AiPD: Autoinhibited Protein Database

Q9Y232

Gene name	CDYL
Protein name	Chromodomain Y-like protein
Names	CDY-like, Crotonyl-CoA hydratase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9425
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

115-259 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

115-259 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q9Y232

Entry ID	Method	Resolution	Chain	Position	Source
2DNT	NMR	-	A	63-119	PDB
2GTR	X-ray	190 A	A/B/C	338-598	PDB
7N27	X-ray	185 A	A/B/C/D/E/F	62-113	PDB
AF-Q9Y232-F1	Predicted				AlphaFoldDB

380 variants for Q9Y232

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA3622425 VAR_032936 rs3812179	2	T>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs753465732 CA3622426	2	T>I		No	ClinGen ExAC TOPMed gnomAD
CA362637793 rs3812179	2	T>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs3812179 CA362637794	2	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3622428 rs764688356	4	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA3622429 rs752130129	5	A>E		No	ClinGen ExAC TOPMed gnomAD
CA3622431 rs781624523	7	H>R		No	ClinGen ExAC gnomAD
CA3622430 COSM3949285 rs148239840	7	H>Y	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
VAR_032937 CA3622432 rs3812178	9	S>P		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs3812178 CA362637838	9	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA134200520 rs969199144	10	A>P		No	ClinGen gnomAD
rs778194226 CA3622434	11	W>*		No	ClinGen ExAC
CA3622433 rs756536468	11	W>*		No	ClinGen ExAC gnomAD
rs756536468 CA362637852	11	W>L		No	ClinGen ExAC gnomAD
rs1219867736 CA362637849	11	W>R		No	ClinGen gnomAD
CA134200525 rs371683698	12	G>E		No	ClinGen ESP TOPMed gnomAD
CA362637855 rs1582271866	12	G>R		No	ClinGen Ensembl
CA3622435 rs749493194	13	K>I		No	ClinGen ExAC gnomAD
CA362637864 rs749493194	13	K>R		No	ClinGen ExAC gnomAD
TCGA novel	14	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	14	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779073346 CA3622438	17	K>*		No	ClinGen ExAC gnomAD
CA362637892 rs1561819738	17	K>T		No	ClinGen Ensembl
TCGA novel CA362637900 rs1408669280	18	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
CA362637912 rs1162407948	19	W>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA134200535 rs749250122	19	W>L		No	ClinGen Ensembl
CA362637915 rs1351446666	20	Q>*		No	ClinGen gnomAD
rs146548277 CA3622439	21	Y>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148796217 CA134200540	22	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746826274 CA3622442	22	E>D		No	ClinGen ExAC gnomAD
rs148796217 CA3622441	22	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3622443 rs573907785	23	G>A		No	ClinGen 1000Genomes ExAC gnomAD
rs776296290 CA3622444	25	T>I		No	ClinGen ExAC TOPMed gnomAD
rs764741482 CA3622446	26	Q>*		No	ClinGen ExAC
rs142478254 CA3622448	27	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA362637967 rs1582271964	28	L>*		No	ClinGen Ensembl
rs1455117441 TCGA novel CA362637971	29	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed NCI-TCGA
CA362637981 rs1257035146	30	L>P		No	ClinGen gnomAD
rs753228046 CA3622450	31	K>E		No	ClinGen ExAC TOPMed gnomAD
CA134200556 rs571956532	32	R>I		No	ClinGen ExAC gnomAD
CA3622451 rs571956532	32	R>T		No	ClinGen ExAC gnomAD
rs542544380 CA3622452	33	N>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1205442663 CA362637997	33	N>S		No	ClinGen TOPMed
CA3622453 rs754122072	34	N>T		No	ClinGen ExAC gnomAD
rs372317441 CA3622455	35	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1376616410 CA362638022	36	S>T		No	ClinGen gnomAD
CA134205234 rs905054750	37	A>V		No	ClinGen Ensembl
