AiPD: Autoinhibited Protein Database

Q9Y4X4

Gene name	KLF12 (AP2REP, HSPC122)
Protein name	Krueppel-like factor 12
Names	Transcriptional repressor AP-2rep
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11278
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

57-154 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

57-154 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9Y4X4

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9Y4X4-F1	Predicted				AlphaFoldDB

265 variants for Q9Y4X4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	1	M>?	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757932259 CA7003177	4	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA388353294 rs1369304945	5	M>T		No	ClinGen gnomAD
CA7003175 rs185300395	9	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1566497222 CA388353264	9	T>S		No	ClinGen Ensembl
CA7003174 rs754990074	10	I>R		No	ClinGen ExAC gnomAD
CA252704826 rs112263520	10	I>V		No	ClinGen Ensembl
rs764303635 CA7003149	14	N>S		No	ClinGen ExAC gnomAD
CA7003148 rs762948057	15	T>I		No	ClinGen ExAC gnomAD
CA388353199 rs762948057	15	T>N		No	ClinGen ExAC gnomAD
rs765691786 CA7003146	18	N>S		No	ClinGen ExAC gnomAD
CA7003145 rs759947614	19	R>G		No	ClinGen ExAC gnomAD
rs777183578 CA7003144	20	M>V		No	ClinGen ExAC gnomAD
CA7003142 rs761622207	22	M>T		No	ClinGen ExAC TOPMed gnomAD
CA7003143 rs553035366	22	M>V		No	ClinGen ExAC TOPMed gnomAD
rs375136358 CA252699016	23	L>F		No	ClinGen TOPMed
rs1285834611 CA388353139	24	D>G		No	ClinGen TOPMed
rs773876873 CA7003141	24	D>N		No	ClinGen ExAC gnomAD
rs768158278 CA7003140	25	G>R		No	ClinGen ExAC gnomAD
rs748773890 CA7003139	26	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1427910552 CA388353127	26	M>K		No	ClinGen gnomAD
TCGA novel	27	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs561758371 CA7003137	28	A>P		No	ClinGen 1000Genomes ExAC gnomAD
CA7003135 rs542604703	30	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1480963536 CA388353102	30	R>I		No	ClinGen gnomAD
CA7003132 rs777879429	35	L>F		No	ClinGen ExAC gnomAD
CA7003130 rs376042261	36	L>F		No	ClinGen ESP ExAC gnomAD
CA7003131 rs758462923	36	L>S		No	ClinGen ExAC TOPMed gnomAD
CA7003129 rs765752275	40	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1255038767 CA388353028	41	G>E		No	ClinGen gnomAD
CA388353001 rs1297551042	42	S>C		No	ClinGen TOPMed
rs1462410334 CA388353004	42	S>P		No	ClinGen gnomAD
TCGA novel	42	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388352992 rs1245797111	44	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs776657675 CA7003104	45	V>I		No	ClinGen ExAC gnomAD
rs200631472 CA7003103	46	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA388352971 rs1226484491	47	N>D		No	ClinGen gnomAD
rs764662531 CA7003102	47	N>I		No	ClinGen ExAC TOPMed gnomAD
rs1314506702 CA388352964	48	Y>H		No	ClinGen gnomAD
CA252687733 rs915582199	48	Y>S		No	ClinGen TOPMed
TCGA novel	49	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1246774933 CA388352956	49	P>S		No	ClinGen gnomAD
CA7003100 rs574902537	50	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1430467920 CA388352939	51	M>I		No	ClinGen gnomAD
CA7003099 rs770893161	51	M>T		No	ClinGen ExAC
rs746796522 CA7003098	52	E>K		No	ClinGen ExAC TOPMed
rs772937895 CA7003097	53	A>V		No	ClinGen ExAC gnomAD
CA7003095 rs376189616	54	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA388352915 rs1365476163	55	P>L		No	ClinGen gnomAD
rs1445914506 CA388352912	56	L>P		No	ClinGen gnomAD
CA388352904 rs1430383558	57	L>F		No	ClinGen TOPMed
CA7003093 rs755057199	58	L>Q		No	ClinGen ExAC gnomAD
CA388352898 rs1185512609	59	N>D		No	ClinGen gnomAD
CA7003092 rs749413395	60	N>H		No	ClinGen ExAC gnomAD
CA388352883 rs1435312697	61	V>L		No	ClinGen TOPMed
rs961087593 CA252687731	62	K>R		No	ClinGen Ensembl
CA7003091 rs780677974	63	G>A		No	ClinGen ExAC gnomAD
