Q9WVM6

PR
Gene name
Tll2
Protein name
Tolloid-like protein 2
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:24087
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-177 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9WVM6

Entry ID Method Resolution Chain Position Source
AF-Q9WVM6-F1 Predicted AlphaFoldDB

60 variants for Q9WVM6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389486364 22 A>D No EVA
rs3389548461 23 E>* No EVA
rs252223987 26 G>E No EVA
rs3389532432 36 G>R No EVA
rs3389519460 52 D>N No EVA
rs3389531913 55 K>I No EVA
rs3389447608 57 A>D No EVA
rs37991944 86 I>M No EVA
rs245426936 106 D>Y No EVA
rs262675550 111 A>D No EVA
rs220941235 111 A>T No EVA
rs253901890 128 P>S No EVA
rs36647303 129 N>D No EVA
rs220134035 129 N>K No EVA
rs255595921 130 P>S No EVA
rs246630344 137 A>T No EVA
rs3389540577 139 T>A No EVA
rs3389550709 191 T>S No EVA
rs3389550719 209 C>Y No EVA
rs3389555394 221 G>R No EVA
rs3389495604 249 H>R No EVA
rs3389486296 255 D>Y No EVA
rs3389518194 280 A>V No EVA
rs3389535538 292 F>V No EVA
rs3389532510 293 D>E No EVA
rs3389550666 313 L>I No EVA
rs3389550711 321 V>I No EVA
rs3389539391 367 G>D No EVA
rs3389548492 384 E>K No EVA
rs3389447580 394 D>N No EVA
rs3412613772 413 W>C No EVA
rs3389555353 454 F>Y No EVA
rs3389550655 463 G>E No EVA
rs3413055864 480 D>V No EVA
rs3389495517 488 V>L No EVA
rs36371755 511 H>Q No EVA
rs3389447658 529 S>N No EVA
rs3389486330 549 N>D No EVA
rs230658607 550 R>Q No EVA
rs3389447579 564 A>T No EVA
rs3389540561 587 Q>* No EVA
rs3409067413 600 C>S No EVA
rs3409673211 600 C>W No EVA
rs3408194648 601 D>V No EVA
rs3409442297 602 P>T No EVA
rs3389518187 651 V>A No EVA
rs1134918525 651 V>M No EVA
rs3389550692 694 S>Y No EVA
rs1133813075 695 E>K No EVA
rs3389533004 744 C>Y No EVA
rs3389486382 761 L>Q No EVA
rs3389539761 769 K>N No EVA
rs36417394 820 I>V No EVA
rs3389540562 836 G>E No EVA
rs3389486314 836 G>V No EVA
rs3389531929 838 D>G No EVA
rs3389495542 898 E>D No EVA
rs3389539385 898 E>K No EVA
rs3389539777 953 G>V No EVA
rs1132325142 998 R>Q No EVA

No associated diseases with Q9WVM6

16 regional properties for Q9WVM6

Type Name Position InterPro Accession
ptm EGF-type aspartate/asparagine hydroxylation site 589 - 600 IPR000152-1
ptm EGF-type aspartate/asparagine hydroxylation site 744 - 755 IPR000152-2
domain EGF-like domain 573 - 614 IPR000742-1
domain EGF-like domain 732 - 769 IPR000742-2
domain CUB domain 348 - 460 IPR000859-1
domain CUB domain 461 - 573 IPR000859-2
domain CUB domain 617 - 729 IPR000859-3
domain CUB domain 773 - 885 IPR000859-4
domain CUB domain 886 - 1002 IPR000859-5
domain Peptidase M12A 146 - 346 IPR001506
domain EGF-like calcium-binding domain 573 - 614 IPR001881-1
domain EGF-like calcium-binding domain 729 - 769 IPR001881-2
domain Peptidase, metallopeptidase 152 - 294 IPR006026
conserved_site EGF-like calcium-binding, conserved site 573 - 598 IPR018097-1
conserved_site EGF-like calcium-binding, conserved site 729 - 753 IPR018097-2
domain Tolloid/BMP1 peptidase domain 147 - 346 IPR034036

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding Binding to a zinc ion (Zn).

