Q9XIC7
PR
Gene name |
SERK2 |
Protein name |
Somatic embryogenesis receptor kinase 2 |
Names |
AtSERK2, Somatic embryogenesis receptor-like kinase 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G34210 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q9XIC7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4Z61 | X-ray | 275 A | C/D | 1-216 | PDB |
| 5GQR | X-ray | 350 A | K | 30-214 | PDB |
| 6G3W | X-ray | 220 A | A/C | 28-216 | PDB |
| AF-Q9XIC7-F1 | Predicted | AlphaFoldDB |
57 variants for Q9XIC7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04725205 | 11 | F>L | No | 1000Genomes | |
| ENSVATH00064375 | 14 | L>F | No | 1000Genomes | |
| ENSVATH04725232 | 38 | S>T | No | 1000Genomes | |
| ENSVATH01175120 | 47 | N>Y | No | 1000Genomes | |
| ENSVATH12831526 | 49 | V>I | No | 1000Genomes | |
| tmp_1_12459708_A_G | 75 | I>V | No | 1000Genomes | |
| ENSVATH00064380 | 83 | D>H | No | 1000Genomes | |
| ENSVATH00064380 | 83 | D>N | No | 1000Genomes | |
| tmp_1_12460143_A_G | 108 | I>M | No | 1000Genomes | |
| ENSVATH14069103 | 121 | N>K | No | 1000Genomes | |
| ENSVATH04725257 | 131 | S>R | No | 1000Genomes | |
| tmp_1_12460223_C_A | 135 | P>Q | No | 1000Genomes | |
| tmp_1_12460235_C_T | 139 | S>F | No | 1000Genomes | |
| ENSVATH12831707 | 159 | P>L | No | 1000Genomes | |
| ENSVATH14069155 | 166 | N>D | No | 1000Genomes | |
| ENSVATH00064383 | 168 | M>T | No | 1000Genomes | |
| ENSVATH12831708 | 179 | R>Q | No | 1000Genomes | |
| ENSVATH14069156 | 190 | F>L | No | 1000Genomes | |
| ENSVATH00064386 | 202 | L>F | No | 1000Genomes | |
| ENSVATH04725285 | 218 | P>S | No | 1000Genomes | |
| ENSVATH01175139 | 232 | P>T | No | 1000Genomes | |
| ENSVATH01175148 | 236 | G>V | No | 1000Genomes | |
| ENSVATH04725288 | 244 | A>V | No | 1000Genomes | |
| tmp_1_12461297_G_A | 245 | G>R | No | 1000Genomes | |
| tmp_1_12461315_G_A | 251 | A>T | No | 1000Genomes | |
| tmp_1_12461361_G_A | 266 | R>H | No | 1000Genomes | |
| ENSVATH00064389 | 268 | R>K | No | 1000Genomes | |
| tmp_1_12461371_A_C | 269 | K>N | No | 1000Genomes | |
| ENSVATH14069163 | 269 | K>Q | No | 1000Genomes | |
| ENSVATH04725292 | 282 | D>Y | No | 1000Genomes | |
| tmp_1_12461540_C_T | 296 | R>W | No | 1000Genomes | |
| ENSVATH12831896 | 300 | V>I | No | 1000Genomes | |
| tmp_1_12461559_C_T | 302 | T>I | No | 1000Genomes | |
| tmp_1_12461574_A_T | 307 | N>I | No | 1000Genomes | |
| tmp_1_12461579_A_T | 309 | N>Y | No | 1000Genomes | |
| ENSVATH00064392 | 325 | A>S | No | 1000Genomes | |
| tmp_1_12461660_A_C | 336 | K>Q | No | 1000Genomes | |
| tmp_1_12461751_G_A | 366 | R>H | No | 1000Genomes | |
| ENSVATH04725294 | 378 | V>I | No | 1000Genomes | |
| tmp_1_12462024_G_A | 412 | G>E | No | 1000Genomes | |
| tmp_1_12462050_C_T | 421 | H>Y | No | 1000Genomes | |
| tmp_1_12462114_A_T | 442 | E>V | No | 1000Genomes | |
| tmp_1_12462158_A_C | 457 | M>L | No | 1000Genomes | |
| tmp_1_12462227_C_T | 480 | L>F | No | 1000Genomes | |
| ENSVATH12831897 | 503 | T>I | No | 1000Genomes | |
| ENSVATH04725299 | 538 | V>M | No | 1000Genomes | |
| tmp_1_12462493_A_G | 543 | Q>R | No | 1000Genomes | |
| ENSVATH01175186 | 544 | S>G | No | 1000Genomes | |
| tmp_1_12462505_C_A | 547 | T>K | No | 1000Genomes | |
| tmp_1_12462508_A_G | 548 | E>G | No | 1000Genomes | |
| tmp_1_12462516_G_C | 551 | V>L | No | 1000Genomes | |
| tmp_1_12462531_C_T | 556 | Q>* | No | 1000Genomes | |
| tmp_1_12462651_G_A | 596 | V>I | No | 1000Genomes | |
| tmp_1_12462658_G_A | 598 | R>K | No | 1000Genomes | |
| ENSVATH04725301 | 604 | S>C | No | 1000Genomes | |
| tmp_1_12462725_T_A,G | 620 | H>Q | No | 1000Genomes | |
| tmp_1_12462741_G_T | 626 | G>C | No | 1000Genomes |