rs1594163430 CA388352870	63	G>R		No	ClinGen Ensembl
CA388352858 rs1594163412	64	E>D		No	ClinGen Ensembl
CA388352865 rs1173461029	64	E>K		No	ClinGen TOPMed
rs1292336168 CA388352856	65	P>A		No	ClinGen TOPMed gnomAD
CA388352857 rs1292336168	65	P>T		No	ClinGen TOPMed gnomAD
rs373909446 CA7003090	66	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA252687729 rs373909446	66	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	66	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388352844 rs1293776619	67	E>A		No	ClinGen gnomAD
rs767837826 CA7003088	68	D>H		No	ClinGen ExAC gnomAD
CA7003087 COSM348863 rs757646750	69	S>L	lung Variant assessed as Somatic; 0.0 impact. endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA388352810 rs1345445166	72	V>A		No	ClinGen gnomAD
CA388352798 rs1304207455	74	H>Y		No	ClinGen gnomAD
CA388352791 rs1438014979	75	F>L		No	ClinGen gnomAD
CA388352775 rs1566412693	77	T>A		No	ClinGen Ensembl
CA7003083 rs776166386	86	I>R		No	ClinGen ExAC TOPMed gnomAD
rs766290106 CA7003082	90	R>T		No	ClinGen ExAC TOPMed gnomAD
CA388352678 rs569483080	91	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7003081 rs569483080	91	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA252687727 rs775332866	93	P>S		No	ClinGen Ensembl
rs747994217 CA7003078	94	T>P		No	ClinGen ExAC gnomAD
rs531869423 CA388352660	95	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs531869423 CA7003077	95	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771843770 CA7003075	96	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	97	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780342553 CA388352637	99	S>A		No	ClinGen ExAC TOPMed gnomAD
CA7003074 rs780342553	99	S>P		No	ClinGen ExAC TOPMed gnomAD
rs756641598 CA7003073	100	P>L		No	ClinGen ExAC gnomAD
rs746294490 CA7003072	103	M>V		No	ClinGen ExAC gnomAD
CA7003071 rs781729948	104	T>I		No	ClinGen ExAC gnomAD
rs1303625637 CA388352602	105	A>P		No	ClinGen TOPMed
rs1303625637 CA388352601	105	A>S		No	ClinGen TOPMed
rs751960316 CA7003069	106	S>P		No	ClinGen ExAC TOPMed gnomAD
CA388352589 rs1292719018	107	A>V		No	ClinGen TOPMed
rs1373852859 CA388352585	108	S>A		No	ClinGen TOPMed
CA388352578 rs1447757902	109	S>A		No	ClinGen TOPMed
rs1311779192 CA388352569	110	P>L		No	ClinGen TOPMed
CA388352556 rs1442228223	113	T>A		No	ClinGen gnomAD
CA388352554 rs1442228223	113	T>P		No	ClinGen gnomAD
CA252687724 rs1057562	116	S>P		No	ClinGen Ensembl
CA7003064 rs150943448	118	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA7003062 rs777942888	119	S>F		No	ClinGen ExAC TOPMed gnomAD
CA7003061 rs142451819	122	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144692979 CA7003060	122	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA388352494 rs1234877447	124	A>T		No	ClinGen gnomAD
rs768991101 CA7003058	124	A>V		No	ClinGen ExAC gnomAD
rs769706394 CA7003055	125	S>T		No	ClinGen ExAC gnomAD
CA7003053 rs144313130	128	T>A		No	ClinGen ESP ExAC gnomAD
CA388352459 rs1223921454	130	I>N		No	ClinGen gnomAD
CA388352458 rs1223921454	130	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7003052 rs369653133	130	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	131	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs150040933 COSM1212573 CA7003051	136	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
COSM948399 CA7003048 rs753427035	139	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA7003046 rs755535662	140	S>T		No	ClinGen ExAC TOPMed gnomAD
CA252687721 rs945920415	141	T>A		No	ClinGen TOPMed
rs538182823 CA7003045	142	V>I		No	ClinGen ExAC TOPMed gnomAD
CA388352392 rs538182823	142	V>L		No	ClinGen ExAC TOPMed gnomAD
CA7003044 rs767338522	144	T>I		No	ClinGen ExAC gnomAD
rs1289815867 CA388352355	148	L>F		No	ClinGen TOPMed
rs1345278868 CA388352346	149	V>G		No	ClinGen TOPMed gnomAD
rs751399618 CA7003042	152	A>P		No	ClinGen ExAC gnomAD
