Q9XT26

SS
Gene name
CCNT1
Protein name
Cyclin-T1
Names
CycT1, Cyclin-T
Species
Equus caballus (Horse)
KEGG Pathway
ecb:100033893
EC number
Protein Class

Descriptions

Cyclin-T1 combines with cyclin-dependent kinase (Cdk9) and these complex is called positive transcription elongation facror B (P-TEFb). An intramolecular interaction between the N- and C-terminal regions of cyclin T1 sterically blocks the P-TEFb밫AR interaction. Binding of Tat-SF1 to the CycT1 C-terminal region stabilizes the P-TEFb-Tat-TAR complex and stimulates HIV-1 transcription. The efficient interaction between P-TEFb and TAR RNA requires suppression of the autoinhibitory activity of the CycT1 C-terminal region.

Autoinhibitory domains (AIDs)

335-727 (C-terminal autoinhibitory region) SS

Target domain

13-259 (N-terminal cyclin box)

Relief mechanism

PTM, Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9XT26

Entry ID Method Resolution Chain Position Source
2W2H X-ray 325 A A/B 5-267 PDB
AF-Q9XT26-F1 Predicted AlphaFoldDB

No variants for Q9XT26

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9XT26

No associated diseases with Q9XT26

3 regional properties for Q9XT26

Type Name Position InterPro Accession
domain Cyclin, N-terminal 13 - 148 IPR006671
domain Cyclin-like domain 43 - 142 IPR013763
domain Cyclin-T1, second cyclin box 151 - 259 IPR047320

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cyclin/CDK positive transcription elongation factor complex A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
7SK snRNA binding Binding to a 7SK small nuclear RNA (7SK snRNA).
cyclin-dependent protein serine/threonine kinase activator activity Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase.
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

5 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
positive regulation of DNA-templated transcription, elongation Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
transcription, DNA-templated The synthesis of an RNA transcript from a DNA template.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6T8E9 CCNT1 Cyclin-T1 Bos taurus (Bovine) SS
Q8HXN7 CCNT1 Cyclin-T1 Pan troglodytes (Chimpanzee) SS
O60563 CCNT1 Cyclin-T1 Homo sapiens (Human) EV
Q9QWV9 Ccnt1 Cyclin-T1 Mus musculus (Mouse) SS
Q2QQS5 CYCT1-1 Cyclin-T1-4 Oryza sativa subsp japonica (Rice) PR
Q6Z7H3 CYCT1_2 Cyclin-T1-2 Oryza sativa subsp japonica (Rice) PR
Q2RAC5 CYCT1-3 Cyclin-T1-3 Oryza sativa subsp japonica (Rice) PR
Q8GYM6 CYCT1-4 Cyclin-T1-4 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEGERKNNNK RWYFTREQLE NSPSRRFGLD PDKELSYRQQ AANLLQDMGQ RLNVSQLTIN
70 80 90 100 110 120
TAIVYMHRFY MIQSFTQFHR NSVAPAALFL AAKVEEQPKK LEHVIKVAHA CLHPQESLPD
130 140 150 160 170 180
TRSEAYLQQV QDLVILESII LQTLGFELTI DHPHTHVVKC TQLVRASKDL AQTSYFMATN
190 200 210 220 230 240
SLHLTTFSLQ YTPPVVACVC IHLACKWSNW EIPVSTDGKH WWEYVDATVT LELLDELTHE
250 260 270 280 290 300
FLQILEKTPN RLKRIRNWRA CQAAKKTKAD DRGTDENTSE QTILNMISQS SSDTTIAGLM
310 320 330 340 350 360
SMSTSSTTST VPSLPTTEES SSNLSGVEML QGERWLSSQP PFKLEPAQGH RTSENLALIG
370 380 390 400 410 420
VDHSLQQDGS NAFISQKQNS SKSVPSAKVS LKEYRAKHAE ELAAQKRQLE NMEANVKSQY
430 440 450 460 470 480
AYAAQNLLSH HDSHSSVILK MPIEGSENPE RPFLEKPDKT ALKMRIPVAS GDKAASSKPE
490 500 510 520 530 540
EIKMRIKVHA APDKHNSIDD SVTKSREHKE KHKTHPSNHH HHHNHHSHKH SHSQLPAGTG
550 560 570 580 590 600
NKRPGDPKHS SQTSTLAHKT YSLSSSFSSS SSSRKRGPPE ETGGALFDHP AKIAKSTKSS
610 620 630 640 650 660
SINFFPPLPT MAQLPGHSSD TSGLPFSQPS CKTRVPHMKL DKGPTGANGH NTTQTIDYQD
670 680 690 700 710 720
TVNMLHSLLH AQGVQPTQPP ALEFVHSYGE YLNPRAGGMP SRSGNTDKPR LPPLPSEPPP
PLPPLPK