AiPD: Autoinhibited Protein Database

Q9Y490

Gene name	TLN1 (KIAA1027, TLN)
Protein name	Talin-1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7094
EC number
Protein Class	TALIN (PTHR19981)

Descriptions

Talin-1, a FERM domain-containing protein, forms a direct link between integrin adhesion receptors and the actin cytoskeleton and is an important regulator of integrin function. The PTB domain within the FERM domain is responsible for binding to integrin. A segment in the C-terminal rod domain (Talin-R) interacts with the FERM domain for autoinhibition.

Autoinhibitory domains (AIDs)

Target domain	86-403 (FERM domain)
Relief mechanism	Ligand binding
Assay	Deletion assay, Structural analysis

AID

1654-2344 (C-terminal rod domain)

Target domain

86-403 (FERM domain)

Relief mechanism

Ligand binding (Binding of phosphatidylinositol 4,5-bisphosphate to FERM domain)

Assay

Deletion assay, Structural analysis

Accessory elements

No accessory elements

References

Goksoy E et al. (2008) "Structural basis for the autoinhibition of talin in regulating integrin activation", Molecular cell, 31, 124-33

Dedden D et al. (2019) "The Architecture of Talin1 Reveals an Autoinhibition Mechanism", Cell, 179, 120-131.e13

Autoinhibited structure

Activated structure

5 structures for Q9Y490

Entry ID	Method	Resolution	Chain	Position	Source
1SYQ	X-ray	242 A	B	607-631	PDB
2MWN	NMR	-	B	308-400	PDB
4DJ9	X-ray	225 A	B	2075-2103	PDB
6R9T	EM	620 A	A	1-2541	PDB
AF-Q9Y490-F1	Predicted				AlphaFoldDB