CA388352333 rs751399618	152	A>T		No	ClinGen ExAC gnomAD
CA7003041 rs763915082	154	G>S		No	ClinGen ExAC gnomAD
CA7003040 rs762855334	156	G>R		No	ClinGen ExAC gnomAD
CA7003039 rs146327323	156	G>V		No	ClinGen ESP ExAC gnomAD
TCGA novel	160	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388352277 rs1367308651	161	L>M		No	ClinGen TOPMed gnomAD
CA252687720 rs968928097	163	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	165	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs535553088 CA7003036	166	P>R		No	ClinGen ExAC gnomAD
rs138812420 CA7003034	167	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs138812420 CA7003035	167	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs150626364 CA7003033	168	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	169	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1594162689 CA388352181	175	L>S		No	ClinGen Ensembl
TCGA novel	175	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7003028 rs755841328	176	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs745359535 CA7003027	179	K>R		No	ClinGen ExAC gnomAD
rs1444016344 CA388352141	181	S>C		No	ClinGen gnomAD
rs1427161626 CA388352111	185	R>H		No	ClinGen gnomAD
CA7003026 rs780825753	185	R>S		No	ClinGen ExAC gnomAD
rs558170937 CA252687717	188	V>M		No	ClinGen gnomAD
CA388352087 rs1290145938	189	V>E		No	ClinGen gnomAD
rs1359526637 CA388352084	190	V>I		No	ClinGen gnomAD
rs371734093 CA252687716	191	Q>E		No	ClinGen ESP TOPMed
CA7003021 rs533540212	191	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA388352069 rs1296059893	192	S>L		No	ClinGen gnomAD
rs1317742057 CA388352071	192	S>P		No	ClinGen TOPMed
rs1238472276 CA388352059	194	P>A		No	ClinGen gnomAD
TCGA novel	196	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388352048 rs766424247	196	V>F		No	ClinGen ExAC TOPMed gnomAD
CA7003017 rs766424247	196	V>I		No	ClinGen ExAC TOPMed gnomAD
CA388352039 rs1424161860	197	Y>C		No	ClinGen gnomAD
TCGA novel	198	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7003016 rs151327230	203	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs752099787 CA7003014	206	V>A		No	ClinGen ExAC
rs887336943 CA252687715	206	V>M		No	ClinGen TOPMed
rs1372669285 CA388351968	208	N>S		No	ClinGen gnomAD
rs748487379 CA388351963	209	T>A		No	ClinGen ExAC gnomAD
rs748487379 CA7003013	209	T>S		No	ClinGen ExAC gnomAD
rs774840041 CA7003012	210	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs780721355 CA7003009	212	V>A		No	ClinGen ExAC gnomAD
CA388351947 rs375091947	212	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7003010 COSM288440 rs375091947	212	V>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA7003008 rs756779759	213	P>L		No	ClinGen ExAC gnomAD
rs1338362150 CA388351941	213	P>S		No	ClinGen gnomAD
rs1405450710 CA388351905	218	G>E		No	ClinGen gnomAD
rs372760583 CA7003004	222	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs375557815 CA7002983	225	Q>E		No	ClinGen ESP ExAC gnomAD
CA388351840 rs1412663813	226	M>R		No	ClinGen TOPMed gnomAD
rs756384551 CA7002982	226	M>V		No	ClinGen ExAC TOPMed gnomAD
rs750500573 CA388351830	227	D>E		No	ClinGen ExAC gnomAD
rs200260466 CA388351822	229	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs200260466 CA252683837	229	R>G		No	ClinGen gnomAD
rs767522822 CA7002980	229	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1282132326 CA388351815	230	G>D		No	ClinGen TOPMed gnomAD
CA388351818 rs1462483269	230	G>S		No	ClinGen gnomAD
rs537130260 CA7002978	232	S>A		No	ClinGen 1000Genomes ExAC gnomAD
rs764541268 CA7002977	234	R>G		No	ClinGen ExAC TOPMed gnomAD
rs757861922 CA252683836	235	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1380867379 CA388351775	237	K>E		No	ClinGen gnomAD
rs776047704 CA7002975	237	K>R		No	ClinGen ExAC gnomAD
rs770700596 CA7002974	239	D>G		No	ClinGen ExAC gnomAD
CA388351743 rs1316893658	241	D>V		No	ClinGen gnomAD
