Q9XTG7
Gene name |
akt-2 (F28H6.1) |
Protein name |
Serine/threonine-protein kinase akt-2 |
Names |
EC 2.7.11.1 , Protein kinase B akt-2 , PKB akt-2 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F28H6.1 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|

Descriptions
Autoinhibitory domains (AIDs)
Target domain |
150-528 (Kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Target domain |
180-437 (Protein kinase domain) |
Relief mechanism |
Ligand binding, PTM |
Assay |
|
Accessory elements
No accessory elements
References
- Huang X et al. (2003) "Crystal structure of an inactive Akt2 kinase domain", Structure (London, England : 1993), 11, 21-30
- Truebestein L et al. (2021) "Structure of autoinhibited Akt1 reveals mechanism of PIP(3)-mediated activation", Proceedings of the National Academy of Sciences of the United States of America, 118,
- Lučić I et al. (2018) "Conformational sampling of membranes by Akt controls its activation and inactivation", Proceedings of the National Academy of Sciences of the United States of America, 115, E3940-E3949
- Ashwell MA et al. (2012) "Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors", Journal of medicinal chemistry, 55, 5291-310
Autoinhibited structure

Activated structure

1 structures for Q9XTG7
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-Q9XTG7-F1 | Predicted | AlphaFoldDB |
No variants for Q9XTG7
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
No variants for Q9XTG7 |
No associated diseases with Q9XTG7
5 regional properties for Q9XTG7
Type | Name | Position | InterPro Accession |
---|---|---|---|
domain | Protein kinase domain | 249 - 500 | IPR000719 |
active_site | Serine/threonine-protein kinase, active site | 364 - 376 | IPR008271 |
binding_site | Protein kinase, ATP binding site | 255 - 278 | IPR017441 |
domain | p21 activated kinase binding domain | 72 - 117 | IPR033923 |
domain | p21-activated kinase 2, catalytic domain | 229 - 524 | IPR035064 |
Functions
Description | ||
---|---|---|
EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
Subcellular Localization |
|
|
PANTHER Family | ||
PANTHER Subfamily | ||
PANTHER Protein Class | ||
PANTHER Pathway Category | No pathway information available |
3 GO annotations of cellular component
Name | Definition |
---|---|
cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
protein kinase complex | A protein complex which is capable of protein kinase activity. |
6 GO annotations of molecular function
Name | Definition |
---|---|
ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
metal ion binding | Binding to a metal ion. |
phosphatidylinositol-3,4,5-trisphosphate binding | Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. |
protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction |
protein serine kinase activity | Catalysis of the reactions |
protein serine/threonine kinase activity | Catalysis of the reactions |
7 GO annotations of biological process
Name | Definition |
---|---|
determination of adult lifespan | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. |
innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
insulin receptor signaling pathway | The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. |
intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
regulation of synaptic assembly at neuromuscular junction | Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions. |
17 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
Q01314 | AKT1 | RAC-alpha serine/threonine-protein kinase | Bos taurus (Bovine) | SS |
Q8INB9 | Akt | RAC serine/threonine-protein kinase | Drosophila melanogaster (Fruit fly) | SS |
P31749 | AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens (Human) | EV |
P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens (Human) | EV SS |
Q9Y243 | AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens (Human) | SS |
P31750 | Akt1 | RAC-alpha serine/threonine-protein kinase | Mus musculus (Mouse) | PR |
Q60823 | Akt2 | RAC-beta serine/threonine-protein kinase | Mus musculus (Mouse) | PR |
Q9WUA6 | Akt3 | RAC-gamma serine/threonine-protein kinase | Mus musculus (Mouse) | PR |
P47196 | Akt1 | RAC-alpha serine/threonine-protein kinase | Rattus norvegicus (Rat) | PR |
P47197 | Akt2 | RAC-beta serine/threonine-protein kinase | Rattus norvegicus (Rat) | SS |
Q63484 | Akt3 | RAC-gamma serine/threonine-protein kinase | Rattus norvegicus (Rat) | PR |
Q17941 | akt-1 | Serine/threonine-protein kinase akt-1 | Caenorhabditis elegans | PR |
Q19266 | pkc-3 | Protein kinase C-like 3 | Caenorhabditis elegans | SS |
Q9Y1J3 | pdk-1 | 3-phosphoinositide-dependent protein kinase 1 | Caenorhabditis elegans | SS |
P34722 | tpa-1 | Protein kinase C-like 1 | Caenorhabditis elegans | PR |
P90980 | pkc-2 | Protein kinase C-like 2 | Caenorhabditis elegans | SS |
Q2L6W9 | sax-1 | Serine/threonine-protein kinase sax-1 | Caenorhabditis elegans | SS |
10 | 20 | 30 | 40 | 50 | 60 |
MSTENAHLQK | EDIVIESWLH | KKGEHIRNWR | PRYFILFRDG | TLLGFRSKPK | EDQPLPEPLN |
70 | 80 | 90 | 100 | 110 | 120 |
NFMIRDAATV | CLDKPRPNMF | IVRCLQWTTV | IERTFYADSA | DFRQMWIEAI | QAVSSHNRLK |
130 | 140 | 150 | 160 | 170 | 180 |
ENAGNTSMQE | EDTNGNPSGE | SDVNMDATST | RSDNDFESTV | MNIDEPEEVP | RKNTVTMDDF |
190 | 200 | 210 | 220 | 230 | 240 |
DFLKVLGQGT | FGKVILCREK | SSDKLYAIKI | IRKEMVVDRS | EVAHTLTENR | VLYACVHPFL |
250 | 260 | 270 | 280 | 290 | 300 |
TLLKYSFQAQ | YHICFVMEFA | NGGELFTHLQ | RCKTFSEART | RFYGSEIILA | LGYLHHRNIV |
310 | 320 | 330 | 340 | 350 | 360 |
YRDMKLENLL | LDRDGHIKIT | DFGLCKEEIK | YGDKTSTFCG | TPEYLAPEVI | EDIDYDRSVD |
370 | 380 | 390 | 400 | 410 | 420 |
WWGVGVVMYE | MMCGRLPFSA | KENGKLFELI | TTCDLKFPNR | LSPEAVTLLS | GLLERVPAKR |
430 | 440 | 450 | 460 | 470 | 480 |
LGAGPDDARE | VSRAEFFKDV | DWEATLRKEV | EPPFKPNVMS | ETDTSFFDRE | FTSMPVQLTP |
490 | 500 | 510 | 520 | ||
PRRGEELPTV | DEEEELQANF | IQFASYYVSG | SLERSYDTNR | SADKYEIR |