1500 variants for Q9Y490

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA373386129 rs1227892113	9	S>N		No	ClinGen gnomAD
rs1285719610 CA373385933	16	T>K		No	ClinGen TOPMed gnomAD
rs1285719610 CA373385922	16	T>M		No	ClinGen TOPMed gnomAD
CA373385872 rs1587991243	17	M>I		No	ClinGen Ensembl
CA373385797 rs1322985698	20	E>Q		No	ClinGen TOPMed
CA5049590 rs764312097	21	P>L		No	ClinGen ExAC gnomAD
CA373385684 rs1587991234	23	T>P		No	ClinGen Ensembl
CA5049588 rs373447882	24	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs774294631 CA5049584	27	D>A		No	ClinGen ExAC gnomAD
CA5049585 rs759500904	27	D>H		No	ClinGen ExAC gnomAD
CA5049582 rs201410003	28	A>P		No	ClinGen ExAC gnomAD
CA192749959 rs931802569	30	R>C		No	ClinGen TOPMed gnomAD
CA5049581 rs772875479	30	R>H		No	ClinGen ExAC gnomAD
CA5049578 rs765432963	33	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5049576 rs746403233	33	R>H		No	ClinGen ExAC gnomAD
CA5049577 rs765432963	33	R>S		No	ClinGen ExAC TOPMed gnomAD
rs192509639 CA5049574	35	R>L		No	ClinGen 1000Genomes ExAC gnomAD
rs192509639 CA5049575	35	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1160694477 CA373385329	35	R>W		No	ClinGen TOPMed
rs764353381 CA5049572	36	I>V		No	ClinGen ExAC gnomAD
CA5049571 rs756368221	37	P>A		No	ClinGen ExAC TOPMed gnomAD
CA192749918 rs954081417	39	A>V		No	ClinGen TOPMed
rs368772384 CA5049570	40	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA373385182 rs1362657311	41	A>D		No	ClinGen TOPMed gnomAD
rs1362657311 CA373385180	41	A>V		No	ClinGen TOPMed gnomAD
rs767604786 CA5049569	42	G>C		No	ClinGen ExAC gnomAD
rs759553785 CA5049568	43	P>S		No	ClinGen ExAC gnomAD
CA5049567 rs543841478	44	P>A		No	ClinGen 1000Genomes ExAC gnomAD
CA5049566 rs543841478 COSM3675330	44	P>S	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA192749830 rs536669266	45	S>G		No	ClinGen 1000Genomes
rs536669266 CA192749836	45	S>R		No	ClinGen 1000Genomes
rs954067726 CA192749821	51	L>M		No	ClinGen TOPMed gnomAD
CA373384803 rs1303513893	54	D>H		No	ClinGen gnomAD
CA373384796 rs1303513893	54	D>Y		No	ClinGen gnomAD
CA5049546 rs371976092	57	K>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA5049547 rs371976092	57	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA5049544 rs750292056	60	I>K		No	ClinGen ExAC
CA5049543 rs765151284	60	I>M		No	ClinGen ExAC gnomAD
rs761646598 CA5049542	64	A>S		No	ClinGen ExAC gnomAD
CA5049541 rs776429133	66	K>E		No	ClinGen ExAC gnomAD
CA373384444 rs1587991003	69	D>G		No	ClinGen Ensembl
CA192749813 rs200024752	70	Y>C		No	ClinGen 1000Genomes TOPMed
rs760233959 CA5049539	72	M>I		No	ClinGen ExAC gnomAD
CA373384285 rs1396892544	74	R>*		No	ClinGen gnomAD
CA5049538 rs201713560	74	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1287560935 CA373383999	77	D>E		No	ClinGen gnomAD
CA5049523 rs753744411	78	T>I		No	ClinGen ExAC gnomAD
CA5049522 rs145717496	79	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373383717 rs1294480042	85	Q>E		No	ClinGen TOPMed
rs758902731 CA373383593	91	R>C		No	ClinGen ExAC gnomAD
rs773845413 CA5049517	91	R>H		No	ClinGen ExAC gnomAD
CA5049518 rs758902731	91	R>S		No	ClinGen ExAC gnomAD
CA5049516 rs770339411	98	K>R		No	ClinGen ExAC gnomAD
rs777017174 CA5049514	109	T>A		No	ClinGen ExAC TOPMed gnomAD
CA373383157 rs1554663565	109	T>S		No	ClinGen Ensembl
CA373383054 rs1447271147	113	M>T		No	ClinGen TOPMed gnomAD
CA373383063 rs1563947434	113	M>V		No	ClinGen Ensembl
rs536004861 CA192749667	115	I>V		No	ClinGen gnomAD
rs780086317 CA5049511	118	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1192780746 CA373382950	118	R>H		No	ClinGen gnomAD
rs746012205 CA5049509	119	I>T		No	ClinGen ExAC gnomAD
rs374516720 CA5049510	119	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5049488 rs749249409	121	I>V		No	ClinGen ExAC gnomAD
CA373382786 rs1443370181	122	T>I		No	ClinGen gnomAD
rs1372073790 CA373382732	124	H>R		No	ClinGen gnomAD
rs777503374 CA5049487	132	E>V		No	ClinGen ExAC gnomAD
rs776334510 CA5049486	134	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1398400329 CA373382441	137	K>T		No	ClinGen gnomAD
rs1367577993 CA373382327	142	T>P		No	ClinGen TOPMed gnomAD
rs1168373512 CA373382310	143	G>A		No	ClinGen gnomAD
rs1465494218 CA373382124	149	K>R		No	ClinGen gnomAD
CA373382093 rs1311050272	150	T>R		No	ClinGen TOPMed
CA373382029 rs1195021793	153	R>Q		No	ClinGen TOPMed gnomAD
rs1316192196 CA373382006	154	D>G		No	ClinGen TOPMed
CA373381891 rs1431227433	157	K>R		No	ClinGen gnomAD
CA373381850 rs1330239582	158	M>I		No	ClinGen gnomAD
rs765893152 CA5049481	163	Q>*		No	ClinGen ExAC gnomAD
rs777131457 CA5049479	171	L>M		No	ClinGen ExAC TOPMed gnomAD
rs749963448 CA5049458	175	D>G		No	ClinGen ExAC gnomAD
CA373381031 rs1168790689	176	H>R		No	ClinGen gnomAD
CA5049456 rs761126857	177	G>S		No	ClinGen ExAC TOPMed gnomAD
CA5049454 rs767796509	178	R>Q		No	ClinGen ExAC gnomAD
CA5049455 rs145664330	178	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs774849472 CA5049452	182	E>K		No	ClinGen ExAC gnomAD
rs763245321 CA5049451	183	Q>H		No	ClinGen ExAC gnomAD
CA192749402 rs950042940	186	E>A		No	ClinGen TOPMed
CA373380669 rs1304193914	187	E>G		No	ClinGen Ensembl
rs769874189 CA5049448	190	T>M		No	ClinGen ExAC TOPMed gnomAD
rs779816111 CA5049444	195	R>S		No	ClinGen ExAC gnomAD
rs1432332562 CA373380331	201	D>A		No	ClinGen gnomAD
rs758096909 CA5049442	202	Q>K		No	ClinGen ExAC gnomAD
rs1322410850 CA373380134	207	R>Q		No	ClinGen gnomAD
rs1403873435 CA373380138	207	R>W		No	ClinGen TOPMed
CA373380119 rs1459559662	208	D>G		No	ClinGen gnomAD
CA373379729 rs1349463571	220	R>Q		No	ClinGen gnomAD
rs1303627949 CA373379701 COSM1108755	222	D>N	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs199774975 CA192749299	228	H>R		No	ClinGen 1000Genomes
CA373379445 rs1307295586	234	K>E		No	ClinGen gnomAD
rs776744554 CA5049410	236	C>Y		No	ClinGen ExAC gnomAD
rs764128875 CA5049409	237	E>D		No	ClinGen ExAC gnomAD
rs1432897013 CA373379314	239	A>V		No	ClinGen gnomAD
CA373379293 rs1396987940	241	F>L		No	ClinGen gnomAD
rs775359225 CA5049407	244	Q>E		No	ClinGen ExAC gnomAD
rs771869977 CA5049406	244	Q>H		No	ClinGen ExAC gnomAD
rs745741479 CA5049405	245	I>V		No	ClinGen ExAC TOPMed gnomAD
rs770665238 CA5049403	246	Q>H		No	ClinGen ExAC gnomAD
rs1208671195 CA373379069	251	N>D		No	ClinGen gnomAD
rs748861684 CA5049402	251	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1486334735 CA373379062	251	N>S		No	ClinGen TOPMed gnomAD
rs1238971230 CA373378941	255	H>R		No	ClinGen gnomAD
rs1305283038 CA373378929	256	K>R		No	ClinGen gnomAD
rs1374550823 CA373378922	257	A>T		No	ClinGen gnomAD
rs1413483904 CA373378856	260	L>P		No	ClinGen gnomAD
CA5049382 rs747725273	267	P>A		No	ClinGen ExAC gnomAD
rs372294034 CA5049381	268	K>E		No	ClinGen ESP ExAC gnomAD
rs372294034 CA373377205	268	K>Q		No	ClinGen ESP ExAC gnomAD
CA373377152 rs1212263218	271	V>M		No	ClinGen gnomAD
rs1484079127 CA373377114	272	K>R		No	ClinGen gnomAD
CA5049377 rs757515254	277	R>H		No	ClinGen ExAC gnomAD
CA373376931 rs1252621660	279	I>V		No	ClinGen gnomAD
CA5049376 rs371166073	280	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA192748405 rs879105325	282	A>T		No	ClinGen TOPMed
CA373376648 rs1371373533	283	H>R		No	ClinGen gnomAD
CA5049353 rs751516819	284	K>N		No	ClinGen ExAC gnomAD
CA5049352 rs766292569	285	N>S		No	ClinGen ExAC gnomAD
CA5049351 rs147185234	286	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA373376537 rs1433514904	287	G>E		No	ClinGen gnomAD
rs750294970 CA5049350	288	Q>H		No	ClinGen ExAC gnomAD
rs1175057298 CA373376510	289	M>L		No	ClinGen TOPMed gnomAD
CA5049349 rs201793772	289	M>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5049348 rs761589467	290	S>N		No	ClinGen ExAC gnomAD
CA5049347 rs758805095	293	E>Q		No	ClinGen ExAC gnomAD
CA192748359 rs763016657	295	K>N		No	ClinGen Ensembl
COSM1108753 CA5049344 rs145146362	297	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs878988086 CA192748352	297	R>H		No	ClinGen TOPMed gnomAD
rs749761240 CA5049342	299	V>M		No	ClinGen ExAC
rs773595542 CA5049341	303	R>H		No	ClinGen ExAC gnomAD
rs1337342369 CA373376002	306	K>N		No	ClinGen gnomAD
rs1236664537 CA373376012	306	K>R		No	ClinGen gnomAD
rs781204087 CA373375972 COSM3848487	308	Y>*	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA373375966 rs1272365785	309	G>S		No	ClinGen TOPMed
rs370968659 CA5049336	313	F>L		No	ClinGen ESP ExAC gnomAD
CA5049319 rs747225981	319	M>I		No	ClinGen ExAC gnomAD
rs75137786 CA192748166	323	N>T		No	ClinGen Ensembl
CA373375512 rs1212881819	323	N>Y		No	ClinGen gnomAD
CA373375211 rs778932042	335	E>D		No	ClinGen ExAC gnomAD
rs1166541102 CA373375206	336	C>R		No	ClinGen TOPMed
CA192748157 rs1047971031	336	C>Y		No	ClinGen TOPMed
rs1462467823 CA373375011	342	E>G		No	ClinGen TOPMed
CA373374996 rs1325630521	343	K>N		No	ClinGen TOPMed
CA5049313 rs753636681	358	R>L		No	ClinGen ExAC gnomAD
rs777591594 CA5049312	360	A>T		No	ClinGen ExAC gnomAD
CA373372932 rs1452909593	365	S>T		No	ClinGen gnomAD
rs775996667 CA5049282	374	Q>E		No	ClinGen ExAC gnomAD
rs1303821612 CA373372306	375	D>G		No	ClinGen gnomAD
COSM1240424 rs376501141 CA5049280	377	Y>C	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs770990438 CA5049278	388	I>V		No	ClinGen ExAC gnomAD
CA5049276 rs150744632	396	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA5049273 rs780941031	402	K>R		No	ClinGen ExAC gnomAD
CA5049243 rs768004634	407	D>E		No	ClinGen ExAC gnomAD
rs368235194 CA5049241	410	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA192747719 rs868729826	410	G>V		No	ClinGen Ensembl
rs1391584560 CA373371688	415	E>K		No	ClinGen gnomAD
rs765189547 CA5049237	416	E>G		No	ClinGen ExAC gnomAD
CA5049238 rs773380469	416	E>K		No	ClinGen ExAC gnomAD
CA373371621 rs1208571911	419	M>V		No	ClinGen TOPMed gnomAD
CA192747709 rs910238793	425	S>F		No	ClinGen TOPMed gnomAD
rs1327910304 CA373371525	426	P>A		No	ClinGen TOPMed
rs776494903 CA5049235	427	K>I		No	ClinGen ExAC gnomAD
rs776494903 CA192747707	427	K>R		No	ClinGen ExAC gnomAD
rs764077402 CA5049215	429	S>T		No	ClinGen ExAC gnomAD
CA373371421 rs1378580706	430	T>A		No	ClinGen gnomAD
rs760510356 CA5049214	433	Q>E		No	ClinGen ExAC gnomAD
rs994842848 CA192747638	435	Q>E		No	ClinGen TOPMed
CA373371323 rs1183041344	437	N>D		No	ClinGen gnomAD
rs759258592 CA5049211	437	N>S		No	ClinGen ExAC TOPMed gnomAD
CA192747626 rs527316013	438	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5049209 rs527316013	438	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA192747631 rs879022300	438	R>W		No	ClinGen TOPMed gnomAD
CA373371282 rs1259994379	440	G>R		No	ClinGen gnomAD
rs1288394763 CA373371205	445	G>C		No	ClinGen gnomAD
rs777398726 CA5049207	447	V>L		No	ClinGen ExAC gnomAD
rs1587987883 CA373371172	448	A>P		No	ClinGen Ensembl
CA373371110 COSM753494 rs1224311715	452	I>V	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
CA373371086 rs1222624665	453	M>R		No	ClinGen TOPMed gnomAD
rs1414751173 CA373371073	454	R>C		No	ClinGen gnomAD
rs375834194 CA5049204	454	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs758633696 CA5049203	457	A>T		No	ClinGen ExAC gnomAD
CA5049202 rs750664229	457	A>V		No	ClinGen ExAC gnomAD
rs753970978 CA5049199	459	G>D		No	ClinGen ExAC TOPMed gnomAD
CA373370990 rs1563945827	460	P>R		No	ClinGen Ensembl
rs1587987846 CA373370994	460	P>S		No	ClinGen Ensembl
CA192747614 rs1045686328	462	N>T		No	ClinGen Ensembl
CA5049197 rs760699836	464	Q>H		No	ClinGen ExAC gnomAD
COSM1242928 CA5049198 rs764131285	464	Q>R	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA5049196 rs752530521	465	V>L		No	ClinGen ExAC gnomAD
CA5049195 rs767346200	466	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1206632552 CA373370860	469	P>L		No	ClinGen gnomAD
CA5049194 rs759314155	470	P>A		No	ClinGen ExAC TOPMed gnomAD
CA5049193 rs148182997	470	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA373370856 rs759314155	470	P>S		No	ClinGen ExAC TOPMed gnomAD
CA373370851 rs1587987813	471	A>T		No	ClinGen Ensembl
CA373370841 rs1353641340	471	A>V		No	ClinGen gnomAD
CA5049192 rs144393265	472	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs559753613 CA5049191	473	Q>E		No	ClinGen 1000Genomes ExAC gnomAD
CA5049189 rs769135736	478	G>S		No	ClinGen ExAC gnomAD
rs1321728049 CA373370687	481	H>Q		No	ClinGen gnomAD
CA5049187 rs775795708	481	H>R		No	ClinGen ExAC gnomAD
CA5049188 rs747563060	481	H>Y		No	ClinGen ExAC gnomAD
rs772630969 CA5049186	482	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA373370663 rs1230355297	483	G>A		No	ClinGen TOPMed
rs1349253474 CA373370669	483	G>R		No	ClinGen TOPMed
rs1372679017 CA373370606	487	P>S		No	ClinGen gnomAD
rs982322527 CA192747582	488	L>V		No	ClinGen TOPMed
CA373370441 rs1371353477	492	Q>K		No	ClinGen gnomAD
rs1175648832 CA373370418	493	Q>R		No	ClinGen gnomAD
rs774733255 CA5049167	494	A>G		No	ClinGen ExAC TOPMed gnomAD
CA373370410 rs1412482188	494	A>T		No	ClinGen gnomAD
rs1587987641 CA373370268	501	S>Y		No	ClinGen Ensembl
CA373370219 rs1183767060	503	M>I		No	ClinGen gnomAD
rs1279105349 CA373370166	505	A>D		No	ClinGen gnomAD
CA373370168 rs1483115967	505	A>T		No	ClinGen gnomAD
rs778033300 CA5049164	506	V>M		No	ClinGen ExAC gnomAD
rs1219946412 CA373370124	507	Q>R		No	ClinGen TOPMed
CA373370041 rs1329120959	510	Q>*		No	ClinGen gnomAD
rs1587987613 CA373370036	510	Q>P		No	ClinGen Ensembl
rs1287035234 CA373369998	511	A>V		No	ClinGen gnomAD
CA373369992 rs1587987606	512	T>P		No	ClinGen Ensembl
rs748221925 CA5049162	515	D>N		No	ClinGen ExAC TOPMed gnomAD
rs781297713 CA5049161	518	T>P		No	ClinGen ExAC TOPMed gnomAD
rs1302408195 CA373369806	519	L>V		No	ClinGen gnomAD
rs754902274 CA5049160	520	P>L		No	ClinGen ExAC TOPMed gnomAD
CA192747508 rs879187317	522	L>F		No	ClinGen TOPMed
CA5049158 rs766290819	524	Q>H		No	ClinGen ExAC gnomAD
rs1409613714 CA373369671	526	A>T		No	ClinGen gnomAD
rs1161314089 CA373369651	526	A>V		No	ClinGen gnomAD
CA373368653 rs1323605766	530	A>S		No	ClinGen TOPMed gnomAD
rs1323605766 CA373368656	530	A>T		No	ClinGen TOPMed gnomAD
CA5049133 rs368180525	532	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1362763382 CA373368583	533	K>R		No	ClinGen gnomAD
CA5049132 rs763529791	534	N>K		No	ClinGen ExAC gnomAD
CA192747272 rs934995169	537	D>E		No	ClinGen TOPMed
rs1435684203 CA373368427	538	E>D		No	ClinGen gnomAD
rs1457039310 CA373368369	541	H>L		No	ClinGen TOPMed
rs1157230916 CA373368286	544	H>Y		No	ClinGen TOPMed
rs906153024 CA192747271	546	Q>E		No	ClinGen TOPMed
CA373368155 rs1458939089	550	I>L		No	ClinGen gnomAD
CA5049130 rs145834435	552	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs145834435 CA373368087	552	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA373368070 rs1167561677	553	G>D		No	ClinGen gnomAD
rs1447341848 CA373368044	554	T>I		No	ClinGen gnomAD
rs1046684551 CA192747270	555	A>V		No	ClinGen TOPMed gnomAD
rs1267218525 CA373367975	557	V>M		No	ClinGen gnomAD
rs773478129 CA5049127	559	N>K		No	ClinGen ExAC TOPMed gnomAD