rs140565156 CA3622474	39	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1315621398 CA362638055	41	P>H		No	ClinGen TOPMed
rs758036367 CA134205236	42	S>P		No	ClinGen Ensembl
rs1582294085 CA362638066	43	D>A		No	ClinGen Ensembl
rs1296703993 CA362638081	45	S>T		No	ClinGen gnomAD
rs757680739 CA3622475	46	I>V		No	ClinGen ExAC gnomAD
TCGA novel	47	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs13196069 VAR_032938 CA3622479	48	V>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA3622478 rs750626007	48	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA362638112 rs1280593516	50	S>N		No	ClinGen TOPMed gnomAD
rs1348481331 CA362638117	51	E>K		No	ClinGen TOPMed gnomAD
rs751512230 CA3622481	52	Q>*		No	ClinGen ExAC gnomAD
TCGA novel	52	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	53	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM596823 CA3622484 rs375915779	54	G>R	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA3622486 rs777334119	55	A>V		No	ClinGen ExAC gnomAD
rs965102780 CA134205238	58	P>S		No	ClinGen TOPMed
CA362638173 rs1561830267	59	P>S		No	ClinGen Ensembl
VAR_032939 CA3622490 rs28360500	60	A>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA3622489 rs773840585	60	A>T		No	ClinGen ExAC gnomAD
rs777252998 CA3622492	62	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA3622491 rs769340906	62	Q>R		No	ClinGen ExAC gnomAD
CA362654020 rs1373358695	63	V>I		No	ClinGen gnomAD
CA3622528 rs778746146	64	E>D		No	ClinGen ExAC gnomAD
rs538333704 CA133860329	65	R>K		No	ClinGen Ensembl
rs1383897072 CA362654384	73	K>N		No	ClinGen TOPMed
CA362654378 rs1400344750	73	K>R		No	ClinGen TOPMed
rs1561689754 CA362654405	74	K>R		No	ClinGen Ensembl
CA362654420 rs1156650190	75	G>R		No	ClinGen TOPMed
TCGA novel	76	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1080046 rs1186573267 CA362654583	82	R>Q	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA133860336 rs930012575	87	D>A		No	ClinGen TOPMed
rs770399503 CA3622533	88	S>I		No	ClinGen ExAC gnomAD
rs770399503 CA362654687	88	S>T		No	ClinGen ExAC gnomAD
rs377393556 CA3622537	91	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs145622412 CA3622541	100	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs764138201 CA3622542	104	E>A		No	ClinGen ExAC gnomAD
TCGA novel	104	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362654852 rs1331209220	106	I>M		No	ClinGen TOPMed gnomAD
CA362654848 rs1441777102	106	I>V		No	ClinGen gnomAD
rs61749071 CA133860342	107	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs146246309 CA3622545	108	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs954380105 CA133860346	110	N>S		No	ClinGen Ensembl
CA3622546 rs200651601	112	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs200111001 CA3622547	112	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs200111001 CA133860348	112	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779849243 CA3622548	114	T>A		No	ClinGen ExAC gnomAD
rs766462758 COSM1284064 CA3622549	114	T>M	Variant assessed as Somatic; 0.0 impact. autonomic_ganglia [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1213745803 CA362654961	116	K>E		No	ClinGen gnomAD
rs370917045 CA3622551	118	K>N		No	ClinGen ESP ExAC gnomAD
CA133860352 rs113031834	120	S>G		No	ClinGen Ensembl
CA362655050 rs1479614446	121	T>A		No	ClinGen TOPMed gnomAD
CA362655053 rs1479614446	121	T>P		No	ClinGen TOPMed gnomAD
rs554548467 CA3622554	122	L>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775548129 CA3622557	127	R>G		No	ClinGen ExAC gnomAD
CA362655155 rs1170021646	127	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA362655161 rs1398289550	127	R>S		No	ClinGen gnomAD
