOPMed
CA8106011 rs761598605	693	T>I		No	ClinGen ExAC TOPMed gnomAD
rs148737699 CA8106009	696	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1353368378 CA396284074	698	K>N		No	ClinGen TOPMed gnomAD
CA8106008 rs759719315	699	R>C		No	ClinGen ExAC gnomAD
rs777028123 CA8106007	699	R>H		No	ClinGen ExAC TOPMed gnomAD
CA396283912 rs1381198049	701	N>D		No	ClinGen gnomAD
rs144361447 CA8106006	701	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs773788569 CA8106004 COSM1470824	702	A>T	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA282311201 rs919044428	704	N>D		No	ClinGen TOPMed
rs772521918 CA8106003	704	N>I		No	ClinGen ExAC gnomAD
rs919044428 CA282311194	704	N>Y		No	ClinGen TOPMed
rs1304159592 CA396283807	705	I>T		No	ClinGen gnomAD
CA282311164 rs138444737	706	G>D		No	ClinGen ESP
rs372426679 CA8106001	706	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1247336870 CA396283724	710	L>Q		No	ClinGen TOPMed
CA396283697 rs1366599306	712	P>L		No	ClinGen gnomAD
rs754625636 CA8106000	713	V>M		No	ClinGen ExAC TOPMed gnomAD
CA8105998 rs779699758	714	H>R		No	ClinGen ExAC
CA8105995 rs749936714	718	A>V		No	ClinGen ExAC gnomAD
CA396283398 rs1264229276	719	A>D		No	ClinGen TOPMed gnomAD
CA396283397 rs1264229276	719	A>V		No	ClinGen TOPMed gnomAD
CA396283355 rs1357781614	721	L>P		No	ClinGen gnomAD
rs981586641 CA282311127	723	F>C		No	ClinGen TOPMed
rs1246179053 CA396283267	723	F>L		No	ClinGen gnomAD
rs375932243 CA8105993	726	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA396283175 rs1397639242	727	A>P		No	ClinGen gnomAD
rs1339421086 CA396283161	728	V>I		No	ClinGen gnomAD
CA396283104 rs1298457316	729	S>T		No	ClinGen gnomAD
rs1318631643 CA396283040	730	K>N		No	ClinGen gnomAD
CA8105992 rs757193319	732	G>A		No	ClinGen ExAC gnomAD
CA396282961 rs868302613	733	I>N		No	ClinGen TOPMed gnomAD
CA282311104 rs868302613	733	I>T		No	ClinGen TOPMed gnomAD
rs751343080 CA8105991	733	I>V		No	ClinGen ExAC TOPMed gnomAD
CA8105965 rs752607604	739	M>I		No	ClinGen ExAC gnomAD
rs766696745 CA8105964	740	M>R		No	ClinGen ExAC gnomAD
rs766696745 CA396281252	740	M>T		No	ClinGen ExAC gnomAD
CA396281168 rs750497587	742	T>K		No	ClinGen ExAC TOPMed gnomAD
rs750497587 CA8105962	742	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1567384664 CA396281120	744	E>V		No	ClinGen Ensembl
CA8105959 rs774658881	746	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8105960 rs761974488	746	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1245201455 CA396280941	749	I>T		No	ClinGen TOPMed
rs1468918530 CA396280850	751	E>D		No	ClinGen gnomAD
CA8105957 rs147119985	755	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA282308806 rs941796786	756	N>I		No	ClinGen Ensembl
rs775888417 CA8105956	756	N>K		No	ClinGen ExAC gnomAD
rs941796786 CA396280697	756	N>T		No	ClinGen Ensembl
rs1445862391 CA396280664	757	P>R		No	ClinGen gnomAD
CA8105955 rs769408637	757	P>S		No	ClinGen ExAC gnomAD
CA396280645 rs1597316964	758	D>A		No	ClinGen Ensembl
rs763379100 CA282308788	759	I>M		No	ClinGen Ensembl
rs147740113 CA8105953	759	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8105952 rs780924011	760	P>S		No	ClinGen ExAC gnomAD
CA8105950 rs746534527	761	L>M		No	ClinGen ExAC gnomAD
CA8105949 rs777568988	761	L>P		No	ClinGen ExAC
rs758470004 CA8105948	763	P>L		No	ClinGen ExAC gnomAD
rs778889430 CA8105946	765	E>K		No	ClinGen ExAC gnomAD
CA396280393 rs1276855416	767	F>C		No	ClinGen TOPMed
rs1236370540 CA396280398	767	F>L		No	ClinGen gnomAD
rs1260651623 CA396280267	773	S>Y		No	ClinGen gnomAD
rs750561534 CA8105943	774	I>T		No	ClinGen ExAC TOPMed gnomAD
CA396280188 rs140802253	776	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8105941 rs140802253	776	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs751725905 CA8105940	776	G>V		No	ClinGen ExAC TOPMed gnomAD
CA396280149 rs1597316830	777	L>P		No	ClinGen Ensembl