CA373367860 rs1292680149	562	A>V		No	ClinGen gnomAD
CA373367615 rs1587987289	564	D>A		No	ClinGen Ensembl
rs543975449 CA5049098	564	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA5049097 rs770773021	565	P>S		No	ClinGen ExAC TOPMed gnomAD
rs749152363 CA5049096	570	Y>C		No	ClinGen ExAC gnomAD
CA373367459 rs1182780311	570	Y>H		No	ClinGen gnomAD
rs755791683 CA5049094	571	T>A		No	ClinGen ExAC TOPMed gnomAD
rs747746834 CA5049093	571	T>I		No	ClinGen ExAC gnomAD
rs746285293 CA5049091	572	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1587987269 CA373367381	573	V>L		No	ClinGen Ensembl
CA192747253 rs1028888156	574	G>A		No	ClinGen TOPMed gnomAD
rs1279686601 CA373367280	576	A>T		No	ClinGen gnomAD
CA5049088 rs757683436	579	T>I		No	ClinGen ExAC gnomAD
CA5049086 rs764515818	580	I>V		No	ClinGen ExAC TOPMed gnomAD
CA192747252 rs1030761518	582	S>T		No	ClinGen TOPMed
rs1456166163 CA373367093	583	N>K		No	ClinGen gnomAD
CA373367113 rs1320468153	583	N>S		No	ClinGen gnomAD
rs200664793 CA373367049	585	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200664793 CA5049085	585	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373367005 rs1472529953	586	E>G		No	ClinGen gnomAD
CA192747251 rs890193369	587	M>T		No	ClinGen gnomAD
CA5049083 rs759490877	589	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5049081 rs368422507	589	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA5049082 rs368422507	589	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs773010808 CA5049078	590	G>A		No	ClinGen ExAC gnomAD
rs749136653 CA5049080	590	G>R		No	ClinGen ExAC TOPMed gnomAD
rs749136653 CA5049079	590	G>W		No	ClinGen ExAC TOPMed gnomAD
rs769518806 CA5049077	591	V>L		No	ClinGen ExAC gnomAD
CA5049076 rs747802105	598	L>M		No	ClinGen ExAC
CA373366691 rs1383967562	601	E>K		No	ClinGen gnomAD
rs1433483925 CA373366617	603	G>R		No	ClinGen TOPMed gnomAD
rs1433483925 CA373366620	603	G>S		No	ClinGen TOPMed gnomAD
rs878946268 CA192747248	604	S>I		No	ClinGen TOPMed
rs776650695 CA5049073	605	G>A		No	ClinGen ExAC gnomAD
rs776650695 CA192747247	605	G>D		No	ClinGen ExAC gnomAD
rs757816384 CA5049072	606	R>G		No	ClinGen ExAC gnomAD
CA5049070 rs754349057	606	R>Q		No	ClinGen ExAC gnomAD
CA5049071 rs757816384	606	R>W		No	ClinGen ExAC gnomAD
CA5049069 rs778298599	608	L>P		No	ClinGen ExAC gnomAD
CA373366512 rs1445530691	612	A>T		No	ClinGen TOPMed gnomAD
CA192747246 rs878976620	614	G>S		No	ClinGen TOPMed gnomAD
rs756483237 CA5049068	616	A>V		No	ClinGen ExAC gnomAD
rs371493482 CA5049066	619	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373366407 rs1185034404	620	S>P		No	ClinGen gnomAD
CA373366385 rs1198082201	621	E>D		No	ClinGen gnomAD
CA5049065 rs759643203	621	E>K		No	ClinGen ExAC gnomAD
COSM1108747 CA5049064 rs373629805	624	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA5049063 rs766317254	624	R>H		No	ClinGen ExAC TOPMed gnomAD
rs766317254 CA373366346	624	R>L		No	ClinGen ExAC TOPMed gnomAD
CA5049062 rs762959619	625	S>G		No	ClinGen ExAC gnomAD
rs1261826285 CA373366326	625	S>R		No	ClinGen TOPMed
rs138910002 CA5049059	627	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs370472269 CA192747245	630	S>G		No	ClinGen ESP gnomAD
CA5049058 rs776388665	630	S>I		No	ClinGen ExAC gnomAD
rs367875252 CA5049057	632	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA373366208 rs1349952403	633	P>H		No	ClinGen TOPMed gnomAD
rs776442599 CA5049040	634	R>C		No	ClinGen ExAC TOPMed gnomAD
CA373366204 rs776442599	634	R>G		No	ClinGen ExAC TOPMed gnomAD
CA5049039 rs768287685	634	R>H		No	ClinGen ExAC TOPMed gnomAD
rs898935792 CA192747235	635	Q>K		No	ClinGen TOPMed gnomAD
CA373366185 rs1412574170	637	L>V		No	ClinGen gnomAD
CA192747234 rs1037299168	638	L>V		No	ClinGen TOPMed gnomAD
rs150216234 CA5049037	640	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1382696230 CA373366157	642	G>R		No	ClinGen gnomAD
CA373366144 rs1409221403	644	V>M		No	ClinGen TOPMed gnomAD
rs371169599 CA192747233	645	G>S		No	ClinGen ESP TOPMed gnomAD
CA5049035 rs551161464	646	Q>E		No	ClinGen 1000Genomes ExAC gnomAD
rs778548070 CA5049034	646	Q>R		No	ClinGen ExAC gnomAD
COSM4152281 rs1209808173 CA373366110	649	G>E	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
rs781627839 CA5049031	655	I>T		No	ClinGen ExAC TOPMed gnomAD
CA5049029 rs747393772	657	E>D		No	ClinGen ExAC gnomAD
rs1225647414 CA373366048	658	S>N		No	ClinGen gnomAD
rs780197868 CA5049028	660	T>A		No	ClinGen ExAC TOPMed gnomAD
rs780197868 CA192747232	660	T>P		No	ClinGen ExAC TOPMed gnomAD
rs1302505470 CA373366026	661	D>E		No	ClinGen gnomAD
rs758597217 CA5049027	662	P>H		No	ClinGen ExAC gnomAD
CA373366021 rs758597217	662	P>L		No	ClinGen ExAC gnomAD
rs1203680035 CA373366024	662	P>T		No	ClinGen TOPMed
CA192747230 rs949671844	663	H>R		No	ClinGen TOPMed gnomAD
rs878859855 CA192747231	663	H>Y		No	ClinGen gnomAD
CA373365878 rs1184546209	667	A>T		No	ClinGen gnomAD
CA5049011 rs747380188	667	A>V		No	ClinGen ExAC TOPMed gnomAD
CA373365825 rs1170401089	669	M>I		No	ClinGen TOPMed
rs1410956490 CA373365836	669	M>T		No	ClinGen TOPMed
rs746042156 CA5049008	670	Q>H		No	ClinGen ExAC gnomAD
rs758650652 CA5049009	670	Q>R		No	ClinGen ExAC gnomAD
rs778979555 CA5049007	671	L>F		No	ClinGen ExAC gnomAD
CA192747111 rs767808091	672	A>T		No	ClinGen gnomAD
rs1292818814 CA373365722	674	A>T		No	ClinGen gnomAD
CA373365705 rs1227335669	674	A>V		No	ClinGen gnomAD
rs909164828 CA192747110	675	V>A		No	ClinGen Ensembl
rs1362788513 CA373365700	675	V>M		No	ClinGen gnomAD
CA373365678 rs1297630964	676	A>P		No	ClinGen TOPMed gnomAD
CA373365674 rs1297630964	676	A>S		No	ClinGen TOPMed gnomAD
CA5049005 rs753950809	678	A>T		No	ClinGen ExAC gnomAD
CA5049002 rs752479194	687	K>E		No	ClinGen ExAC TOPMed gnomAD
CA5049003 rs752479194	687	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA5049000 rs759272319	689	V>M		No	ClinGen ExAC gnomAD
CA192747108 rs955187028	690	A>T		No	ClinGen TOPMed
rs1371771648 CA373365196	692	R>Q		No	ClinGen TOPMed gnomAD
CA5048999 COSM1462270 rs774077967	692	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1204141309 CA373365149	694	E>G		No	ClinGen TOPMed
CA5048997 rs762426705	696	S>L		No	ClinGen ExAC TOPMed gnomAD
rs769082652 CA5048995	698	L>F		No	ClinGen ExAC gnomAD
CA373364913 rs879130999	701	Q>H		No	ClinGen gnomAD
rs779174630 CA5048990	702	V>A		No	ClinGen ExAC TOPMed gnomAD
rs746097112 CA5048991	702	V>I		No	ClinGen ExAC gnomAD
CA5048988 rs749380014	705	A>T		No	ClinGen ExAC gnomAD
rs371303515 CA373364695	708	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1407678372 CA373364513	714	S>C		No	ClinGen gnomAD
CA5048956 rs768049106	726	T>A		No	ClinGen ExAC gnomAD
CA5048955 rs760011688	726	T>K		No	ClinGen ExAC gnomAD
rs774716881 CA5048954	727	I>V		No	ClinGen ExAC gnomAD
CA373362017 rs1563944800	729	S>L		No	ClinGen Ensembl
CA373361984 rs1563944793	731	V>A		No	ClinGen Ensembl
CA5048952 rs763101851	733	Q>E		No	ClinGen ExAC gnomAD
rs1382468166 CA373361829	735	Q>R		No	ClinGen gnomAD
rs1279662929 CA373361769	737	V>A		No	ClinGen Ensembl
rs1367536138 CA373361713	739	A>T		No	ClinGen TOPMed
rs769907194 CA5048950	741	R>Q		No	ClinGen ExAC gnomAD
CA373361625 rs1302498866	742	L>Q		No	ClinGen TOPMed
CA373361477 rs1587986067	747	V>G		No	ClinGen Ensembl
CA5048947 rs768737732	747	V>M		No	ClinGen ExAC gnomAD
CA5048946 rs746904145	749	G>S		No	ClinGen ExAC gnomAD
CA5048945 rs779717733	751	V>M		No	ClinGen ExAC gnomAD
CA373361384 rs1587986060	752	S>Y		No	ClinGen Ensembl
rs745636689 CA5048943	754	S>F		No	ClinGen ExAC gnomAD
CA373361332 rs1185161419	755	Q>*		No	ClinGen gnomAD
rs753392385 CA5048940	758	T>I		No	ClinGen ExAC gnomAD
rs1038152375 CA192747091	759	E>D		No	ClinGen TOPMed
CA373361149 rs1247278822	761	G>V		No	ClinGen TOPMed gnomAD
rs755505606 CA5048938	765	R>G		No	ClinGen ExAC gnomAD
CA5048937 rs752009662	765	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM4007187 CA373361031 rs1587986027	767	V>G	urinary_tract [Cosmic]	No	ClinGen cosmic curated Ensembl
rs773420949 CA5048935	767	V>I		No	ClinGen ExAC gnomAD
rs773420949 CA5048934	767	V>L		No	ClinGen ExAC gnomAD
CA5048933 rs762079887	769	A>G		No	ClinGen ExAC gnomAD
CA5048932 rs762079887	769	A>V		No	ClinGen ExAC gnomAD
rs776883097 CA5048931	770	A>P		No	ClinGen ExAC gnomAD
CA373360945 rs1360617250	770	A>V		No	ClinGen gnomAD
rs1429308563 CA373360812	777	A>T		No	ClinGen gnomAD
rs775555825 CA5048928	779	N>S		No	ClinGen ExAC gnomAD
rs745713204 CA5048926	783	Q>E		No	ClinGen ExAC gnomAD
CA5048924 rs374670309	785	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5048925 rs778547092	785	V>L		No	ClinGen ExAC TOPMed gnomAD
CA373360618 rs1166077399	787	A>T		No	ClinGen gnomAD
rs1476373198 CA373360582	788	H>Q		No	ClinGen gnomAD
CA373360522 rs1197485279	791	G>R		No	ClinGen gnomAD
rs908301461 CA192747090	792	A>S		No	ClinGen TOPMed
CA373360480 rs755683252	794	P>A		No	ClinGen ExAC gnomAD
rs755683252 CA5048921	794	P>S		No	ClinGen ExAC gnomAD
CA192747089 rs937744830	795	A>T		No	ClinGen Ensembl
rs1439742550 CA373360388	797	R>C		No	ClinGen gnomAD
COSM41037 rs142231892 CA5048919	797	R>H	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1490611480 CA373360363	798	Y>H		No	ClinGen gnomAD
CA373360286 rs1213295190	801	A>T		No	ClinGen gnomAD
CA5048915 rs762131166	802	T>A		No	ClinGen ExAC gnomAD
rs1162815949 CA373360229	804	T>A		No	ClinGen TOPMed
rs1196182420 CA373360224	804	T>I		No	ClinGen TOPMed gnomAD
rs754056540 CA192747088	806	L>V		No	ClinGen ExAC gnomAD
rs147636996 CA5048911	808	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs368558976 CA192747087	812	I>L		No	ClinGen ESP TOPMed
rs759339086 CA5048909	815	S>F		No	ClinGen ExAC gnomAD
CA373359860 rs1316740682	816	M>V		No	ClinGen TOPMed
CA373359472 rs1337328248	822	M>I		No	ClinGen gnomAD
rs778231196 CA5048878	822	M>V		No	ClinGen ExAC gnomAD
CA192747020 rs1026172808	824	R>*		No	ClinGen gnomAD
rs776552609 CA192747019	824	R>L		No	ClinGen ExAC TOPMed gnomAD
CA5048877 rs776552609	824	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1400984372 CA373359399	826	A>S		No	ClinGen gnomAD
rs376004331 CA192747018	827	R>C		No	ClinGen ESP TOPMed gnomAD
COSM247844 rs372987518 CA5048876	827	R>H	prostate [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA373359369 rs1443177380	828	I>L		No	ClinGen TOPMed gnomAD
CA373359360 rs1245432359	828	I>S		No	ClinGen gnomAD
CA373359373 rs1443177380	828	I>V		No	ClinGen TOPMed gnomAD
rs1587985411 CA373359346	829	L>R		No	ClinGen Ensembl
rs145269012 CA5048875	838	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1218171844 CA373359092	846	G>E		No	ClinGen TOPMed gnomAD
rs1218171844 CA373359094	846	G>V		No	ClinGen TOPMed gnomAD
rs755083449 CA5048874	847	E>G		No	ClinGen ExAC gnomAD
CA373359084 rs1488866886	847	E>K		No	ClinGen TOPMed
rs766355449 CA5048872	848	S>G		No	ClinGen ExAC gnomAD
rs1361335828 CA373359049	848	S>R		No	ClinGen TOPMed gnomAD
CA5048871 rs762831961	849	D>N		No	ClinGen ExAC gnomAD
rs1381639969 CA373358990	852	N>K		No	ClinGen gnomAD
CA373358993 rs1481649683	852	N>S		No	ClinGen TOPMed
CA373358995 rs1481649683	852	N>T		No	ClinGen TOPMed
CA5048869 rs746443647	854	R>C		No	ClinGen ExAC TOPMed gnomAD
rs761541158 CA5048868	854	R>H		No	ClinGen ExAC TOPMed gnomAD
CA373358950 rs1364503993	855	K>N		No	ClinGen TOPMed gnomAD
CA192747016 rs369551109	857	L>F		No	ClinGen Ensembl
rs1161284535 CA373358914	858	S>N		No	ClinGen gnomAD
CA373358905 rs1423122256	858	S>R		No	ClinGen gnomAD
rs1387532351 CA373358871	861	K>R		No	ClinGen gnomAD
rs776205158 CA5048867	862	I>F		No	ClinGen ExAC gnomAD
rs1361248549 CA373358742	870	M>I		No	ClinGen TOPMed
rs960348930 CA192747015	873	A>S		No	ClinGen Ensembl
CA373358692 rs1587985325	874	A>G		No	ClinGen Ensembl
CA373358686 rs1587985322	875	K>Q		No	ClinGen Ensembl
rs760323305 CA373357260	879	A>G		No	ClinGen ExAC TOPMed gnomAD
rs760323305 CA5048848	879	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1587984639 CA373357247	880	H>P		No	ClinGen Ensembl
CA373357180 rs1194967300	884	E>K		No	ClinGen gnomAD
CA5048847 rs775170088	885	E>D		No	ClinGen ExAC gnomAD
CA373357113 rs1199251456	887	Q>R		No	ClinGen gnomAD
CA373357091 rs1322179253	888	Q>R		No	ClinGen gnomAD
CA5048844 rs540431162	889	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5048846 rs749822890	889	R>W		No	ClinGen ExAC TOPMed gnomAD
rs770307539 CA373357055	891	R>G		No	ClinGen ExAC TOPMed gnomAD
CA192746879 rs1044604188	891	R>Q		No	ClinGen Ensembl
CA5048843 rs770307539	891	R>W		No	ClinGen ExAC TOPMed gnomAD
CA373357009 rs1587984608	893	A>G		No	ClinGen Ensembl
CA373357020 rs1394871946	893	A>T		No	ClinGen TOPMed gnomAD
rs1466649405 CA373356941	898	R>C		No	ClinGen TOPMed gnomAD
CA373356940 rs1405406696	898	R>H		No	ClinGen gnomAD
rs1405406696 CA373356938	898	R>L		No	ClinGen gnomAD
CA5048840 rs755189562	899	M>I		No	ClinGen ExAC gnomAD
CA373356931 rs755189562	899	M>I		No	ClinGen ExAC gnomAD
rs781573640 CA373356937	899	M>L		No	ClinGen ExAC TOPMed gnomAD
rs781573640 CA5048841	899	M>V		No	ClinGen ExAC TOPMed gnomAD
CA5048839 rs747168571	900	A>V		No	ClinGen ExAC
rs1378368988 CA373356912	901	T>I		No	ClinGen gnomAD
CA373356888 rs1181440375	903	A>V		No	ClinGen gnomAD
CA192746878 rs893252064	905	A>S		No	ClinGen TOPMed
rs1467184007 CA373356864	905	A>V		No	ClinGen TOPMed
rs750498641 CA373356808	909	I>L		No	ClinGen ExAC gnomAD
CA373356789 rs1179143398	909	I>N		No	ClinGen gnomAD
rs750498641 COSM326680 CA5048836	909	I>V	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA5048835 rs778755374	910	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1470483454 CA373356757	911	K>E		No	ClinGen gnomAD
CA5048833 rs753595858	915	Q>R		No	ClinGen ExAC gnomAD
CA5048832 rs574795385	916	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA5048831 rs760405428	916	R>H		No	ClinGen ExAC gnomAD
rs759181283 CA5048828	918	E>D		No	ClinGen ExAC gnomAD
rs369955917 CA192746865	920	A>T		No	ClinGen Ensembl
CA373356243 rs1383216842	927	S>L		No	ClinGen gnomAD
rs752531999 CA5048812	929	T>I		No	ClinGen ExAC gnomAD
CA373356206 rs1372468059	930	Q>*		No	ClinGen gnomAD
CA373356204 rs1333211327	930	Q>P		No	ClinGen TOPMed
rs759219436 CA5048810	931	T>A		No	ClinGen ExAC TOPMed gnomAD
CA373356188 rs1263375797	931	T>I		No	ClinGen gnomAD
CA373356190 rs1263375797	931	T>N		No	ClinGen gnomAD
CA373356195 rs759219436	931	T>P		No	ClinGen ExAC TOPMed gnomAD
CA5048808 rs373794155	933	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1357611485 CA373356127	936	Q>*		No	ClinGen gnomAD
CA5048806 rs777255391	936	Q>H		No	ClinGen ExAC gnomAD
rs1587984374 CA373356110	937	H>P		No	ClinGen Ensembl
CA373356099 rs761068682	938	A>P		No	ClinGen ExAC TOPMed gnomAD
CA5048804 rs761068682	938	A>T		No	ClinGen ExAC TOPMed gnomAD
CA373356091 rs1587984362	938	A>V		No	ClinGen Ensembl
CA373356080 rs1279065416	939	A>V		No	ClinGen gnomAD
rs139655425 CA5048803	941	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA373356060 rs1587984358	941	T>P		No	ClinGen Ensembl
