AiPD: Autoinhibited Protein Database

Q9Y2H1

Gene name	STK38L
Protein name	Serine/threonine-protein kinase 38-like
Names	NDR2 protein kinase, Nuclear Dbf2-related kinase 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23012
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class	SERINE/THREONINE-PROTEIN KINASE (PTHR24356)

Descriptions

STK38L, called nuclear Dbf2-related kinase 2 (NDR2 protein kinase), is a subclass of the AGC family of protein kinases that are involved in the regulation of cell division and cell morphology. NDR kinase activity is regulated by phosphorylation and by the Ca2+-binding protein, S100B.
A common feature of the NDR family of kinases is an insert in the catalytic domain of 30 - 60 amino acids between subdomains VII and VIII. The insert sequence is not highly conserved but contains in all cases many positively charged amino acids. Mutations of the residues within the insert (autoinhibitory element) increase kinase activity and the binding of MOB1 or S100B to the N-terminal domain (SMA domain) of NDR induces the release of autoinhibition.

Autoinhibitory domains (AIDs)

Target domain	90-383 (Protein kinase domain)
Relief mechanism	Partner binding
Assay	Mutagenesis experiment

AID

265-276 (Autoinhibitory segment)

Target domain

90-383 (Protein kinase domain)

Relief mechanism

Partner binding (Binding of MOB1 or S100B to the N-terminal SMA domain)

Assay

Mutagenesis experiment

Accessory elements

230-242 (Activation loop from InterPro)

Target domain	90-383 (Protein kinase domain)
Relief mechanism
Assay

279-288 (Activation loop from InterPro)

Target domain	90-383 (Protein kinase domain)
Relief mechanism
Assay

References

Bichsel SJ et al. (2004) "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein", The Journal of biological chemistry, 279, 35228-35

Stegert MR et al. (2004) "Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein", The Journal of biological chemistry, 279, 23806-12

Autoinhibited structure

Activated structure

2 structures for Q9Y2H1

Entry ID	Method	Resolution	Chain	Position	Source
5XQZ	X-ray	210 A	C/D	25-87	PDB
AF-Q9Y2H1-F1	Predicted				AlphaFoldDB