CA282308678 rs982289513	778	A>T		No	ClinGen TOPMed gnomAD
rs763493505 CA8105938	779	A>T		No	ClinGen ExAC gnomAD
rs776011103 CA8105937	779	A>V		No	ClinGen ExAC gnomAD
CA8105936 rs753143941	780	R>C		No	ClinGen ExAC TOPMed gnomAD
rs150955613 CA8105934	780	R>H		No	ClinGen ESP TOPMed
rs1163185613 CA396280005	783	L>R		No	ClinGen gnomAD
rs372427394 CA8105933	783	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776081875 CA8105932	784	W>*		No	ClinGen ExAC gnomAD
rs1009622266 CA282308655	784	W>G		No	ClinGen Ensembl
rs1163307830 CA396279901	788	L>P		No	ClinGen gnomAD
CA8105929 rs772829318	793	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1192489419 CA396279761	793	M>V		No	ClinGen gnomAD
rs1243623444 CA396279699	794	E>D		No	ClinGen gnomAD
rs117880323 CA8105927	795	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8105928 rs772102709	795	R>W		No	ClinGen ExAC TOPMed gnomAD
rs779945795 CA8105904	800	P>S		No	ClinGen ExAC gnomAD
CA8105901 rs376122137	803	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA282308441 rs376122137	803	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA8105900 rs752842034	806	V>A		No	ClinGen ExAC TOPMed gnomAD
CA8105899 rs752842034	806	V>G		No	ClinGen ExAC TOPMed gnomAD
CA8105898 rs779379018	809	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA8105897 rs755559629	810	Q>H		No	ClinGen ExAC gnomAD
rs1425585929 CA396279168	812	V>I		No	ClinGen gnomAD
rs754121800 CA8105896	814	N>K		No	ClinGen ExAC TOPMed gnomAD
CA396279103 rs1237545557	815	A>T		No	ClinGen gnomAD
CA282308419 rs199498142	815	A>V		No	ClinGen 1000Genomes
CA8105895 rs766724851	817	F>L		No	ClinGen ExAC gnomAD
CA8105894 rs145700198	818	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396279022 rs1254418766	818	R>H		No	ClinGen TOPMed gnomAD
rs750037896 CA8105893	819	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA282308398 rs767135405	824	L>I		No	ClinGen Ensembl
CA396278846 rs1238484050	826	A>V		No	ClinGen gnomAD
rs542514076 CA8105889	827	V>L		No	ClinGen ExAC gnomAD
CA396278814 rs1391427441	828	G>D		No	ClinGen gnomAD
rs1300626192 CA396278735	832	N>S		No	ClinGen gnomAD
rs1314062683 CA396278717	833	G>S		No	ClinGen TOPMed
CA8105887 rs762986161	834	S>P		No	ClinGen ExAC gnomAD
rs201097013 CA282308310	836	S>N		No	ClinGen 1000Genomes
CA8105873 rs750881597	837	S>N		No	ClinGen ExAC gnomAD
CA8105872 rs767261910	838	G>D		No	ClinGen ExAC gnomAD
CA396278418 rs1397835458 COSM194367	838	G>S	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs761603743 CA396278398	839	F>C		No	ClinGen ExAC TOPMed gnomAD
CA8105871 rs761603743	839	F>S		No	ClinGen ExAC TOPMed gnomAD
rs751080567 CA8105870	840	E>K		No	ClinGen ExAC gnomAD
rs1567383866 CA396278326	842	S>R		No	ClinGen Ensembl
CA8105869 rs763613073	845	E>*		No	ClinGen ExAC gnomAD
CA282308281 rs926875447	846	K>E		No	ClinGen TOPMed gnomAD
rs982747750 CA282308275	846	K>M		No	ClinGen TOPMed gnomAD
CA396278227 rs1597316103	846	K>N		No	ClinGen Ensembl
rs1191788128 CA396278208	847	V>A		No	ClinGen gnomAD
CA396278218 rs1375566713	847	V>M		No	ClinGen TOPMed gnomAD
rs1207298615 CA396278101	850	V>A		No	ClinGen gnomAD
rs775435349 CA8105867	850	V>M		No	ClinGen ExAC TOPMed gnomAD
CA8105866 rs765158746	852	D>A		No	ClinGen ExAC TOPMed gnomAD
CA8105865 rs759313072	853	T>M		No	ClinGen ExAC TOPMed gnomAD
rs772252359 CA8105863	855	R>C		No	ClinGen ExAC gnomAD
rs748331837 COSM972358 CA8105862	855	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs774576031 CA8105861	856	R>*		No	ClinGen ExAC gnomAD
rs528427631 CA8105860	856	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1473529788 CA396277937	860	L>P		No	ClinGen TOPMed
rs1473529788 CA396277939	860	L>Q		No	ClinGen TOPMed
CA282308229 rs988348329	861	H>R		No	ClinGen TOPMed
CA8105857 rs756633530	865	S>F		No	ClinGen ExAC TOPMed gnomAD
rs746209224 CA8105856	867	V>L		No	ClinGen ExAC gnomAD