CA5048802 rs370001042	942	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA5048801 rs370001042	942	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5048800 rs370001042	942	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA373356051 rs1325238036	942	P>S		No	ClinGen TOPMed gnomAD
rs879138645 CA192746864	943	K>T		No	ClinGen Ensembl
rs570598486 CA5048797	947	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA373355979 rs1479227688	948	P>S		No	ClinGen gnomAD
CA373355957 rs1224162595	950	P>A		No	ClinGen gnomAD
CA373355952 rs1415524488	950	P>L		No	ClinGen TOPMed
rs1587984319 CA373355914	953	V>G		No	ClinGen Ensembl
CA192746862 rs770145763	956	C>Y		No	ClinGen TOPMed gnomAD
CA373355805 rs1280996926	958	A>T		No	ClinGen gnomAD
CA373355774 rs1220095141	961	E>K		No	ClinGen gnomAD
rs1349639963 CA373355751	962	Q>E		No	ClinGen gnomAD
rs781151911 CA5048777	968	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1336004833 CA373355590	969	G>V		No	ClinGen gnomAD
CA5048775 rs371183695	970	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA5048774 rs779798775	971	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs144500833 CA5048773	973	S>R		No	ClinGen ESP ExAC gnomAD
CA373355494 rs1405385859	974	Q>K		No	ClinGen gnomAD
CA192746853 rs961439767	974	Q>R		No	ClinGen gnomAD
rs1433488694 CA373355469	975	A>T		No	ClinGen gnomAD
CA5048771 rs568812149	977	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs756617846 CA5048770	979	S>R		No	ClinGen ExAC gnomAD
rs756617846 CA373355348	979	S>R		No	ClinGen ExAC gnomAD
rs1460030272 CA373355334	980	P>L		No	ClinGen TOPMed gnomAD
rs1460030272 CA373355325	980	P>R		No	ClinGen TOPMed gnomAD
rs767995679 CA5048768	982	A>T		No	ClinGen ExAC TOPMed gnomAD
CA192746852 rs13298317	982	A>V		No	ClinGen Ensembl
CA373355190 rs1380719240	983	Q>R		No	ClinGen TOPMed
rs760008336 CA5048767	985	A>V		No	ClinGen ExAC TOPMed gnomAD
rs13298307 CA192746850	986	L>F		No	ClinGen Ensembl
CA373355097 rs1282435442	987	I>T		No	ClinGen gnomAD
CA373355069 rs1241962459	988	A>V		No	ClinGen gnomAD
rs1354231934 CA373355062	989	A>S		No	ClinGen gnomAD
CA373355048 rs1322940122	989	A>V		No	ClinGen gnomAD
rs1314277226 CA373354968	992	S>G		No	ClinGen gnomAD
CA5048766 rs774546215	994	L>R		No	ClinGen ExAC gnomAD
CA373354883 rs1380670159	995	Q>E		No	ClinGen gnomAD
CA5048733 rs748842975	1000	M>I		No	ClinGen ExAC gnomAD
CA373354644 rs748842975	1000	M>I		No	ClinGen ExAC gnomAD
rs777095203 CA192746831	1001	V>L		No	ClinGen ExAC gnomAD
rs777095203 CA5048732	1001	V>M		No	ClinGen ExAC gnomAD
rs1280976729 CA373354618	1002	A>T		No	ClinGen gnomAD
CA5048731 rs755516701	1004	A>P		No	ClinGen ExAC gnomAD
rs1370248431 CA373354565	1004	A>V		No	ClinGen gnomAD
CA373354540 rs1294607366	1006	A>T		No	ClinGen gnomAD
CA192746830 rs1031625832	1007	S>L		No	ClinGen TOPMed
rs1461955960 CA373354516	1008	V>M		No	ClinGen gnomAD
rs1398782590 CA373354489	1010	T>A		No	ClinGen TOPMed gnomAD
CA5048730 rs149680408	1010	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs758760333 CA5048728	1011	I>V		No	ClinGen ExAC gnomAD
rs1434677114 CA373354404	1014	Q>*		No	ClinGen gnomAD
rs1267861356 CA373354373	1015	A>P		No	ClinGen gnomAD
rs1231036875 CA373354270	1021	S>G		No	ClinGen TOPMed
CA192746829 rs907073777	1024	A>T		No	ClinGen TOPMed
CA5048724 rs576948451	1030	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764011686 CA5048723	1030	A>V		No	ClinGen ExAC TOPMed gnomAD
CA5048721 rs373243370	1032	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373353942 rs373243370	1032	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1587983973 CA373353934	1033	E>K		No	ClinGen Ensembl
rs1302365624 CA373353892	1035	R>W		No	ClinGen gnomAD
CA373353831 rs1391200571	1036	T>M		No	ClinGen gnomAD
CA373353813 rs1333958064	1037	A>V		No	ClinGen gnomAD
rs1425976947 CA373353802	1038	A>G		No	ClinGen TOPMed
CA373353785 rs1403198566	1039	Q>*		No	ClinGen gnomAD
CA373353633 rs1381992219	1041	A>S		No	ClinGen gnomAD
CA5048701 rs759417184	1045	C>Y		No	ClinGen ExAC gnomAD
rs192874482 CA5048700	1046	G>E		No	ClinGen 1000Genomes ExAC
rs1366668030 CA373353399	1050	M>T		No	ClinGen gnomAD
CA5048699 rs139378393	1051	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1188951923 CA373353370	1051	D>G		No	ClinGen gnomAD
CA373353332 rs1222833782	1053	A>T		No	ClinGen gnomAD
rs762725840 CA373353290	1056	V>L		No	ClinGen ExAC TOPMed gnomAD
CA5048698 rs762725840	1056	V>M		No	ClinGen ExAC TOPMed gnomAD
CA192746820 rs371395463	1059	N>S		No	ClinGen ESP TOPMed gnomAD
rs747661964 CA5048695	1061	E>K		No	ClinGen ExAC gnomAD
rs1356208811 CA373353068	1063	D>E		No	ClinGen gnomAD
rs772738984 CA5048693	1067	V>L		No	ClinGen ExAC TOPMed gnomAD
CA373352867 rs1398426596	1072	R>*		No	ClinGen gnomAD
CA5048690 rs757752315	1072	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA373352824 rs1423783109	1074	G>V		No	ClinGen gnomAD
CA192746819 rs1019021083	1075	K>Q		No	ClinGen Ensembl
rs1007607956 CA192746818	1075	K>R		No	ClinGen Ensembl
rs887606125 CA192746817	1076	L>F		No	ClinGen TOPMed
rs1219244522 CA373352805	1076	L>P		No	ClinGen TOPMed
CA373352768 rs1388405468	1078	P>L		No	ClinGen gnomAD
rs1372050591 CA373352671	1083	T>I		No	ClinGen gnomAD
rs1372050591 CA373352672	1083	T>R		No	ClinGen gnomAD
rs1231100687 CA373351324	1085	E>K		No	ClinGen TOPMed
rs1231100687 CA373351320	1085	E>Q		No	ClinGen TOPMed
rs768221303 CA192746698	1086	K>N		No	ClinGen ExAC gnomAD
CA5048672 rs768221303	1086	K>N		No	ClinGen ExAC gnomAD
rs1245395603 CA373351292	1086	K>R		No	ClinGen gnomAD
CA373351268 rs1307616576	1088	T>A		No	ClinGen TOPMed
CA5048671 rs777181798	1088	T>N		No	ClinGen ExAC TOPMed gnomAD
rs1008642332 CA192746694	1093	N>D		No	ClinGen TOPMed
CA192746691 rs534210542	1095	T>N		No	ClinGen Ensembl
rs771534168 CA5048669	1098	V>M		No	ClinGen ExAC gnomAD
CA5048668 rs749659924	1099	S>N		No	ClinGen ExAC
rs769936744 CA373350879	1103	A>S		No	ClinGen ExAC TOPMed gnomAD
rs769936744 CA5048666	1103	A>T		No	ClinGen ExAC TOPMed gnomAD
CA5048665 rs748333389	1107	G>E		No	ClinGen ExAC gnomAD
rs1342582049 CA373350752	1108	E>G		No	ClinGen gnomAD
CA5048663 rs755121405	1112	G>D		No	ClinGen ExAC gnomAD
CA373350648 rs1436966490	1112	G>S		No	ClinGen gnomAD
rs879217287 CA192746679	1115	N>D		No	ClinGen Ensembl
CA5048661 rs780020416	1117	A>T		No	ClinGen ExAC gnomAD
CA373350247 rs1421906894	1119	I>V		No	ClinGen gnomAD
rs1164759348 CA373350191	1120	A>V		No	ClinGen gnomAD
CA373350126 rs763888196	1122	R>L		No	ClinGen ExAC gnomAD
CA5048638 rs763888196	1122	R>Q		No	ClinGen ExAC gnomAD
rs1563943058 CA373350075	1124	V>M		No	ClinGen Ensembl
rs766982396 CA373349978	1128	L>M		No	ClinGen ExAC gnomAD
CA5048634 rs763380440	1128	L>R		No	ClinGen ExAC
rs766982396 CA5048635	1128	L>V		No	ClinGen ExAC gnomAD
rs765634282 CA5048632	1129	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs773838436 CA5048633	1129	R>W		No	ClinGen ExAC gnomAD
CA5048631 rs762217867	1130	S>A		No	ClinGen ExAC gnomAD
CA373349901 rs1563943042	1131	L>P		No	ClinGen Ensembl
CA192746581 rs986261609	1132	A>T		No	ClinGen Ensembl
CA5048629 rs146392528	1135	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM267579 CA5048628 rs146392528	1135	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1309499319 CA373349684	1137	G>A		No	ClinGen gnomAD
rs1217514071 CA373349677	1138	V>I		No	ClinGen gnomAD
CA5048626 rs772253612	1139	A>T		No	ClinGen ExAC gnomAD
rs1402219711 CA373349636	1140	A>E		No	ClinGen gnomAD
rs1266285255 CA373349640	1140	A>S		No	ClinGen TOPMed
rs1293439398 CA373349625	1141	L>Q		No	ClinGen gnomAD
rs778948183 CA5048624	1142	T>M		No	ClinGen ExAC TOPMed gnomAD
CA373349513 rs755829722	1145	P>A		No	ClinGen ExAC TOPMed gnomAD
CA5048620 rs755829722	1145	P>T		No	ClinGen ExAC TOPMed gnomAD
CA5048619 rs142185225	1146	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs142185225 CA5048618	1146	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA192746558 rs982163521	1147	V>M		No	ClinGen TOPMed
rs1428862216 CA373349385	1150	I>V		No	ClinGen gnomAD
CA373349303 rs1189271381	1152	L>F		No	ClinGen gnomAD
CA5048616 rs373006458	1152	L>P		No	ClinGen ESP ExAC gnomAD
rs776984443 CA5048613	1153	D>G		No	ClinGen ExAC gnomAD
CA5048615 rs765799488	1153	D>H		No	ClinGen ExAC TOPMed gnomAD
CA5048614 rs776984443	1153	D>V		No	ClinGen ExAC gnomAD
rs764386370 CA373349228	1154	T>K		No	ClinGen ExAC TOPMed gnomAD
rs764386370 CA5048612	1154	T>M		No	ClinGen ExAC TOPMed gnomAD
CA373349185 rs1324635450	1156	S>N		No	ClinGen TOPMed
rs775846249 CA373349169	1157	D>N		No	ClinGen ExAC gnomAD
CA5048610 rs775846249	1157	D>Y		No	ClinGen ExAC gnomAD
rs1217842362 CA373349059	1160	D>G		No	ClinGen gnomAD
rs1300974193 CA373349067	1160	D>N		No	ClinGen gnomAD
CA373349048 rs1327233576	1161	K>T		No	ClinGen gnomAD
CA5048608 rs143289726	1162	A>T		No	ClinGen ESP ExAC gnomAD
CA373349005 rs1398253386	1163	S>N		No	ClinGen gnomAD
CA5048607 rs149157349	1164	S>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149157349 CA5048606	1164	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373348960 rs1434972077	1165	L>F		No	ClinGen TOPMed
CA373348944 rs1462643556	1166	I>L		No	ClinGen gnomAD
CA192746535 rs958488647	1166	I>M		No	ClinGen Ensembl
CA5048605 rs373157684	1166	I>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5048604 rs777721084	1168	E>*		No	ClinGen ExAC TOPMed gnomAD
CA373348867 rs756028633	1168	E>G		No	ClinGen ExAC TOPMed gnomAD
rs777721084 CA373348882	1168	E>K		No	ClinGen ExAC TOPMed gnomAD
CA5048603 rs756028633	1168	E>V		No	ClinGen ExAC TOPMed gnomAD
rs552100458 CA5048602	1169	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780950471 CA5048601	1171	K>R		No	ClinGen ExAC
CA5048599 rs751116301	1172	A>E		No	ClinGen ExAC TOPMed gnomAD
CA5048600 rs754542433	1172	A>P		No	ClinGen ExAC TOPMed gnomAD
rs765740689 CA5048598	1173	A>P		No	ClinGen ExAC TOPMed gnomAD
CA373348763 rs765740689	1173	A>T		No	ClinGen ExAC TOPMed gnomAD
CA373348755 rs1482688406	1173	A>V		No	ClinGen gnomAD
rs878857179 CA192746523	1174	G>D		No	ClinGen gnomAD
CA373348663 rs1233237980	1178	D>E		No	ClinGen TOPMed
CA373348669 rs1208447452	1178	D>H		No	ClinGen gnomAD
CA373348668 rs1208447452	1178	D>N		No	ClinGen gnomAD
rs757776168 CA5048597	1179	P>S		No	ClinGen ExAC gnomAD
rs1240123488 CA373348656	1180	E>K		No	ClinGen gnomAD
rs754402540 CA373348634	1181	S>I		No	ClinGen ExAC gnomAD
CA5048596 rs754402540	1181	S>N		No	ClinGen ExAC gnomAD
CA373348579 rs761066476	1184	R>P		No	ClinGen ExAC TOPMed gnomAD
CA5048594 rs761066476	1184	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs528772099 CA5048595	1184	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5048593 rs560048567	1185	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1467381961 CA373348554	1186	A>T		No	ClinGen gnomAD
rs1157854224 CA373348506	1187	Q>*		No	ClinGen gnomAD
CA5048592 rs767799790	1187	Q>P		No	ClinGen ExAC
CA373348284 rs1436289480	1188	V>E		No	ClinGen TOPMed
rs1012448272 CA192746356	1188	V>M		No	ClinGen TOPMed
CA373348200 rs1587982645	1192	V>L		No	ClinGen Ensembl
CA192746354 rs752941688	1193	T>I		No	ClinGen TOPMed
rs1264469439 CA373348145	1194	Q>R		No	ClinGen gnomAD
rs1355697480 CA373348094	1195	A>G		No	ClinGen TOPMed gnomAD
rs1355697480 CA373348098	1195	A>V		No	ClinGen TOPMed gnomAD
rs550588728 CA192746352	1196	L>V		No	ClinGen TOPMed gnomAD
rs141520624 CA5048574	1198	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA5048572 rs765433665	1198	R>H		No	ClinGen ExAC TOPMed gnomAD
CA5048573 rs765433665	1198	R>L		No	ClinGen ExAC TOPMed gnomAD
CA5048571 rs759816391	1200	V>I		No	ClinGen ExAC gnomAD
rs1397908505 CA373347960	1201	S>I		No	ClinGen gnomAD
CA373347887 rs1318866452 COSM753495	1204	P>S	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs763176903 CA5048568	1207	R>H		No	ClinGen ExAC gnomAD
CA192746337 rs879081024	1208	D>N		No	ClinGen gnomAD
CA5048563 rs202140727	1214	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA373347387 rs1194387777	1215	A>V		No	ClinGen gnomAD
rs899409166 CA192746327	1217	G>R		No	ClinGen TOPMed
rs376939605 CA5048561	1219	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5048560 rs771688185	1220	S>G		No	ClinGen ExAC TOPMed gnomAD
CA5048559 rs745401805	1222	R>Q		No	ClinGen ExAC gnomAD
rs778350293 CA5048558	1223	L>F		No	ClinGen ExAC gnomAD
CA5048557 rs756644086	1223	L>P		No	ClinGen ExAC gnomAD
CA192746314 rs373167883	1225	S>G		No	ClinGen ESP TOPMed
CA5048554 VAR_023751 rs2295795	1227	S>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs781714922 CA5048555	1227	S>T		No	ClinGen ExAC TOPMed gnomAD
rs185407414 CA5048533	1230	P>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1282133449 CA373346655	1232	T>P		No	ClinGen TOPMed gnomAD
rs1426133857 CA373346617	1233	G>E		No	ClinGen gnomAD
CA5048531 rs151188301	1234	T>S		No	ClinGen ESP ExAC TOPMed
CA5048530 rs199987514	1238	A>S		No	ClinGen ExAC gnomAD
rs753934231 CA5048529	1240	S>G		No	ClinGen ExAC gnomAD
CA373346243 rs1283216229	1241	R>Q		No	ClinGen TOPMed gnomAD
rs770655381 CA192746226 COSM455920	1241	R>W	endometrium breast [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1357010116 CA373346187	1243	N>T		No	ClinGen gnomAD
CA373346123 rs1315100473	1246	A>S		No	ClinGen gnomAD
CA373346105 rs1435742688	1247	A>T		No	ClinGen gnomAD
CA373346026 rs1587982278	1251	Q>R		No	ClinGen Ensembl
CA373346010 rs1587982274	1252	A>P		No	ClinGen Ensembl
rs763958290 CA5048528	1252	A>V		No	ClinGen ExAC gnomAD
rs1162757846 CA373345885	1257	V>G		No	ClinGen gnomAD
CA373345895 rs1408864952	1257	V>M		No	ClinGen gnomAD
CA5048527 rs760617650	1258	Q>R		No	ClinGen ExAC gnomAD
rs1259877136 CA373345835	1260	S>C		No	ClinGen gnomAD
CA373345820 rs775265211	1261	R>W		No	ClinGen ExAC TOPMed gnomAD
CA192746218 rs936554876	1262	G>A		No	ClinGen TOPMed
rs1487880653 CA373345805	1262	G>R		No	ClinGen TOPMed gnomAD
CA192746215 rs556141342	1263	T>A		No	ClinGen 1000Genomes
CA373345764 rs1216294864	1263	T>N		No	ClinGen TOPMed
CA373345783 rs556141342	1263	T>P		No	ClinGen 1000Genomes
rs759312960 CA5048524	1265	Q>*		No	ClinGen ExAC gnomAD
rs1317471415 CA373345718	1265	Q>R		No	ClinGen gnomAD
CA5048523 rs536145683	1266	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA373345665 rs1226123457	1267	L>V		No	ClinGen gnomAD
rs770585429 CA373345247	1269	R>P		No	ClinGen ExAC TOPMed gnomAD
CA5048522 rs770585429	1269	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5048521 rs748796421	1272	G>S		No	ClinGen ExAC TOPMed gnomAD
CA5048519 COSM1462266 rs769049864	1273	R>*	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA5048518 rs747462166	1273	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1433438508 CA373345114	1275	G>R		No	ClinGen gnomAD
rs1322892463 CA373344995	1279	S>G		No	ClinGen gnomAD
CA5048516 rs772636531	1280	T>A		No	ClinGen ExAC gnomAD
CA5048515 rs746207333	1281	F>L		No	ClinGen ExAC gnomAD
rs1191127335 CA373344868	1283	E>D		No	ClinGen TOPMed
rs1165980732 CA373344836	1285	G>S		No	ClinGen gnomAD
CA373344771 rs1429453883	1287	E>Q		No	ClinGen TOPMed
rs757448438 CA5048513	1289	A>G		No	ClinGen ExAC gnomAD
CA5048512 rs753891770	1290	G>S		No	ClinGen ExAC TOPMed gnomAD