rs373341263 CA252683835	242	D>V		No	ClinGen ESP TOPMed
CA7002973 rs760335816	244	D>Y		No	ClinGen ExAC gnomAD
rs1428763512 CA388351712	245	L>P		No	ClinGen TOPMed
rs201686630 CA7002971	247	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA388351696 rs1323573774	248	V>M		No	ClinGen TOPMed
CA388351675 rs1384294936	251	D>G		No	ClinGen TOPMed gnomAD
CA388351665 rs754841548	252	S>R		No	ClinGen ExAC gnomAD
CA7002967 rs375809451 COSM948395	253	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs755910688 CA7002965	259	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1287996767 CA388351620	259	T>M		No	ClinGen TOPMed gnomAD
CA7002962 rs141351721	262	S>P		No	ClinGen ESP ExAC
rs1357358434 CA388351595	264	A>T		No	ClinGen gnomAD
rs1208829798 CA388351576	267	V>I		No	ClinGen TOPMed
rs767184668 CA7002935	272	P>L		No	ClinGen ExAC gnomAD
rs774060156 CA7002933	273	S>P		No	ClinGen ExAC gnomAD
CA388351515 rs1489502158	274	P>S		No	ClinGen TOPMed gnomAD
CA388351509 rs1221480689	275	V>L		No	ClinGen TOPMed
TCGA novel	277	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388351497 rs1204066088	277	R>W		No	ClinGen gnomAD
rs1458521636 CA388351491	278	V>I		No	ClinGen gnomAD
rs775367228 CA7002930	279	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA388351479 rs1302584442	280	G>C		No	ClinGen gnomAD
CA388351478 rs1220513306	280	G>D		No	ClinGen gnomAD
rs1302584442 CA388351481	280	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7002928 rs745644480	281	N>Y		No	ClinGen ExAC gnomAD
TCGA novel	282	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1401964191 CA388351462	283	M>V		No	ClinGen gnomAD
CA388351435 rs935764081	286	Q>P		No	ClinGen TOPMed gnomAD
CA252678525 rs935764081	286	Q>R		No	ClinGen TOPMed gnomAD
rs184383555 CA7002926	287	K>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7002924 rs145849663	290	C>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1275748841 CA388350941	294	P>A		No	ClinGen TOPMed
rs1203920280 CA388350935	295	F>L		No	ClinGen TOPMed
rs1183914353 CA388350927	296	S>G		No	ClinGen gnomAD
rs891600489 CA252672745	297	I>T		No	ClinGen Ensembl
CA7002901 rs768858509	297	I>V		No	ClinGen ExAC gnomAD
CA7002899 rs780634032	299	S>N		No	ClinGen ExAC gnomAD
rs1216790452 CA388350902	299	S>R		No	ClinGen gnomAD
rs1355210044 CA388350900	300	T>P		No	ClinGen gnomAD
CA252672744 COSM551749 rs200541651	302	R>H	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA7002898 rs200541651	302	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	304	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7002896 rs777273071	305	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs750839981 CA7002897	305	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA252672743 rs1044483879	306	S>C		No	ClinGen Ensembl
rs930953419 CA252672742	307	E>K		No	ClinGen Ensembl
rs199620438 CA7002894	308	S>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1417298987 CA388350843	309	P>L		No	ClinGen TOPMed
CA388350811 rs1361186909	314	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	314	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA252672741 rs1036701622	315	R>C		No	ClinGen gnomAD
COSM3384894 CA7002891 rs753676273	315	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1161710419 CA388350785	318	R>K		No	ClinGen gnomAD
CA388350716 rs1432443795	327	V>A		No	ClinGen TOPMed
rs766377177 CA7002890	329	T>A		No	ClinGen ExAC gnomAD
CA7002889 rs760360931	331	S>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	331	S>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7002887 rs772418501	338	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs773116704 CA7002888	338	R>W		No	ClinGen ExAC gnomAD
rs753432392 CA7002873	345	K>R		No	ClinGen ExAC gnomAD
rs1042318340 CA252670611	348	K>E		No	ClinGen TOPMed
CA388351334 rs1593966173	351	W>*		No	ClinGen Ensembl