CA3622558 rs760861481	128	T>N		No	ClinGen ExAC gnomAD
rs776663806 CA3622561	132	N>D		No	ClinGen ExAC TOPMed gnomAD
CA3622560 rs776663806	132	N>H		No	ClinGen ExAC TOPMed gnomAD
rs765139049 CA3622563 CA3622562	134	R>S		No	ClinGen ExAC gnomAD
rs200764082 CA133860359	137	I>M		No	ClinGen Ensembl
CA3622564 rs762836740	141	T>S		No	ClinGen ExAC
CA362655393 rs1233592554	143	S>G		No	ClinGen gnomAD
rs1305270612 CA362655418	144	N>S		No	ClinGen TOPMed gnomAD
rs751147723 CA3622566	145	F>S		No	ClinGen ExAC gnomAD
CA362655430 rs1300031654	145	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs754537308 CA3622567	146	S>C		No	ClinGen ExAC gnomAD
TCGA novel	146	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA133860362 rs985994885	148	T>A		No	ClinGen TOPMed
CA362655496 rs1185502005	150	P>S		No	ClinGen TOPMed gnomAD
rs780525041 CA3622568	151	K>E		No	ClinGen ExAC gnomAD
CA362655539 rs1475656585	152	A>V		No	ClinGen gnomAD
rs1561690034 CA362655548	154	V>E		No	ClinGen Ensembl
CA362655546 rs757700421 CA362655547	154	V>L		No	ClinGen ExAC TOPMed gnomAD
rs757700421 CA3622570	154	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3622571 rs779392958	156	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1351617758 CA362655558	156	G>R		No	ClinGen TOPMed
rs367701620 CA133860367	157	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs367701620 CA3622573	157	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs780347868 CA3622574	157	K>R		No	ClinGen ExAC gnomAD
CA362655570 rs768787781	158	D>A		No	ClinGen ExAC gnomAD
CA3622576 rs768787781	158	D>G		No	ClinGen ExAC gnomAD
CA133860370 rs906767899	158	D>N		No	ClinGen Ensembl
TCGA novel	158	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1414956038 CA362655575	159	H>D		No	ClinGen gnomAD
rs370862716 CA3622578 CA362655580	159	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA3622579 rs769918692	160	E>A		No	ClinGen ExAC gnomAD
CA133860372 rs976298118	160	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1273157635 CA362655592	161	S>F		No	ClinGen gnomAD
rs1394841057 CA362655589	161	S>T		No	ClinGen TOPMed
rs1489735852 CA362655594	162	K>E		No	ClinGen TOPMed
CA362655604 rs1581240010	163	N>T		No	ClinGen Ensembl
CA362655610 rs1282186180	164	S>G		No	ClinGen gnomAD
CA3622583 rs766037143	165	Q>R		No	ClinGen ExAC
rs751253394 CA3622584	166	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1240616049 CA362655652	170	S>T		No	ClinGen gnomAD
CA362655657 rs1476539182	171	Q>E		No	ClinGen gnomAD
rs1187147858 CA362655678	173	F>L		No	ClinGen gnomAD
CA3622585 rs759040134	174	R>G		No	ClinGen ExAC TOPMed gnomAD
rs200953580 CA133860379	176	N>D		No	ClinGen 1000Genomes TOPMed
rs752257604 CA362655697	176	N>I		No	ClinGen ExAC TOPMed gnomAD
rs752257604 CA3622587	176	N>S		No	ClinGen ExAC TOPMed gnomAD
CA3622588 rs755595055	177	T>I		No	ClinGen ExAC gnomAD
rs895253776 CA133860381	178	A>V		No	ClinGen Ensembl
CA362655715 rs1561690221	179	P>L		No	ClinGen Ensembl
rs1021491896 CA362655722	181	L>F		No	ClinGen gnomAD
rs1021491896 CA133860384	181	L>V		No	ClinGen gnomAD
rs758795798 CA3622592	184	R>L		No	ClinGen ExAC TOPMed gnomAD
CA3622591 rs758795798	184	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3622590 rs374024219	184	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1270178655 CA362655765	187	M>T		No	ClinGen Ensembl
CA3622593 rs747269304	189	L>Q		No	ClinGen ExAC gnomAD
CA362655782 rs1250460107	190	A>T		No	ClinGen gnomAD
CA362655787 rs1429990315	190	A>V		No	ClinGen TOPMed
CA362655800 rs1238255830	192	S>L		No	ClinGen gnomAD
rs139710301 CA3622595	192	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA3622597 rs769971723	194	I>T		No	ClinGen ExAC gnomAD