CA396277720 rs757725556	869	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1373901784 CA396277732	869	Q>K		No	ClinGen gnomAD
rs1195716658 CA396277730	869	Q>R		No	ClinGen gnomAD
CA396277716 rs1454851535	870	T>A		No	ClinGen gnomAD
CA396277695 rs1458619991	870	T>I		No	ClinGen TOPMed
rs916106027 CA282308207 COSM137060	871	R>Q	skin [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA8105853 rs117505411	871	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8105852 rs763661503	874	S>F		No	ClinGen ExAC gnomAD
rs953482783 CA282308203	874	S>P		No	ClinGen Ensembl
CA623118698 rs1567383605	875	S>*		No	ClinGen Ensembl
CA8105851 rs757925016	875	S>F		No	ClinGen ExAC
rs1274501740 CA396277581	875	S>T		No	ClinGen gnomAD
rs1196254564 CA396277512	877	L>F		No	ClinGen gnomAD
rs1316899505 CA396277469	878	Y>C		No	ClinGen gnomAD
CA8105850 rs146794927	879	S>L		No	ClinGen ESP ExAC gnomAD
rs1229291055 CA396277352	882	P>R		No	ClinGen gnomAD
CA8105848 rs139818136	886	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8105847 rs377382219 COSM3771985	886	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA396277198 rs1329368084	889	K>*		No	ClinGen TOPMed gnomAD
rs1329368084 CA396277200	889	K>E		No	ClinGen TOPMed gnomAD
CA282307879 rs932053764	890	V>L		No	ClinGen TOPMed gnomAD
rs747381605 CA396276175	891	D>N		No	ClinGen ExAC TOPMed gnomAD
rs747381605 CA8105816	891	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs778039880 CA8105815	895	L>P		No	ClinGen ExAC gnomAD
CA396276079 rs1354000540	895	L>V		No	ClinGen gnomAD
CA8105814 rs150643297	897	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA282307868 rs976040730	897	E>G		No	ClinGen TOPMed gnomAD
CA396276008 rs1597315215	898	N>T		No	ClinGen Ensembl
CA396276013 rs1401759543	898	N>Y		No	ClinGen gnomAD
CA8105812 rs547019932	900	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs962042374 CA282307857	902	L>M		No	ClinGen gnomAD
rs754416899 CA8105811	902	L>P		No	ClinGen ExAC gnomAD
rs1014894880 CA282307847	903	E>D		No	ClinGen TOPMed
CA8105810 rs753412615	903	E>K		No	ClinGen ExAC gnomAD
rs779953131 CA8105809	904	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1486481234 CA396275916	904	R>H		No	ClinGen TOPMed gnomAD
rs112730433 CA282307806	905	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8105807 rs112730433	905	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8105808 rs375713096	905	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs767173203 CA8105806	906	S>R		No	ClinGen ExAC gnomAD
rs752798062 CA8105804	907	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8105805 rs761688398	907	R>W		No	ClinGen ExAC gnomAD
rs765662304 CA8105803	909	A>S		No	ClinGen ExAC TOPMed gnomAD
CA396275796 rs1294073309	909	A>V		No	ClinGen gnomAD
CA8105801 rs776903658	910	E>K		No	ClinGen ExAC TOPMed gnomAD
CA396275709 rs1347420143	912	S>G		No	ClinGen gnomAD
CA8105797 rs147506405	914	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8105798 rs750103540	914	R>W		No	ClinGen ExAC TOPMed gnomAD
CA282307747 rs891440219	916	L>F		No	ClinGen TOPMed gnomAD
rs891440219 CA396275574	916	L>F		No	ClinGen TOPMed gnomAD
CA282307743 rs1054133982	917	A>S		No	ClinGen Ensembl
CA8105794 rs34590217	918	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs975398430 CA282307729	919	H>Q		No	ClinGen TOPMed gnomAD
rs748769560 CA8105793	921	L>P		No	ClinGen ExAC gnomAD
CA282307725 rs139347380	925	L>V		No	ClinGen ESP TOPMed
rs755679813 CA8105791	926	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8105790 rs750277750	926	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1468026208 CA396275201	928	R>C		No	ClinGen gnomAD
rs781200583 CA8105789 COSM1378868	928	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA396275101 rs1397050571	931	H>Y		No	ClinGen TOPMed
COSM3782973 rs563505509 CA8105786	932	F>L	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA396275012 rs1272599096	932	F>Y		No	ClinGen gnomAD