CA7002871 rs756142584	353	G>A		No	ClinGen ExAC TOPMed gnomAD
rs756142584 CA388351317	353	G>D		No	ClinGen ExAC TOPMed gnomAD
rs750330965 CA252670609	358	F>L		No	ClinGen ExAC TOPMed gnomAD
CA388351269 rs1258496698	360	R>G		No	ClinGen gnomAD
CA388351267 rs767360300	360	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7002869 rs767360300	360	R>P		No	ClinGen ExAC TOPMed gnomAD
rs775701056 CA7002864	375	K>R		No	ClinGen ExAC gnomAD
CA388351148 rs1332469280	378	K>E		No	ClinGen gnomAD
rs746322196 CA7002862	380	A>T		No	ClinGen ExAC TOPMed gnomAD
rs777139465 CA7002861	380	A>V		No	ClinGen ExAC gnomAD
rs778511394 CA7002858	381	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1178989834 CA388351118	382	C>Y		No	ClinGen gnomAD
CA252670603 rs941817144 COSM1706840	384	R>C	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1438715687 CA388351103	384	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA388351101 rs1438715687	384	R>L		No	ClinGen gnomAD
TCGA novel	390	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1200377387 CA388351039	393	A>V		No	ClinGen TOPMed gnomAD
CA388351031 rs1262487531	395	H>Y		No	ClinGen gnomAD
rs1257857115 CA388351018	397	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs755590689 CA7002854	400	M>V		No	ClinGen ExAC gnomAD
rs1310253531 CA388350984	402	V>M		No	ClinGen gnomAD

No associated diseases with Q9Y4X4

3 regional properties for Q9Y4X4

Type	Name	Position	InterPro Accession
domain	Zinc finger C2H2-type	317 - 346	IPR013087-1
domain	Zinc finger C2H2-type	347 - 376	IPR013087-2
domain	Zinc finger C2H2-type	377 - 399	IPR013087-3

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

7 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription repressor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion binding	Binding to a metal ion.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

3 GO annotations of biological process

Name	Definition
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

177 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q08DS3	OSR1	Protein odd-skipped-related 1	Bos taurus (Bovine)	PR
Q2VWH6	FEZF2	Fez family zinc finger protein 2	Bos taurus (Bovine)	PR
A6QNZ0	ZSCAN26	Zinc finger and SCAN domain-containing protein 26	Bos taurus (Bovine)	PR
A7MBI1	ZFP69	Zinc finger protein 69 homolog	Bos taurus (Bovine)	PR
Q08705	CTCF	Transcriptional repressor CTCF	Gallus gallus (Chicken)	PR
O42409	GFI1B	Zinc finger protein Gfi-1b	Gallus gallus (Chicken)	PR
A2T6W2	ZNF449	Zinc finger protein 449	Pan troglodytes (Chimpanzee)	PR
Q9U405	grau	Transcription factor grauzone	Drosophila melanogaster (Fruit fly)	PR
Q7K0S9	sug	Zinc finger protein GLIS2 homolog	Drosophila melanogaster (Fruit fly)	PR
P20385	Cf2	Chorion transcription factor Cf2	Drosophila melanogaster (Fruit fly)	PR
Q86P48	ATbp	AT-rich binding protein	Drosophila melanogaster (Fruit fly)	PR
P28698	MZF1	Myeloid zinc finger 1	Homo sapiens (Human)	PR
Q9NTW7	ZFP64	Zinc finger protein 64	Homo sapiens (Human)	PR
O14978	ZNF263	Zinc finger protein 263	Homo sapiens (Human)	PR
O60304	ZNF500	Zinc finger protein 500	Homo sapiens (Human)	PR
P08151	GLI1	Zinc finger protein GLI1	Homo sapiens (Human)	PR
Q9UFB7	ZBTB47	Zinc finger and BTB domain-containing protein 47	Homo sapiens (Human)	PR
Q9UNY5	ZNF232	Zinc finger protein 232	Homo sapiens (Human)	PR
Q96SZ4	ZSCAN10	Zinc finger and SCAN domain-containing protein 10	Homo sapiens (Human)	PR
P17028	ZNF24	Zinc finger protein 24	Homo sapiens (Human)	PR
P25490	YY1	Transcriptional repressor protein YY1	Homo sapiens (Human)	SS
O43296	ZNF264	Zinc finger protein 264	Homo sapiens (Human)	PR
P49711	CTCF	Transcriptional repressor CTCF	Homo sapiens (Human)	PR
Q9NQX1	PRDM5	PR domain zinc finger protein 5	Homo sapiens (Human)	PR
Q9HBE1	PATZ1	POZ-, AT hook-, and zinc finger-containing protein 1	Homo sapiens (Human)	PR
