Q9XFH4
PR
Gene name |
DDM1 |
Protein name |
ATP-dependent DNA helicase DDM1 |
Names |
Protein CHROMATIN REMODELING 1, AtCHR1, CHR01, Protein DECREASED DNA METHYLATION 1, AtDDM1, Protein SOMNIFEROUS 1, SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin DDM1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G66750 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9XFH4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7UX9 | EM | 320 A | P | 1-764 | PDB |
| AF-Q9XFH4-F1 | Predicted | AlphaFoldDB |
43 variants for Q9XFH4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00756171 | 9 | V>F | No | 1000Genomes | |
| ENSVATH07491267 | 11 | P>Q | No | 1000Genomes | |
| tmp_5_26649291_T_G | 13 | S>A | No | 1000Genomes | |
| tmp_5_26649299_G_T | 15 | M>I | No | 1000Genomes | |
| ENSVATH07491272 | 22 | E>A | No | 1000Genomes | |
| ENSVATH12958468 | 38 | E>K | No | 1000Genomes | |
| tmp_5_26649522_G_T | 45 | V>F | No | 1000Genomes | |
| ENSVATH07491274 | 115 | E>V | No | 1000Genomes | |
| ENSVATH07491275 | 126 | I>N | No | 1000Genomes | |
| ENSVATH00756175 | 129 | I>K | No | 1000Genomes | |
| ENSVATH07491280 | 151 | S>T | No | 1000Genomes | |
| ENSVATH12958471 | 173 | G>D | No | 1000Genomes | |
| ENSVATH07491283 | 176 | I>L | No | 1000Genomes | |
| ENSVATH00756177 | 176 | I>T | No | 1000Genomes | |
| ENSVATH08588445 | 186 | V>A | No | 1000Genomes | |
| ENSVATH00756178 | 187 | I>M | No | 1000Genomes | |
| ENSVATH12958472 | 205 | Y>F | No | 1000Genomes | |
| tmp_5_26650239_T_C | 214 | I>T | No | 1000Genomes | |
| tmp_5_26650313_G_T | 239 | G>C | No | 1000Genomes | |
| ENSVATH00756179 | 245 | K>R | No | 1000Genomes | |
| ENSVATH12958474 | 269 | I>V | No | 1000Genomes | |
| tmp_5_26650532_A_T | 285 | K>I | No | 1000Genomes | |
| tmp_5_26650565_T_C | 296 | M>T | No | 1000Genomes | |
| tmp_5_26650573_A_T | 299 | T>S | No | 1000Genomes | |
| ENSVATH07491287 | 320 | R>K | No | 1000Genomes | |
| ENSVATH12958495 | 330 | V>A | No | 1000Genomes | |
| tmp_5_26651102_G_A | 403 | E>K | No | 1000Genomes | |
| ENSVATH12958498 | 411 | K>T | No | 1000Genomes | |
| ENSVATH00756181 | 434 | C>F | No | 1000Genomes | |
| tmp_5_26651281_G_A | 437 | E>K | No | 1000Genomes | |
| ENSVATH14651860 | 442 | R>Q | No | 1000Genomes | |
| tmp_5_26651350_C_G | 460 | Q>E | No | 1000Genomes | |
| tmp_5_26651832_G_A | 543 | V>I | No | 1000Genomes | |
| ENSVATH14651863 | 565 | F>L | No | 1000Genomes | |
| tmp_5_26651925_G_C | 574 | V>L | No | 1000Genomes | |
| tmp_5_26651934_G_A | 577 | D>N | No | 1000Genomes | |
| tmp_5_26652450_C_T | 656 | T>I | No | 1000Genomes | |
| tmp_5_26652462_A_T | 660 | K>I | No | 1000Genomes | |
| ENSVATH12958503 | 694 | I>V | No | 1000Genomes | |
| ENSVATH07491311 | 711 | T>I | No | 1000Genomes | |
| tmp_5_26652721_C_T | 716 | A>V | No | 1000Genomes | |
| tmp_5_26652747_A_T | 725 | S>C | No | 1000Genomes | |
| ENSVATH07491312 | 753 | P>A | No | 1000Genomes |
No associated diseases with Q9XFH4
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleosome | A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent activity, acting on DNA | Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. |
| ATP-dependent chromatin remodeler activity | An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA methylation-dependent heterochromatin assembly | Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. |
| DNA-mediated transformation | The direct uptake and incorporation of exogenous genetic material (DNA or RNA) into a cell from its surroundings through the cell envelope. |
| negative regulation of histone H4 acetylation | Any process that decreases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. |
| positive regulation of histone H3-K9 methylation | Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. |
| regulation of DNA methylation | Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. |