CA362656226 rs1561690299	196	I>V		No	ClinGen Ensembl
CA362656249 rs1460440367	198	V>M		No	ClinGen gnomAD
rs1246141238 CA362656290	201	S>G		No	ClinGen gnomAD
CA3622599 rs367906819	201	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA3622602 rs371998448	203	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs371998448 CA3622603	203	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1439674505 CA362656332	204	K>T		No	ClinGen gnomAD
CA3622606 rs760203897	207	T>I		No	ClinGen ExAC TOPMed gnomAD
rs748320096 CA362656389	208	A>S		No	ClinGen ExAC TOPMed gnomAD
CA3622608 rs748320096	208	A>T		No	ClinGen ExAC TOPMed gnomAD
CA3622610 rs766896693	210	D>G		No	ClinGen ExAC gnomAD
rs755337916 CA3622612	211	G>S		No	ClinGen ExAC TOPMed gnomAD
rs573123342 CA3622614 COSM3353860	215	E>K	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs756291337 CA3622615	217	P>H		No	ClinGen ExAC gnomAD
CA3622616 rs376981385	219	K>I		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1080048 rs770828221 CA3622618	223	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs770828221 CA362656587	223	V>L		No	ClinGen ExAC TOPMed gnomAD
CA362656603 rs771854902 CA362656602	224	E>D		No	ClinGen ExAC TOPMed gnomAD
CA3622620 rs147719814	224	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA133860405 rs147719814	224	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA3622624 rs368633486	229	D>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3622625 rs776179242	230	T>P		No	ClinGen ExAC gnomAD
rs761383706 CA3622626	232	A>T		No	ClinGen ExAC
rs766835823 CA3622627	233	P>S		No	ClinGen ExAC gnomAD
CA3622628 rs141221618	234	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA3622629 rs141221618	234	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs767953130 CA3622630	235	V>M		No	ClinGen ExAC TOPMed gnomAD
CA3622631 rs372736124	236	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs756344276 CA3622632	237	A>T		No	ClinGen ExAC TOPMed gnomAD
rs548377074 CA3622633	237	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1332916350 CA362656687	238	E>G		No	ClinGen gnomAD
CA3622634 rs145170473	240	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA362656708 rs1581240349	241	V>G		No	ClinGen Ensembl
CA3622637 COSM1080049 rs150926278	242	G>R	endometrium Variant assessed as Somatic; 0.0002311 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA gnomAD
CA3622641 rs768365537	246	G>V		No	ClinGen ExAC TOPMed gnomAD
CA362656745 rs1417864494	248	G>S		No	ClinGen TOPMed gnomAD
CA3622644 rs769298744 COSM1200632	249	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA3622646 rs372980060	250	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA362656767 rs1483553358	251	R>K		No	ClinGen gnomAD
rs1483553358 CA362656765	251	R>M		No	ClinGen gnomAD
rs1312045097 CA362656788	254	M>I		No	ClinGen gnomAD
rs768004472 CA3622647	254	M>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	256	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362656820 rs1561690560	259	R>K		No	ClinGen Ensembl
CA362656829 rs1353394685	260	I>T		No	ClinGen TOPMed gnomAD
CA362656847 rs1416794557	263	L>V		No	ClinGen TOPMed gnomAD
CA362656854 rs1225365201	264	V>A		No	ClinGen gnomAD
CA3622648 rs753167622	264	V>L		No	ClinGen ExAC gnomAD
CA133860422 rs1008812563	265	P>S		No	ClinGen TOPMed gnomAD
CA3622650 rs764448188	266	Q>R		No	ClinGen ExAC gnomAD
CA3622651 rs754045685	267	V>L		No	ClinGen ExAC gnomAD
CA362656869 rs754045685	267	V>M		No	ClinGen ExAC gnomAD
rs778986943 CA3622653	269	G>S		No	ClinGen ExAC TOPMed gnomAD
CA362656888 rs758389859	270	P>L		No	ClinGen ExAC gnomAD
rs758389859 CA3622655	270	P>R		No	ClinGen ExAC gnomAD