rs1364539149 CA396274957	934	D>N		No	ClinGen gnomAD
CA282307698 rs1030769147	935	Q>*		No	ClinGen TOPMed gnomAD
CA396274881 rs1440812557	935	Q>L		No	ClinGen gnomAD
CA282307697 rs981924024	936	C>R		No	ClinGen TOPMed
rs1372412602 CA396274840	936	C>S		No	ClinGen TOPMed gnomAD
rs1372412602 CA396274843	936	C>Y		No	ClinGen TOPMed gnomAD
CA396274817 rs1325969837	937	A>V		No	ClinGen gnomAD
rs201732128 CA8105785	938	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8105784 rs754148641	938	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8105783 rs766521087	939	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8105782 rs143903337	939	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1189324533 CA396274753	940	V>L		No	ClinGen gnomAD
rs768133756 CA8105779	942	M>I		No	ClinGen ExAC gnomAD
rs1253567084 CA396274690	942	M>L		No	ClinGen gnomAD
CA8105780 rs773523134	942	M>T		No	ClinGen ExAC TOPMed gnomAD
CA8105778 rs111846078	944	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774055683 CA282307629	945	I>M		No	ClinGen Ensembl
rs976114086 CA282307643	945	I>V		No	ClinGen gnomAD
rs768265790 CA8105776	946	V>A		No	ClinGen ExAC TOPMed gnomAD
rs768265790 CA396274559	946	V>G		No	ClinGen ExAC TOPMed gnomAD
CA396274537 rs1597314806	947	H>P		No	ClinGen Ensembl
CA396274522 rs1444543599	947	H>Q		No	ClinGen TOPMed
CA396274505 rs1276907965	948	R>C		No	ClinGen gnomAD
rs907847751 CA282307608	948	R>H		No	ClinGen gnomAD
CA8105775 rs748898328	949	R>C		No	ClinGen ExAC gnomAD
CA8105773 rs769125781	949	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8105774 rs769125781	949	R>P		No	ClinGen ExAC TOPMed gnomAD
CA396274375 rs745452115	951	C>*		No	ClinGen ExAC gnomAD
CA396274376 rs1442382673	951	C>F		No	ClinGen gnomAD
rs1232294778 CA396273956	960	Y>*		No	ClinGen TOPMed gnomAD
rs766454816 CA282307452	962	G>D		No	ClinGen Ensembl
rs764765882 CA8105737	962	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1380335517 CA396273887	964	T>N		No	ClinGen TOPMed gnomAD
rs140269091 CA8105735	965	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773281297 CA8105733	967	A>P		No	ClinGen ExAC TOPMed gnomAD
CA8105732 rs773281297	967	A>T		No	ClinGen ExAC TOPMed gnomAD
rs190207170 CA8105731	967	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1469368619 CA396273834	968	A>D		No	ClinGen gnomAD
rs778804997 CA8105729	969	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8105728 rs768363225	969	R>H		No	ClinGen ExAC gnomAD
rs746053817 CA8105727	970	E>K		No	ClinGen ExAC gnomAD
rs781283797 CA8105726	971	V>L		No	ClinGen ExAC gnomAD
rs751703092 CA8105724	972	R>C		No	ClinGen ExAC TOPMed gnomAD
rs138705012 CA8105723	972	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA396273767 rs530863029	973	I>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8105722 rs530863029	973	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396273749 rs1307321947	974	M>I		No	ClinGen gnomAD
rs367934888 CA8105721	974	M>L		No	ClinGen ESP ExAC gnomAD
rs763650649 CA282307367	974	M>R		No	ClinGen Ensembl
CA396273757 rs367934888	974	M>V		No	ClinGen ESP ExAC gnomAD
rs144753004 CA8105720	977	C>W		No	ClinGen ESP ExAC gnomAD
rs759835715 CA8105719	978	H>D		No	ClinGen ExAC gnomAD
CA8105718 rs762980260	978	H>R		No	ClinGen ExAC TOPMed gnomAD
CA396273720 rs759835715	978	H>Y		No	ClinGen ExAC gnomAD
rs766205021 CA396273697	979	T>K		No	ClinGen ExAC TOPMed gnomAD
CA8105717 rs766205021	979	T>M		No	ClinGen ExAC TOPMed gnomAD
rs766205021 CA396273695	979	T>R		No	ClinGen ExAC TOPMed gnomAD
CA8105715 rs772896045 COSM471932	980	L>P	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA8105713 rs569958308	981	R>P		No	ClinGen 1000Genomes ExAC gnomAD
rs569958308 CA8105714	981	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs200317614 CA8105712	982	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396273626 rs1159569968	984	A>T		No	ClinGen TOPMed
