AiPD: Autoinhibited Protein Database

Q9Y371

Gene name	SH3GLB1 (KIAA0491, CGI-61)
Protein name	Endophilin-B1
Names	Bax-interacting factor 1, Bif-1, SH3 domain-containing GRB2-like protein B1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51100
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

44-115 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

44-115 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q9Y371

Entry ID	Method	Resolution	Chain	Position	Source
6UP6	EM	900 A	A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/a/b/c/d/e/f/g/h	1-365	PDB
6UPN	EM	1000 A	A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/X/Y/a/b/c/d/e/f	1-365	PDB
AF-Q9Y371-F1	Predicted				AlphaFoldDB

212 variants for Q9Y371

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA341125202 rs1570397844	2	N>S		No	ClinGen Ensembl
CA341125212 rs754775213	3	I>M		No	ClinGen ExAC gnomAD
rs1389288016 CA341125207	3	I>V		No	ClinGen gnomAD
CA936154 rs199927597	4	M>K		No	ClinGen 1000Genomes ExAC gnomAD
CA936153 rs199927597	4	M>T		No	ClinGen 1000Genomes ExAC gnomAD
CA936152 rs778761098	4	M>V		No	ClinGen ExAC gnomAD
rs773104832 CA25925845	5	D>N		No	ClinGen Ensembl
rs776538627 CA936155	7	N>S		No	ClinGen ExAC gnomAD
rs1347775293 CA341125244	8	V>L		No	ClinGen gnomAD
rs1017850515 CA25925846	9	K>R		No	ClinGen TOPMed
TCGA novel	11	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341125308 rs1176860347	18	F>L		No	ClinGen gnomAD
rs774085197 CA25925848	22	A>T		No	ClinGen gnomAD
CA936160 rs764542244	22	A>V		No	ClinGen ExAC gnomAD
rs762195846 CA936162	23	V>L		No	ClinGen ExAC gnomAD
rs1307565672 CA341125373	26	T>A		No	ClinGen TOPMed
CA936188 rs764915947	28	E>Q		No	ClinGen ExAC gnomAD
TCGA novel	29	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1467874963 CA341125418	32	Q>L		No	ClinGen gnomAD
CA936189 rs752385047	33	A>T		No	ClinGen ExAC gnomAD
CA341125482 rs1249889155	41	H>L		No	ClinGen gnomAD
CA341125479 rs1558300465	41	H>Y		No	ClinGen Ensembl
rs777505306 CA936191	44	N>K		No	ClinGen ExAC TOPMed gnomAD
rs758241962 CA936190	44	N>T		No	ClinGen ExAC gnomAD
TCGA novel	45	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757330913 CA341125512	46	L>I		No	ClinGen ExAC gnomAD
rs757330913 CA936193	46	L>V		No	ClinGen ExAC gnomAD
rs369632434 CA936194	47	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA341125527 rs1416623991	48	K>I		No	ClinGen TOPMed gnomAD
CA341125530 CA341125531 rs1458106954	48	K>N		No	ClinGen TOPMed gnomAD
CA341125528 rs1416623991	48	K>R		No	ClinGen TOPMed gnomAD
CA341125545 rs1322953743	50	E>D		No	ClinGen gnomAD
CA936195 rs749429791	51	C>Y		No	ClinGen ExAC gnomAD
CA936197 rs779312362	54	I>T		No	ClinGen ExAC gnomAD
CA936196 rs550301160	54	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1434972542 CA341125572	55	W>R		No	ClinGen TOPMed
CA936198 rs748397689	65	V>A		No	ClinGen ExAC TOPMed gnomAD
rs201622706 CA936213	72	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA25927470 rs911801011	73	A>S		No	ClinGen TOPMed
CA341126071 rs1208187006	74	R>K		No	ClinGen TOPMed gnomAD
CA341126082 rs1176678218	75	I>V		No	ClinGen TOPMed
CA936214 rs778949424	78	F>L		No	ClinGen ExAC TOPMed gnomAD
rs748392734 CA936215	79	V>I		No	ClinGen ExAC gnomAD
CA341126154 rs1469962206	80	Y>C		No	ClinGen TOPMed gnomAD
CA341126151 rs1230774626	80	Y>D		No	ClinGen gnomAD