207 variants for Q9Y2H1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1326997121 CA384333636	3	M>V		No	ClinGen TOPMed
rs769405820 CA6491904	4	T>M		No	ClinGen ExAC TOPMed gnomAD
CA384333655 rs1380088858	6	G>R		No	ClinGen TOPMed
CA384333660 rs1392192254	6	G>V		No	ClinGen TOPMed
CA384333663 rs1325173205	7	T>A		No	ClinGen gnomAD
CA234870968 rs1000113203	8	T>P		No	ClinGen TOPMed
rs368306630 CA6491908	10	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1417616236 CA384333684	11	F>L		No	ClinGen TOPMed
CA6491910 rs761216778	13	M>I		No	ClinGen ExAC gnomAD
CA6491911 rs761216778	13	M>I		No	ClinGen ExAC gnomAD
CA384333700 rs1349582007	13	M>T		No	ClinGen gnomAD
rs774479388 CA6491909	13	M>V		No	ClinGen ExAC gnomAD
rs147758452 CA6491912	15	N>S		No	ClinGen ESP ExAC gnomAD
rs147758452 CA234870969	15	N>T		No	ClinGen ESP ExAC gnomAD
CA6491913 rs760392409	17	T>N		No	ClinGen ExAC gnomAD
CA384333732 rs1376483908	18	R>Q		No	ClinGen TOPMed gnomAD
COSM693528 CA384333731 rs1213566302	18	R>W	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA384333773 rs1439884455	24	A>V		No	ClinGen gnomAD
rs766678690 CA6491914	25	K>R		No	ClinGen ExAC gnomAD
CA234870970 rs1056825424	27	T>A		No	ClinGen gnomAD
rs1468742613 CA384333791	27	T>I		No	ClinGen gnomAD
rs372289940 CA6491916	31	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA384333856 rs1461007837	36	I>S		No	ClinGen gnomAD
CA384333860 rs1164100345	37	L>*		No	ClinGen gnomAD
CA384333869 rs1193082021	38	Q>R		No	ClinGen TOPMed
CA234870971 COSM938387 rs912875222	40	E>G	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
CA384333903 rs1411436687	43	E>K		No	ClinGen gnomAD
rs145124460 CA234871369	47	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA234871370 rs905792857	49	L>*		No	ClinGen Ensembl
CA384333977 rs1175342637	51	V>A		No	ClinGen gnomAD
rs148355950 CA6491935	52	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776310727 CA6491936	62	E>K		No	ClinGen ExAC gnomAD
rs1246036634 CA384334101	67	R>*		No	ClinGen TOPMed
CA234871998 rs948046373	67	R>Q		No	ClinGen TOPMed gnomAD
rs577911410 CA6491954	70	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA234872000 rs779068249	71	A>V		No	ClinGen Ensembl
CA6491956 rs773060776	72	R>C		No	ClinGen ExAC TOPMed gnomAD
rs746501951 CA6491957 COSM430965	72	R>H	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA384334132 rs746501951	72	R>L		No	ClinGen ExAC TOPMed gnomAD
CA384334130 rs773060776	72	R>S		No	ClinGen ExAC TOPMed gnomAD
CA384334140 rs1455860370	73	K>N		No	ClinGen TOPMed
CA234872001 rs1045151675	75	T>R		No	ClinGen TOPMed
CA6491958 rs770482297	79	R>Q		No	ClinGen ExAC gnomAD
CA384334187 rs1215430681	80	L>R		No	ClinGen gnomAD
rs770083865 CA6491961	81	K>R		No	ClinGen ExAC gnomAD
rs1189320275 CA384334219	85	L>H		No	ClinGen gnomAD
rs1252214201 CA384334233	87	L>F		No	ClinGen gnomAD
rs1591928487 CA384334237	88	D>G		No	ClinGen Ensembl
CA6491962 rs775944298	88	D>Y		No	ClinGen ExAC
CA384334260 rs1591928496	91	E>A		No	ClinGen Ensembl
CA384334265 rs1591928517	92	S>A		No	ClinGen Ensembl
CA384334289 rs1591928544	95	V>G		No	ClinGen Ensembl
CA384334284 rs1409067668	95	V>I		No	ClinGen gnomAD
CA6491965 rs752064286	97	G>R		No	ClinGen ExAC gnomAD
CA6491966 rs150452352	98	R>K		No	ClinGen ESP ExAC
rs529033839 CA6491985	105	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs774856321 CA6491983	105	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1377110922 CA384334399	110	K>N		No	ClinGen gnomAD
rs1565551229 CA384334401	111	D>H		No	ClinGen Ensembl
CA6491987 rs760873616	115	I>V		No	ClinGen ExAC gnomAD
CA6491988 rs766597994	116	Y>H		No	ClinGen ExAC gnomAD
CA384334456 rs1307830246	119	K>Q		No	ClinGen gnomAD
rs867685921 CA234872114	124	S>F		No	ClinGen Ensembl
rs899114142 CA234872113	124	S>P		No	ClinGen Ensembl
CA384334516 rs1272030961	127	L>V		No	ClinGen gnomAD
rs1483641457 CA384334538	130	E>*		No	ClinGen TOPMed
CA384334551 rs1486417528	131	Q>H		No	ClinGen gnomAD
CA234872428 rs1024350437	135	I>V		No	ClinGen TOPMed