CA5048511 rs777839026	1291	Q>H		No	ClinGen ExAC gnomAD
CA5048510 rs34033956	1293	P>L		No	ClinGen ExAC TOPMed gnomAD
rs986942368 CA192777181	1296	E>K		No	ClinGen TOPMed
CA192777171 rs201216076	1297	D>Y		No	ClinGen 1000Genomes
rs773678140 CA192777156	1298	R>G		No	ClinGen Ensembl
CA373397478 rs189605894	1298	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs189605894 CA5048491	1298	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA192777133 rs770469558	1299	A>T		No	ClinGen Ensembl
CA373397473 rs1479414054	1299	A>V		No	ClinGen gnomAD
rs1432871328 CA373397470	1300	Q>*		No	ClinGen TOPMed
CA5048490 rs371857243	1300	Q>P		No	ClinGen ExAC gnomAD
CA192777122 rs371857243	1300	Q>R		No	ClinGen ExAC gnomAD
CA192777111 rs201783008	1307	G>D		No	ClinGen 1000Genomes
rs1308491075 CA373397425	1307	G>S		No	ClinGen gnomAD
CA192777105 rs878917589	1309	S>C		No	ClinGen TOPMed
CA373397407 rs766141848	1310	M>L		No	ClinGen ExAC gnomAD
CA5048487 rs766141848	1310	M>V		No	ClinGen ExAC gnomAD
rs1373869694 CA373397393	1312	S>P		No	ClinGen gnomAD
CA5048486 rs762642967	1313	S>G		No	ClinGen ExAC TOPMed gnomAD
CA5048485 rs750156961	1313	S>T		No	ClinGen ExAC gnomAD
rs1431766736 CA373397355	1318	A>S		No	ClinGen Ensembl
CA373397350 rs1371442368	1319	A>T		No	ClinGen gnomAD
rs761462874 CA5048483	1322	L>R		No	ClinGen ExAC gnomAD
CA192777050 rs1028376828	1323	S>Y		No	ClinGen TOPMed
CA5048481 rs185474328	1324	T>M		No	ClinGen 1000Genomes ExAC gnomAD
rs370754191 CA5048482	1324	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA373397306 rs1327687675	1325	D>E		No	ClinGen gnomAD
CA5048477 rs749611041	1326	P>R		No	ClinGen ExAC gnomAD
CA5048478 rs771380800	1326	P>S		No	ClinGen ExAC TOPMed gnomAD
rs775197727 CA192777014	1327	A>V		No	ClinGen Ensembl
rs983546599 CA192777007	1328	A>D		No	ClinGen Ensembl
rs1563942205 CA373397258	1333	S>N		No	ClinGen Ensembl
CA373397254 rs1252194742	1333	S>R		No	ClinGen gnomAD
rs1482739223 CA373397211	1337	A>E		No	ClinGen TOPMed gnomAD
CA373397212 rs1482739223	1337	A>V		No	ClinGen TOPMed gnomAD
rs1376091516 CA373397200	1338	A>G		No	ClinGen TOPMed
CA192776810 rs974374325	1341	A>T		No	ClinGen TOPMed gnomAD
rs1258790517 CA373397083	1345	S>N		No	ClinGen gnomAD
rs1205108939 CA373397056	1347	N>S		No	ClinGen gnomAD
CA373396985 rs1435933463	1351	T>I		No	ClinGen gnomAD
rs763423059 CA5048458	1352	M>T		No	ClinGen ExAC TOPMed gnomAD
rs144937466 CA5048459	1352	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5048457 rs773398422	1353	C>S		No	ClinGen ExAC gnomAD
rs748313420 CA5048455	1356	Q>R		No	ClinGen ExAC gnomAD
rs776822293 CA5048454	1358	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1297381787 CA373396847	1359	G>D		No	ClinGen gnomAD
rs941771913 CA192776750	1359	G>S		No	ClinGen TOPMed gnomAD
rs1257016674 CA373396763	1364	D>G		No	ClinGen TOPMed
CA192776721 rs746908388	1366	A>S		No	ClinGen ExAC TOPMed gnomAD
CA5048448 rs746908388	1366	A>T		No	ClinGen ExAC TOPMed gnomAD
COSM1229370 rs1476377555 CA373396739	1368	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA373396740 COSM1462264 rs1166692117	1368	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA5048446 rs753598417	1371	E>D		No	ClinGen ExAC gnomAD
CA5048426 rs752281502	1372	T>M		No	ClinGen ExAC gnomAD
CA373396671 rs1341264893	1373	V>F		No	ClinGen gnomAD
rs752783993 CA5048424	1374	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs556004234 CA192776630	1374	R>W		No	ClinGen 1000Genomes TOPMed gnomAD
CA5048421 rs762215768	1379	N>S		No	ClinGen ExAC gnomAD
CA373396576 rs1450025514	1383	P>L		No	ClinGen TOPMed
CA5048418 rs576683799 COSM3664332	1385	N>S	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1587981686 CA373396539	1387	M>I		No	ClinGen Ensembl
rs376371537 CA192776530	1387	M>T		No	ClinGen ESP TOPMed gnomAD
rs775656107 CA5048417	1387	M>V		No	ClinGen ExAC gnomAD
CA192776525 rs997375582	1391	G>D		No	ClinGen gnomAD
rs997375582 CA373396498	1391	G>V		No	ClinGen gnomAD
rs1454819324 CA373396465	1395	S>G		No	ClinGen gnomAD
rs1587981671 CA373396444	1396	V>I		No	ClinGen Ensembl
CA373396432 rs1232490412	1397	M>L		No	ClinGen gnomAD
rs146395635 CA192776493	1398	E>K		No	ClinGen ESP
CA192776486 rs1013376748	1399	N>S		No	ClinGen TOPMed gnomAD
CA192776473 rs941890715	1401	K>E		No	ClinGen gnomAD
CA5048398 rs142197660	1402	V>M		No	ClinGen ESP ExAC
CA5048395 rs762916118	1405	E>D		No	ClinGen ExAC gnomAD
CA5048396 rs766448496	1405	E>K		No	ClinGen ExAC TOPMed gnomAD
CA192776328 rs926910005	1407	M>V		No	ClinGen Ensembl
CA373396080 rs1240130259	1414	A>V		No	ClinGen TOPMed
CA5048394 rs773071664	1415	K>N		No	ClinGen ExAC gnomAD
CA373396069 rs1292370917	1415	K>R		No	ClinGen gnomAD
CA5048392 rs747944920	1417	G>E		No	ClinGen ExAC gnomAD
CA373396043 rs1315216327 COSM753496	1417	G>R	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA373396021 rs1423982729	1418	N>S		No	ClinGen TOPMed
CA373396019 rs1423982729	1418	N>T		No	ClinGen TOPMed
CA192776291 rs988162039	1419	L>V		No	ClinGen Ensembl
rs570805918 CA5048390	1421	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs570805918 CA5048391	1421	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA5048388 rs779474454	1424	D>H		No	ClinGen ExAC TOPMed gnomAD
rs779474454 CA5048389	1424	D>N		No	ClinGen ExAC TOPMed gnomAD
CA373395859 rs1402579742	1428	T>R		No	ClinGen gnomAD
CA373395838 rs1412969165	1430	S>T		No	ClinGen gnomAD
CA373395830 rs1156701248	1431	K>E		No	ClinGen Ensembl
rs757778441 CA5048387	1431	K>N		No	ClinGen ExAC TOPMed gnomAD
CA5048386 rs749855173	1432	A>T		No	ClinGen ExAC gnomAD
rs1419695028 CA373395787	1433	L>V		No	ClinGen gnomAD
CA192776266 rs996842209	1434	C>F		No	ClinGen Ensembl
CA373395767 rs1029600166	1434	C>G		No	ClinGen gnomAD
CA192776270 rs1029600166	1434	C>R		No	ClinGen gnomAD
rs1240344668 CA373395705	1438	E>K		No	ClinGen gnomAD
CA373395640 rs1458230521	1441	A>V		No	ClinGen TOPMed
CA373394462 rs199732295	1452	P>L		No	ClinGen 1000Genomes gnomAD
CA192774493 rs199732295	1452	P>R		No	ClinGen 1000Genomes gnomAD
rs539650286 CA5048359	1453	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA192774483 rs539650286	1453	N>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA373394430 rs1171179735	1455	Q>H		No	ClinGen gnomAD
CA192774481 rs956451049	1457	G>R		No	ClinGen Ensembl
CA5048352 rs771686282	1468	A>D		No	ClinGen ExAC gnomAD
CA192774456 rs771686282	1468	A>V		No	ClinGen ExAC gnomAD
rs758988730 CA5048351	1469	R>C		No	ClinGen ExAC gnomAD
CA373394136 rs758988730	1469	R>G		No	ClinGen ExAC gnomAD
rs773870967 CA5048349	1469	R>H		No	ClinGen ExAC TOPMed
rs148120870 CA5048348	1470	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1302104297 CA373394082	1471	N>H		No	ClinGen gnomAD
CA5048347 rs368416717	1473	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA373393945 rs1563940981	1476	M>T		No	ClinGen Ensembl
rs781761015 CA5048346	1478	C>F		No	ClinGen ExAC gnomAD
CA373393889 rs1587980004	1480	S>N		No	ClinGen Ensembl
CA5048344 rs375040162	1484	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA5048342 rs371110557	1484	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs375040162 CA5048343	1484	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs750856015 CA192774384	1486	C>R		No	ClinGen TOPMed
rs1157769681 CA373393751 COSM95343	1489	A>T	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
CA5048341 rs750475849	1489	A>V		No	ClinGen ExAC TOPMed gnomAD
CA5048322 rs143009347	1491	V>G		No	ClinGen ESP ExAC
rs1283240091 CA373393557	1491	V>M		No	ClinGen TOPMed
rs1215836347 CA373393478	1495	A>G		No	ClinGen TOPMed
rs1376270357 CA373393485	1495	A>T		No	ClinGen TOPMed
rs138986367 CA5048320	1497	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA373393424 rs1294821944	1499	A>T		No	ClinGen gnomAD
CA373393342 rs753888778	1503	S>P		No	ClinGen ExAC gnomAD
CA5048319 rs753888778	1503	S>T		No	ClinGen ExAC gnomAD
CA5048318 rs777707064	1507	N>S		No	ClinGen ExAC gnomAD
rs1040886850 CA192773862	1508	S>N		No	ClinGen Ensembl
CA5048317 rs756002749	1510	R>H		No	ClinGen ExAC gnomAD
rs1459827294 CA13049131	1511	L>R		No	ClinGen gnomAD
CA5048316 rs758176386	1515	R>C		No	ClinGen ExAC TOPMed gnomAD
rs758176386 CA192773853	1515	R>G		No	ClinGen ExAC TOPMed gnomAD
rs148894711 CA5048315	1515	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA373393071 rs1189298508	1517	T>I		No	ClinGen TOPMed gnomAD
CA192773842 rs372921366	1518	N>S		No	ClinGen ESP ExAC gnomAD
rs372921366 CA5048314	1518	N>T		No	ClinGen ESP ExAC gnomAD
rs751292021 CA5048313	1520	T>I		No	ClinGen ExAC TOPMed gnomAD
rs751292021 CA192773836	1520	T>N		No	ClinGen ExAC TOPMed gnomAD
CA373393017 rs1211383332	1521	A>T		No	ClinGen gnomAD
COSM1462261 rs1424218976 CA373392972	1523	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA192773810 rs201537122	1524	Q>H		No	ClinGen 1000Genomes ExAC TOPMed
CA192773809 rs768597997	1526	V>I		No	ClinGen TOPMed gnomAD
CA373392871 rs1225107776	1529	A>P		No	ClinGen gnomAD
CA373392873 rs1225107776	1529	A>T		No	ClinGen gnomAD
rs1426924218 CA373392861	1529	A>V		No	ClinGen TOPMed
CA192773798 rs952442752	1532	V>M		No	ClinGen TOPMed gnomAD
rs1333035165 CA373392790	1533	A>T		No	ClinGen TOPMed
CA373392770 rs1367277686	1534	N>S		No	ClinGen gnomAD
rs151033435 CA5048309	1539	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5048308 rs761209160	1541	K>R		No	ClinGen ExAC gnomAD
rs1587979666 CA373392518	1543	I>V		No	ClinGen Ensembl
CA373392490 rs1424133597	1544	K>R		No	ClinGen gnomAD
CA192773510 rs943902713	1545	A>V		No	ClinGen TOPMed
CA373392374 rs1458898641	1547	D>G		No	ClinGen TOPMed
rs1363503500 CA373392327	1549	A>P		No	ClinGen gnomAD
CA373392324 rs1363503500	1549	A>S		No	ClinGen gnomAD
CA373392317 rs1179394179	1549	A>V		No	ClinGen TOPMed gnomAD
rs781212644 CA5048280	1550	F>I		No	ClinGen ExAC gnomAD
CA5048279 rs754832772	1552	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1252416617 CA373392270	1552	E>G		No	ClinGen gnomAD
CA373392237 rs781565789	1554	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1587979516 CA373392245	1554	N>T		No	ClinGen Ensembl
CA192773488 rs796217856	1555	R>C		No	ClinGen TOPMed gnomAD
rs1219317167 CA373392225	1555	R>H		No	ClinGen TOPMed gnomAD
rs544122167 CA192773474	1559	R>G		No	ClinGen TOPMed
CA192773473 rs758191289	1559	R>Q		No	ClinGen gnomAD
CA373392145 rs1392956509	1560	A>T		No	ClinGen TOPMed
CA373392127 rs1277478868	1561	A>T		No	ClinGen gnomAD
rs1226919078 CA373392108	1562	T>A		No	ClinGen gnomAD
rs1414635838 CA373392008	1567	E>K		No	ClinGen gnomAD
CA373391941 rs1336234837	1569	V>M		No	ClinGen gnomAD
rs778680871 CA5048274	1576	A>V		No	ClinGen ExAC gnomAD
CA373391734 rs1473705745	1577	S>F		No	ClinGen TOPMed gnomAD
rs759890811 CA5048270	1584	I>F		No	ClinGen ExAC gnomAD
rs182406064 CA192773445	1584	I>T		No	ClinGen 1000Genomes TOPMed
rs776900168 COSM247845 CA5048244	1593	R>Q	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA192773309 rs267602229	1593	R>W		No	ClinGen TOPMed
CA373390593 rs768688053	1594	A>S		No	ClinGen ExAC TOPMed gnomAD
CA5048243 rs768688053	1594	A>T		No	ClinGen ExAC TOPMed gnomAD
CA373390579 rs1325527112	1595	A>P		No	ClinGen gnomAD
CA5048242 rs760780040	1596	M>T		No	ClinGen ExAC gnomAD
rs1587979360 CA373390458	1599	I>T		No	ClinGen Ensembl
CA373390425 rs1165224187	1600	V>L		No	ClinGen TOPMed gnomAD
rs772090309 CA5048240	1606	M>V		No	ClinGen ExAC gnomAD
rs1449591031 CA373390272	1609	S>R		No	ClinGen gnomAD
rs1251968309 CA373390270	1610	A>T		No	ClinGen TOPMed gnomAD
CA373390262 rs1235179044	1611	G>R		No	ClinGen TOPMed
rs770717000 CA5048237	1614	I>L		No	ClinGen ExAC gnomAD
rs777475398 CA5048235	1615	Q>E		No	ClinGen ExAC gnomAD
CA192773250 rs879031982	1616	T>I		No	ClinGen TOPMed
CA5048234 rs755618623	1617	A>G		No	ClinGen ExAC
CA5048233 rs780560798	1618	R>P		No	ClinGen ExAC TOPMed gnomAD
CA5048232 COSM3848484 rs780560798	1618	R>Q	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA373390140 rs1207300600	1618	R>W		No	ClinGen TOPMed gnomAD
CA373390132 rs1273187077	1619	A>D		No	ClinGen gnomAD
rs1273187077 CA373390126	1619	A>V		No	ClinGen gnomAD
rs555267067 CA5048229	1621	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs555267067 CA5048230	1621	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA373390060 rs1302808194	1624	P>S		No	ClinGen gnomAD
CA373390041 rs1293884475	1625	R>L		No	ClinGen TOPMed gnomAD
CA373390044 rs1293884475	1625	R>Q		No	ClinGen TOPMed gnomAD
CA5048227 rs200231964	1625	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA373390025 rs1587979309	1626	D>A		No	ClinGen Ensembl
rs1309834154 CA373390015	1626	D>E		No	ClinGen gnomAD
rs1368602865 CA373390032	1626	D>N		No	ClinGen gnomAD
CA5048225 rs372348691	1628	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs372348691 CA373389992	1628	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1430361730 CA373389998	1628	P>T		No	ClinGen gnomAD
CA373389981 rs1587979304	1629	S>N		No	ClinGen Ensembl
CA373389956 rs767562560	1630	W>C		No	ClinGen ExAC gnomAD
rs767562560 CA5048223	1630	W>C		No	ClinGen ExAC gnomAD
CA5048222 rs759485112	1631	S>L		No	ClinGen ExAC gnomAD
rs1359829487 CA373389924	1632	V>A		No	ClinGen TOPMed
CA373389934 rs1192133634	1632	V>M		No	ClinGen TOPMed gnomAD
rs749077133 CA5048218	1635	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1563940495 CA373389876	1636	H>N		No	ClinGen Ensembl
rs772787562 CA5048217	1638	R>C		No	ClinGen ExAC gnomAD
rs538218511 CA5048216	1638	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5048215 rs747616908	1639	T>I		No	ClinGen ExAC gnomAD
rs780623928 CA5048214	1642	D>G		No	ClinGen ExAC gnomAD
CA192773137 rs879010817	1642	D>H		No	ClinGen TOPMed
rs754472265 CA5048213	1643	S>A		No	ClinGen ExAC gnomAD
CA373389748 rs1353754465	1645	K>E		No	ClinGen TOPMed
rs757609430 CA5048210	1649	T>K		No	ClinGen ExAC gnomAD
rs1374783353 CA373389659	1650	S>N		No	ClinGen TOPMed gnomAD
CA373389653 rs1300550435	1651	M>V		No	ClinGen gnomAD
rs779307601 CA5048193	1653	D>N		No	ClinGen ExAC gnomAD
CA192772981 rs879215147	1658	Q>K		No	ClinGen TOPMed
rs144377720 CA5048191	1663	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA192772960 rs766069516	1664	A>V		No	ClinGen Ensembl
CA5048189 rs756425071	1665	I>T		No	ClinGen ExAC gnomAD
CA373389468 rs372917627	1666	A>E		No	ClinGen ExAC gnomAD
rs1176685303 CA373389469	1666	A>S		No	ClinGen TOPMed
CA5048188 rs372917627	1666	A>V		No	ClinGen ExAC gnomAD
rs1046383806 CA192772945	1667	A>V		No	ClinGen Ensembl
rs375933712 CA192772935	1669	N>K		No	ClinGen Ensembl
rs781536225 CA373389443	1669	N>S		No	ClinGen ExAC gnomAD
CA5048187 rs781536225	1669	N>T		No	ClinGen ExAC gnomAD
CA5048186 rs755159548	1670	S>G		No	ClinGen ExAC gnomAD
CA192772890 rs949013301	1673	R>L		No	ClinGen Ensembl
rs762882126 CA5048183	1673	R>W		No	ClinGen ExAC gnomAD
CA192772888 rs760427707	1674	D>V		No	ClinGen gnomAD
rs990359261 CA192772857	1681	A>T		No	ClinGen TOPMed gnomAD
CA5048180 rs761563243	1682	A>S		No	ClinGen ExAC gnomAD
rs1189398552 CA373389325	1682	A>V		No	ClinGen gnomAD
