Q9XGM3

PR
Gene name
RPS4
Protein name
Disease resistance protein RPS4
Names
Probable NAD(+) hydrolase RPS4, Resistance to Pseudomonas syringae 4, TIR-NBS-LRR class disease resistance protein
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G45250
EC number
3.2.2.6: Hydrolyzing N-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1143-1213 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q9XGM3

Entry ID Method Resolution Chain Position Source
4C6R X-ray 205 A A/B/C/D 11-178 PDB
4C6T X-ray 265 A B/D 11-178 PDB
AF-Q9XGM3-F1 Predicted AlphaFoldDB

95 variants for Q9XGM3

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH07341478 4 S>P No 1000Genomes
ENSVATH07341477 14 P>Q No 1000Genomes
ENSVATH14592935 53 D>E No 1000Genomes
ENSVATH12543115 67 E>G No 1000Genomes
ENSVATH14592924 70 I>V No 1000Genomes
tmp_5_18325680_C_A 115 V>F No 1000Genomes
tmp_5_18325643_C_T 127 R>K No 1000Genomes
ENSVATH07341475 134 E>Q No 1000Genomes
tmp_5_18325604_T_A 140 K>M No 1000Genomes
ENSVATH00710276 153 I>T No 1000Genomes
ENSVATH03359650 154 I>V No 1000Genomes
ENSVATH07341471 188 V>A No 1000Genomes
ENSVATH00710273 195 N>D No 1000Genomes
ENSVATH00710272 206 E>D No 1000Genomes
tmp_5_18325231_T_A 215 K>N No 1000Genomes
ENSVATH09532175 225 K>I No 1000Genomes
ENSVATH12543068 242 K>* No 1000Genomes
ENSVATH12543067 244 T>I No 1000Genomes
ENSVATH07341468 244 T>S No 1000Genomes
ENSVATH03359641 264 D>H No 1000Genomes
tmp_5_18325082_T_A 265 Q>L No 1000Genomes
ENSVATH00710271 282 L>V No 1000Genomes
tmp_5_18325026_C_G 284 G>R No 1000Genomes
ENSVATH00710269 291 H>N No 1000Genomes
tmp_5_18324991_G_T 295 D>E No 1000Genomes
ENSVATH14592922 295 D>N No 1000Genomes
tmp_5_18324987_G_T 297 L>I No 1000Genomes
tmp_5_18324867_C_A 337 E>* No 1000Genomes
tmp_5_18324754_G_C 374 H>Q No 1000Genomes
ENSVATH03359638 379 I>L No 1000Genomes
ENSVATH07341465 383 A>G No 1000Genomes
ENSVATH07341465 383 A>V No 1000Genomes
tmp_5_18324712_T_A 388 K>N No 1000Genomes
tmp_5_18324689_C_T 396 G>E No 1000Genomes
tmp_5_18324657_C_T 407 A>T No 1000Genomes
ENSVATH03359637 410 V>I No 1000Genomes
ENSVATH12543066 411 L>F No 1000Genomes
tmp_5_18324641_C_G 412 G>A No 1000Genomes
tmp_5_18324551_A_G 442 F>S No 1000Genomes
ENSVATH03359636 443 Q>R No 1000Genomes
tmp_5_18324518_T_A 453 Q>L No 1000Genomes
ENSVATH12543065 459 D>E No 1000Genomes
tmp_5_18324471_C_T 469 D>N No 1000Genomes
ENSVATH07341463 473 S>C No 1000Genomes
ENSVATH12543044 493 T>K No 1000Genomes
tmp_5_18324349_A_T 509 D>E No 1000Genomes
ENSVATH00710267 518 V>I No 1000Genomes
tmp_5_18324244_T_C 544 I>M No 1000Genomes
ENSVATH07341462 545 I>V No 1000Genomes
tmp_5_18324037_G_A 585 R>W No 1000Genomes
tmp_5_18324019_T_C 591 N>D No 1000Genomes
tmp_5_18324012_T_C 593 H>R No 1000Genomes
ENSVATH07341460 640 V>A No 1000Genomes
ENSVATH00710266 649 M>T No 1000Genomes
tmp_5_18323673_T_C 671 S>G No 1000Genomes
ENSVATH03359632 674 C>R No 1000Genomes
ENSVATH07341456 705 K>N No 1000Genomes
tmp_5_18323568_T_G 706 M>L No 1000Genomes
tmp_5_18323528_C_T 719 S>N No 1000Genomes
ENSVATH07341455 721 E>D No 1000Genomes
tmp_5_18323463_T_C 741 T>A No 1000Genomes
ENSVATH07341454 748 I>V No 1000Genomes
ENSVATH12543036 752 I>V No 1000Genomes
ENSVATH07341453 776 V>A No 1000Genomes
ENSVATH07341450 798 A>T No 1000Genomes
ENSVATH03359631 817 D>N No 1000Genomes
tmp_5_18323232_T_C 818 I>V No 1000Genomes
ENSVATH07341447 893 C>Y No 1000Genomes
ENSVATH14592916 895 S>L No 1000Genomes
ENSVATH07341446 905 R>H No 1000Genomes
ENSVATH07341445 950 Y>H No 1000Genomes
tmp_5_18322708_G_T 954 L>I No 1000Genomes
ENSVATH14592913 977 T>I No 1000Genomes
ENSVATH03359627 981 E>A No 1000Genomes
tmp_5_18322619_T_G 983 E>D No 1000Genomes
tmp_5_18322582_C_A 996 A>S No 1000Genomes
ENSVATH00710263 1004 V>I No 1000Genomes
ENSVATH12543012 1008 D>N No 1000Genomes
tmp_5_18322497_A_G 1024 V>A No 1000Genomes
tmp_5_18322489_C_T 1027 E>K No 1000Genomes
ENSVATH00710262 1033 A>P No 1000Genomes
tmp_5_18322432_C_A 1046 G>C No 1000Genomes
ENSVATH03359626 1046 G>V No 1000Genomes
tmp_5_18322424_T_G 1048 K>N No 1000Genomes
tmp_5_18322417_T_C 1051 I>V No 1000Genomes
tmp_5_18322364_T_A 1068 K>N No 1000Genomes
tmp_5_18322339_C_T 1077 E>K No 1000Genomes
ENSVATH03359624 1102 L>F No 1000Genomes
ENSVATH07341439 1146 T>R No 1000Genomes
tmp_5_18322077_C_T 1164 G>E No 1000Genomes
tmp_5_18322078_C_T 1164 G>R No 1000Genomes
ENSVATH03359623 1170 N>K No 1000Genomes
tmp_5_18322023_G_A 1182 P>L No 1000Genomes
tmp_5_18322008_C_T 1187 R>K No 1000Genomes
ENSVATH00710260 1189 G>E No 1000Genomes