CA3622656 rs375314618	272	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA362656905 rs1209217749	273	A>V		No	ClinGen TOPMed
CA362656906 rs1263161789	274	A>T		No	ClinGen TOPMed
CA3622659 rs780729401	275	M>T		No	ClinGen ExAC gnomAD
rs199558668 CA3622658	275	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA362656928 rs1436393658	277	T>K		No	ClinGen gnomAD
CA133860431 rs142838178	278	G>D		No	ClinGen ESP TOPMed
CA133860429 rs552358447	278	G>S		No	ClinGen 1000Genomes TOPMed gnomAD
CA362656944 rs1225768182	280	A>S		No	ClinGen TOPMed
rs747795630 CA3622660	281	V>I		No	ClinGen ExAC TOPMed gnomAD
rs747795630 CA362656948	281	V>L		No	ClinGen ExAC TOPMed gnomAD
rs369374629 CA3622662 COSM1173240	283	G>R	oesophagus Variant assessed as Somatic; 4.792e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA gnomAD
CA3622685 rs376206066	288	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3622687 rs770647906	289	F>L		No	ClinGen ExAC TOPMed gnomAD
CA3622688 rs762081301	290	M>L		No	ClinGen ExAC TOPMed gnomAD
CA362647666 rs1581277261	293	L>*		No	ClinGen Ensembl
rs371162404 CA3622690	294	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs371162404 CA3622689	294	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA133861972 rs373375953	295	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA3622691 rs373375953	295	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA3622692 rs746042185	296	N>S		No	ClinGen ExAC TOPMed gnomAD
rs751502269 CA3622693	300	N>K		No	ClinGen ExAC gnomAD
rs1581277309 CA362647781	300	N>S		No	ClinGen Ensembl
CA362647809 rs1162873403	302	Q>L		No	ClinGen gnomAD
rs1402495622 CA362647824	303	T>I		No	ClinGen TOPMed
rs1396854076 CA362647816	303	T>P		No	ClinGen gnomAD
CA3622694 rs754850622	304	S>C		No	ClinGen ExAC gnomAD
rs1298110513 CA362647864	306	T>A		No	ClinGen gnomAD
CA3622695 rs767342622	306	T>K		No	ClinGen ExAC gnomAD
rs1157881555 CA362647918	310	A>T		No	ClinGen TOPMed
rs1009337706 CA133861989	310	A>V		No	ClinGen Ensembl
CA3622697 rs755831522	311	S>N		No	ClinGen ExAC gnomAD
CA3622698 rs777526567	311	S>R		No	ClinGen ExAC gnomAD
CA362647967 rs1477181277	314	K>R		No	ClinGen TOPMed gnomAD
CA3622699 rs748913405	315	F>L		No	ClinGen ExAC gnomAD
rs756836897 CA3622700	315	F>Y		No	ClinGen ExAC gnomAD
CA133862003 rs772165220	316	I>V		No	ClinGen Ensembl
CA3622701 rs778511112	317	D>G		No	ClinGen ExAC TOPMed gnomAD
CA3622703 rs769274205	318	D>N		No	ClinGen ExAC TOPMed gnomAD
CA362648030 rs1479641505	319	R>G		No	ClinGen TOPMed gnomAD
CA362648034 rs1425976374	319	R>K		No	ClinGen gnomAD
CA362648039 rs1581277406	320	R>G		No	ClinGen Ensembl
CA362648051 rs1178705946	321	D>N		No	ClinGen gnomAD
CA3622704 rs776974579	323	P>L		No	ClinGen ExAC gnomAD
rs1475001236 CA362648159	326	K>E		No	ClinGen gnomAD
TCGA novel	327	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	329	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1207056666 CA362648244	332	V>L		No	ClinGen TOPMed
rs773452834 CA3622708	333	R>S		No	ClinGen ExAC TOPMed gnomAD
CA133862017 rs1044448885	344	I>T		No	ClinGen TOPMed gnomAD
CA133862015 rs368087602	344	I>V		No	ClinGen ESP gnomAD
rs1449598953 CA362648531	350	D>E		No	ClinGen TOPMed
CA133862023 rs765624666	354	H>Y		No	ClinGen Ensembl
CA362648766 rs1455305270	369	P>A		No	ClinGen TOPMed
TCGA novel	377	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3622738 rs148330526	381	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs778247904 CA3622742	383	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	384	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362649149 rs1342878630	385	D>N		No	ClinGen TOPMed gnomAD
