Q9WUT3

SS
Gene name
Rps6ka2 (Mapkapk1c, Rsk3)
Protein name
Ribosomal protein S6 kinase alpha-2
Names
S6K-alpha-2 , EC 2.7.11.1 , 90 kDa ribosomal protein S6 kinase 2 , p90-RSK 2 , p90RSK2 , MAP kinase-activated protein kinase 1c , MAPK-activated protein kinase 1c , MAPKAP kinase 1c , MAPKAPK-1c , Protein-tyrosine kinase Mpk-9 , Ribosomal S6 kinase 3 , RSK-3 , pp90RSK3
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:20112
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

RSK1 plays an important role in many cellular processes. RSK1 is expressed ubiquitously in almost all human tissues, predominantly in kidney, lung and pancreas.The crystal structure of human RSK1 C-terminal kinase domain (CTKD) has been reported. The structure indicates that the autoinhibition of the CTKD is caused by an α-helix occupying the substrate-binding groove.The structure shows autoinhibition of RSK1 CTKD by its αL helix, suggesting that ERK1/2 may activate RSK1 by phosphorylating RSK1 followed by the displacement of αL from its inhibitory position. A similar regulatory mechanism has been observed previously in MAPKAP kinase 2 and murine RSK2 CTKD. The atomic structure of human RSK1 CTKD is of great interest in order to understand the mechanism of RSK activation and for structure-based anticancer-drug development.

Autoinhibitory domains (AIDs)

688-703 (αL helix) SS

Target domain

413-703 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

201-224 (Activation loop from InterPro)

Target domain

59-379 (Protein kinase domain)

Relief mechanism

Assay

553-576 (Activation loop from InterPro)

Target domain

411-703 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9WUT3

Entry ID Method Resolution Chain Position Source
AF-Q9WUT3-F1 Predicted AlphaFoldDB

39 variants for Q9WUT3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389391807 47 V>M No EVA
rs3389425060 104 V>G No EVA
rs3389447456 117 N>K No EVA
rs3411699743 142 R>Q No EVA
rs3389422875 166 A>T No EVA
rs213560466 197 H>Q No EVA
rs3389412127 209 A>T No EVA
rs3389391846 226 M>V No EVA
rs3389345532 229 E>* No EVA
rs3389412087 280 Q>H No EVA
rs3389432655 293 L>P No EVA
rs3389400416 355 R>M No EVA
rs243923702 388 S>L No EVA
rs3389430846 403 Q>* No EVA
rs3389378958 428 V>M No EVA
rs3389378986 442 A>T No EVA
rs3389345556 456 E>D No EVA
rs3389447384 457 I>T No EVA
rs3389437143 506 E>K No EVA
rs3405596257 526 Q>S No EVA
rs3413134968 536 S>N No EVA
rs3389437189 559 K>Q No EVA
rs3389400411 563 A>V No EVA
rs3407034261 575 A>T No EVA
rs3407413876 578 V>A No EVA
rs3389447460 592 C>Y No EVA
rs3389400466 593 D>E No EVA
rs3389345580 595 W>* No EVA
rs3389430790 608 F>Y No EVA
rs3389432214 613 N>D No EVA
rs864299284 613 N>K No EVA
rs3407034281 628 S>I No EVA
rs3389391805 649 V>L No EVA
rs3389378966 658 Q>H No EVA
rs3407699279 660 R>H No EVA
rs3389345605 668 K>* No EVA
rs3389432645 679 S>T No EVA
rs3389412096 691 V>M No EVA
rs864268031 715 L>R No EVA

No associated diseases with Q9WUT3

10 regional properties for Q9WUT3

Type Name Position InterPro Accession
domain Protein kinase domain 59 - 318 IPR000719-1
domain Protein kinase domain 415 - 672 IPR000719-2
domain AGC-kinase, C-terminal 319 - 388 IPR000961
active_site Serine/threonine-protein kinase, active site 180 - 192 IPR008271-1
active_site Serine/threonine-protein kinase, active site 528 - 540 IPR008271-2
binding_site Protein kinase, ATP binding site 65 - 91 IPR017441-1
binding_site Protein kinase, ATP binding site 421 - 444 IPR017441-2
domain Protein kinase, C-terminal 342 - 378 IPR017892
domain Ribosomal S6 kinase, N-terminal catalytic domain 63 - 379 IPR041906
domain RSK3, C-terminal catalytic domain 411 - 703 IPR042766

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
meiotic spindle A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions
ribosomal protein S6 kinase activity Catalysis of the reaction