CA8105710 rs749039758	984	A>V		No	ClinGen ExAC gnomAD
CA396273600 rs1567382165	986	E>Q		No	ClinGen Ensembl
rs373944685 CA8105708	987	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA396273579 rs1457644301	987	Y>H		No	ClinGen TOPMed
rs747061959 CA8105707	988	R>W		No	ClinGen ExAC TOPMed gnomAD
rs777791137 CA8105706	989	T>I		No	ClinGen ExAC gnomAD
rs779295641 CA8105703	991	R>Q		No	ClinGen ExAC gnomAD
CA8105704 rs116268850	991	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1193390972 CA396273478	993	R>*		No	ClinGen Ensembl
rs1338388632 CA396273476	993	R>Q		No	ClinGen TOPMed gnomAD
CA282307299 rs951567787	996	Q>R		No	ClinGen TOPMed gnomAD
rs766104188 CA8105699	1000	K>M		No	ClinGen ExAC gnomAD
CA8105698 rs755869068	1001	Q>*		No	ClinGen ExAC gnomAD
rs775224846 CA8105697	1002	A>D		No	ClinGen ExAC TOPMed gnomAD
rs775224846 CA8105696	1002	A>V		No	ClinGen ExAC TOPMed gnomAD
CA282307248 rs998356242	1004	Y>H		No	ClinGen TOPMed gnomAD
CA8105694 rs769648476	1005	R>C		No	ClinGen ExAC TOPMed gnomAD
CA282307235 rs769648476	1005	R>G		No	ClinGen ExAC TOPMed gnomAD
CA282307223 rs1039772478	1005	R>H		No	ClinGen TOPMed gnomAD
rs769648476 CA8105693	1005	R>S		No	ClinGen ExAC TOPMed gnomAD
CA8105691 rs775305958	1007	R>C		No	ClinGen ExAC gnomAD
CA8105690 rs769610007	1007	R>H		No	ClinGen ExAC TOPMed gnomAD
rs747184984 CA8105689	1008	N>K		No	ClinGen ExAC gnomAD
rs1567382001 CA396273277	1009	K>Q		No	ClinGen Ensembl
CA396273261 rs1436846845	1011	R>Q		No	ClinGen gnomAD
CA396273257 rs1249481021	1012	G>R		No	ClinGen TOPMed
rs1206941866 CA396273250	1013	R>C		No	ClinGen TOPMed gnomAD
CA8105687 rs773436492	1013	R>H		No	ClinGen ExAC TOPMed gnomAD
rs772076551 CA8105686	1014	M>T		No	ClinGen ExAC gnomAD
CA8105685 rs559455218	1016	T>S		No	ClinGen 1000Genomes ExAC gnomAD
CA8105683 COSM123170 rs755490026	1017	E>K	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs751257468 CA8105657	1018	T>A		No	ClinGen ExAC gnomAD
CA396273207 rs1245120239	1018	T>I		No	ClinGen TOPMed
CA282307097 rs996408352	1019	E>*		No	ClinGen gnomAD
rs1447553534 CA8105654	1019	E>D		No	ClinGen gnomAD
rs373077110 CA8105656	1019	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs373077110 CA282307087	1019	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA282307068 rs990689517	1022	S>*		No	ClinGen TOPMed
CA396273182 rs1412104945	1022	S>A		No	ClinGen TOPMed
CA282307067 rs867548759	1023	G>D		No	ClinGen gnomAD
CA396273175 rs867548759	1023	G>V		No	ClinGen gnomAD
CA8105652 rs752564255	1025	A>D		No	ClinGen ExAC gnomAD
CA396273164 rs752564255	1025	A>V		No	ClinGen ExAC gnomAD
CA8105651 rs765229597	1026	G>E		No	ClinGen ExAC
rs759317021 CA8105649	1027	E>G		No	ClinGen ExAC gnomAD
rs767751100 CA8105647	1028	A>D		No	ClinGen ExAC TOPMed
rs767751100 CA8105648	1028	A>G		No	ClinGen ExAC TOPMed
rs1432109802 CA396273143	1029	P>L		No	ClinGen TOPMed gnomAD
rs1040516891 CA282307046	1029	P>S		No	ClinGen Ensembl
CA396273128 rs1339110864	1031	N>T		No	ClinGen TOPMed
rs1383053363 CA396273110	1032	P>L		No	ClinGen TOPMed
rs557236288 CA8105645	1032	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA8105644 rs146514223	1034	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA282307031 rs146514223	1034	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA282307018 rs146514223	1034	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs763128197 CA396273073	1036	V>I		No	ClinGen ExAC gnomAD
rs763128197 CA8105642	1036	V>L		No	ClinGen ExAC gnomAD
CA396273029 rs1363514595	1037	A>V		No	ClinGen TOPMed
CA282306980 rs908962749	1038	V>A		No	ClinGen TOPMed
rs886507546 CA282306993	1038	V>L		No	ClinGen TOPMed gnomAD
CA8105641 rs776135636	1040	S>G		No	ClinGen ExAC gnomAD
rs1049123335 CA282306971	1040	S>N		No	ClinGen Ensembl
CA282306968 rs546547630	1040	S>R		No	ClinGen ExAC TOPMed gnomAD
CA8105639 rs577832197	1041	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8105638 rs781372321	1042	P>S		No	ClinGen ExAC gnomAD