TCGA novel	84	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341126206 rs1192130798	87	A>V		No	ClinGen gnomAD
COSM912830 CA25927471 rs778164999	90	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA936217 rs778164999	90	R>G		No	ClinGen ExAC gnomAD
CA936218 rs747420023	90	R>H		No	ClinGen ExAC gnomAD
rs777152064 CA936221	91	I>M		No	ClinGen ExAC TOPMed gnomAD
CA936219 rs143094715	91	I>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA936222 rs142378035	92	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	93	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1441282660 CA341126278	99	Q>K		No	ClinGen TOPMed gnomAD
CA936225 rs369336536	99	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA25927474 rs139332321	100	Y>C		No	ClinGen ESP
rs774149973 CA936226	100	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs774149973 CA341126285	100	Y>N		No	ClinGen ExAC TOPMed gnomAD
rs1279456935 CA341126306	102	I>M		No	ClinGen gnomAD
rs1327264404 CA341126314	103	D>E		No	ClinGen TOPMed
CA341126307 rs1342290652	103	D>N		No	ClinGen gnomAD
rs1196974944 CA341126325	105	G>A		No	ClinGen TOPMed gnomAD
rs1196974944 CA341126326	105	G>E		No	ClinGen TOPMed gnomAD
CA25927475 rs12035024	106	T>I		No	ClinGen TOPMed
CA341126331 rs12035024	106	T>S		No	ClinGen TOPMed
CA936230 rs568537654	111	G>R		No	ClinGen ExAC TOPMed gnomAD
CA341126408 rs1316076642	116	N>I		No	ClinGen gnomAD
CA341126411 rs1352154834	117	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA341126458 rs766272139	123	E>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	123	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs150243965 CA936250	124	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA936254 rs757532954	130	T>R		No	ClinGen ExAC gnomAD
CA25927798 rs990914248	136	I>T		No	ClinGen Ensembl
CA936255 rs112687194	137	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA936256 rs112687194	137	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA936257 rs777019424	138	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA341126552 rs1261589668	138	T>P		No	ClinGen gnomAD
rs748766833 CA936259	142	N>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	143	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	143	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1358566715 CA341126592	144	L>V		No	ClinGen TOPMed
rs946702002 CA25927799	145	T>A		No	ClinGen Ensembl
CA341126603 rs1474987320	146	P>A		No	ClinGen gnomAD
CA341126605 rs1164018187	146	P>L		No	ClinGen gnomAD
TCGA novel	150	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778625773 CA936261	151	I>L		No	ClinGen ExAC gnomAD
TCGA novel	153	G>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1280287373 CA341126666	155	Y>N		No	ClinGen gnomAD
CA341126675 rs1414930911	156	K>E		No	ClinGen gnomAD
rs150004536 CA936263	158	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs202154654 CA936264	159	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs144540011 CA936265	159	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA936286 rs371893206	164	L>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1253361628 CA341126764	167	N>S		No	ClinGen gnomAD
CA936290 rs201518937	173	D>V		No	ClinGen 1000Genomes ExAC gnomAD
CA341126813 rs1454513118	174	A>D		No	ClinGen TOPMed gnomAD
CA341126815 rs1454513118	174	A>V		No	ClinGen TOPMed gnomAD
rs925229886 CA25927972	175	A>T		No	ClinGen Ensembl
rs759734266 CA936292	177	T>M		No	ClinGen ExAC TOPMed gnomAD
