Q9Y4K4

PR
Gene name
MAP4K5
Protein name
Mitogen-activated protein kinase kinase kinase kinase 5
Names
Kinase homologous to SPS1/STE20, KHS, MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5, MEKKK 5
Species
Homo sapiens (Human)
KEGG Pathway
hsa:11183
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

266-508 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

157-180 (Activation loop from InterPro)

Target domain

20-277 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9Y4K4

Entry ID Method Resolution Chain Position Source
AF-Q9Y4K4-F1 Predicted AlphaFoldDB

7 variants for Q9Y4K4

Variant ID(s) Position Change Description Diseaes Association Provenance
CA7180083
VAR_057102
rs34726242
 41 H>Y No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
VAR_040747
rs12881869
CA7179853
 334 A>T No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
CA7179771
rs34818002
VAR_040748
 407 P>L No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
VAR_040749
rs55815015
CA7179754
 446 I>V No ClinGen
UniProt
1000Genomes
TOPMed
dbSNP
CA7179730
rs35768475
VAR_040750
 473 K>N No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
VAR_040751
rs55997280
CA7179643
 552 R>Q No ClinGen
UniProt
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs17780143
CA7179550
VAR_040752
 633 T>M No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD

No associated diseases with Q9Y4K4

3 regional properties for Q9Y4K4

Type Name Position InterPro Accession
domain Protein kinase domain 20 - 277 IPR000719
domain Citron homology (CNH) domain 506 - 826 IPR001180
binding_site Protein kinase, ATP binding site 26 - 49 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase kinase activity Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H2G2 SLK STE20-like serine/threonine-protein kinase Homo sapiens (Human) PR
O94804 STK10 Serine/threonine-protein kinase 10 Homo sapiens (Human) PR
O95747 OXSR1 Serine/threonine-protein kinase OSR1 Homo sapiens (Human) PR
Q9UEW8 STK39 STE20/SPS1-related proline-alanine-rich protein kinase Homo sapiens (Human) PR
Q92918 MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens (Human) EV
Q12851 MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 Homo sapiens (Human) EV
Q8IVH8 MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 Homo sapiens (Human) SS
Q9P289 STK26 Serine/threonine-protein kinase 26 Homo sapiens (Human) PR
Q9Y6E0 STK24 Serine/threonine-protein kinase 24 Homo sapiens (Human) PR
O00506 STK25 Serine/threonine-protein kinase 25 Homo sapiens (Human) PR
Q99JP0 Map4k3 Mitogen-activated protein kinase kinase kinase kinase 3 Mus musculus (Mouse) SS
Q61161 Map4k2 Mitogen-activated protein kinase kinase kinase kinase 2 Mus musculus (Mouse) SS
P70218 Map4k1 Mitogen-activated protein kinase kinase kinase kinase 1 Mus musculus (Mouse) PR
Q8BPM2 Map4k5 Mitogen-activated protein kinase kinase kinase kinase 5 Mus musculus (Mouse) PR
Q924I2 Map4k3 Mitogen-activated protein kinase kinase kinase kinase 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MEAPLRPAAD ILRRNPQQDY ELVQRVGSGT YGDVYKARNV HTGELAAVKI IKLEPGDDFS
70 80 90 100 110 120
LIQQEIFMVK ECKHCNIVAY FGSYLSREKL WICMEYCGGG SLQDIYHVTG PLSELQIAYV
130 140 150 160 170 180
CRETLQGLAY LHTKGKMHRD IKGANILLTD HGDVKLADFG VAAKITATIA KRKSFIGTPY
190 200 210 220 230 240
WMAPEVAAVE KNGGYNQLCD IWAVGITAIE LGELQPPMFD LHPMRALFLM SKSNFQPPKL
250 260 270 280 290 300
KDKTKWSSTF HNFVKIALTK NPKKRPTAER LLTHTFVAQP GLSRALAVEL LDKVNNPDNH
310 320 330 340 350 360
AHYTEADDDD FEPHAIIRHT IRSTNRNARA ERTASEINFD KLQFEPPLRK ETEARDEMGL
370 380 390 400 410 420
SSDPNFMLQW NPFVDGANTG KSTSKRAIPP PLPPKPRISS YPEDNFPDEE KASTIKHCPD
430 440 450 460 470 480
SESRAPQILR RQSSPSCGPV AETSSIGNGD GISKLMSENT EGSAQAPQLP RKKDKRDFPK
490 500 510 520 530 540
PAINGLPPTP KVLMGACFSK VFDGCPLKIN CATSWIHPDT KDQYIIFGTE DGIYTLNLNE
550 560 570 580 590 600
LHEATMEQLF PRKCTWLYVI NNTLMSLSVG KTFQLYSHNL IALFEHAKKP GLAAHIQTHR
610 620 630 640 650 660
FPDRILPRKF ALTTKIPDTK GCHKCCIVRN PYTGHKYLCG ALQSGIVLLQ WYEPMQKFML
670 680 690 700 710 720
IKHFDFPLPS PLNVFEMLVI PEQEYPMVCV AISKGTESNQ VVQFETINLN SASSWFTEIG
730 740 750 760 770 780
AGSQQLDSIH VTQLERDTVL VCLDKFVKIV NLQGKLKSSK KLASELSFDF RIESVVCLQD
790 800 810 820 830 840
SVLAFWKHGM QGKSFKSDEV TQEISDETRV FRLLGSDRVV VLESRPTENP TAHSNLYILA
GHENSY