rs1253805819 CA396272905	1043	G>D		No	ClinGen gnomAD
CA282306959 rs983111425	1043	G>S		No	ClinGen TOPMed
CA8105636 rs746584932	1044	R>Q		No	ClinGen ExAC TOPMed
rs373710737 CA8105637	1044	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1374616921 CA396272887	1045	G>V		No	ClinGen gnomAD
rs1215538499 CA396272853	1047	A>G		No	ClinGen gnomAD
rs1301925038 CA396272816	1049	S>N		No	ClinGen TOPMed gnomAD
rs1231378117 CA396272754	1051	A>D		No	ClinGen TOPMed gnomAD
rs1231378117 CA396272747	1051	A>V		No	ClinGen TOPMed gnomAD
CA8105634 rs757844941	1052	S>N		No	ClinGen ExAC gnomAD
CA396272696 rs1456358265	1053	M>I		No	ClinGen TOPMed
rs376653596 CA8105632	1053	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8105633 rs142647972	1053	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396272634 rs1436168158	1056	L>P		No	ClinGen TOPMed gnomAD
rs1395256688 CA396272616	1057	L>P		No	ClinGen gnomAD
CA8105631 rs754951818	1058	T>A		No	ClinGen ExAC TOPMed gnomAD
CA396272595 rs1430735204	1058	T>I		No	ClinGen TOPMed
CA396272584 rs1273744400	1059	S>N		No	ClinGen TOPMed
rs1365394272 CA396272564	1060	R>K		No	ClinGen TOPMed
rs753800789 CA282306926	1061	P>A		No	ClinGen ExAC TOPMed gnomAD
rs753800789 CA8105630	1061	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1180504194 CA396272524	1062	E>K		No	ClinGen gnomAD
rs760527651 CA396272495	1063	D>E		No	ClinGen ExAC gnomAD
CA8105629 rs766037000	1063	D>N		No	ClinGen ExAC gnomAD
CA282306904 rs1018830041	1065	T>I		No	ClinGen TOPMed
rs1027949280 CA282306899	1066	H>N		No	ClinGen Ensembl
CA396272427 rs1597313264	1067	N>S		No	ClinGen Ensembl
rs1007067939 CA282306898	1067	N>Y		No	ClinGen TOPMed gnomAD
CA8105626 rs369591941	1068	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8105625 rs763111646	1068	R>H		No	ClinGen ExAC gnomAD
CA8105624 rs775759444 COSM1252433	1069	R>C	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA8105623 rs145161451	1069	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1210758389 CA396272385	1070	S>G		No	ClinGen gnomAD
rs759693508 CA8105602	1073	M>I		No	ClinGen ExAC gnomAD
rs1352014880 CA396272274	1073	M>V		No	ClinGen gnomAD
rs777000933 CA8105601	1074	V>F		No	ClinGen ExAC TOPMed gnomAD
rs375544264 CA8105600	1075	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1224580764 CA396272154	1079	P>R		No	ClinGen TOPMed
rs1304538370 CA396272160	1079	P>S		No	ClinGen gnomAD
CA282306798 rs555521387	1080	I>T		No	ClinGen 1000Genomes TOPMed
rs773670831 CA8105598	1080	I>V		No	ClinGen ExAC TOPMed gnomAD
CA8105597 rs747207376	1081	M>L		No	ClinGen ExAC TOPMed gnomAD
CA396272124 rs1459008134	1081	M>T		No	ClinGen gnomAD
CA8105596 rs747207376	1081	M>V		No	ClinGen ExAC TOPMed gnomAD
CA8105595 rs774001965	1084	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1235031666 CA396270321	1087	S>P		No	ClinGen TOPMed
rs372458150 CA8105594	1089	A>S		No	ClinGen ESP ExAC gnomAD
CA282306777 rs994894216	1091	P>S		No	ClinGen TOPMed gnomAD
rs748893339 CA8105593	1092	E>*		No	ClinGen ExAC gnomAD
rs1485847943 CA396270178	1093	E>A		No	ClinGen gnomAD
CA8105591 rs756124197	1094	P>L		No	ClinGen ExAC gnomAD
rs202229073 CA8105592	1094	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs570015015 CA8105590	1095	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396270027 rs1436308195	1099	L>*		No	ClinGen gnomAD
CA282306754 rs771797116	1100	P>S		No	ClinGen Ensembl
CA396269993 rs1425963581	1101	S>G		No	ClinGen TOPMed
CA8105589 rs781092903	1101	S>T		No	ClinGen ExAC gnomAD
CA396269904 rs1232404830	1103	T>I		No	ClinGen gnomAD
CA396269829 rs1369814018	1106	E>G		No	ClinGen TOPMed
rs1380453437 CA396269810	1107	I>V		No	ClinGen gnomAD
CA8105588 rs757132766	1108	M>T		No	ClinGen ExAC TOPMed gnomAD
CA396269759 rs1321235583	1109	D>N		No	ClinGen gnomAD
CA8105587 rs752899995	1110	L>F		No	ClinGen ExAC TOPMed gnomAD