CA25927973 rs1037727894	178	R>K		No	ClinGen TOPMed gnomAD
rs774365922 CA936295	180	K>R		No	ClinGen ExAC gnomAD
rs761912992 CA936296	183	K>N		No	ClinGen ExAC TOPMed gnomAD
CA341126898 rs1252653068	187	T>S		No	ClinGen TOPMed
CA936363 rs767051848	191	S>C		No	ClinGen ExAC gnomAD
rs1570288411 CA341128005	192	E>V		No	ClinGen Ensembl
CA341128016 rs1404546915	194	E>K		No	ClinGen Ensembl
CA936365 rs760302020	197	I>V		No	ClinGen ExAC TOPMed gnomAD
CA936366 rs766046170	199	Q>R		No	ClinGen ExAC gnomAD
CA341128060 rs1290921745	200	S>N		No	ClinGen TOPMed
COSM350131 rs753595065 CA936367	203	D>Y	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs370892729 CA936368	204	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1209805059 CA341128104	206	A>E		No	ClinGen gnomAD
TCGA novel	206	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA936369 rs778655002	208	I>V		No	ClinGen ExAC gnomAD
rs1191092462 CA341128127	210	R>G		No	ClinGen gnomAD
CA936371 rs532928583	211	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs753201405 CA25929003	214	E>K		No	ClinGen Ensembl
CA936373 rs745993375	216	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1162603980 CA341128179	218	S>N		No	ClinGen gnomAD
CA936375 rs375726643	219	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs558475875 CA25929006	220	H>R		No	ClinGen TOPMed gnomAD
rs749607204 CA936376	220	H>Y		No	ClinGen ExAC gnomAD
rs750491388 CA936393	222	H>R		No	ClinGen ExAC gnomAD
TCGA novel rs1348691053 CA341128227	223	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
TCGA novel	224	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA25929038 rs954237126	225	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs756276751 COSM912836 CA936394	225	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1483030619 CA341128256	228	N>S		No	ClinGen gnomAD
rs780338485 CA936395	230	F>S		No	ClinGen ExAC TOPMed gnomAD
CA341128295 rs1558331225	233	A>V		No	ClinGen Ensembl
rs1251006835 CA341128303	234	Q>H		No	ClinGen gnomAD
rs749520521 CA936396	235	M>V		No	ClinGen ExAC TOPMed gnomAD
CA936397 rs755193646	238	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA341128329 rs755193646	238	Y>S		No	ClinGen ExAC gnomAD
CA341128336 rs1454377376	239	A>E		No	ClinGen gnomAD
TCGA novel	243	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341128375 rs1558331371	244	Y>C		No	ClinGen Ensembl
CA25929040 rs962441730	245	M>V		No	ClinGen Ensembl
rs1244013916 CA341128390	246	L>S		No	ClinGen TOPMed
COSM3977942 rs965425782 CA25929041	249	Q>R	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
rs773708467 CA936401	253	G>E		No	ClinGen ExAC gnomAD
CA341128627 rs1443520705	257	S>Y		No	ClinGen TOPMed
CA341128634 rs1292256271	258	N>S		No	ClinGen TOPMed gnomAD
CA936418 rs200898007	261	S>G		No	ClinGen 1000Genomes ExAC gnomAD
rs1298069442 CA341128659	262	N>H		No	ClinGen gnomAD
rs977731111 CA25929790	262	N>K		No	ClinGen TOPMed
rs533090731 COSM1474232 CA936419	264	N>S	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
TCGA novel	265	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1216610042 CA341128697	267	S>P		No	ClinGen gnomAD
rs1570303311 CA341128698	267	S>Y		No	ClinGen Ensembl
CA341128712 rs1335181821	269	T>K		No	ClinGen gnomAD
rs1215518202 CA341128715	270	P>S		No	ClinGen gnomAD
rs977708561 CA25929792	271	V>A		No	ClinGen Ensembl
CA25929793 rs924839928	275	L>S		No	ClinGen gnomAD