rs988109824 CA192772848	1684	S>G		No	ClinGen TOPMed gnomAD
CA5048178 COSM1462259 rs768245253	1690	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs760206039 CA5048177	1690	R>H		No	ClinGen ExAC TOPMed gnomAD
CA373389240 rs1445502263	1691	E>D		No	ClinGen TOPMed
rs771359668 CA5048175	1692	G>R		No	ClinGen ExAC gnomAD
CA373389226 rs1484302527	1693	I>V		No	ClinGen gnomAD
rs767125543 CA5048155	1700	T>I		No	ClinGen ExAC gnomAD
CA373389113 rs1474940296	1701	Q>H		No	ClinGen TOPMed
rs758941726 CA5048154	1702	M>I		No	ClinGen ExAC gnomAD
CA192772596 rs1019645077	1702	M>V		No	ClinGen TOPMed
CA5048153 rs773820311	1703	L>F		No	ClinGen ExAC TOPMed gnomAD
CA373389068 rs1452381004	1706	V>I		No	ClinGen TOPMed gnomAD
rs748555839 CA5048151	1709	I>M		No	ClinGen ExAC gnomAD
rs1329618657 CA373389021	1710	S>F		No	ClinGen gnomAD
CA5048150 rs373244419	1711	H>Y		No	ClinGen ESP ExAC gnomAD
rs889345331 CA192772548	1713	I>T		No	ClinGen TOPMed gnomAD
CA5048149 rs769013675	1715	P>L		No	ClinGen ExAC gnomAD
CA5048147 rs780106905	1716	L>V		No	ClinGen ExAC TOPMed gnomAD
rs745884248 CA5048145	1717	A>G		No	ClinGen ExAC TOPMed gnomAD
COSM1666315 CA5048146 rs544636956	1717	A>T	eye [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs202143177 CA5048144	1718	N>S		No	ClinGen ExAC gnomAD
rs1186190219 CA373388937	1720	A>V		No	ClinGen TOPMed gnomAD
rs757116039 CA5048143	1721	R>Q		No	ClinGen ExAC TOPMed
CA373388933 rs1280158076	1721	R>W		No	ClinGen gnomAD
CA5048142 rs753640062	1722	A>G		No	ClinGen ExAC gnomAD
rs199962431 CA373388912	1723	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5048139 rs139337833	1729	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1352834690 CA373388855	1729	H>Y		No	ClinGen gnomAD
rs1447969386 CA373388840	1730	K>R		No	ClinGen TOPMed gnomAD
rs1331607060 CA373388773	1733	Q>H		No	ClinGen gnomAD
rs1285427208 COSM1267909 CA373388770	1734	M>V	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
COSM1489992 CA5048130 rs775801466	1735	A>V	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1217620904 CA588144993	1737	Y>P		No	ClinGen gnomAD
rs1286012448 CA373388719	1738	F>S		No	ClinGen gnomAD
CA5048128 rs745962007	1739	E>V		No	ClinGen ExAC TOPMed gnomAD
CA373388696 rs1318847050	1740	P>L		No	ClinGen gnomAD
CA373388697 rs1364695758	1740	P>S		No	ClinGen gnomAD
CA373388674 rs1345526205	1742	T>I		No	ClinGen gnomAD
CA373388680 rs1587978793	1742	T>P		No	ClinGen Ensembl
CA5048124 rs777660256	1747	G>D		No	ClinGen ExAC TOPMed gnomAD
CA373388626 rs1587978779	1748	A>P		No	ClinGen Ensembl
rs1587978774 CA373388589	1752	T>P		No	ClinGen Ensembl
CA5048123 rs755988954	1753	L>R		No	ClinGen ExAC gnomAD
CA373388551 rs1203250395	1756	P>A		No	ClinGen TOPMed
CA5048121 rs376156981	1757	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1419908136 CA373388454	1765	T>P		No	ClinGen gnomAD
rs894141178 CA192772358	1768	L>S		No	ClinGen gnomAD
CA5048117 rs538785316	1769	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1162101459 CA373388385	1771	S>C		No	ClinGen gnomAD
rs1295541234 CA373388375	1773	L>V		No	ClinGen gnomAD
rs1362939516 CA373388362	1774	Q>R		No	ClinGen gnomAD
CA5048115 rs768710092	1775	L>F		No	ClinGen ExAC TOPMed gnomAD
CA373388349 rs1587978729	1775	L>S		No	ClinGen Ensembl
CA5048112 rs374958442	1781	E>K		No	ClinGen ESP ExAC gnomAD
rs903347991 CA192772337	1782	A>T		No	ClinGen gnomAD
rs780792750 CA373388185	1789	A>G		No	ClinGen ExAC gnomAD
CA5048102 rs780792750	1789	A>V		No	ClinGen ExAC gnomAD
CA192772236 rs754790750	1790	A>P		No	ClinGen ExAC TOPMed gnomAD
CA5048101 rs754790750	1790	A>T		No	ClinGen ExAC TOPMed gnomAD
CA373388155 rs1217712104	1791	H>Q		No	ClinGen TOPMed gnomAD
CA373388146 rs1369411932	1792	T>I		No	ClinGen TOPMed gnomAD
CA192772216 COSM1674482 rs931960025	1793	Q>L	breast [Cosmic]	No	ClinGen cosmic curated Ensembl
rs779830899 CA5048099	1795	A>D		No	ClinGen ExAC TOPMed gnomAD
CA5048100 rs751297121	1795	A>S		No	ClinGen ExAC TOPMed gnomAD
CA5048097 rs201457771	1797	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758003423 CA5048098	1797	E>K		No	ClinGen ExAC gnomAD
CA192772166 rs920609151	1797	E>V		No	ClinGen TOPMed gnomAD
CA5048096 rs764663644	1799	A>T		No	ClinGen ExAC gnomAD
CA373388055 rs1249424745	1800	V>A		No	ClinGen TOPMed
COSM1555094 rs879011046 CA192772147	1803	M>I	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
rs761026853 CA5048095	1804	T>S		No	ClinGen ExAC gnomAD
rs767833622 CA5048093	1805	E>K		No	ClinGen ExAC gnomAD
rs771095398 CA5048090	1807	V>I		No	ClinGen ExAC TOPMed gnomAD
CA373387920 rs1480971934	1808	E>D		No	ClinGen gnomAD
CA192772129 rs34723987	1808	E>G		No	ClinGen Ensembl
rs769786192 CA5048087	1812	T>A		No	ClinGen ExAC gnomAD
CA373387874 rs1263511653	1812	T>I		No	ClinGen gnomAD
rs1587978602 CA373387872	1813	T>P		No	ClinGen Ensembl
COSM346127 rs768383698 CA5048084	1816	E>K	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs868567765 CA192772093	1818	A>V		No	ClinGen gnomAD
rs878899170 CA192772076	1820	A>V		No	ClinGen gnomAD
rs1177596250 CA373387725	1824	V>M		No	ClinGen gnomAD
CA5048080 rs749964239	1825	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1587978553 CA373387640	1828	V>G		No	ClinGen Ensembl
CA373387623 rs1255487270	1829	D>E		No	ClinGen TOPMed gnomAD
rs1180246774 CA373387603	1831	I>V		No	ClinGen gnomAD
CA373387577 rs1337824035	1833	Q>E		No	ClinGen gnomAD
CA5048077 rs564861791	1833	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA192772027 rs769092885	1835	I>V		No	ClinGen Ensembl
rs771977833 CA5048061	1839	D>G		No	ClinGen ExAC TOPMed gnomAD
CA192771859 rs920583265	1842	P>L		No	ClinGen Ensembl
rs932070202 CA192771874	1842	P>S		No	ClinGen TOPMed gnomAD
CA373387360 rs932070202	1842	P>T		No	ClinGen TOPMed gnomAD
rs745578738 CA5048060	1843	M>V		No	ClinGen ExAC TOPMed gnomAD
rs747472950 CA192771850	1844	G>A		No	ClinGen ExAC TOPMed gnomAD
CA5048059 rs747472950	1844	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1359485487 CA373387330	1844	G>R		No	ClinGen gnomAD
rs1206242922 CA373387325	1845	E>Q		No	ClinGen TOPMed
CA192771849 rs1031141145	1846	P>L		No	ClinGen TOPMed
CA5048058 rs756770125	1848	G>D		No	ClinGen ExAC gnomAD
CA373387249 rs756770125	1848	G>V		No	ClinGen ExAC gnomAD
CA373387210 rs1390613112	1851	V>M		No	ClinGen TOPMed gnomAD
rs1453843384 CA373387116	1856	T>I		No	ClinGen TOPMed
CA373387112 rs766789345	1857	M>L		No	ClinGen ExAC TOPMed gnomAD
rs1587978420 CA373387106	1857	M>T		No	ClinGen Ensembl
CA5048053 rs766789345	1857	M>V		No	ClinGen ExAC TOPMed gnomAD
rs750652395 CA5048051	1859	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs758758658 CA5048052	1859	R>W		No	ClinGen ExAC gnomAD
rs778074771 CA192771827	1862	K>E		No	ClinGen TOPMed
CA5048050 rs146471988	1867	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1563939916 CA373386979	1868	V>G		No	ClinGen Ensembl
CA373386985 rs1265029717	1868	V>I		No	ClinGen gnomAD
rs1410183885 CA373386729	1877	T>S		No	ClinGen TOPMed
CA373386622 rs1332089542	1884	P>S		No	ClinGen TOPMed gnomAD
rs368693885 CA5048033	1885	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs779004981 CA5048032	1886	A>D		No	ClinGen ExAC gnomAD
CA373386591 rs1261650264	1887	N>H		No	ClinGen TOPMed gnomAD
CA373386587 rs1587978328	1887	N>T		No	ClinGen Ensembl
CA5048031 rs757441905	1888	Q>E		No	ClinGen ExAC gnomAD
rs753991048 CA5048030	1890	T>N		No	ClinGen ExAC gnomAD
CA373386518 rs1389990010	1891	S>I		No	ClinGen TOPMed gnomAD
CA373386520 rs1389990010	1891	S>N		No	ClinGen TOPMed gnomAD
rs760801956 CA5048028	1895	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5048027 rs567336438	1895	R>H		No	ClinGen ExAC TOPMed
CA192771701 rs779743307	1898	S>L		No	ClinGen gnomAD
CA192771690 rs940640050	1900	A>T		No	ClinGen Ensembl
rs774131777 CA373386384	1901	K>R		No	ClinGen ExAC TOPMed gnomAD
CA5048024 rs774131777	1901	K>T		No	ClinGen ExAC TOPMed gnomAD
rs770507067 CA5048023	1902	P>S		No	ClinGen ExAC gnomAD
rs762726209 CA5048022	1903	A>V		No	ClinGen ExAC gnomAD
CA373386334 rs1471124291	1904	A>T		No	ClinGen gnomAD
CA5048020 rs373819052	1904	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5048018 rs780568851	1905	V>L		No	ClinGen ExAC TOPMed gnomAD
CA373386311 rs780568851	1905	V>M		No	ClinGen ExAC TOPMed gnomAD
CA373386291 rs1205945141	1906	A>T		No	ClinGen gnomAD
rs879009491 CA192771634	1909	N>D		No	ClinGen TOPMed
CA192771627 rs907878717	1909	N>T		No	ClinGen TOPMed gnomAD
CA373384726 rs1268198953	1912	I>T		No	ClinGen gnomAD
CA192770945 rs900330251	1916	I>V		No	ClinGen TOPMed
CA373384664 rs1372768361	1917	K>Q		No	ClinGen TOPMed
CA373384628 rs1432688705	1919	R>Q		No	ClinGen gnomAD
rs17854239 VAR_023752 CA192770944	1919	R>W		No	ClinGen UniProt Ensembl dbSNP
CA373384621 rs1587977851	1920	V>I		No	ClinGen Ensembl
CA5047997 rs768037985	1921	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs374846996 CA192770942	1923	L>M		No	ClinGen ESP TOPMed
CA373384450 rs1366822788	1926	G>A		No	ClinGen gnomAD
CA373384447 rs1366822788	1926	G>D		No	ClinGen gnomAD
rs1163730315 CA373384430	1927	C>Y		No	ClinGen gnomAD
CA5047994 rs771374255	1929	A>T		No	ClinGen ExAC TOPMed gnomAD
CA5047993 rs749618464	1932	T>I		No	ClinGen ExAC gnomAD
rs778175682 CA5047992	1934	A>T		No	ClinGen ExAC gnomAD
rs748255410 CA5047990	1936	A>T		No	ClinGen ExAC gnomAD
rs376241579 CA5047988	1940	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs751555908 CA5047987	1941	P>S		No	ClinGen ExAC gnomAD
CA192770882 rs200540143	1944	A>G		No	ClinGen TOPMed
CA5047986 rs766206728	1946	T>I		No	ClinGen ExAC gnomAD
CA5047985 rs758237462	1948	K>E		No	ClinGen ExAC TOPMed gnomAD
rs750149814 CA5047984	1948	K>N		No	ClinGen ExAC gnomAD
CA5047983 rs764881165	1950	L>F		No	ClinGen ExAC gnomAD
rs1303414489 CA373383942	1951	I>L		No	ClinGen TOPMed
CA373383928 rs1460518301	1951	I>M		No	ClinGen TOPMed gnomAD
rs143195358 CA5047982	1951	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs779613979 CA192770842	1952	E>Q		No	ClinGen Ensembl
rs1254797233 CA373383912	1952	E>V		No	ClinGen TOPMed
rs776261434 CA5047981	1953	C>R		No	ClinGen ExAC gnomAD
rs878966751 CA192770828	1954	A>V		No	ClinGen TOPMed gnomAD
rs771306375 CA5047977	1955	R>P		No	ClinGen ExAC TOPMed gnomAD
rs771306375 CA5047978	1955	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs760076950 CA5047980 COSM1229373	1955	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1172030566 CA373383855	1956	R>K		No	ClinGen gnomAD
rs763602150 CA5047962	1962	S>F		No	ClinGen ExAC gnomAD
CA5047959 rs755674368	1964	V>I		No	ClinGen ExAC TOPMed gnomAD
rs763617817 CA5047958	1966	A>P		No	ClinGen ExAC gnomAD
rs369224826 CA192770727	1973	R>C		No	ClinGen ESP TOPMed gnomAD
CA192770726 rs374829218	1975	T>I		No	ClinGen ESP
CA373383444 rs1587977709	1975	T>P		No	ClinGen Ensembl
CA373383376 rs1587977697	1980	T>P		No	ClinGen Ensembl
CA373383358 rs1223894509	1982	A>T		No	ClinGen TOPMed gnomAD
CA5047953 rs35642290	1984	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs35642290 CA5047952 VAR_055538	1984	A>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs780053028 CA5047951	1985	V>A		No	ClinGen ExAC gnomAD
CA5047950 rs772134028	1987	G>C		No	ClinGen ExAC TOPMed gnomAD
rs772134028 CA192770704	1987	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1235582549 CA373383276	1988	I>T		No	ClinGen TOPMed
CA5047949 rs745844999	1988	I>V		No	ClinGen ExAC gnomAD
CA373383265 rs1453658760	1989	I>L		No	ClinGen TOPMed gnomAD
rs1453658760 CA373383262	1989	I>V		No	ClinGen TOPMed gnomAD
rs149639715 CA5047947	1993	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5047946 rs753534027	1994	T>S		No	ClinGen ExAC gnomAD
rs1181900524 CA373383158	1996	I>V		No	ClinGen gnomAD
rs569058643 CA192770663	1999	A>T		No	ClinGen TOPMed
CA373383100 rs1249581446	2000	T>I		No	ClinGen TOPMed
rs1476056866 CA373383084	2001	A>G		No	ClinGen TOPMed
CA5047942 rs147500636	2005	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA192770654 rs1055810800	2006	R>C		No	ClinGen TOPMed gnomAD
rs759087292 CA5047941 COSM3943019	2006	R>H	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA373383007 rs759087292	2006	R>L		No	ClinGen ExAC TOPMed gnomAD
CA192770625 rs938264529	2010	E>K		No	ClinGen TOPMed gnomAD
rs1307932255 CA373382936	2011	T>S		No	ClinGen TOPMed
CA192770618 rs144809355	2013	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5047939 COSM186425 rs144809355	2013	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA373382873 rs1382059912	2016	R>Q		No	ClinGen gnomAD
CA5047937 rs769049532	2016	R>W		No	ClinGen ExAC TOPMed gnomAD
rs761077558 CA5047916	2017	E>G		No	ClinGen ExAC gnomAD
CA192770516 rs762781098	2017	E>Q		No	ClinGen Ensembl
CA192770493 rs879087301	2021	K>T		No	ClinGen TOPMed
rs72727037 CA192770485	2022	T>I		No	ClinGen 1000Genomes gnomAD
CA5047911 rs770989007	2025	V>L		No	ClinGen ExAC TOPMed gnomAD
rs770989007 CA373382694	2025	V>M		No	ClinGen ExAC TOPMed gnomAD
CA373382677 rs1217747118	2027	V>G		No	ClinGen TOPMed
rs1242336772 CA373382657	2028	E>D		No	ClinGen TOPMed
rs747927980 CA5047908	2030	T>I		No	ClinGen ExAC gnomAD
CA5047907 rs747927980	2030	T>S		No	ClinGen ExAC gnomAD
rs773175504 CA5047909	2030	T>S		No	ClinGen ExAC gnomAD
rs754612816 CA5047905	2032	V>G		No	ClinGen ExAC gnomAD
rs779775853 CA5047903	2034	V>G		No	ClinGen ExAC TOPMed gnomAD
CA5047901 rs754350709	2037	A>T		No	ClinGen ExAC TOPMed gnomAD
rs764608419 CA5047900	2038	A>T		No	ClinGen ExAC gnomAD
rs1480728267 CA373382490	2040	S>G		No	ClinGen gnomAD
rs534539011 CA192770437	2043	K>E		No	ClinGen 1000Genomes
rs1454358813 CA373382409	2045	A>T		No	ClinGen TOPMed
rs756462203 CA5047899	2045	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1439162078 CA373382390	2046	Q>*		No	ClinGen gnomAD
rs1250854579 CA373382371	2047	A>P		No	ClinGen gnomAD
CA373382320 rs1413111157	2049	Q>P		No	ClinGen TOPMed
rs759815488 CA5047896	2050	S>F		No	ClinGen ExAC TOPMed gnomAD
CA5047892 rs773046339	2052	V>E		No	ClinGen ExAC gnomAD
rs763070231 CA5047894	2052	V>L		No	ClinGen ExAC TOPMed gnomAD
CA5047893 rs763070231	2052	V>M		No	ClinGen ExAC TOPMed gnomAD
rs747900794 CA373382242	2053	A>G		No	ClinGen ExAC TOPMed gnomAD
CA373382251 rs1237029924	2053	A>T		No	ClinGen gnomAD
CA5047890 rs747900794 COSM1108724	2053	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1013321882 CA192770378	2055	I>V		No	ClinGen TOPMed
rs896203302 CA192770372	2056	T>N		No	ClinGen TOPMed
rs1587977452 CA373382190	2056	T>P		No	ClinGen Ensembl
rs768564215 CA5047888	2057	R>C		No	ClinGen ExAC TOPMed gnomAD
rs373576316 CA5047887	2057	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA192770358 rs757869013	2059	A>S		No	ClinGen ExAC TOPMed gnomAD
CA5047885 rs757869013	2059	A>T		No	ClinGen ExAC TOPMed gnomAD
CA5047884 rs745339374	2061	V>E		No	ClinGen ExAC gnomAD
rs1197617332 CA373382085	2065	G>S		No	ClinGen TOPMed
rs778144062 CA5047883	2066	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1179485684 CA373382013	2068	S>N		No	ClinGen TOPMed
CA373381970 rs1363911712	2070	G>V		No	ClinGen gnomAD
CA192770342 rs992376960	2074	P>A		No	ClinGen gnomAD
