Q9WVL4
Gene name |
Grk1 |
Protein name |
Rhodopsin kinase GRK1 |
Names |
RK, G protein-coupled receptor kinase 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
|
EC number |
2.7.11.14: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
334-357 (Activation loop from InterPro)
Target domain |
188-475 (Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9WVL4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9WVL4-F1 | Predicted | AlphaFoldDB |
No variants for Q9WVL4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9WVL4 | |||||
No associated diseases with Q9WVL4
6 regional properties for Q9WVL4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 190 - 455 | IPR000719 |
| domain | AGC-kinase, C-terminal | 456 - 535 | IPR000961 |
| active_site | Serine/threonine-protein kinase, active site | 313 - 325 | IPR008271 |
| domain | RGS domain | 57 - 175 | IPR016137 |
| binding_site | Protein kinase, ATP binding site | 196 - 219 | IPR017441 |
| domain | Rhodopsin kinase, catalytic domain | 188 - 475 | IPR037716 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.14 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| photoreceptor outer segment | The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| rhodopsin kinase activity | Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| negative regulation of neuron apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| photoreceptor cell morphogenesis | The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster. |
| positive regulation of phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. |
| post-embryonic retina morphogenesis in camera-type eye | The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of rhodopsin mediated signaling pathway | Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling. |
| regulation of signal transduction | Any process that modulates the frequency, rate or extent of signal transduction. |
| response to light stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. |
| retinal rod cell apoptotic process | Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P26818 | GRK3 | Beta-adrenergic receptor kinase 2 | Bos taurus (Bovine) | PR |
| P43249 | GRK5 | G protein-coupled receptor kinase 5 | Bos taurus (Bovine) | SS |
| P21146 | GRK2 | Beta-adrenergic receptor kinase 1 | Bos taurus (Bovine) | PR |
| P32865 | Gprk1 | G protein-coupled receptor kinase 1 | Drosophila melanogaster (Fruit fly) | PR |
| P25098 | GRK2 | Beta-adrenergic receptor kinase 1 | Homo sapiens (Human) | PR |
| P35626 | GRK3 | Beta-adrenergic receptor kinase 2 | Homo sapiens (Human) | PR |
| P34947 | GRK5 | G protein-coupled receptor kinase 5 | Homo sapiens (Human) | EV |
| P32298 | GRK4 | G protein-coupled receptor kinase 4 | Homo sapiens (Human) | SS |
| P43250 | GRK6 | G protein-coupled receptor kinase 6 | Homo sapiens (Human) | EV |
| Q15835 | GRK1 | Rhodopsin kinase GRK1 | Homo sapiens (Human) | PR |
| O70293 | Grk6 | G protein-coupled receptor kinase 6 | Mus musculus (Mouse) | SS |
| Q3UYH7 | Adrbk2 | Beta-adrenergic receptor kinase 2 | Mus musculus (Mouse) | PR |
| Q8VEB1 | Grk5 | G protein-coupled receptor kinase 5 | Mus musculus (Mouse) | SS |
| Q99MK8 | Grk2 | Beta-adrenergic receptor kinase 1 | Mus musculus (Mouse) | PR |
| Q62833 | Grk5 | G protein-coupled receptor kinase 5 | Rattus norvegicus (Rat) | SS |
| P26817 | Grk2 | Beta-adrenergic receptor kinase 1 | Rattus norvegicus (Rat) | PR |
| P97711 | Grk6 | G protein-coupled receptor kinase 6 | Rattus norvegicus (Rat) | SS |
| Q09639 | grk-2 | G protein-coupled receptor kinase 2 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDFGSLETVV | ANSAFIAARG | SFDGSSTPSS | RDKKYLAKLR | LPPLSKCEGL | RDNLSLEFES |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LCSEQPIGKR | LFQQFLKTDE | RHVPALELWK | DIEDYDTADD | DLRPQKAQAI | LAEYLDPQGT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LFCNFLDQGM | VTRVKEGPTG | SQDGLFQPLL | QATMEHLSQA | PFQEYLESLY | FLRFLQWKWL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EAQPIGEDWF | LDFRVLGKGG | FGEVSACQMK | ATGKMYACKK | LNKKRLKKKK | GYQGAIVEKR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ILTKVHSRFI | VSLAYAFETK | TDLCLVMTIM | NGGDVRYHIY | NVDEDNPGFS | EPRAIYYTAQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IISGLEHLHQ | RRIVYRDLKP | ENVLLDNDGN | IRISDLGLAV | ELKEGQNKTK | GYAGTPGFMA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PELLRGEEYD | FSVDYFALGV | TLYEMIAARG | PFRARGEKVE | NKELKQRIIS | EPVKYPEKFS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QASKDFCEQL | LEKDPEKRLG | FRDGTCDALR | ANVLFKDISW | RQLEAGMLIP | PFIPDSRTVY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AKNIQDVGAF | STVKGVVFDK | ADTEFFQEFA | SGNCSIPWQE | EMIETGLFGD | LNVWRADGQM |
| 550 | 560 | ||||
| PDDMKGITTE | EAAPTAKSGM | CLIS |