Q9XYM0

SS
Gene name
Crk (CG1587)
Protein name
Adapter molecule Crk
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG1587
EC number
Protein Class

Descriptions

CRK regulates transcription and cytoskeletal reorganization for cell growth and motility by linking tyrosine kinases to small G proteins. The mouse c-Crk protein contains The SH2 and nSH3 domains are used to recruit their target proteins. The cSH3 negatively regulates the function of nSH3. In human Crk, nSH3 domain is also regulated by SH2 domain and inter-SH3 domain region.

Autoinhibitory domains (AIDs)

199-260 (cSH3 domain) SS

Target domain

109-163 (N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9XYM0

Entry ID Method Resolution Chain Position Source
AF-Q9XYM0-F1 Predicted AlphaFoldDB

No variants for Q9XYM0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9XYM0

No associated diseases with Q9XYM0

5 regional properties for Q9XYM0

Type Name Position InterPro Accession
domain SH2 domain 10 - 104 IPR000980
domain SH3 domain 106 - 166 IPR001452-1
domain SH3 domain 199 - 260 IPR001452-2
domain CRK, N-terminal SH3 domain 109 - 163 IPR035457
domain CRK, C-terminal SH3 domain 201 - 257 IPR035458

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
receptor tyrosine kinase binding Binding to a receptor that possesses protein tyrosine kinase activity.
signaling adaptor activity The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.

11 GO annotations of biological process

Name Definition
border follicle cell migration The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.
ephrin receptor signaling pathway The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
imaginal disc fusion, thorax closure The joining of the parts of the wing imaginal discs, giving rise to the adult thorax.
myoblast fusion A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
phagocytosis, engulfment The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms
positive regulation of JNK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
vascular endothelial growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04929 CRK Adapter molecule crk Gallus gallus (Chicken) SS
P46109 CRKL Crk-like protein Homo sapiens (Human) SS
P46108 CRK Adapter molecule crk Homo sapiens (Human) EV
P47941 Crkl Crk-like protein Mus musculus (Mouse) SS
Q64010 Crk Adapter molecule crk Mus musculus (Mouse) EV SS
Q5U2U2 Crkl Crk-like protein Rattus norvegicus (Rat) SS
Q63768 Crk Adapter molecule crk Rattus norvegicus (Rat) SS
Q9NHC3 ced-2 Cell death abnormality protein 2 Caenorhabditis elegans SS
10 20 30 40 50 60
MDTFDVSDRN SWYFGPMSRQ DATEVLMNER ERGVFLVRDS NSIAGDYVLC VREDTKVSNY
70 80 90 100 110 120
IINKVQQQDQ IVYRIGDQSF DNLPKLLTFY TLHYLDTTPL KRPACRRVEK VIGKFDFVGS
130 140 150 160 170 180
DQDDLPFQRG EVLTIVRKDE DQWWTARNSS GKIGQIPVPY IQQYDDYMDE DAIDKNEPSI
190 200 210 220 230 240
SGSSNVFEST LKRTDLNRKL PAYARVKQSR VPNAYDKTAL KLEIGDIIKV TKTNINGQWE
250 260 270
GELNGKNGHF PFTHVEFVDD CDLSKNSTEI C