CA5047857 rs758590245	2079	V>I		No	ClinGen ExAC TOPMed gnomAD
rs750600117 CA5047856	2080	L>V		No	ClinGen ExAC gnomAD
CA192770178 rs754215577	2082	N>I		No	ClinGen Ensembl
rs761961290 CA5047854	2083	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1472459367 CA373381593	2084	V>A		No	ClinGen TOPMed
rs1164951972 CA373381571	2085	K>N		No	ClinGen gnomAD
CA373381491 rs1409021891	2089	K>N		No	ClinGen gnomAD
rs1010558566 CA192770155	2095	I>T		No	ClinGen TOPMed gnomAD
CA5047852 rs764082603	2096	S>R		No	ClinGen ExAC gnomAD
CA5047853 rs753849020	2096	S>T		No	ClinGen ExAC
CA192770146 rs532941560	2097	A>V		No	ClinGen 1000Genomes
rs760546504 CA5047851	2098	T>A		No	ClinGen ExAC TOPMed gnomAD
CA5047850 rs149573730	2098	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs966971440 CA192770143	2102	A>S		No	ClinGen TOPMed
rs150589376 CA5047848	2104	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs112062216 CA192770139	2105	V>I		No	ClinGen gnomAD
CA192770122 rs879002543	2108	D>G		No	ClinGen TOPMed gnomAD
rs770526341 CA5047846	2111	V>L		No	ClinGen ExAC gnomAD
rs748751139 CA5047845	2113	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs141770878 CA5047844	2115	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs746634982 CA192770059	2116	N>S		No	ClinGen Ensembl
CA5047827 rs759232681	2120	V>L		No	ClinGen ExAC gnomAD
rs1336553169 CA373380804	2121	M>V		No	ClinGen gnomAD
CA373380780 rs1476425423	2122	V>L		No	ClinGen TOPMed
rs774078738 CA5047826	2123	T>A		No	ClinGen ExAC gnomAD
rs1361450118 CA373380619	2129	L>P		No	ClinGen gnomAD
CA373380582 rs1418532640	2132	V>L		No	ClinGen gnomAD
rs1302719221 CA373380556	2134	A>T		No	ClinGen TOPMed gnomAD
rs373973771 CA5047824	2135	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs373973771 CA5047823	2135	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1440608491 CA373380349	2140	T>I		No	ClinGen gnomAD
rs1440608491 CA373380351	2140	T>S		No	ClinGen gnomAD
CA373380327 rs1427685052	2141	K>R		No	ClinGen TOPMed
CA5047822 rs769283876	2142	G>S		No	ClinGen ExAC gnomAD
CA5047821 rs144785896	2143	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA5047820 rs775836359	2144	R>Q		No	ClinGen ExAC gnomAD
rs145490598 CA5047818	2149	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs779196316 CA5047817	2149	T>I		No	ClinGen ExAC gnomAD
CA373380184 rs1287556766	2150	T>A		No	ClinGen gnomAD
rs370983784 CA5047815	2153	I>V		No	ClinGen ESP ExAC gnomAD
CA5047814 rs376777953	2154	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1057127324 CA192769862	2154	R>W		No	ClinGen TOPMed gnomAD
rs376996591 CA5047813	2157	L>Q		No	ClinGen ESP ExAC gnomAD
CA373380027 rs1381830057	2158	A>T		No	ClinGen gnomAD
rs1422769328 CA373380016	2158	A>V		No	ClinGen TOPMed gnomAD
rs1170295136 CA373378555	2160	F>C		No	ClinGen TOPMed
rs746256916 CA5047799	2163	P>L		No	ClinGen ExAC gnomAD
rs1587975662 CA373378503	2164	E>D		No	ClinGen Ensembl
CA5047798 rs776058619	2166	P>S		No	ClinGen ExAC gnomAD
rs1161833081 CA373378451	2169	T>A		No	ClinGen gnomAD
CA5047796 rs749560358	2169	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1587975653 CA373378431	2171	T>P		No	ClinGen Ensembl
CA5047795 rs778120838	2172	P>Q		No	ClinGen ExAC gnomAD
CA5047794 rs756242496	2177	R>G		No	ClinGen ExAC gnomAD
CA373378356 rs1425752432	2177	R>Q		No	ClinGen TOPMed gnomAD
rs1220555825 CA373378303	2181	G>D		No	ClinGen gnomAD
rs1587975643 CA373378286	2183	T>P		No	ClinGen Ensembl
rs781194388 CA5047792	2184	M>I		No	ClinGen ExAC gnomAD
rs879165236 CA192766428	2184	M>V		No	ClinGen TOPMed gnomAD
rs1587975634 CA373378248	2186	T>P		No	ClinGen Ensembl
rs201563518 CA5047790	2187	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1108718 rs201563518 CA373378232	2187	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA373378224 rs1232708700	2187	A>V		No	ClinGen TOPMed
CA5047788 rs758160563	2190	V>I		No	ClinGen ExAC gnomAD
rs764826141 CA5047786	2194	N>I		No	ClinGen ExAC TOPMed gnomAD
CA5047787 COSM132771 rs764826141	2194	N>S	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1285073586 CA373378123	2196	C>G		No	ClinGen TOPMed
CA5047785 rs761387809	2197	R>C		No	ClinGen ExAC TOPMed gnomAD
CA192766397 rs200428164	2197	R>H		No	ClinGen TOPMed
rs374219676 CA5047784	2199	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA373378087 rs1344898063	2199	E>K		No	ClinGen gnomAD
CA192766393 rs1019489575	2201	V>A		No	ClinGen Ensembl
rs74431517 CA192766389	2204	T>P		No	ClinGen Ensembl
rs1388740033 CA373378035	2207	L>V		No	ClinGen gnomAD
CA373378020 rs1297371769	2209	R>C		No	ClinGen gnomAD
CA192766363 rs1007964919	2209	R>H		No	ClinGen Ensembl
CA5047782 rs760027665	2210	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5047781 rs369648672	2210	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA192766359 rs760027665	2210	R>S		No	ClinGen ExAC TOPMed gnomAD
CA373378009 rs1171223488	2211	A>G		No	ClinGen gnomAD
rs138625537 CA5047780	2212	I>V		No	ClinGen ESP ExAC TOPMed
rs763362601 CA5047779	2213	A>T		No	ClinGen ExAC gnomAD
CA373377986 rs1200420015	2215	M>T		No	ClinGen gnomAD
CA192766331 rs770202937	2215	M>V		No	ClinGen gnomAD
CA5047777 rs769841997 COSM3848482	2217	R>Q	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA5047778 rs143073968	2217	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA192766318 rs11541910	2218	A>S		No	ClinGen gnomAD
CA5047776 rs148578435	2218	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1260409827 CA373377959	2220	K>E		No	ClinGen gnomAD
rs771935637 CA5047750	2221	E>K		No	ClinGen ExAC gnomAD
rs1386215958 CA373377929	2222	A>G		No	ClinGen TOPMed
rs149034259 CA192766206	2223	A>T		No	ClinGen ESP
CA192766202 rs879119546	2224	Y>C		No	ClinGen TOPMed
CA373377902 rs1383597850	2226	P>L		No	ClinGen gnomAD
CA5047749 rs745787793	2229	A>P		No	ClinGen ExAC TOPMed gnomAD
rs1421107023 CA373377880	2230	P>S		No	ClinGen gnomAD
rs749106140 CA192766181	2232	V>L		No	ClinGen ExAC gnomAD
rs749106140 CA5047747	2232	V>M		No	ClinGen ExAC gnomAD
CA373377863 rs544154004	2233	R>L		No	ClinGen ExAC TOPMed gnomAD
CA5047745 rs544154004	2233	R>P		No	ClinGen ExAC TOPMed gnomAD
CA5047744 rs544154004	2233	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5047746 rs748941469	2233	R>W		No	ClinGen ExAC TOPMed gnomAD
CA5047743 rs752190315	2235	R>Q		No	ClinGen ExAC gnomAD
CA373377837 rs767008341	2238	H>L		No	ClinGen ExAC TOPMed gnomAD
CA5047742 rs767008341	2238	H>R		No	ClinGen ExAC TOPMed gnomAD
CA5047739 rs144879123	2241	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs750965317 CA5047740	2241	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1245521985 CA373377797	2244	A>G		No	ClinGen gnomAD
rs1252630461 CA373377795	2245	N>H		No	ClinGen TOPMed
CA5047738 rs368513332	2245	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA5047737 rs776747087	2246	G>A		No	ClinGen ExAC gnomAD
rs1285792192 CA373377787	2246	G>S		No	ClinGen gnomAD
rs374151556 CA5047736	2249	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA373377762 rs1295788569	2250	L>V		No	ClinGen gnomAD
rs760753833 CA5047735	2253	H>R		No	ClinGen ExAC gnomAD
rs1587975092 CA373377710	2257	T>P		No	ClinGen Ensembl
CA5047717 rs775657730	2258	L>V		No	ClinGen ExAC gnomAD
rs1563937617 CA373377702	2259	Q>K		No	ClinGen Ensembl
CA373377684 rs1190725309 COSM1108714	2261	P>S	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1329833033 CA373377674	2262	S>R		No	ClinGen TOPMed
CA373377669 rs1342638389	2263	P>L		No	ClinGen TOPMed
CA5047714 rs774185391	2271	G>E		No	ClinGen ExAC TOPMed gnomAD
CA5047712 rs749052015	2272	H>R		No	ClinGen ExAC gnomAD
rs770836745 CA5047713	2272	H>Y		No	ClinGen ExAC gnomAD
rs1200443234 CA373377604	2273	S>A		No	ClinGen gnomAD
CA5047711 rs773118269	2275	R>C		No	ClinGen ExAC TOPMed gnomAD
rs773118269 CA373377590	2275	R>G		No	ClinGen ExAC TOPMed gnomAD
rs73438721 CA5047710	2275	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1217021624 CA373377586	2276	V>L		No	ClinGen gnomAD
CA5047708 rs780974070	2280	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1196681235 CA373377552	2282	E>K		No	ClinGen TOPMed
CA373377532 rs1376609089	2284	I>M		No	ClinGen gnomAD
rs768307016 CA5047707	2286	A>T		No	ClinGen ExAC gnomAD
CA373377513 rs1467615008	2287	A>V		No	ClinGen gnomAD
rs1265006010 CA373377512	2288	E>K		No	ClinGen TOPMed
CA373377499 rs1401722475	2289	A>V		No	ClinGen gnomAD
CA192765508 rs780140944	2292	G>E		No	ClinGen TOPMed gnomAD
CA5047686 rs746625724	2293	T>A		No	ClinGen ExAC gnomAD
rs1303480705 CA373376628	2299	E>D		No	ClinGen gnomAD
rs1587974875 CA373376607	2300	D>A		No	ClinGen Ensembl
rs1272933392 CA373376551	2303	V>D		No	ClinGen TOPMed
rs771447783 CA5047683	2304	I>V		No	ClinGen ExAC gnomAD
rs778203119 CA5047681	2308	E>Q		No	ClinGen ExAC gnomAD
rs1355759744 CA373376405	2309	L>V		No	ClinGen TOPMed
rs752991296 CA5047679	2311	G>R		No	ClinGen ExAC gnomAD
rs1162478099 CA373376376	2311	G>V		No	ClinGen gnomAD
rs781408239 CA5047678	2312	A>P		No	ClinGen ExAC gnomAD
rs1486983988 CA373376323	2315	A>T		No	ClinGen TOPMed gnomAD
rs1450474693 CA373376249	2318	A>T		No	ClinGen TOPMed
rs1216869896 CA373376206	2320	A>T		No	ClinGen gnomAD
CA5047674 rs762923546	2322	K>N		No	ClinGen ExAC gnomAD
rs750413519 CA5047673	2324	E>K		No	ClinGen ExAC TOPMed gnomAD
rs147951718 CA5047672	2327	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA373375990 rs117039868	2329	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5047669 rs768328246	2329	R>P		No	ClinGen ExAC TOPMed gnomAD
rs768328246 CA5047670	2329	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs117039868 CA5047671	2329	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA373375981 rs1280248661	2330	A>T		No	ClinGen TOPMed gnomAD
rs368994558 CA5047668	2330	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1391551183 CA373375943	2332	P>A		No	ClinGen TOPMed
rs1487450968 CA373375803	2337	E>K		No	ClinGen TOPMed gnomAD
rs773910550 CA5047645	2338	S>C		No	ClinGen ExAC TOPMed gnomAD
CA373375765 rs1254019628	2340	N>T		No	ClinGen gnomAD
rs748693979 CA5047643	2343	E>D		No	ClinGen ExAC gnomAD
CA373375718 rs1456728372	2343	E>Q		No	ClinGen TOPMed gnomAD
rs1240499457 CA373375713	2343	E>V		No	ClinGen TOPMed gnomAD
CA5047642 rs777100987	2345	I>T		No	ClinGen ExAC gnomAD
CA373375626 rs1348952155	2350	K>R		No	ClinGen gnomAD
rs780331136 CA5047639	2351	S>F		No	ClinGen ExAC TOPMed gnomAD
CA373375561 rs1587974693	2352	I>M		No	ClinGen Ensembl
rs572853368 CA192765339	2357	S>N		No	ClinGen TOPMed gnomAD
rs1242109986 CA373375392	2358	A>V		No	ClinGen TOPMed
CA5047634 rs753847404	2362	A>T		No	ClinGen ExAC gnomAD
rs763897212 CA5047633	2363	A>V		No	ClinGen ExAC gnomAD
rs773963763 CA5047628	2370	L>V		No	ClinGen ExAC gnomAD
rs765923768 CA5047627	2371	V>A		No	ClinGen ExAC gnomAD
rs1442390327 CA373375147	2371	V>M		No	ClinGen gnomAD
CA192765247 rs377411171	2376	V>M		No	ClinGen ESP TOPMed gnomAD
rs776040475 CA5047604	2377	G>D		No	ClinGen ExAC TOPMed gnomAD
CA373374950 rs776040475	2377	G>V		No	ClinGen ExAC TOPMed gnomAD
rs772585317 CA5047603	2378	A>T		No	ClinGen ExAC gnomAD
rs144875708 CA5047602	2378	A>V		No	ClinGen ESP ExAC gnomAD
CA5047601 rs774718226	2379	I>F		No	ClinGen ExAC gnomAD
rs1401457998 CA373374902	2380	P>L		No	ClinGen gnomAD
CA5047599 rs775393589	2382	N>S		No	ClinGen ExAC gnomAD
CA5047598 rs777783366	2383	A>V		No	ClinGen ExAC gnomAD
rs941317380 CA192765238	2385	D>N		No	ClinGen gnomAD
CA192765234 rs886924508	2391	Q>E		No	ClinGen gnomAD
CA373374719 rs1191675783	2392	G>D		No	ClinGen gnomAD
CA373374599 rs556571189	2398	R>L		No	ClinGen 1000Genomes TOPMed
CA192765202 rs556571189	2398	R>Q		No	ClinGen 1000Genomes TOPMed
CA373374605 rs1200484122	2398	R>W		No	ClinGen gnomAD
CA373374577 rs1307513373	2400	V>M		No	ClinGen gnomAD
rs200286479 CA5047577 COSM1108710	2402	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1587974433 CA373374535	2404	T>P		No	ClinGen Ensembl
rs147275602 CA5047574	2405	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1587974416 CA373374415	2412	N>H		No	ClinGen Ensembl
CA5047572 rs745524706	2413	A>V		No	ClinGen ExAC gnomAD
rs1397057712 CA373374364	2416	Q>*		No	ClinGen gnomAD
CA373374359 rs1452475426	2416	Q>R		No	ClinGen TOPMed
rs778584411 CA5047571	2417	G>S		No	ClinGen ExAC gnomAD
CA5047570 rs756724126	2418	H>R		No	ClinGen ExAC TOPMed gnomAD
CA5047569 rs753329869	2427	S>P		No	ClinGen ExAC TOPMed gnomAD
rs755608601 CA5047567	2429	K>Q		No	ClinGen ExAC gnomAD
CA373374217 rs1236375862	2430	Q>L		No	ClinGen gnomAD
rs1239007791 CA373374032	2443	K>R		No	ClinGen gnomAD
CA5047563 rs773339165	2447	D>A		No	ClinGen ExAC gnomAD
rs1445829432 CA373373964	2448	Q>*		No	ClinGen gnomAD
rs1445829432 CA373373962	2448	Q>K		No	ClinGen gnomAD
rs913381794 CA192765175 COSM487428	2450	S>L	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1217495611 CA373373848	2454	K>N		No	ClinGen gnomAD
rs1419379866 CA373373841	2455	R>*		No	ClinGen TOPMed gnomAD
CA373373715 rs1442005264	2458	A>G		No	ClinGen TOPMed
CA5047545 rs555751291	2458	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1192375694 CA373373698	2459	A>V		No	ClinGen gnomAD
rs762166245 CA5047543	2462	A>T		No	ClinGen ExAC gnomAD
CA5047542 rs754032655	2465	R>Q		No	ClinGen ExAC gnomAD
CA5047541 rs764178055	2468	D>G		No	ClinGen ExAC gnomAD
CA5047540 rs760702598	2469	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs775408333 CA5047539	2475	Q>R		No	ClinGen ExAC gnomAD
CA5047538 rs771985775	2476	K>E		No	ClinGen ExAC gnomAD
rs1332685594 CA373373422	2480	F>L		No	ClinGen TOPMed
rs759375838 CA5047537	2482	E>A		No	ClinGen ExAC gnomAD
CA5047536 rs774268390	2483	Q>H		No	ClinGen ExAC gnomAD
CA373373304 rs1442995061	2486	E>K		No	ClinGen gnomAD
rs748999092 CA5047534	2494	M>I		No	ClinGen ExAC gnomAD
rs1463570444 CA373373108	2496	G>S		No	ClinGen gnomAD
CA192765109 rs1014017315	2497	G>S		No	ClinGen Ensembl
rs769461396 CA5047532	2497	G>V		No	ClinGen ExAC gnomAD
CA192765106 rs1034707935	2498	I>V		No	ClinGen TOPMed
rs1432274064 CA373373045	2499	A>V		No	ClinGen gnomAD
rs895664543 CA192765103	2500	Q>L		No	ClinGen Ensembl
CA5047505 COSM1108708 rs148513341	2503	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA192765019 rs370137759	2513	R>Q		No	ClinGen ESP
rs1195830701 CA373372717	2514	E>Q		No	ClinGen gnomAD
rs1307631134 CA373372653	2518	A>T		No	ClinGen gnomAD
rs1394876123 CA373372638	2519	R>W		No	ClinGen TOPMed gnomAD
rs954831035 CA192765017	2520	K>N		No	ClinGen Ensembl
rs1235966423 CA373372630	2520	K>Q		No	ClinGen gnomAD
CA192765014 rs902731014	2523	A>G		No	ClinGen TOPMed gnomAD
rs1314310484 CA373372510	2526	R>Q		No	ClinGen gnomAD
CA373372418 rs1298910771	2529	Q>P		No	ClinGen TOPMed
rs751547692 CA5047502	2536	E>D		No	ClinGen ExAC TOPMed gnomAD
CA5047503 rs754964639	2536	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1276610928 CA373372234	2538	R>*		No	ClinGen TOPMed
rs1468937293 CA373372202	2539	D>V		No	ClinGen gnomAD
CA373372155 rs1365992523	2541	H>P		No	ClinGen gnomAD
rs754137494 CA5047501	2542	H>L		No	ClinGen ExAC gnomAD