CA8105585 rs755096285	1111	L>P		No	ClinGen ExAC gnomAD
rs754002414 CA8105584	1114	S>*		No	ClinGen ExAC gnomAD
rs761208251 CA8105582	1117	K>N		No	ClinGen ExAC gnomAD
rs1428384716 CA396269472	1118	S>R		No	ClinGen gnomAD
rs1283776200 CA396269435	1119	S>R		No	ClinGen TOPMed
CA396269424 rs1391333943	1120	P>S		No	ClinGen TOPMed gnomAD
CA396269431 rs1391333943	1120	P>T		No	ClinGen TOPMed gnomAD
CA396269414 rs1260057612	1121	R>C		No	ClinGen TOPMed
rs551708643 CA8105580	1121	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA396269383 rs1465882587	1123	L>S		No	ClinGen gnomAD
CA282306679 rs941911219	1125	A>T		No	ClinGen TOPMed
CA396269332 rs1212648190	1126	R>G		No	ClinGen TOPMed gnomAD
rs767808985 CA8105579	1128	R>H		No	ClinGen ExAC gnomAD
rs1224984485 CA396269249	1129	K>E		No	ClinGen TOPMed gnomAD
CA8105576 rs539707576	1130	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM4141838 rs762346925 CA8105575	1130	R>H	ovary [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs775105803 CA8105574	1132	R>C		No	ClinGen ExAC TOPMed gnomAD
rs775105803 CA396269165	1132	R>G		No	ClinGen ExAC TOPMed gnomAD
CA8105573 rs777850281	1132	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1052999923 CA282306622	1133	G>D		No	ClinGen gnomAD
COSM1235627 rs758366092 CA8105571	1133	G>S	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1052999923 CA396269135	1133	G>V		No	ClinGen gnomAD
COSM972354 rs770847586 CA8105570	1135	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs746859450 CA8105569	1135	R>H		No	ClinGen ExAC TOPMed gnomAD
CA396269092 rs746859450	1135	R>L		No	ClinGen ExAC TOPMed gnomAD
CA396269047 rs1257374208	1137	S>P		No	ClinGen TOPMed gnomAD
CA8105558 rs763703372	1140	R>K		No	ClinGen ExAC TOPMed gnomAD
CA8105557 rs762626115	1141	T>M		No	ClinGen ExAC gnomAD
rs1466130979 CA396268722	1144	S>R		No	ClinGen gnomAD
rs1247054323 CA396268700	1145	G>A		No	ClinGen TOPMed
rs376778624 CA8105552	1147	G>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA8105553 rs376778624	1147	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8105551 rs771041970	1148	D>N		No	ClinGen ExAC gnomAD
CA396268594 rs1239796547	1149	D>E		No	ClinGen TOPMed gnomAD
CA8105550 rs746773202	1150	L>V		No	ClinGen ExAC gnomAD
rs777674042 CA8105549	1153	A>V		No	ClinGen ExAC gnomAD
rs144815381 CA8105548	1154	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA8105547 rs749473379	1154	L>P		No	ClinGen ExAC gnomAD
CA396268456 rs1201063436	1155	G>E		No	ClinGen gnomAD
rs750557765 CA8105544	1157	S>G		No	ClinGen ExAC gnomAD
CA8105543 rs750557765	1157	S>R		No	ClinGen ExAC gnomAD
rs781646540 CA8105542	1158	K>R		No	ClinGen ExAC gnomAD
CA396268334 rs1408075460	1160	P>T		No	ClinGen TOPMed
rs757800624 CA8105541	1161	G>S		No	ClinGen ExAC gnomAD
rs752089928 CA8105540	1164	V>A		No	ClinGen ExAC gnomAD
CA396268226 rs1337583326	1164	V>M		No	ClinGen TOPMed

No associated diseases with Q9Y613

2 regional properties for Q9Y613

Type	Name	Position	InterPro Accession
domain	SUN domain	555 - 716	IPR012919
domain	SUN coiled coil domain 2	481 - 538	IPR040994

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Cytoplasm, cytoskeleton Cell projection, bleb	Predominantly cytoplasmic
PANTHER Family	PTHR45920	FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I
PANTHER Subfamily	PTHR45920:SF2	FH1_FH2 DOMAIN-CONTAINING PROTEIN 1
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
bleb	A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)]
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intercalated disc	A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name	Definition
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
identical protein binding	Binding to an identical protein or proteins.
protein domain specific binding	Binding to a specific domain of a protein.
protein self-association	Binding to a domain within the same polypeptide.

