Q9Y5W8
Gene name |
SNX13 (KIAA0713) |
Protein name |
Sorting nexin-13 |
Names |
RGS domain- and PHOX domain-containing protein, RGS-PX1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:23161 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9Y5W8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7WF6 | X-ray | 325 A | A | 372-516 | PDB |
| AF-Q9Y5W8-F1 | Predicted | AlphaFoldDB |
1 variants for Q9Y5W8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs35113148 VAR_057333 |
472 | L>S | No |
UniProt dbSNP |
No associated diseases with Q9Y5W8
6 regional properties for Q9Y5W8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phox homology | 570 - 691 | IPR001683 |
| domain | Phox-associated domain | 97 - 284 | IPR003114 |
| domain | Sorting nexin, C-terminal | 803 - 912 | IPR013937 |
| domain | RGS domain | 373 - 513 | IPR016137 |
| domain | Sorting nexin-13, PX domain | 557 - 687 | IPR037437 |
| domain | SNX13, RGS domain | 377 - 511 | IPR037896 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| phosphatidylinositol-3-phosphate binding | Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| negative regulation of signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96S38 | RPS6KC1 | Ribosomal protein S6 kinase delta-1 | Homo sapiens (Human) | PR |
| Q96BR1 | SGK3 | Serine/threonine-protein kinase Sgk3 | Homo sapiens (Human) | SS |
| Q9Y5W7 | SNX14 | Sorting nexin-14 | Homo sapiens (Human) | PR |
| Q8BLK9 | Rps6kc1 | Ribosomal protein S6 kinase delta-1 | Mus musculus (Mouse) | PR |
| Q3ZT31 | Snx25 | Sorting nexin-25 | Mus musculus (Mouse) | PR |
| Q9ERE3 | Sgk3 | Serine/threonine-protein kinase Sgk3 | Mus musculus (Mouse) | PR |
| Q8BHY8 | Snx14 | Sorting nexin-14 | Mus musculus (Mouse) | PR |
| Q6PHS6 | Snx13 | Sorting nexin-13 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLTEASLSIW | GWGSLGIVLF | LITFGPFVIF | YLTFYILCFV | GGGLVVTLLF | GKTNSEKYLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QCEHSFLPPT | SPGVPKCLEE | MKREARTIKI | DRRLTGANII | DEPLQQVIQF | SLRDYVQYWY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YTLSDDESFL | LEIRQTLQNA | LIQFATRSKE | IDWQPYFTTR | IVDDFGTHLR | VFRKAQQKIT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EKDDQVKGTA | EDLVDTFFEV | EVEMEKEVCR | DLVCTSPKDE | EGFLRDLCEV | LLYLLLPPGD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FQNKIMRYFV | REILARGILL | PLINQLSDPD | YINQYVIWMI | RDSNCNYEAF | MNIIKLSDNI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GELEAVRDKA | AEELQYLRSL | DTAGDDINTI | KNQINSLLFV | KKVCDSRIQR | LQSGKEINTV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KLAANFGKLC | TVPLDSILVD | NVALQFFMDY | MQQTGGQAHL | FFWMTVEGYR | VTAQQQLEVL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LSRQRDGKHQ | TNQTKGLLRA | AAVGIYEQYL | SEKASPRVTV | DDYLVAKLAD | TLNHEDPTPE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IFDDIQRKVY | ELMLRDERFY | PSFRQNALYV | RMLAELDMLK | DPSFRGSDDG | DGESFNGSPT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GSINLSLDDL | SNVSSDDSVQ | LHAYISDTVY | ADYDPYAVAG | VCNDHGKTYA | LYAITVHRRN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LNSEEMWKTY | RRYSDFHDFH | MRITEQFESL | SSILKLPGKK | TFNNMDRDFL | EKRKKDLNAY |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LQLLLAPEMM | KASPALAHYV | YDFLENKAYS | KGKGDFARKM | DTFVNPLRNS | MRNVSNAVKS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LPDSLAEGMT | KMSDNMGKMS | ERLGQDIKQS | FFKVPPLIPK | TDSDPEHRRV | SAQLDDNVDD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NIPLRVMLLL | MDEVFDLKER | NQWLRRNIKN | LLQQLIRATY | GDTINRKIVD | HVDWMTSPEQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VADSVKRFRD | AFWPNGILAE | AVPCRDKSIR | MRTRVAGKTK | LLAIMPDELK | HIIGAETTRK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GILRVFEMFQ | HNQLNRRMVY | VFLEGFLETL | FPQYKFRELF | NKLHSRSKQM | QKYKQKLQTT |
| QAPSLQKR |