Q8TAX0	OSR1	Protein odd-skipped-related 1	Homo sapiens (Human)	PR
Q9UL58	ZNF215	Zinc finger protein 215	Homo sapiens (Human)	PR
Q8TBJ5	FEZF2	Fez family zinc finger protein 2	Homo sapiens (Human)	PR
Q96SR6	ZNF382	Zinc finger protein 382	Homo sapiens (Human)	PR
Q96IT1	ZNF496	Zinc finger protein 496	Homo sapiens (Human)	PR
Q96N95	ZNF396	Zinc finger protein 396	Homo sapiens (Human)	PR
Q9ULJ3	ZBTB21	Zinc finger and BTB domain-containing protein 21	Homo sapiens (Human)	PR
Q9H9D4	ZNF408	Zinc finger protein 408	Homo sapiens (Human)	PR
Q13127	REST	RE1-silencing transcription factor	Homo sapiens (Human)	PR
Q8IZM8	ZNF654	Zinc finger protein 654	Homo sapiens (Human)	PR
Q14526	HIC1	Hypermethylated in cancer 1 protein	Homo sapiens (Human)	PR
P17022	ZNF18	Zinc finger protein 18	Homo sapiens (Human)	PR
Q86XF7	ZNF575	Zinc finger protein 575	Homo sapiens (Human)	PR
Q8NAM6	ZSCAN4	Zinc finger and SCAN domain-containing protein 4	Homo sapiens (Human)	PR
Q08ER8	ZNF543	Zinc finger protein 543	Homo sapiens (Human)	PR
P17029	ZKSCAN1	Zinc finger protein with KRAB and SCAN domains 1	Homo sapiens (Human)	PR
Q8N680	ZBTB2	Zinc finger and BTB domain-containing protein 2	Homo sapiens (Human)	PR
O95625	ZBTB11	Zinc finger and BTB domain-containing protein 11	Homo sapiens (Human)	PR
Q9NPC7	MYNN	Myoneurin	Homo sapiens (Human)	PR
Q96BV0	ZNF775	Zinc finger protein 775	Homo sapiens (Human)	PR
Q8NF99	ZNF397	Zinc finger protein 397	Homo sapiens (Human)	PR
Q63HK3	ZKSCAN2	Zinc finger protein with KRAB and SCAN domains 2	Homo sapiens (Human)	PR
Q5FWF6	ZNF789	Zinc finger protein 789	Homo sapiens (Human)	PR
Q15776	ZKSCAN8	Zinc finger protein with KRAB and SCAN domains 8	Homo sapiens (Human)	PR
Q53GI3	ZNF394	Zinc finger protein 394	Homo sapiens (Human)	PR
O95125	ZNF202	Zinc finger protein 202	Homo sapiens (Human)	PR
Q05516	ZBTB16	Zinc finger and BTB domain-containing protein 16	Homo sapiens (Human)	PR
Q9H116	GZF1	GDNF-inducible zinc finger protein 1	Homo sapiens (Human)	PR
Q8N0Y2	ZNF444	Zinc finger protein 444	Homo sapiens (Human)	PR
Q6P9G9	ZNF449	Zinc finger protein 449	Homo sapiens (Human)	PR
Q8IW36	ZNF695	Zinc finger protein 695	Homo sapiens (Human)	PR
Q5VTD9	GFI1B	Zinc finger protein Gfi-1b	Homo sapiens (Human)	PR
Q6PG37	ZNF790	Zinc finger protein 790	Homo sapiens (Human)	PR
Q9NQV6	PRDM10	PR domain zinc finger protein 10	Homo sapiens (Human)	PR
Q9Y2D9	ZNF652	Zinc finger protein 652	Homo sapiens (Human)	PR
Q5TC79	ZBTB37	Zinc finger and BTB domain-containing protein 37	Homo sapiens (Human)	PR
Q9Y4E5	ZNF451	E3 SUMO-protein ligase ZNF451	Homo sapiens (Human)	PR
Q8ND82	ZNF280C	Zinc finger protein 280C	Homo sapiens (Human)	PR
Q49AA0	ZFP69	Zinc finger protein 69 homolog	Homo sapiens (Human)	PR
O43298	ZBTB43	Zinc finger and BTB domain-containing protein 43	Homo sapiens (Human)	PR
Q9Y330	ZBTB12	Zinc finger and BTB domain-containing protein 12	Homo sapiens (Human)	PR
Q13105	ZBTB17	Zinc finger and BTB domain-containing protein 17	Homo sapiens (Human)	PR
P51508	ZNF81	Zinc finger protein 81	Homo sapiens (Human)	PR
Q5JNZ3	ZNF311	Zinc finger protein 311	Homo sapiens (Human)	PR
Q9BRR0	ZKSCAN3	Zinc finger protein with KRAB and SCAN domains 3	Homo sapiens (Human)	PR
Q969J2	ZKSCAN4	Zinc finger protein with KRAB and SCAN domains 4	Homo sapiens (Human)	PR
P49910	ZNF165	Zinc finger protein 165	Homo sapiens (Human)	PR
P10074	ZBTB48	Telomere zinc finger-associated protein	Homo sapiens (Human)	PR
P17010	ZFX	Zinc finger X-chromosomal protein	Homo sapiens (Human)	PR
Q9H5H4	ZNF768	Zinc finger protein 768	Homo sapiens (Human)	PR
Q6NSZ9	ZSCAN25	Zinc finger and SCAN domain-containing protein 25	Homo sapiens (Human)	PR
Q9Y2L8	ZKSCAN5	Zinc finger protein with KRAB and SCAN domains 5	Homo sapiens (Human)	PR
Q86UZ6	ZBTB46	Zinc finger and BTB domain-containing protein 46	Homo sapiens (Human)	PR
Q9NX65	ZSCAN32	Zinc finger and SCAN domain-containing protein 32	Homo sapiens (Human)	PR