rs1372876016 CA384334589	136	R>*		No	ClinGen TOPMed gnomAD
rs757083298 CA6492014	136	R>Q		No	ClinGen ExAC gnomAD
rs1041370466 CA234872429	140	D>G		No	ClinGen Ensembl
CA384334626 rs1317351285	141	I>T		No	ClinGen TOPMed
CA384334634 rs767429248	142	L>F		No	ClinGen ExAC TOPMed gnomAD
CA384334683 rs1565553392	149	W>C		No	ClinGen Ensembl
CA6492018 rs779445140	152	K>R		No	ClinGen ExAC
CA384334725 rs1378160207	155	Y>C		No	ClinGen TOPMed
CA384334729 rs1275642921	156	S>G		No	ClinGen gnomAD
rs754620405 CA6492020	158	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA384334748 rs754620405	158	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA234872431 rs896953858	159	D>N		No	ClinGen Ensembl
CA384334762 rs113318303	160	K>M		No	ClinGen gnomAD
CA234872432 rs113318303	160	K>R		No	ClinGen gnomAD
rs1591936213 CA384334803	166	I>N		No	ClinGen Ensembl
CA384334829 rs1471240770	169	F>C		No	ClinGen gnomAD
rs1157556024 CA384334833	170	L>F		No	ClinGen TOPMed
rs1157556024 CA384334834	170	L>I		No	ClinGen TOPMed
rs138365234 CA234872434	172	G>R		No	ClinGen ESP
CA6492021 rs778752373	172	G>V		No	ClinGen ExAC gnomAD
rs1226109707 CA384334878	175	M>T		No	ClinGen gnomAD
rs1212113825 CA384334970	188	E>K		No	ClinGen gnomAD
rs887848651 CA234872615	190	T>I		No	ClinGen TOPMed gnomAD
CA234872616 rs1006329365	191	Q>*		No	ClinGen gnomAD
CA384334991 rs1006329365	191	Q>K		No	ClinGen gnomAD
rs142852159 CA234872617	191	Q>R		No	ClinGen ESP
CA384335003 rs1272772856	192	F>L		No	ClinGen gnomAD
COSM2156614 rs759763204 CA6492031	194	I>V	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6492033 rs534311579	199	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA6492032 rs765344869	199	L>V		No	ClinGen ExAC gnomAD
rs761591925 CA6492035	203	A>G		No	ClinGen ExAC gnomAD
rs761591925 CA6492034	203	A>V		No	ClinGen ExAC gnomAD
rs1248786013 CA384335082	205	H>Y		No	ClinGen gnomAD
rs1411491277 CA384335105	208	G>C		No	ClinGen gnomAD
CA384335104 rs1411491277	208	G>R		No	ClinGen gnomAD
rs1411491277 CA384335103	208	G>S		No	ClinGen gnomAD
rs750304673 CA6492036	211	H>R		No	ClinGen ExAC gnomAD
rs1034073326 CA234872618	212	R>W		No	ClinGen Ensembl
CA6492037 rs756030339	218	N>D		No	ClinGen ExAC gnomAD
CA6492038 rs765875075	220	L>V		No	ClinGen ExAC gnomAD
rs1282998442 CA384335209	223	A>D		No	ClinGen gnomAD
rs1341875905 CA384335218	224	K>N		No	ClinGen gnomAD
CA384335239 rs1297241017	226	H>D		No	ClinGen gnomAD
CA384335238 rs1297241017	226	H>N		No	ClinGen gnomAD
CA384335278 rs1236711543	231	D>G		No	ClinGen TOPMed gnomAD
CA384335296 rs1417705057	234	L>V		No	ClinGen TOPMed
rs1198858335 CA384335315	236	T>M		No	ClinGen gnomAD
rs1247126976 CA384335422	251	T>I		No	ClinGen gnomAD
CA384335427 rs1047907482	252	H>L		No	ClinGen TOPMed
CA234872655 rs146061018	252	H>Q		No	ClinGen ESP TOPMed gnomAD
CA234872654 rs1047907482	252	H>R		No	ClinGen TOPMed
rs1267026235 CA384335433	253	N>S		No	ClinGen TOPMed
CA6492061 rs758962045	254	P>L		No	ClinGen ExAC gnomAD
CA6492062 rs764841037	256	S>N		No	ClinGen ExAC gnomAD
rs1565555314 CA384335448	256	S>R		No	ClinGen Ensembl
rs752335839 CA6492063	257	D>A		No	ClinGen ExAC TOPMed gnomAD
rs758144760 CA6492064	258	F>L		No	ClinGen ExAC gnomAD
CA384335494 rs1456745082	260	F>L		No	ClinGen gnomAD
CA6492092 rs780581159	262	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1224542455 CA384335587	273	K>*		No	ClinGen TOPMed
CA384335682 rs1428780208	285	G>R		No	ClinGen TOPMed gnomAD
rs1277603083 CA384335747	294	V>A		No	ClinGen TOPMed
rs767735353 CA6492106	306	W>R		No	ClinGen ExAC gnomAD
CA6492108 rs756523656	312	I>M		No	ClinGen ExAC gnomAD
CA6492109 rs370057147	313	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1227178811 CA384335909	316	M>T		No	ClinGen gnomAD
CA6492110 rs754414646	317	L>Q		No	ClinGen ExAC
rs1272087052 CA384335915	317	L>V		No	ClinGen TOPMed gnomAD
CA384336058 rs1216585861	325	S>F		No	ClinGen gnomAD
rs753220093 CA234872868	330	E>G		No	ClinGen Ensembl
rs1478456390 CA384336121	332	Y>*		No	ClinGen gnomAD