14 GO annotations of biological process

Name Definition
brain renin-angiotensin system The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system.
cardiac muscle cell apoptotic process A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
cellular response to carbohydrate stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.
heart contraction The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of meiotic nuclear division Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.
oocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of protein processing Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P18652 RPS6KA Ribosomal protein S6 kinase 2 alpha Gallus gallus (Chicken) SS
Q5F3L1 RPS6KA5 Ribosomal protein S6 kinase alpha-5 Gallus gallus (Chicken) SS
Q9UK32 RPS6KA6 Ribosomal protein S6 kinase alpha-6 Homo sapiens (Human) SS
O75676 RPS6KA4 Ribosomal protein S6 kinase alpha-4 Homo sapiens (Human) SS
Q96S38 RPS6KC1 Ribosomal protein S6 kinase delta-1 Homo sapiens (Human) PR
P51812 RPS6KA3 Ribosomal protein S6 kinase alpha-3 Homo sapiens (Human) EV
Q15418 RPS6KA1 Ribosomal protein S6 kinase alpha-1 Homo sapiens (Human) EV
O75582 RPS6KA5 Ribosomal protein S6 kinase alpha-5 Homo sapiens (Human) SS
Q15349 RPS6KA2 Ribosomal protein S6 kinase alpha-2 Homo sapiens (Human) SS
Q8BLK9 Rps6kc1 Ribosomal protein S6 kinase delta-1 Mus musculus (Mouse) PR
P18653 Rps6ka1 Ribosomal protein S6 kinase alpha-1 Mus musculus (Mouse) SS
P18654 Rps6ka3 Ribosomal protein S6 kinase alpha-3 Mus musculus (Mouse) SS
Q9Z2B9 Rps6ka4 Ribosomal protein S6 kinase alpha-4 Mus musculus (Mouse) SS
Q8C050 Rps6ka5 Ribosomal protein S6 kinase alpha-5 Mus musculus (Mouse) PR
Q9Z1M4 Rps6kb2 Ribosomal protein S6 kinase beta-2 Mus musculus (Mouse) SS
Q8BSK8 Rps6kb1 Ribosomal protein S6 kinase beta-1 Mus musculus (Mouse) SS
Q63531 Rps6ka1 Ribosomal protein S6 kinase alpha-1 Rattus norvegicus (Rat) SS
Q18846 rskn-2 Putative ribosomal protein S6 kinase alpha-2 Caenorhabditis elegans PR
Q21734 rskn-1 Putative ribosomal protein S6 kinase alpha-1 Caenorhabditis elegans SS
10 20 30 40 50 60
MELSMKKFTV RRFFSVYLRK KSRSKSSSLS RLEEEGIVKE IDISNHVKEG FEKADPSQFE
70 80 90 100 110 120
LLKVLGQGSY GKVFLVRKVT GSDAGQLYAM KVLKKATLKV RDRVRSKMER DILAEVNHPF
130 140 150 160 170 180
IVKLHYAFQT EGKLYLILDF LRGGDLFTRL SKEVMFTEED VKFYLAELAL ALDHLHGLGI
190 200 210 220 230 240
IYRDLKPENI LLDEEGHIKI TDFGLSKEAT DHDKRAYSFC GTIEYMAPEV VNRRGHTQSA
250 260 270 280 290 300
DWWSFGVLMF EMLTGSLPFQ GKDRKETMAL ILKAKLGMPQ FLSAEAQSLL RALFKRNPCN
310 320 330 340 350 360
RLGAGVDGVE EIKRHPFFVT IDWNKLYRKE IKPPFKPAVG RPEDTFHFDP EFTARTPTDS
370 380 390 400 410 420
PGVPPSANAH HLFRGFSFVA SSLVQEPSQQ DVPKAPIHPI VQQLHGNNIH FTDGYEIKED
430 440 450 460 470 480
IGVGSYSVCK RCVHKATDAE YAVKIIDKSK RDPSEEIEIL LRYGQHPNII TLKDVYDDGK
490 500 510 520 530 540
YVYLVMELMR GGELLDRILR QRCFSEREAS DVLYTIARTM DYLHSQGVVH RDLKPSNILY
550 560 570 580 590 600
MDESGNPESI RICDFGFAKQ LRAENGLLMT PCYTANFVAP EVLKRQGYDA ACDVWSLGIL
610 620 630 640 650 660
LYTMLAGFTP FANGPDDTPE EILARIGSGK YALSGGNWDS ISDAAKDVVS KMLHVDPQQR
670 680 690 700 710 720
LTAVQVLKHP WIVNREYLSQ NQLSRQDVHL VKGAMAATYF ALNRTPQAPR LEPVLSSSLA
730
QRRGMKRLTS TRL