No associated diseases with Q9Y490

9 regional properties for Q9Y490

Type	Name	Position	InterPro Accession
domain	FERM domain	86 - 403	IPR000299
domain	I/LWEQ domain	2293 - 2533	IPR002558
domain	Talin, central	491 - 652	IPR015224
conserved_site	FERM conserved site	173 - 201	IPR019747-1
conserved_site	FERM conserved site	283 - 312	IPR019747-2
domain	FERM central domain	202 - 313	IPR019748
domain	Band 4.1 domain	82 - 313	IPR019749
domain	Talin, N-terminal F0 domain	4 - 83	IPR032425
domain	Talin-1/2, rod-segment	1654 - 1826	IPR037438

Functions

		Description
EC Number
Subcellular Localization	Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton Cell surface Cell junction, focal adhesion	Colocalizes with LAYN at the membrane ruffles Localized preferentially in focal adhesions than fibrillar adhesions (By similarity)
PANTHER Family	PTHR19981	TALIN
PANTHER Subfamily	PTHR19981:SF7	TALIN-1
PANTHER Protein Class
PANTHER Pathway Category	Integrin signalling pathway Talin

10 GO annotations of cellular component

Name	Definition
adherens junction	A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
cell surface	The external part of the cell wall and/or plasma membrane.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
ruffle	Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
ruffle membrane	The portion of the plasma membrane surrounding a ruffle.

8 GO annotations of molecular function

Name	Definition
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
integrin binding	Binding to an integrin.
LIM domain binding	Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.
phosphatidylinositol binding	Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphatidylserine binding	Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
structural constituent of cytoskeleton	The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
vinculin binding	Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane.

7 GO annotations of biological process

Name	Definition
cell-cell adhesion	The attachment of one cell to another cell via adhesion molecules.
cell-cell junction assembly	The aggregation, arrangement and bonding together of a set of components to form a junction between cells.
cell-substrate junction assembly	The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.
cortical actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
integrin activation	The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands.
integrin-mediated signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
platelet aggregation	The adhesion of one platelet to one or more other platelets via adhesion molecules.

14 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q32LP0	FERMT3	Fermitin family homolog 3	Bos taurus (Bovine)	SS
P54939	TLN1	Talin-1	Gallus gallus (Chicken)	SS
Q9VZI3	Fit1	Unc-112-related protein	Drosophila melanogaster (Fruit fly)	SS
Q9Y4G6	TLN2	Talin-2	Homo sapiens (Human)	SS
Q96AC1	FERMT2	Fermitin family homolog 2	Homo sapiens (Human)	SS
Q86UX7	FERMT3	Fermitin family homolog 3	Homo sapiens (Human)	EV
Q9BQL6	FERMT1	Fermitin family homolog 1	Homo sapiens (Human)	SS
Q71LX4	Tln2	Talin-2	Mus musculus (Mouse)	SS
P26039	Tln1	Talin-1	Mus musculus (Mouse)	EV
Q8K1B8	Fermt3	Fermitin family homolog 3	Mus musculus (Mouse)	SS
P59113	Fermt1	Fermitin family homolog 1	Mus musculus (Mouse)	SS
Q8CIB5	Fermt2	Fermitin family homolog 2	Mus musculus (Mouse)	SS
Q18685	unc-112	Protein unc-112	Caenorhabditis elegans	SS
F1Q8X5	fermt2	Fermitin family homolog 2	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MVALSLKISI	GNVVKTMQFE	PSTMVYDACR	IIRERIPEAP	AGPPSDFGLF	LSDDDPKKGI
70	80	90	100	110	120
WLEAGKALDY	YMLRNGDTME	YRKKQRPLKI	RMLDGTVKTI	MVDDSKTVTD	MLMTICARIG
130	140	150	160	170	180
ITNHDEYSLV	RELMEEKKEE	ITGTLRKDKT	LLRDEKKMEK	LKQKLHTDDE	LNWLDHGRTL
190	200	210	220	230	240
REQGVEEHET	LLLRRKFFYS	DQNVDSRDPV	QLNLLYVQAR	DDILNGSHPV	SFDKACEFAG
250	260	270	280	290	300
FQCQIQFGPH	NEQKHKAGFL	DLKDFLPKEY	VKQKGERKIF	QAHKNCGQMS	EIEAKVRYVK
310	320	330	340	350	360
LARSLKTYGV	SFFLVKEKMK	GKNKLVPRLL	GITKECVMRV	DEKTKEVIQE	WNLTNIKRWA
370	380	390	400	410	420
ASPKSFTLDF	GDYQDGYYSV	QTTEGEQIAQ	LIAGYIDIIL	KKKKSKDHFG	LEGDEESTML
430	440	450	460	470	480
EDSVSPKKST	VLQQQYNRVG	KVEHGSVALP	AIMRSGASGP	ENFQVGSMPP	AQQQITSGQM
490	500	510	520	530	540
HRGHMPPLTS	AQQALTGTIN	SSMQAVQAAQ	ATLDDFDTLP	PLGQDAASKA	WRKNKMDESK
550	560	570	580	590	600
HEIHSQVDAI	TAGTASVVNL	TAGDPAETDY	TAVGCAVTTI	SSNLTEMSRG	VKLLAALLED
610	620	630	640	650	660
EGGSGRPLLQ	AAKGLAGAVS	ELLRSAQPAS	AEPRQNLLQA	AGNVGQASGE	LLQQIGESDT
670	680	690	700	710	720
DPHFQDALMQ	LAKAVASAAA	ALVLKAKSVA	QRTEDSGLQT	QVIAAATQCA	LSTSQLVACT
730	740	750	760	770	780
KVVAPTISSP	VCQEQLVEAG	RLVAKAVEGC	VSASQAATED	GQLLRGVGAA	ATAVTQALNE
790	800	810	820	830	840
LLQHVKAHAT	GAGPAGRYDQ	ATDTILTVTE	NIFSSMGDAG	EMVRQARILA	QATSDLVNAI
850	860	870	880	890	900
KADAEGESDL	ENSRKLLSAA	KILADATAKM	VEAAKGAAAH	PDSEEQQQRL	REAAEGLRMA
910	920	930	940	950	960
TNAAAQNAIK	KKLVQRLEHA	AKQAAASATQ	TIAAAQHAAS	TPKASAGPQP	LLVQSCKAVA
970	980	990	1000	1010	1020
EQIPLLVQGV	RGSQAQPDSP	SAQLALIAAS	QSFLQPGGKM	VAAAKASVPT	IQDQASAMQL
1030	1040	1050	1060	1070	1080
SQCAKNLGTA	LAELRTAAQK	AQEACGPLEM	DSALSVVQNL	EKDLQEVKAA	ARDGKLKPLP
1090	1100	1110	1120	1130	1140
GETMEKCTQD	LGNSTKAVSS	AIAQLLGEVA	QGNENYAGIA	ARDVAGGLRS	LAQAARGVAA
1150	1160	1170	1180	1190	1200
LTSDPAVQAI	VLDTASDVLD	KASSLIEEAK	KAAGHPGDPE	SQQRLAQVAK	AVTQALNRCV
1210	1220	1230	1240	1250	1260
SCLPGQRDVD	NALRAVGDAS	KRLLSDSLPP	STGTFQEAQS	RLNEAAAGLN	QAATELVQAS
1270	1280	1290	1300	1310	1320
RGTPQDLARA	SGRFGQDFST	FLEAGVEMAG	QAPSQEDRAQ	VVSNLKGISM	SSSKLLLAAK
1330	1340	1350	1360	1370	1380
ALSTDPAAPN	LKSQLAAAAR	AVTDSINQLI	TMCTQQAPGQ	KECDNALREL	ETVRELLENP
1390	1400	1410	1420	1430	1440
VQPINDMSYF	GCLDSVMENS	KVLGEAMTGI	SQNAKNGNLP	EFGDAISTAS	KALCGFTEAA
1450	1460	1470	1480	1490	1500
AQAAYLVGVS	DPNSQAGQQG	LVEPTQFARA	NQAIQMACQS	LGEPGCTQAQ	VLSAATIVAK
1510	1520	1530	1540	1550	1560
HTSALCNSCR	LASARTTNPT	AKRQFVQSAK	EVANSTANLV	KTIKALDGAF	TEENRAQCRA
1570	1580	1590	1600	1610	1620
ATAPLLEAVD	NLSAFASNPE	FSSIPAQISP	EGRAAMEPIV	ISAKTMLESA	GGLIQTARAL
1630	1640	1650	1660	1670	1680
AVNPRDPPSW	SVLAGHSRTV	SDSIKKLITS	MRDKAPGQLE	CETAIAALNS	CLRDLDQASL
1690	1700	1710	1720	1730	1740
AAVSQQLAPR	EGISQEALHT	QMLTAVQEIS	HLIEPLANAA	RAEASQLGHK	VSQMAQYFEP
1750	1760	1770	1780	1790	1800
LTLAAVGAAS	KTLSHPQQMA	LLDQTKTLAE	SALQLLYTAK	EAGGNPKQAA	HTQEALEEAV
1810	1820	1830	1840	1850	1860
QMMTEAVEDL	TTTLNEAASA	AGVVGGMVDS	ITQAINQLDE	GPMGEPEGSF	VDYQTTMVRT
1870	1880	1890	1900	1910	1920
AKAIAVTVQE	MVTKSNTSPE	ELGPLANQLT	SDYGRLASEA	KPAAVAAENE	EIGSHIKHRV
1930	1940	1950	1960	1970	1980
QELGHGCAAL	VTKAGALQCS	PSDAYTKKEL	IECARRVSEK	VSHVLAALQA	GNRGTQACIT
1990	2000	2010	2020	2030	2040
AASAVSGIIA	DLDTTIMFAT	AGTLNREGTE	TFADHREGIL	KTAKVLVEDT	KVLVQNAAGS
2050	2060	2070	2080	2090	2100
QEKLAQAAQS	SVATITRLAD	VVKLGAASLG	AEDPETQVVL	INAVKDVAKA	LGDLISATKA
2110	2120	2130	2140	2150	2160
AAGKVGDDPA	VWQLKNSAKV	MVTNVTSLLK	TVKAVEDEAT	KGTRALEATT	EHIRQELAVF
2170	2180	2190	2200	2210	2220
CSPEPPAKTS	TPEDFIRMTK	GITMATAKAV	AAGNSCRQED	VIATANLSRR	AIADMLRACK
2230	2240	2250	2260	2270	2280
EAAYHPEVAP	DVRLRALHYG	RECANGYLEL	LDHVLLTLQK	PSPELKQQLT	GHSKRVAGSV
2290	2300	2310	2320	2330	2340
TELIQAAEAM	KGTEWVDPED	PTVIAENELL	GAAAAIEAAA	KKLEQLKPRA	KPKEADESLN
2350	2360	2370	2380	2390	2400
FEEQILEAAK	SIAAATSALV	KAASAAQREL	VAQGKVGAIP	ANALDDGQWS	QGLISAARMV
2410	2420	2430	2440	2450	2460
AAATNNLCEA	ANAAVQGHAS	QEKLISSAKQ	VAASTAQLLV	ACKVKADQDS	EAMKRLQAAG
2470	2480	2490	2500	2510	2520
NAVKRASDNL	VKAAQKAAAF	EEQENETVVV	KEKMVGGIAQ	IIAAQEEMLR	KERELEEARK
2530	2540
KLAQIRQQQY	KFLPSELRDE	H