No associated diseases with Q9XGM3

4 regional properties for Q9XGM3

Type Name Position InterPro Accession
domain Toll/interleukin-1 receptor homology (TIR) domain 14 - 184 IPR000157
domain NB-ARC 211 - 449 IPR002182
repeat Leucine-rich repeat 3 638 - 657 IPR011713
domain C-JID domain 964 - 1113 IPR045344

Functions

Description
EC Number 3.2.2.6 Hydrolyzing N-glycosyl compounds
Subcellular Localization
  • Endomembrane system
  • Cytoplasm
  • Nucleus
  • Nuclear accumulation is necessary for triggering EDS1-dependent defense (PubMed:17997306)
  • Found in microsomes when interacting with SRFR1 (PubMed:21079790)
  • Accumulates in the cytoplasm and the nucleus, when associated with EDS1 (PubMed:22158818)
  • Accumulates in nucleus at 22 degrees Celsius, but not at 28 degrees Celsius (PubMed:22454454)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ADP binding Binding to ADP, adenosine 5'-diphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding Binding to an identical protein or proteins.
NAD(P)+ nucleosidase activity Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide.
NAD+ nucleotidase, cyclic ADP-ribose generating Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose that proceeds in a stepwise fashion by ADP-ribosyl cyclase activity followed by cyclic ADP-ribose hydrolase activity.