No associated diseases with Q9XIC7
5 regional properties for Q9XIC7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 305 - 592 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 308 - 579 | IPR001245 |
| active_site | Serine/threonine-protein kinase, active site | 428 - 440 | IPR008271 |
| domain | Leucine-rich repeat-containing N-terminal, plant-type | 30 - 69 | IPR013210 |
| binding_site | Protein kinase, ATP binding site | 311 - 333 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| lipid binding | Binding to a lipid. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| receptor serine/threonine kinase binding | Binding to a receptor that possesses protein serine/threonine kinase activity. |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
| transmembrane receptor protein serine/threonine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| brassinosteroid mediated signaling pathway | The series of molecular signals mediated by the detection of brassinosteroid. |
| microsporogenesis | The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores. |
| pollen maturation | The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
46 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P04629 | NTRK1 | High affinity nerve growth factor receptor | Homo sapiens (Human) | EV |
| Q16288 | NTRK3 | NT-3 growth factor receptor | Homo sapiens (Human) | SS |
| Q16620 | NTRK2 | BDNF/NT-3 growth factors receptor | Homo sapiens (Human) | EV |
| O15146 | MUSK | Muscle, skeletal receptor tyrosine-protein kinase | Homo sapiens (Human) | EV |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P24786 | NTRK3 | NT-3 growth factor receptor | Sus scrofa (Pig) | SS |
| P35739 | Ntrk1 | High affinity nerve growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q03351 | Ntrk3 | NT-3 growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q63604 | Ntrk2 | BDNF/NT-3 growth factors receptor | Rattus norvegicus (Rat) | SS |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JQ4 | PRK2 | Pollen receptor-like kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LIG2 | At3g21340 | Receptor-like protein kinase At3g21340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGX1 | At5g65240 | Probable LRR receptor-like serine/threonine-protein kinase At5g65240 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGRKKFEAFG | FVCLISLLLL | FNSLWLASSN | MEGDALHSLR | ANLVDPNNVL | QSWDPTLVNP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CTWFHVTCNN | ENSVIRVDLG | NADLSGQLVP | QLGQLKNLQY | LELYSNNITG | PVPSDLGNLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NLVSLDLYLN | SFTGPIPDSL | GKLFKLRFLR | LNNNSLTGPI | PMSLTNIMTL | QVLDLSNNRL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SGSVPDNGSF | SLFTPISFAN | NLDLCGPVTS | RPCPGSPPFS | PPPPFIPPPI | VPTPGGYSAT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GAIAGGVAAG | AALLFAAPAL | AFAWWRRRKP | QEFFFDVPAE | EDPEVHLGQL | KRFSLRELQV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ATDSFSNKNI | LGRGGFGKVY | KGRLADGTLV | AVKRLKEERT | PGGELQFQTE | VEMISMAVHR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NLLRLRGFCM | TPTERLLVYP | YMANGSVASC | LRERPPSQLP | LAWSIRQQIA | LGSARGLSYL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HDHCDPKIIH | RDVKAANILL | DEEFEAVVGD | FGLARLMDYK | DTHVTTAVRG | TIGHIAPEYL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| STGKSSEKTD | VFGYGIMLLE | LITGQRAFDL | ARLANDDDVM | LLDWVKGLLK | EKKLEMLVDP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DLQSNYTEAE | VEQLIQVALL | CTQSSPMERP | KMSEVVRMLE | GDGLAEKWDE | WQKVEVLRQE |
| 610 | 620 | ||||
| VELSSHPTSD | WILDSTDNLH | AMELSGPR |