O14771	ZNF213	Zinc finger protein 213	Homo sapiens (Human)	PR
Q8IWY8	ZSCAN29	Zinc finger and SCAN domain-containing protein 29	Homo sapiens (Human)	PR
Q8NCP5	ZBTB44	Zinc finger and BTB domain-containing protein 44	Homo sapiens (Human)	PR
P41182	BCL6	B-cell lymphoma 6 protein	Homo sapiens (Human)	PR
Q9NQX0	PRDM6	Putative histone-lysine N-methyltransferase PRDM6	Homo sapiens (Human)	PR
Q9BU19	ZNF692	Zinc finger protein 692	Homo sapiens (Human)	PR
Q08AG5	ZNF844	Zinc finger protein 844	Homo sapiens (Human)	PR
Q6R2W3	ZBED9	SCAN domain-containing protein 3	Homo sapiens (Human)	PR
P98182	ZNF200	Zinc finger protein 200	Homo sapiens (Human)	PR
Q9UK11	ZNF223	Zinc finger protein 223	Homo sapiens (Human)	PR
O15156	ZBTB7B	Zinc finger and BTB domain-containing protein 7B	Homo sapiens (Human)	PR
Q6ZMS7	ZNF783	Zinc finger protein 783	Homo sapiens (Human)	PR
P59923	ZNF445	Zinc finger protein 445	Homo sapiens (Human)	PR
Q8N859	ZNF713	Zinc finger protein 713	Homo sapiens (Human)	PR
Q8TD17	ZNF398	Zinc finger protein 398	Homo sapiens (Human)	PR
P52739	ZNF131	Zinc finger protein 131	Homo sapiens (Human)	PR
A6NGD5	ZSCAN5C	Zinc finger and SCAN domain-containing protein 5C	Homo sapiens (Human)	PR
Q7Z398	ZNF550	Zinc finger protein 550	Homo sapiens (Human)	PR
Q9Y2K1	ZBTB1	Zinc finger and BTB domain-containing protein 1	Homo sapiens (Human)	PR
Q96N20	ZNF75A	Zinc finger protein 75A	Homo sapiens (Human)	PR
A6NJL1	ZSCAN5B	Zinc finger and SCAN domain-containing protein 5B	Homo sapiens (Human)	PR
A1YPR0	ZBTB7C	Zinc finger and BTB domain-containing protein 7C	Homo sapiens (Human)	PR
Q9NWS9	ZNF446	Zinc finger protein 446	Homo sapiens (Human)	PR
P24278	ZBTB25	Zinc finger and BTB domain-containing protein 25	Homo sapiens (Human)	PR
Q96N38	ZNF714	Zinc finger protein 714	Homo sapiens (Human)	PR
Q86YH2	ZNF280B	Zinc finger protein 280B	Homo sapiens (Human)	PR
Q9Y5W3	KLF2	Krueppel-like factor 2	Homo sapiens (Human)	PR
Q06889	EGR3	Early growth response protein 3	Homo sapiens (Human)	PR
P18146	EGR1	Early growth response protein 1	Homo sapiens (Human)	PR
Q05215	EGR4	Early growth response protein 4	Homo sapiens (Human)	PR
Q99612	KLF6	Krueppel-like factor 6	Homo sapiens (Human)	PR
O75840	KLF7	Krueppel-like factor 7	Homo sapiens (Human)	PR
P57682	KLF3	Krueppel-like factor 3	Homo sapiens (Human)	PR
O08584	Klf6	Krueppel-like factor 6	Mus musculus (Mouse)	PR
Q61164	Ctcf	Transcriptional repressor CTCF	Mus musculus (Mouse)	PR
Q810A1	Znf18	Zinc finger protein 18	Mus musculus (Mouse)	PR
Q8BGS3	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Mus musculus (Mouse)	PR
Q00899	Yy1	Transcriptional repressor protein YY1	Mus musculus (Mouse)	PR
P41183	Bcl6	B-cell lymphoma 6 protein homolog	Mus musculus (Mouse)	PR
Q9DAI4	Zbtb43	Zinc finger and BTB domain-containing protein 43	Mus musculus (Mouse)	PR
O70237	Gfi1b	Zinc finger protein Gfi-1b	Mus musculus (Mouse)	PR
Q99KZ6	Znf639	Zinc finger protein 639	Mus musculus (Mouse)	PR
Q9Z1D9	Znf394	Zinc finger protein 394	Mus musculus (Mouse)	PR
Q9CXE0	Prdm5	PR domain zinc finger protein 5	Mus musculus (Mouse)	PR
P43300	Egr3	Early growth response protein 3	Mus musculus (Mouse)	PR
Q9DAU9	Znf654	Zinc finger protein 654	Mus musculus (Mouse)	PR
Q9R1Y5	Hic1	Hypermethylated in cancer 1 protein	Mus musculus (Mouse)	PR
Q8R0T2	Znf768	Zinc finger protein 768	Mus musculus (Mouse)	PR
Q9WVG7	Osr1	Protein odd-skipped-related 1	Mus musculus (Mouse)	PR
Q8BI73	Znf775	Zinc finger protein 775	Mus musculus (Mouse)	PR
Q8VCZ7	Zbtb7c	Zinc finger and BTB domain-containing protein 7C	Mus musculus (Mouse)	PR
Q91VN1	Znf24	Zinc finger protein 24	Mus musculus (Mouse)	PR
Q9DB38	Znf580	Zinc finger protein 580	Mus musculus (Mouse)	PR
A7KBS4	Zscan4d	Zinc finger and SCAN domain containing protein 4D	Mus musculus (Mouse)	PR
Q91VW9	Zkscan3	Zinc finger protein with KRAB and SCAN domains 3	Mus musculus (Mouse)	PR