CA341128743 rs1186588275	275	L>V		No	ClinGen TOPMed gnomAD
rs1305391140 CA341128750	276	P>S		No	ClinGen TOPMed gnomAD
CA25929794 COSM912838 rs933506005	278	A>V	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA936424 rs769448209	280	G>R		No	ClinGen ExAC gnomAD
rs762724218 CA936427	283	A>S		No	ClinGen ExAC gnomAD
rs768566057 CA936428	283	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	285	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs553134523 CA25929795	285	A>V		No	ClinGen Ensembl
rs1454429938 CA341128821	288	S>G		No	ClinGen gnomAD
CA341128827 rs1290672871	288	S>R		No	ClinGen gnomAD
rs1570303567 CA341128829	289	G>S		No	ClinGen Ensembl
rs1338775943 CA341128835	290	L>I		No	ClinGen gnomAD
CA341128848 rs1388018305	292	I>F		No	ClinGen TOPMed
CA341128847 rs1388018305	292	I>V		No	ClinGen TOPMed
TCGA novel	294	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1402694426 CA341128875	296	S>F		No	ClinGen TOPMed
CA936429 rs774326140	297	N>S		No	ClinGen ExAC gnomAD
CA341128880 rs774326140	297	N>T		No	ClinGen ExAC gnomAD
rs1294089639 CA341128887	298	L>R		No	ClinGen gnomAD
TCGA novel	301	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341128910 rs1570303658	301	L>P		No	ClinGen Ensembl
CA936430 rs761818187	303	E>K		No	ClinGen ExAC gnomAD
CA936431 rs767582673	305	S>N		No	ClinGen ExAC gnomAD
rs1321017409 CA341128945	306	G>D		No	ClinGen gnomAD
CA25929797 rs924214132	307	S>N		No	ClinGen TOPMed
rs753911559 CA341128954	307	S>R		No	ClinGen ExAC gnomAD
rs942472279 CA25929798	311	R>S		No	ClinGen Ensembl
CA341128987 rs1570303762	312	V>G		No	ClinGen Ensembl
TCGA novel	313	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs138533867 CA936433	314	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs138533867 CA25929799	314	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA936434 rs562974321	317	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs758689550 CA936436	320	N>D		No	ClinGen ExAC TOPMed gnomAD
rs1187286476 CA341129054	322	T>I		No	ClinGen TOPMed
rs113079556 CA25929800	324	L>S		No	ClinGen Ensembl
rs1420179278 CA341129092	328	A>V		No	ClinGen gnomAD
CA936439 rs757714891	330	E>D		No	ClinGen ExAC gnomAD
rs1464793993 CA341129104	330	E>G		No	ClinGen TOPMed
rs752866014 CA936454	336	S>R		No	ClinGen ExAC gnomAD
CA25929875 rs1043283757	339	G>E		No	ClinGen gnomAD
rs904322583 CA25929876	340	M>I		No	ClinGen Ensembl
CA341129201 rs1358367325	343	D>N		No	ClinGen TOPMed gnomAD
rs1358367325 CA341129203	343	D>Y		No	ClinGen TOPMed gnomAD
TCGA novel	344	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341129229 rs1442596792	346	M>I		No	ClinGen TOPMed gnomAD
CA341129232 rs1358450575	347	G>R		No	ClinGen gnomAD
CA341129242 rs1570305273	348	E>G		No	ClinGen Ensembl
TCGA novel	348	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	350	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763143617 CA936455 CA341129254	350	G>R		No	ClinGen ExAC gnomAD
CA936456 rs764325200	351	N>S		No	ClinGen ExAC gnomAD
rs369315549 CA936457	353	K>N		No	ClinGen ESP ExAC gnomAD
CA341129285 rs1346443340	354	G>D		No	ClinGen gnomAD
TCGA novel	355	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341129299 rs1570305360	356	V>G		No	ClinGen Ensembl
CA341129334 rs1200896962	362	E>K		No	ClinGen gnomAD
COSM1344681 rs1248562743 CA341129357	365	N>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD

