Q9WV34
PR
Gene name |
Mpp2 |
Protein name |
MAGUK p55 subfamily member 2 |
Names |
Discs large homolog 2, Protein MPP2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:50997 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9WV34
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9WV34-F1 | Predicted | AlphaFoldDB |
25 variants for Q9WV34
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389204661 | 29 | A>E | No | EVA | |
| rs3389141337 | 32 | D>E | No | EVA | |
| rs3389175258 | 41 | E>D | No | EVA | |
| rs3389199970 | 99 | H>R | No | EVA | |
| rs3389141354 | 116 | E>D | No | EVA | |
| rs3389200001 | 124 | L>M | No | EVA | |
| rs3389208075 | 126 | P>S | No | EVA | |
| rs3412866947 | 151 | L>V | No | EVA | |
| rs3389192321 | 167 | I>T | No | EVA | |
| rs3389192342 | 187 | E>D | No | EVA | |
| rs264893708 | 196 | D>N | No | EVA | |
| rs3389205921 | 228 | V>E | No | EVA | |
| rs3389214123 | 276 | E>Q | No | EVA | |
| rs3389202314 | 303 | T>I | No | EVA | |
| rs3389202343 | 313 | L>V | No | EVA | |
| rs3389209427 | 356 | I>L | No | EVA | |
| rs3389204657 | 371 | I>V | No | EVA | |
| rs3389206253 | 386 | S>T | No | EVA | |
| rs3402709747 | 390 | K>* | No | EVA | |
| rs3403013604 | 391 | D>A | No | EVA | |
| rs3389219705 | 406 | E>D | No | EVA | |
| rs3389215784 | 418 | E>* | No | EVA | |
| rs3389204654 | 450 | P>A | No | EVA | |
| rs3389192353 | 510 | R>K | No | EVA | |
| rs3389192317 | 527 | R>M | No | EVA |
No associated diseases with Q9WV34
9 regional properties for Q9WV34
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH3 domain | 225 - 293 | IPR001452 |
| domain | PDZ domain | 140 - 219 | IPR001478 |
| domain | L27 domain | 8 - 121 | IPR004172 |
| domain | Guanylate kinase-like domain | 350 - 537 | IPR008144 |
| domain | Guanylate kinase/L-type calcium channel beta subunit | 349 - 540 | IPR008145 |
| domain | L27 domain, C-terminal | 12 - 63 | IPR014775-1 |
| domain | L27 domain, C-terminal | 69 - 120 | IPR014775-2 |
| conserved_site | Guanylate kinase, conserved site | 385 - 402 | IPR020590 |
| domain | MPP2, SH3 domain | 229 - 287 | IPR035602 |
Functions
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchored component of postsynaptic density membrane | The component of the postsynaptic density membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. |
| cell-cell junction | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| dendrite membrane | The portion of the plasma membrane surrounding a dendrite. |
| dendritic shaft | Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. |
| dendritic spine | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| Schaffer collateral - CA1 synapse | A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| PDZ domain binding | Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. |
| structural constituent of postsynaptic density | The action of a molecule that contributes to the structural integrity of a postsynaptic density. |
| transmembrane transporter binding | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| excitatory postsynaptic potential | A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
| long-term synaptic potentiation | A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. |
| protein homooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q24210 | CASK | Peripheral plasma membrane protein CASK | Drosophila melanogaster (Fruit fly) | SS |
| Q9NZW5 | PALS2 | Protein PALS2 | Homo sapiens (Human) | PR |
| Q00013 | MPP1 | 55 kDa erythrocyte membrane protein | Homo sapiens (Human) | PR |
| O14936 | CASK | Peripheral plasma membrane protein CASK | Homo sapiens (Human) | EV |
| Q96JB8 | MPP4 | MAGUK p55 subfamily member 4 | Homo sapiens (Human) | PR |
| Q14168 | MPP2 | MAGUK p55 subfamily member 2 | Homo sapiens (Human) | PR |
| P70290 | Mpp1 | 55 kDa erythrocyte membrane protein | Mus musculus (Mouse) | PR |
| O70589 | Cask | Peripheral plasma membrane protein CASK | Mus musculus (Mouse) | SS |
| Q9JLB0 | Pals2 | Protein PALS2 | Mus musculus (Mouse) | PR |
| Q6P7F1 | Mpp4 | MAGUK p55 subfamily member 4 | Mus musculus (Mouse) | PR |
| Q8BVD5 | Mpp7 | MAGUK p55 subfamily member 7 | Mus musculus (Mouse) | PR |
| O88910 | Mpp3 | MAGUK p55 subfamily member 3 | Mus musculus (Mouse) | PR |
| Q9QYH1 | Mpp4 | MAGUK p55 subfamily member 4 | Rattus norvegicus (Rat) | PR |
| P54936 | lin-2 | Protein lin-2 | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPVAATNSES | AMQQVLDNLG | SLPNATGAAE | LDLIFLRGIM | ESPIVRSLAK | AHERLEETKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EAVRDNNLEL | VQEILRDLAE | LAEQSSTAAE | LARILQEPHF | QSLLETHDSV | ASKTYETPPP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SPGLDPTFSN | QPVPPDAVRM | VGIRKTAGEH | LGVTFRVEGG | ELVIARILHG | GMVAQQGLLH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VGDIIKEVNG | QPVGSDPRAL | QELLRSASGS | VILKILPSYQ | EPHLPRQVFV | KCHFDYDPAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DSLSPCKEAG | LRFNAGDLLQ | IVNQDDANWW | QACHVEGGSA | GLIPSQLLEE | KRKAFVKRDL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ELTPTSGTLC | GSLSGKKKKR | MMYLTTKNAE | FDRHELLIYE | EVARMPPFRR | KTLVLIGAQG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VGRRSLKNKL | ILWDPDRYGT | TVPYTSRRPK | DSEREGQGYS | FVSRGEMEAD | IRAGRYLEHG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EYEGNLYGTR | IDSIRGVVAS | GKVCVLDVNP | QAVKVLRTAE | FVPYVVFIEA | PDYETLRAMN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RAALESGVST | KQLTEADLRR | TVEESSRIQR | GYGHYFDLSL | VNSNLERTFR | ELQTAMEKLR |
| 550 | |||||
| TEPQWVPVSW | VY |