P10925	Zfy1	Zinc finger Y-chromosomal protein 1	Mus musculus (Mouse)	PR
P08046	Egr1	Early growth response protein 1	Mus musculus (Mouse)	PR
Q3TTC2	Yy2	Transcription factor YY2	Mus musculus (Mouse)	PR
Q3UTQ7	Prdm10	PR domain zinc finger protein 10	Mus musculus (Mouse)	PR
Q6P3Y5	Znf280c	Zinc finger protein 280C	Mus musculus (Mouse)	PR
Q9ERU3	Znf22	Zinc finger protein 22	Mus musculus (Mouse)	PR
Q8VIG1	Rest	RE1-silencing transcription factor	Mus musculus (Mouse)	PR
Q9Z1D8	Zkscan5	Zinc finger protein with KRAB and SCAN domains 5	Mus musculus (Mouse)	PR
Q8BID6	Zbtb46	Zinc finger and BTB domain-containing protein 46	Mus musculus (Mouse)	PR
P17012	Zfx	Zinc finger X-chromosomal protein	Mus musculus (Mouse)	PR
Q9WUK6	Zbtb18	Zinc finger and BTB domain-containing protein 18	Mus musculus (Mouse)	PR
B2RXC5	Znf382	Zinc finger protein 382	Mus musculus (Mouse)	PR
O08900	Ikzf3	Zinc finger protein Aiolos	Mus musculus (Mouse)	PR
Q5DU09	Znf652	Zinc finger protein 652	Mus musculus (Mouse)	PR
Q5RJ54	Zscan26	Zinc finger and SCAN domain-containing protein 26	Mus musculus (Mouse)	PR
Q8BLM0	Klf8	Krueppel-like factor 8	Mus musculus (Mouse)	PR
Q99JB0	Klf7	Krueppel-like factor 7	Mus musculus (Mouse)	PR
Q8R0A2	Zbtb44	Zinc finger and BTB domain-containing protein 44	Mus musculus (Mouse)	PR
P20662	Zfy2	Zinc finger Y-chromosomal protein 2	Mus musculus (Mouse)	PR
Q80VJ6	Zscan4c	Zinc finger and SCAN domain containing protein 4C	Mus musculus (Mouse)	PR
Q3URS2	Zscan4f	Zinc finger and SCAN domain containing protein 4F	Mus musculus (Mouse)	PR
Q60980	Klf3	Krueppel-like factor 3	Mus musculus (Mouse)	PR
Q8K3J5	Znf131	Zinc finger protein 131	Mus musculus (Mouse)	PR
O35738	Klf12	Krueppel-like factor 12	Mus musculus (Mouse)	PR
Q9Z2K3	Znf394	Zinc finger protein 394	Rattus norvegicus (Rat)	PR
Q642B9	Znf18	Zinc finger protein 18	Rattus norvegicus (Rat)	PR
B0K011	Osr1	Protein odd-skipped-related 1	Rattus norvegicus (Rat)	PR
D3ZUU2	Gzf1	GDNF-inducible zinc finger protein 1	Rattus norvegicus (Rat)	PR
B1WBU4	Zbtb8a	Zinc finger and BTB domain-containing protein 8A	Rattus norvegicus (Rat)	PR
Q7TNK3	Znf24	Zinc finger protein 24	Rattus norvegicus (Rat)	PR
O35819	Klf6	Krueppel-like factor 6	Rattus norvegicus (Rat)	PR
Q9R1D1	Ctcf	Transcriptional repressor CTCF	Rattus norvegicus (Rat)	PR
P43301	Egr3	Early growth response protein 3	Rattus norvegicus (Rat)	PR
P08154	Egr1	Early growth response protein 1	Rattus norvegicus (Rat)	PR
A0JPL0	Znf382	Zinc finger protein 382	Rattus norvegicus (Rat)	PR
Q4KLI1	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Rattus norvegicus (Rat)	PR
A1L1J6	Znf652	Zinc finger protein 652	Rattus norvegicus (Rat)	PR
Q9SHD0	ZAT4	Zinc finger protein ZAT4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0P4X6	zbtb44	Zinc finger and BTB domain-containing protein 44	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
A4II20	egr1	Early growth response protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6P882	zbtb8a.2	Zinc finger and BTB domain-containing protein 8A.2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q567C6	znf367	Zinc finger protein 367	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
A7Y7X5	znf711	Zinc finger protein 711	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MNIHMKRKTI	KNINTFENRM	LMLDGMPAVR	VKTELLESEQ	GSPNVHNYPD	MEAVPLLLNN
70	80	90	100	110	120
VKGEPPEDSL	SVDHFQTQTE	PVDLSINKAR	TSPTAVSSSP	VSMTASASSP	SSTSTSSSSS
130	140	150	160	170	180
SRLASSPTVI	TSVSSASSSS	TVLTPGPLVA	SASGVGGQQF	LHIIHPVPPS	SPMNLQSNKL
190	200	210	220	230	240
SHVHRIPVVV	QSVPVVYTAV	RSPGNVNNTI	VVPLLEDGRG	HGKAQMDPRG	LSPRQSKSDS
250	260	270	280	290	300
DDDDLPNVTL	DSVNETGSTA	LSIARAVQEV	HPSPVSRVRG	NRMNNQKFPC	SISPFSIEST
310	320	330	340	350	360
RRQRRSESPD	SRKRRIHRCD	FEGCNKVYTK	SSHLKAHRRT	HTGEKPYKCT	WEGCTWKFAR
370	380	390	400
SDELTRHYRK	HTGVKPFKCA	DCDRSFSRSD	HLALHRRRHM	LV