| regulation of gene expression by genomic imprinting | An epigenetic mechanism of regulation of gene expression in which epigenetic modifications (imprints) are established during gametogenesis. For a given gene to show parentally biased expression, the imprint are established exclusively in one of the two parental genomes, thus generating an asymmetry between the maternal and paternal alleles. |
| regulation of gene expression, epigenetic | A process that modulates the frequency, rate or extent of gene expression through chromatin remodelling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal. |
| transposition, RNA-mediated | Any process involved in a type of transpositional recombination which occurs via an RNA intermediate. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3B7N1 | CHD1L | Chromodomain-helicase-DNA-binding protein 1-like | Bos taurus (Bovine) | SS |
| Q24368 | Iswi | Chromatin-remodeling complex ATPase chain Iswi | Drosophila melanogaster (Fruit fly) | SS |
| Q86WJ1 | CHD1L | Chromodomain-helicase-DNA-binding protein 1-like | Homo sapiens (Human) | EV |
| P28370 | SMARCA1 | Probable global transcription activator SNF2L1 | Homo sapiens (Human) | SS |
| Q9NRZ9 | HELLS | Lymphoid-specific helicase | Homo sapiens (Human) | PR |
| O60264 | SMARCA5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 | Homo sapiens (Human) | EV |
| Q9CXF7 | Chd1l | Chromodomain-helicase-DNA-binding protein 1-like | Mus musculus (Mouse) | SS |
| Q60848 | Hells | Lymphocyte-specific helicase | Mus musculus (Mouse) | PR |
| Q6PGB8 | Smarca1 | Probable global transcription activator SNF2L1 | Mus musculus (Mouse) | SS |
| Q91ZW3 | Smarca5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 | Mus musculus (Mouse) | SS |
| P40201 | Chd1 | Chromodomain-helicase-DNA-binding protein 1 | Mus musculus (Mouse) | PR |
| Q7G8Y3 | Os01g0367900 | Probable chromatin-remodeling complex ATPase chain | Oryza sativa subsp japonica (Rice) | PR |
| P41877 | isw-1 | Chromatin-remodeling complex ATPase chain isw-1 | Caenorhabditis elegans | SS |
| Q22516 | chd-3 | Chromodomain-helicase-DNA-binding protein 3 homolog | Caenorhabditis elegans | PR |
| F4J9M5 | CHR12 | Probable ATP-dependent DNA helicase CHR12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4K128 | CHR23 | Probable ATP-dependent DNA helicase CHR23 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWY3 | CHR11 | ISWI chromatin-remodeling complex ATPase CHR11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVSLRSRKVI | PASEMVSDGK | TEKDASGDSP | TSVLNEEENC | EEKSVTVVEE | EILLAKNGDS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLISEAMAQE | EEQLLKLRED | EEKANNAGSA | VAPNLNETQF | TKLDELLTQT | QLYSEFLLEK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MEDITINGIE | SESQKAEPEK | TGRGRKRKAA | SQYNNTKAKR | AVAAMISRSK | EDGETINSDL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TEEETVIKLQ | NELCPLLTGG | QLKSYQLKGV | KWLISLWQNG | LNGILADQMG | LGKTIQTIGF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSHLKGNGLD | GPYLVIAPLS | TLSNWFNEIA | RFTPSINAII | YHGDKNQRDE | LRRKHMPKTV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GPKFPIVITS | YEVAMNDAKR | ILRHYPWKYV | VIDEGHRLKN | HKCKLLRELK | HLKMDNKLLL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TGTPLQNNLS | ELWSLLNFIL | PDIFTSHDEF | ESWFDFSEKN | KNEATKEEEE | KRRAQVVSKL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HGILRPFILR | RMKCDVELSL | PRKKEIIMYA | TMTDHQKKFQ | EHLVNNTLEA | HLGENAIRGQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GWKGKLNNLV | IQLRKNCNHP | DLLQGQIDGS | YLYPPVEEIV | GQCGKFRLLE | RLLVRLFANN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HKVLIFSQWT | KLLDIMDYYF | SEKGFEVCRI | DGSVKLDERR | RQIKDFSDEK | SSCSIFLLST |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RAGGLGINLT | AADTCILYDS | DWNPQMDLQA | MDRCHRIGQT | KPVHVYRLST | AQSIETRVLK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RAYSKLKLEH | VVIGQGQFHQ | ERAKSSTPLE | EEDILALLKE | DETAEDKLIQ | TDISDADLDR |
| 730 | 740 | 750 | 760 | ||
| LLDRSDLTIT | APGETQAAEA | FPVKGPGWEV | VLPSSGGMLS | SLNS |