CA384336161 rs1235475420	338	W>G		No	ClinGen gnomAD
rs907788113 CA234872869	339	K>R		No	ClinGen TOPMed
CA6492135 rs780018860 COSM938391	343	V>I	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed
rs780018860 CA384336197	343	V>L		No	ClinGen ExAC TOPMed
CA6492138 rs768609762	350	I>T		No	ClinGen ExAC
CA384336243 rs1264670263	350	I>V		No	ClinGen TOPMed
CA6492139 rs778767565	353	K>N		No	ClinGen ExAC TOPMed gnomAD
CA384336273 rs1318225136	354	A>V		No	ClinGen gnomAD
rs747683104 CA6492140	356	D>N		No	ClinGen ExAC TOPMed gnomAD
COSM72837 rs1436693470 CA384336303	359	L>I	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1273933914 CA384336308	359	L>R		No	ClinGen gnomAD
CA384336304 rs1436693470	359	L>V		No	ClinGen gnomAD
rs1416945370 CA384336336	362	C>S		No	ClinGen gnomAD
CA6492160 rs771556609	363	I>T		No	ClinGen ExAC TOPMed gnomAD
CA384336359 rs1325373369	365	S>A		No	ClinGen TOPMed
rs1357487141 CA384336367	366	E>A		No	ClinGen gnomAD
rs974955187 CA234873008	369	I>L		No	ClinGen TOPMed gnomAD
rs746621114 CA6492162	370	G>A		No	ClinGen ExAC TOPMed gnomAD
rs770537407 CA6492163	371	N>S		No	ClinGen ExAC gnomAD
CA384336423 rs1251113269	374	V>A		No	ClinGen gnomAD
rs1482145772 CA384336429	375	E>G		No	ClinGen gnomAD
rs373198367 CA234873009	379	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA6492164 rs370464943	379	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs373198367 CA6492165	379	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA384336460 rs1472997308	380	H>D		No	ClinGen gnomAD
rs770122828 CA384336471	381	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6492166 rs770122828	381	P>R		No	ClinGen ExAC TOPMed gnomAD
rs763392599 CA6492168	383	F>S		No	ClinGen ExAC gnomAD
rs763392599 CA6492169	383	F>Y		No	ClinGen ExAC gnomAD
rs1191103152 CA384336508	387	D>N		No	ClinGen TOPMed
CA384336527 rs1369369010	389	E>G		No	ClinGen gnomAD
rs148477448 CA6492170	391	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA384336547 rs1591947927	392	R>K		No	ClinGen Ensembl
CA384336682 rs1235703958	393	E>K		No	ClinGen gnomAD
CA6492191 rs773421696	396	A>V		No	ClinGen ExAC gnomAD
rs1344459477 CA384336710	397	A>S		No	ClinGen gnomAD
rs1007662676 CA234873249	398	I>V		No	ClinGen Ensembl
CA384336727 rs1199775474	400	I>L		No	ClinGen gnomAD
rs760825755 CA6492192	400	I>M		No	ClinGen ExAC gnomAD
rs1261252858 CA384336730	400	I>T		No	ClinGen gnomAD
CA384336728 rs1199775474	400	I>V		No	ClinGen gnomAD
CA6492193 rs765046515	403	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1247184826 CA384336780	407	D>A		No	ClinGen gnomAD
rs1247184826 CA384336781	407	D>G		No	ClinGen gnomAD
rs1306127143 CA384336800	410	N>T		No	ClinGen TOPMed gnomAD
rs1426322752 CA384336812	411	F>L		No	ClinGen gnomAD
CA384336821 rs1419089559	413	D>N		No	ClinGen TOPMed
CA6492195 rs752407589	416	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1477434761 CA384336853	417	S>Y		No	ClinGen gnomAD
CA384336916 rs1289164996	425	N>D		No	ClinGen TOPMed
rs1390210241 CA384336923	426	T>A		No	ClinGen gnomAD
CA6492211 rs191809701	426	T>N		No	ClinGen 1000Genomes ExAC gnomAD
CA384336947 rs1309886488	429	P>L		No	ClinGen TOPMed gnomAD
CA384336960 rs1399195893	431	Y>C		No	ClinGen TOPMed
CA384336968 rs1338106126	432	K>R		No	ClinGen TOPMed
CA384337036 rs1246799003	441	Y>F		No	ClinGen gnomAD
CA6492218 rs751440994	445	R>S		No	ClinGen ExAC TOPMed gnomAD
CA6492217 rs751440994	445	R>S		No	ClinGen ExAC TOPMed gnomAD
CA6492222 rs779567614	452	R>C		No	ClinGen ExAC gnomAD
CA234873252 rs958417948	452	R>H		No	ClinGen Ensembl
CA6492223 rs753543098	454	S>C		No	ClinGen ExAC gnomAD
CA234873253 rs956455616	455	I>M		No	ClinGen TOPMed
rs755333316 CA6492224	455	I>V		No	ClinGen ExAC gnomAD
CA384337140 rs1256620426	457	T>I		No	ClinGen Ensembl
rs1165841350 CA384337142	458	Y>H		No	ClinGen gnomAD
rs367624705 CA6492226	459	M>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA6492225 rs374704707	459	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs772432092 CA6492227	462	G>A		No	ClinGen ExAC gnomAD

