AiPD: Autoinhibited Protein Database

Gene name	Mok (Rage, Stk30)
Protein name	MAPK/MAK/MRK overlapping kinase
Names	MOK protein kinase, Serine/threonine kinase 30
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:26448
EC number	2.7.11.22: Protein-serine/threonine kinases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

282-414 (Predicted disordered autoinhibitory region) PR

282-414 (Predicted disordered autoinhibitory region)

cis-regPred

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9WVS4-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs215455686	7	I>V	No	EVA
rs3389270448	76	G>D	No	EVA
rs3389228788	129	V>G	No	EVA
rs3389234654	138	Q>H	No	EVA
rs3403745935	154	S>T	No	EVA
rs3389260040	158	Y>C	No	EVA
rs3389275051	234	A>T	No	EVA
rs3389261139	234	A>V	No	EVA
rs3389263761	235	M>K	No	EVA
rs3403745887	256	P>T	No	EVA
rs3389263688	275	A>G	No	EVA
rs3403852461	276	A>S	No	EVA
rs3403910575	287	V>A	No	EVA
rs3389261573	287	V>M	No	EVA
rs3389193100	297	A>V	No	EVA
rs3389274980	302	A>V	No	EVA
rs3389228849	313	S>*	No	EVA
rs258434540	315	S>N	No	EVA
rs3403910489	319	S>*	No	EVA
rs3389234630	322	Q>H	No	EVA
rs240611584	332	R>W	No	EVA
rs3389274992	341	Q>H	No	EVA
rs3389234581	347	M>I	No	EVA
rs3389255872	382	V>M	No	EVA
rs3389234577	421	Y>C	No	EVA

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	4 - 285	IPR000719
active_site	Serine/threonine-protein kinase, active site	124 - 136	IPR008271
binding_site	Protein kinase, ATP binding site	10 - 33	IPR017441

		Description
EC Number	2.7.11.22	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Cell projection, cilium Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
ciliary base	Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
cilium	A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
metal ion binding	Binding to a metal ion.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

Name	Definition
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation	The process of introducing a phosphate group on to a protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P20794	MAK	Serine/threonine-protein kinase MAK	Homo sapiens (Human)	PR
Q9UQ07	MOK	MAPK/MAK/MRK overlapping kinase	Homo sapiens (Human)	PR
Q9JKV2	Cilk1	Serine/threonine-protein kinase ICK	Mus musculus (Mouse)	PR
Q04859	Mak	Serine/threonine-protein kinase MAK	Mus musculus (Mouse)	PR
Q80Y86	Mapk15	Mitogen-activated protein kinase 15	Mus musculus (Mouse)	SS
Q9WTU6	Mapk9	Mitogen-activated protein kinase 9	Mus musculus (Mouse)	PR
Q91Y86	Mapk8	Mitogen-activated protein kinase 8	Mus musculus (Mouse)	PR
Q63844	Mapk3	Mitogen-activated protein kinase 3	Mus musculus (Mouse)	SS
P63085	Mapk1	Mitogen-activated protein kinase 1	Mus musculus (Mouse)	SS
Q6P5G0	Mapk4	Mitogen-activated protein kinase 4	Mus musculus (Mouse)	SS
Q61532	Mapk6	Mitogen-activated protein kinase 6	Mus musculus (Mouse)	SS
Q9WVS8	Mapk7	Mitogen-activated protein kinase 7	Mus musculus (Mouse)	SS
O08911	Mapk12	Mitogen-activated protein kinase 12	Mus musculus (Mouse)	SS
Q9Z1B7	Mapk13	Mitogen-activated protein kinase 13	Mus musculus (Mouse)	SS
Q9WUI1	Mapk11	Mitogen-activated protein kinase 11	Mus musculus (Mouse)	SS
P47811	Mapk14	Mitogen-activated protein kinase 14	Mus musculus (Mouse)	SS
P20793	Mak	Serine/threonine-protein kinase MAK	Rattus norvegicus (Rat)	PR
P43294	MHK	Serine/threonine-protein kinase MHK	Arabidopsis thaliana (Mouse-ear cress)	PR