4 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
dorsal/ventral pattern formation The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
negative regulation of skeletal muscle tissue growth Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth.
protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9DER7 TLL1 Tolloid-like protein 1 Gallus gallus (Chicken) PR
P25723 tld Dorsal-ventral patterning protein tolloid Drosophila melanogaster (Fruit fly) PR
P98066 TNFAIP6 Tumor necrosis factor-inducible gene 6 protein Homo sapiens (Human) PR
O43897 TLL1 Tolloid-like protein 1 Homo sapiens (Human) PR
P13497 BMP1 Bone morphogenetic protein 1 Homo sapiens (Human) PR
Q9Y6L7 TLL2 Tolloid-like protein 2 Homo sapiens (Human) PR
O08859 Tnfaip6 Tumor necrosis factor-inducible gene 6 protein Mus musculus (Mouse) PR
P98063 Bmp1 Bone morphogenetic protein 1 Mus musculus (Mouse) PR
Q6HA09 Astl Astacin-like metalloendopeptidase Mus musculus (Mouse) PR
Q62381 Tll1 Tolloid-like protein 1 Mus musculus (Mouse) PR
Q9U3S9 nas-6 Zinc metalloproteinase nas-6 Caenorhabditis elegans PR
P55112 nas-4 Zinc metalloproteinase nas-4 Caenorhabditis elegans PR
P55113 nas-7 Zinc metalloproteinase nas-7 Caenorhabditis elegans PR
Q18439 nas-8 Zinc metalloproteinase nas-8 Caenorhabditis elegans PR
Q20942 nas-38 Zinc metalloproteinase nas-38 Caenorhabditis elegans PR
Q21252 nas-3 Zinc metalloproteinase nas-3 Caenorhabditis elegans PR
P55115 nas-15 Zinc metalloproteinase nas-15 Caenorhabditis elegans PR
Q20176 nas-39 Zinc metalloproteinase nas-39 Caenorhabditis elegans PR
O57460 tll1 Dorsal-ventral patterning tolloid-like protein 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MPLATTLGTL VLLLLLPLPR GAEVTGDHSN VALDYGALEG EEGTEQQLHY HDPCKAAVFW
70 80 90 100 110 120
GDIALDEDDL KLFHIDKAED WTKPSIDKPG HDTGGLEETS ARWPNDTASN ASIQAPRKDG
130 140 150 160 170 180
KDATTFLPNP GTSNTTAKTF SARVRRATTS RTERIWPGGV IPYVIGGNFT GTQRAIFKQA
190 200 210 220 230 240
MRHWEKHTCV TFVERTDEES FIVFSYRTCG CCSYVGRRGG GPQAISIGKN CDKFGIVAHE
250 260 270 280 290 300
LGHVVGFWHE HTRPDRDQHV TIIRENIQPG QEYNFLKMEA GEVSSLGETY DFDSIMHYAR
310 320 330 340 350 360
NTFSRGVFLD TILPRRDDNG VRPTIGQRVR LSQGDIAQAR KLYKCPACGE TLQDTTGNFS
370 380 390 400 410 420
APGFPNGYPS YSHCVWRISV TPGEKIILNF TSMDLFKSRL CWYDYVEIRD GYWRKAPLLG
430 440 450 460 470 480
RFCGDKIPES LVSSDSRLWV EFRSSSSSLG KGFFAVYEAM CGGDITKDAG QIQSPNYPDD
490 500 510 520 530 540
YRPSKECVWR ITVPDGFHVG LTFQSFEIER HDSCAYDYLE IRDGPTEDST LIGHFCGYEK
550 560 570 580 590 600
PEAVKSSANR LWVKFVSDGS INKAGFAANF FKEVDECSWP DHGGCEQRCV NTLGSYTCAC
610 620 630 640 650 660
DPGYELAADK KTCEVACGGF ITKLNGTITS PGWPKEYPTN KNCVWQVVAP VQYRISLQFE
670 680 690 700 710 720
AFELEGNDVC KYDFVEVRSG LSPDAKLHGK FCGSETPEVI TSQSNNMRVE FKSDNTVSKR
730 740 750 760 770 780
GFRAHFFSDK DECAKDNGGC QQECVNTFGS YLCRCRNGYR LHENGHDCKE AGCAYKISSA
790 800 810 820 830 840
EGTLMSPNWP DKYPSRKECT WNISSTAGHR VKITFSEFEI EQHQECAYDH LELYDGTDSL
850 860 870 880 890 900
APILGRFCGS KKPDPVVATG SSLFLRFYSD ASVQRKGFQA VHSTECGGRL KAEVQTKELY
910 920 930 940 950 960
SHAQFGDNNY PSQARCDWVI VAEDGYGVEL IFRTFEVEEE ADCGYDFMEA YDGYDSSAPR
970 980 990 1000 1010
LGRFCGSGPL EEIYSAGDSL MIRFHTDDTI NKKGFHARYT STKFQDALHM RK