7 GO annotations of biological process

Name	Definition
actin filament network formation	The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments.
cortical actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
establishment of centrosome localization	The directed movement of the centrosome to a specific location.
nuclear migration	The directed movement of the nucleus to a specific location within a cell.
positive regulation of stress fiber assembly	Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of stress fiber assembly	Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2V2M9	FHOD3	FH1/FH2 domain-containing protein 3	Homo sapiens (Human)	SS
Q76LL6	Fhod3	FH1/FH2 domain-containing protein 3	Mus musculus (Mouse)	SS
Q6P9Q4	Fhod1	FH1/FH2 domain-containing protein 1	Mus musculus (Mouse)	SS

10	20	30	40	50	60
MAGGEDRGDG	EPVSVVTVRV	QYLEDTDPFA	CANFPEPRRA	PTCSLDGALP	LGAQIPAVHR
70	80	90	100	110	120
LLGAPLKLED	CALQVSPSGY	YLDTELSLEE	QREMLEGFYE	EISKGRKPTL	ILRTQLSVRV
130	140	150	160	170	180
NAILEKLYSS	SGPELRRSLF	SLKQIFQEDK	DLVPEFVHSE	GLSCLIRVGA	AADHNYQSYI
190	200	210	220	230	240
LRALGQLMLF	VDGMLGVVAH	SDTIQWLYTL	CASLSRLVVK	TALKLLLVFV	EYSENNAPLF
250	260	270	280	290	300
IRAVNSVAST	TGAPPWANLV	SILEEKNGAD	PELLVYTVTL	INKTLAALPD	QDSFYDVTDA
310	320	330	340	350	360
LEQQGMEALV	QRHLGTAGTD	VDLRTQLVLY	ENALKLEDGD	IEEAPGAGGR	RERRKPSSEE
370	380	390	400	410	420
GKRSRRSLEG	GGCPARAPEP	GPTGPASPVG	PTSSTGPALL	TGPASSPVGP	PSGLQASVNL
430	440	450	460	470	480
FPTISVAPSA	DTSSERSIYK	ARFLENVAAA	ETEKQVALAQ	GRAETLAGAM	PNEAGGHPDA
490	500	510	520	530	540
RQLWDSPETA	PAARTPQSPA	PCVLLRAQRS	LAPEPKEPLI	PASPKAEPIW	ELPTRAPRLS
550	560	570	580	590	600
IGDLDFSDLG	EDEDQDMLNV	ESVEAGKDIP	APSPPLPLLS	GVPPPPPLPP	PPPIKGPFPP
610	620	630	640	650	660
PPPLPLAAPL	PHSVPDSSAL	PTKRKTVKLF	WRELKLAGGH	GVSASRFGPC	ATLWASLDPV
670	680	690	700	710	720
SVDTARLEHL	FESRAKEVLP	SKKAGEGRRT	MTTVLDPKRS	NAINIGLTTL	PPVHVIKAAL
730	740	750	760	770	780
LNFDEFAVSK	DGIEKLLTMM	PTEEERQKIE	EAQLANPDIP	LGPAENFLMT	LASIGGLAAR
790	800	810	820	830	840
LQLWAFKLDY	DSMEREIAEP	LFDLKVGMEQ	LVQNATFRCI	LATLLAVGNF	LNGSQSSGFE
850	860	870	880	890	900
LSYLEKVSEV	KDTVRRQSLL	HHLCSLVLQT	RPESSDLYSE	IPALTRCAKV	DFEQLTENLG
910	920	930	940	950	960
QLERRSRAAE	ESLRSLAKHE	LAPALRARLT	HFLDQCARRV	AMLRIVHRRV	CNRFHAFLLY
970	980	990	1000	1010	1020
LGYTPQAARE	VRIMQFCHTL	REFALEYRTC	RERVLQQQQK	QATYRERNKT	RGRMITETEK
1030	1040	1050	1060	1070	1080
FSGVAGEAPS	NPSVPVAVSS	GPGRGDADSH	ASMKSLLTSR	PEDTTHNRRS	RGMVQSSSPI
1090	1100	1110	1120	1130	1140
MPTVGPSTAS	PEEPPGSSLP	SDTSDEIMDL	LVQSVTKSSP	RALAARERKR	SRGNRKSLRR
1150	1160
TLKSGLGDDL	VQALGLSKGP	GLEV