No associated diseases with Q9Y2H1

9 regional properties for Q9Y2H1

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	62 - 310	IPR000719-1
domain	Protein kinase domain	407 - 664	IPR000719-2
domain	AGC-kinase, C-terminal	311 - 380	IPR000961
active_site	Serine/threonine-protein kinase, active site	183 - 195	IPR008271-1
active_site	Serine/threonine-protein kinase, active site	520 - 532	IPR008271-2
binding_site	Protein kinase, ATP binding site	68 - 94	IPR017441-1
binding_site	Protein kinase, ATP binding site	413 - 436	IPR017441-2
domain	Protein kinase, C-terminal	333 - 370	IPR017892
domain	Ribosomal S6 kinase, N-terminal catalytic domain	66 - 371	IPR041906

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Cytoplasm, cytoskeleton Membrane	Associated with the actin cytoskeleton Co-localizes with STK24/MST3 in the membrane
PANTHER Family	PTHR24356	SERINE/THREONINE-PROTEIN KINASE
PANTHER Subfamily	PTHR24356:SF160	SERINE_THREONINE-PROTEIN KINASE 38-LIKE
PANTHER Protein Class	non-receptor serine/threonine protein kinase protein modifying enzyme
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

6 GO annotations of molecular function

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding	Binding to a magnesium (Mg) ion.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

4 GO annotations of biological process

Name	Definition
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of cellular component organization	Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