rs150826447 CA3622746	394	A>T		No	ClinGen ESP ExAC gnomAD
TCGA novel	394	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs145710209 CA3622749	395	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs147295406 CA3622751	397	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3622752 COSM1080053 rs761722419	398	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA3622753 rs765086192	401	C>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA133862762 rs991185648	409	I>V		No	ClinGen gnomAD
CA362649321 rs1440884787	410	R>Q		No	ClinGen TOPMed gnomAD
CA3622754 rs140950492	411	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA362649326 rs1247597785	411	R>H		No	ClinGen gnomAD
CA3622755 rs372880737	413	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs200526998 CA133862770	414	D>G		No	ClinGen 1000Genomes TOPMed gnomAD
CA362649339 rs1176227729	414	D>N		No	ClinGen gnomAD
CA362649346 rs1458531907	415	D>N		No	ClinGen gnomAD
CA362649365 rs1393179287	417	K>R		No	ClinGen gnomAD
CA133862774 rs200171578	420	S>G		No	ClinGen 1000Genomes
rs751096522 CA3622757	421	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1407428607 CA362649427	426	A>T		No	ClinGen gnomAD
CA362649434 rs1193796891	427	I>V		No	ClinGen TOPMed
rs1339287910 CA362650388	429	N>D		No	ClinGen TOPMed gnomAD
rs772936198 CA3622772	433	T>I		No	ClinGen ExAC
CA362650435 rs1277128637	434	F>L		No	ClinGen gnomAD
rs1240805062 CA362650430	434	F>Y		No	ClinGen gnomAD
CA3622773 rs762803541	435	I>V		No	ClinGen ExAC gnomAD
CA3622774 rs765987450	436	Q>E		No	ClinGen ExAC gnomAD
CA3622776 rs371414089	441	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1441757735 CA362650613	448	P>R		No	ClinGen TOPMed
rs765772714 CA3622780	451	G>D		No	ClinGen ExAC gnomAD
CA362650645 rs1201645313	451	G>S		No	ClinGen TOPMed
TCGA novel	453	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362650673 rs1323880797	454	A>T		No	ClinGen TOPMed
COSM3830719 CA362650700 rs1226143691	456	I>V	breast [Cosmic]	No	ClinGen cosmic curated TOPMed
CA362650769 rs1398064326	461	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1352714327 CA362650796	463	V>I		No	ClinGen TOPMed
CA3622784 rs747215746	464	W>*		No	ClinGen ExAC gnomAD
rs1280448641 CA362650841	466	N>S		No	ClinGen TOPMed
CA3622785 rs755116251	468	K>R		No	ClinGen ExAC gnomAD
rs556935041 CA133865157	471	F>L		No	ClinGen Ensembl
CA133865160 rs919864663	476	T>I		No	ClinGen Ensembl
rs1233997549 CA362651022	479	G>R		No	ClinGen gnomAD
CA362651055 rs1387937340	481	S>R		No	ClinGen TOPMed
rs375233596 CA3622791	488	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs375233596 CA3622792	488	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs542941632 CA3622793 CA362651168	489	M>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3622794 rs767024470	489	M>T		No	ClinGen ExAC gnomAD
TCGA novel	489	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362651205 rs1190888463	492	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	496	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372697577 CA3622837	500	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA362653651 rs1201180555	502	M>L		No	ClinGen TOPMed
rs1346745736 CA362653688	504	L>F		No	ClinGen TOPMed
CA133872601 rs376971832	505	S>G		No	ClinGen ESP TOPMed gnomAD
rs1210203534 CA362653738	507	R>Q		No	ClinGen TOPMed gnomAD
rs1238857055 COSM3394235 CA362653731	507	R>W	pancreas [Cosmic]	No	ClinGen cosmic curated TOPMed
CA362653821 rs1561728211	511	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA362653834 rs1382622460	512	Q>H		No	ClinGen TOPMed
rs1412739020 CA362653911	517	K>T		No	ClinGen gnomAD
rs1403266224 CA362653954	520	V>I		No	ClinGen TOPMed