No associated diseases with Q9Y371

2 regional properties for Q9Y371

Type	Name	Position	InterPro Accession
domain	Phospholipid/glycerol acyltransferase	229 - 353	IPR002123
domain	Lysophosphatidylcholine acyltransferase LPCAT1-like	218 - 427	IPR045252

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Golgi apparatus membrane ; Peripheral membrane protein Mitochondrion outer membrane ; Peripheral membrane protein Cytoplasmic vesicle, autophagosome membrane Midbody	Association with the Golgi apparatus depends on the cell type (By similarity) Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes (PubMed:17891140)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
autophagosome membrane	The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle	A vesicle found in the cytoplasm of a cell.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
mitochondrial outer membrane	The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

4 GO annotations of molecular function

Name	Definition
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
identical protein binding	Binding to an identical protein or proteins.
lipid binding	Binding to a lipid.
protein homodimerization activity	Binding to an identical protein to form a homodimer.

17 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
autophagic cell death	A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.
autophagy	The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
cellular response to amino acid starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
cellular response to glucose starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
membrane fission	A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes.
membrane organization	A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
positive regulation of autophagosome assembly	Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly.
positive regulation of autophagy	Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
positive regulation of membrane tubulation	Any process that activates or increases the frequency, rate or extent of membrane tubulation.
positive regulation of protein targeting to mitochondrion	Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
positive regulation of protein-containing complex assembly	Any process that activates or increases the frequency, rate or extent of protein complex assembly.
protein localization to vacuolar membrane	A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane.
receptor catabolic process	The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
regulation of cytokinesis	Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
regulation of macroautophagy	Any process that modulates the frequency, rate or extent of macroautophagy.
regulation of protein stability	Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.

13 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2KJA1	SH3GL1	Endophilin-A2	Bos taurus (Bovine)	PR
Q8AXV1	SH3GL2	Endophilin-A1	Gallus gallus (Chicken)	PR
Q5HYK7	SH3D19	SH3 domain-containing protein 19	Homo sapiens (Human)	PR
Q99962	SH3GL2	Endophilin-A1	Homo sapiens (Human)	PR
Q99961	SH3GL1	Endophilin-A2	Homo sapiens (Human)	PR
Q99963	SH3GL3	Endophilin-A3	Homo sapiens (Human)	PR
Q9Y5K6	CD2AP	CD2-associated protein	Homo sapiens (Human)	SS
Q96B97	SH3KBP1	SH3 domain-containing kinase-binding protein 1	Homo sapiens (Human)	EV
Q9JK48	Sh3glb1	Endophilin-B1	Mus musculus (Mouse)	PR
Q62419	Sh3gl1	Endophilin-A2	Mus musculus (Mouse)	PR
Q62420	Sh3gl2	Endophilin-A1	Mus musculus (Mouse)	PR
Q6AYE2	Sh3glb1	Endophilin-B1	Rattus norvegicus (Rat)	PR
O35179	Sh3gl2	Endophilin-A1	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MNIMDFNVKK	LAADAGTFLS	RAVQFTEEKL	GQAEKTELDA	HLENLLSKAE	CTKIWTEKIM
70	80	90	100	110	120
KQTEVLLQPN	PNARIEEFVY	EKLDRKAPSR	INNPELLGQY	MIDAGTEFGP	GTAYGNALIK
130	140	150	160	170	180
CGETQKRIGT	ADRELIQTSA	LNFLTPLRNF	IEGDYKTIAK	ERKLLQNKRL	DLDAAKTRLK
190	200	210	220	230	240
KAKAAETRNS	SEQELRITQS	EFDRQAEITR	LLLEGISSTH	AHHLRCLNDF	VEAQMTYYAQ
250	260	270	280	290	300
CYQYMLDLQK	QLGSFPSNYL	SNNNQTSVTP	VPSVLPNAIG	SSAMASTSGL	VITSPSNLSD
310	320	330	340	350	360
LKECSGSRKA	RVLYDYDAAN	STELSLLADE	VITVFSVVGM	DSDWLMGERG	NQKGKVPITY

LELLN