28 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P53894	CBK1	Serine/threonine-protein kinase CBK1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
A2VDV2	STK38	Serine/threonine-protein kinase 38	Bos taurus (Bovine)	SS
Q9NBK5	trc	Serine/threonine-protein kinase tricornered	Drosophila melanogaster (Fruit fly)	SS
Q96LW2	RSKR	Ribosomal protein S6 kinase-related protein	Homo sapiens (Human)	PR
O15530	PDPK1	3-phosphoinositide-dependent protein kinase 1	Homo sapiens (Human)	EV
Q05513	PRKCZ	Protein kinase C zeta type	Homo sapiens (Human)	SS
P41743	PRKCI	Protein kinase C iota type	Homo sapiens (Human)	EV
Q16512	PKN1	Serine/threonine-protein kinase N1	Homo sapiens (Human)	EV
Q6P5Z2	PKN3	Serine/threonine-protein kinase N3	Homo sapiens (Human)	SS
Q16513	PKN2	Serine/threonine-protein kinase N2	Homo sapiens (Human)	EV
P24723	PRKCH	Protein kinase C eta type	Homo sapiens (Human)	SS
Q02156	PRKCE	Protein kinase C epsilon type	Homo sapiens (Human)	SS
Q04759	PRKCQ	Protein kinase C theta type	Homo sapiens (Human)	PR
Q05655	PRKCD	Protein kinase C delta type	Homo sapiens (Human)	SS
P17252	PRKCA	Protein kinase C alpha type	Homo sapiens (Human)	EV
P05129	PRKCG	Protein kinase C gamma type	Homo sapiens (Human)	SS
P05771	PRKCB	Protein kinase C beta type	Homo sapiens (Human)	SS
P31751	AKT2	RAC-beta serine/threonine-protein kinase	Homo sapiens (Human)	EV SS
P31749	AKT1	RAC-alpha serine/threonine-protein kinase	Homo sapiens (Human)	EV
Q9Y243	AKT3	RAC-gamma serine/threonine-protein kinase	Homo sapiens (Human)	SS
Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	Homo sapiens (Human)	SS
Q9HBY8	SGK2	Serine/threonine-protein kinase Sgk2	Homo sapiens (Human)	SS
O00141	SGK1	Serine/threonine-protein kinase Sgk1	Homo sapiens (Human)	PR
Q15208	STK38	Serine/threonine-protein kinase 38	Homo sapiens (Human)	EV
Q6A1A2	PDPK2P	Putative 3-phosphoinositide-dependent protein kinase 2	Homo sapiens (Human)	PR
Q91VJ4	Stk38	Serine/threonine-protein kinase 38	Mus musculus (Mouse)	SS
Q7TSE6	Stk38l	Serine/threonine-protein kinase 38-like	Mus musculus (Mouse)	SS
Q2L6W9	sax-1	Serine/threonine-protein kinase sax-1	Caenorhabditis elegans	SS

10	20	30	40	50	60
MAMTAGTTTT	FPMSNHTRER	VTVAKLTLEN	FYSNLILQHE	ERETRQKKLE	VAMEEEGLAD
70	80	90	100	110	120
EEKKLRRSQH	ARKETEFLRL	KRTRLGLDDF	ESLKVIGRGA	FGEVRLVQKK	DTGHIYAMKI
130	140	150	160	170	180
LRKSDMLEKE	QVAHIRAERD	ILVEADGAWV	VKMFYSFQDK	RNLYLIMEFL	PGGDMMTLLM
190	200	210	220	230	240
KKDTLTEEET	QFYISETVLA	IDAIHQLGFI	HRDIKPDNLL	LDAKGHVKLS	DFGLCTGLKK
250	260	270	280	290	300
AHRTEFYRNL	THNPPSDFSF	QNMNSKRKAE	TWKKNRRQLA	YSTVGTPDYI	APEVFMQTGY
310	320	330	340	350	360
NKLCDWWSLG	VIMYEMLIGY	PPFCSETPQE	TYRKVMNWKE	TLVFPPEVPI	SEKAKDLILR
370	380	390	400	410	420
FCIDSENRIG	NSGVEEIKGH	PFFEGVDWEH	IRERPAAIPI	EIKSIDDTSN	FDDFPESDIL
430	440	450	460
QPVPNTTEPD	YKSKDWVFLN	YTYKRFEGLT	QRGSIPTYMK	AGKL