rs1027046045 CA133872642	522	Q>H		No	ClinGen TOPMed gnomAD
CA362654061 rs1581297606	523	V>G		No	ClinGen Ensembl
TCGA novel	526	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs868364655 CA133872655	526	P>S		No	ClinGen Ensembl
CA362654150 rs1394788361	527	G>E		No	ClinGen gnomAD
CA3622845 rs771808805	527	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3622847 rs746598692	528	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs771507480 CA3622851	535	V>I		No	ClinGen ExAC gnomAD
rs774976035 CA3622852	536	R>L		No	ClinGen ExAC
rs760000830 CA3622853	537	I>V		No	ClinGen ExAC gnomAD
rs370584550 COSM1444988 CA3622854	542	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA362654445 rs370584550	542	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	544	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3622857 rs764206298 COSM1696874	545	P>L	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA362654518 rs1581297741	546	V>A		No	ClinGen Ensembl
rs200558204 CA3622858	546	V>L		No	ClinGen ExAC TOPMed gnomAD
rs765234035 CA3622878	550	E>D		No	ClinGen ExAC TOPMed gnomAD
CA362654932 rs1173551097	550	E>G		No	ClinGen gnomAD
rs750374529 CA3622879	551	S>C		No	ClinGen ExAC gnomAD
rs1319360461 CA362654953	552	K>R		No	ClinGen gnomAD
rs1362929818 CA362654974	554	L>F		No	ClinGen gnomAD
CA3622882 rs146123232	555	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	556	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1217639395 CA362655000	556	R>H		No	ClinGen TOPMed gnomAD
rs542366279 CA3622883	556	R>S		No	ClinGen 1000Genomes ExAC gnomAD
CA3622884 rs780919811	558	N>H		No	ClinGen ExAC gnomAD
CA133874708 rs747714804 CA3622885	559	M>L		No	ClinGen ExAC TOPMed gnomAD
CA362655031 rs1196272184	559	M>R		No	ClinGen gnomAD
CA362655026 rs747714804	559	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1215126743 CA362655042	560	K>R		No	ClinGen gnomAD
CA3622886 rs755686574	561	M>V		No	ClinGen ExAC TOPMed gnomAD
CA3622888 rs748790925	568	E>K		No	ClinGen ExAC gnomAD
CA362655171 rs1197642793	571	C>S		No	ClinGen gnomAD
rs1193326779 COSM1546679 CA362655193	573	V>M	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA362655225 rs1426803515	575	K>N		No	ClinGen gnomAD
COSM134109 CA3622890 rs775840808	580	S>L	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs768866066 CA3622892	581	A>V		No	ClinGen ExAC TOPMed gnomAD
CA362655312 rs1561729465 CA362655311	582	Q>H		No	ClinGen Ensembl
rs1213097075 CA362655334	584	M>I		No	ClinGen Ensembl
rs1321165045 CA362655379	587	M>I		No	ClinGen gnomAD
rs1480727749 CA362655468	594	K>R		No	ClinGen TOPMed
CA3622896 rs138000187	596	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1208424071 CA362655521	598	F>L		No	ClinGen TOPMed

No associated diseases with Q9Y232

5 regional properties for Q9Y232

Type	Name	Position	InterPro Accession
domain	Cyclic nucleotide-binding domain	470 - 594	IPR000595
domain	Ion transport domain	158 - 397	IPR005821
conserved_site	Cyclic nucleotide-binding, conserved site	497 - 513	IPR018488-1
conserved_site	Cyclic nucleotide-binding, conserved site	535 - 558	IPR018488-2
domain	Cyclic nucleotide-gated channel, C-terminal leucine zipper domain	586 - 655	IPR032406

Functions

		Description
EC Number
Subcellular Localization	[Isoform 2]: Nucleus Chromosome	Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin (PubMed:19808672) Multimerization is required for chromatin-binding (PubMed:19808672) Recruited to sites of DNA double strand breaks in a PARP1-dependent fashion (PubMed:29177481)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
crotonyl-CoA hydratase activity	Catalysis of the reaction: Acetyl-CoA + -N(6)-acetyl-L-lysine.