3 GO annotations of biological process

Name Definition
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
innate immune response-activating signal transduction The series of molecular signals generated as a consequence of a pathogen or microbial effector binding to a plant 'resistance-gene' receptor to activate a plant immune response, usually plant-type hypersensitive response.
plant-type hypersensitive response The rapid, localized death of plant cells in response to invasion by a pathogen.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
F1MHT9 NLRC4 NLR family CARD domain-containing protein 4 Bos taurus (Bovine) SS
Q9NPP4 NLRC4 NLR family CARD domain-containing protein 4 Homo sapiens (Human) SS
Q3UP24 Nlrc4 NLR family CARD domain-containing protein 4 Mus musculus (Mouse) EV
F1M649 Nlrc4 NLR family CARD domain-containing protein 4 Rattus norvegicus (Rat) SS
F4J339 RPP1 Probable disease resistance protein RPP1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
METSSISTVE DKPPQHQVFI NFRGADLRRR FVSHLVTALK LNNINVFIDD YEDRGQPLDV
70 80 90 100 110 120
LLKRIEESKI VLAIFSGNYT ESVWCVRELE KIKDCTDEGT LVAIPIFYKL EPSTVRDLKG
130 140 150 160 170 180
KFGDRFRSMA KGDERKKKWK EAFNLIPNIM GIIIDKKSVE SEKVNEIVKA VKTALTGIPP
190 200 210 220 230 240
EGSHNAVVGA LGNSNAGTSS GDKKHETFGN EQRLKDLEEK LDRDKYKGTR IIGVVGMPGI
250 260 270 280 290 300
GKTTLLKELY KTWQGKFSRH ALIDQIRVKS KHLELDRLPQ MLLGELSKLN HPHVDNLKDP
310 320 330 340 350 360
YSQLHERKVL VVLDDVSKRE QIDALREILD WIKEGKEGSR VVIATSDMSL TNGLVDDTYM
370 380 390 400 410 420
VQNLNHRDSL QLFHYHAFID DQANPQKKDF MKLSEGFVHY ARGHPLALKV LGGELNKKSM
430 440 450 460 470 480
DHWNSKMKKL AQSPSPNIVS VFQVSYDELT TAQKDAFLDI ACFRSQDKDY VESLLASSDL
490 500 510 520 530 540
GSAEAMSAVK SLTDKFLINT CDGRVEMHDL LYKFSREVDL KASNQDGSRQ RRLWLHQHII
550 560 570 580 590 600
KGGIINVLQN KMKAANVRGI FLDLSEVEDE TSLDRDHFIN MGNLRYLKFY NSHCPQECKT
610 620 630 640 650 660
NNKINIPDKL KLPLKEVRCL HWLKFPLETL PNDFNPINLV DLKLPYSEME QLWEGDKDTP
670 680 690 700 710 720
CLRWVDLNHS SKLCSLSGLS KAEKLQRLNL EGCTTLKAFP HDMKKMKMLA FLNLKGCTSL
730 740 750 760 770 780
ESLPEMNLIS LKTLTLSGCS TFKEFPLISD NIETLYLDGT AISQLPMNME KLQRLVVLNM
790 800 810 820 830 840
KDCKMLEEIP GRVGELKALQ ELILSDCLNL KIFPEIDISF LNILLLDGTA IEVMPQLPSV
850 860 870 880 890 900
QYLCLSRNAK ISCLPVGISQ LSQLKWLDLK YCTSLTSVPE FPPNLQCLDA HGCSSLKTVS
910 920 930 940 950 960
KPLARIMPTE QNHSTFIFTN CENLEQAAKE EITSYAQRKC QLLSYARKRY NGGLVSESLF
970 980 990 1000 1010 1020
STCFPGCEVP SWFCHETVGS ELEVKLLPHW HDKKLAGIAL CAVVSCLDPQ DQVSRLSVTC
1030 1040 1050 1060 1070 1080
TFKVKDEDKS WVAYTCPVGS WTRHGGGKDK IELDHVFIGY TSCPHTIKCH EEGNSDECNP
1090 1100 1110 1120 1130 1140
TEASLKFTVT GGTSENGKYK VLKCGLSLVY AKDKDKNSAL ETKYDMLIGK SFQETSEGVD
1150 1160 1170 1180 1190 1200
GRVKKTKGKY VMPVEKNFQE TTEGVDGRVN KKKKTRMDNG RPKKKQRSGR DDNQTRMQVE
1210
LQEGNINSVI MHTVKNF