identical protein binding	Binding to an identical protein or proteins.
methylated histone binding	Binding to a histone in which a residue has been modified by methylation.
protein-macromolecule adaptor activity	The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
transcription corepressor activity	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

4 GO annotations of biological process

Name	Definition
negative regulation of peptidyl-lysine crotonylation	Any process that stops or reduces the rate of crotonylation of a lysine residue in a protein.
random inactivation of X chromosome	Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex.
spermatid development	The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q99549	MPHOSPH8	M-phase phosphoprotein 8	Homo sapiens (Human)	PR
P83916	CBX1	Chromobox protein homolog 1	Homo sapiens (Human)	PR
Q8N8U2	CDYL2	Chromodomain Y-like protein 2	Homo sapiens (Human)	PR
P83917	Cbx1	Chromobox protein homolog 1	Mus musculus (Mouse)	PR
Q9D5D8	Cdyl2	Chromodomain Y-like protein 2	Mus musculus (Mouse)	PR
Q9WTK2	Cdyl	Chromodomain Y-like protein	Mus musculus (Mouse)	PR
Q6AYK9	Cdyl	Chromodomain Y-like protein	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MTFQASHRSA	WGKSRKKNWQ	YEGPTQKLFL	KRNNVSAPDG	PSDPSISVSS	EQSGAQQPPA
70	80	90	100	110	120
LQVERIVDKR	KNKKGKTEYL	VRWKGYDSED	DTWEPEQHLV	NCEEYIHDFN	RRHTEKQKES
130	140	150	160	170	180
TLTRTNRTSP	NNARKQISRS	TNSNFSKTSP	KALVIGKDHE	SKNSQLFAAS	QKFRKNTAPS
190	200	210	220	230	240
LSSRKNMDLA	KSGIKILVPK	SPVKSRTAVD	GFQSESPEKL	DPVEQGQEDT	VAPEVAAEKP
250	260	270	280	290	300
VGALLGPGAE	RARMGSRPRI	HPLVPQVPGP	VTAAMATGLA	VNGKGTSPFM	DALTANGTTN
310	320	330	340	350	360
IQTSVTGVTA	SKRKFIDDRR	DQPFDKRLRF	SVRQTESAYR	YRDIVVRKQD	GFTHILLSTK
370	380	390	400	410	420
SSENNSLNPE	VMREVQSALS	TAAADDSKLV	LLSAVGSVFC	CGLDFIYFIR	RLTDDRKRES
430	440	450	460	470	480
TKMAEAIRNF	VNTFIQFKKP	IIVAVNGPAI	GLGASILPLC	DVVWANEKAW	FQTPYTTFGQ
490	500	510	520	530	540
SPDGCSTVMF	PKIMGGASAN	EMLLSGRKLT	AQEACGKGLV	SQVFWPGTFT	QEVMVRIKEL
550	560	570	580	590
ASCNPVVLEE	SKALVRCNMK	MELEQANERE	CEVLKKIWGS	AQGMDSMLKY	LQRKIDEF