Q9WTZ3
PR
Gene name |
Mbtps1 (S1p, Ski1) |
Protein name |
Membrane-bound transcription factor site-1 protease |
Names |
Endopeptidase S1P, Subtilisin/kexin isozyme 1, SKI-1 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:89842 |
EC number |
3.4.21.112: Serine endopeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9WTZ3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9WTZ3-F1 | Predicted | AlphaFoldDB |
No variants for Q9WTZ3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9WTZ3 | |||||
No associated diseases with Q9WTZ3
7 regional properties for Q9WTZ3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 139 - 259 | IPR000595-1 |
| domain | Cyclic nucleotide-binding domain | 261 - 388 | IPR000595-2 |
| domain | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | 8 - 45 | IPR003117 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 166 - 182 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 206 - 223 | IPR018488-2 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 288 - 304 | IPR018488-3 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 336 - 353 | IPR018488-4 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.21.112 | Serine endopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| Golgi stack | The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| serine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cholesterol metabolic process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
| lipid metabolic process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
| lysosome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. |
| protein processing | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| regulation of vesicle-mediated transport | Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q14703 | MBTPS1 | Membrane-bound transcription factor site-1 protease | Homo sapiens (Human) | PR |
| Q9WTZ2 | Mbtps1 | Membrane-bound transcription factor site-1 protease | Mus musculus (Mouse) | PR |
| P59996 | Pcsk9 | Proprotein convertase subtilisin/kexin type 9 | Rattus norvegicus (Rat) | SS |
| Q0WUG6 | SBT6.1 | Subtilisin-like protease SBT6.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKLVNIWLLL | LVVLLCGKKH | LGDRLGKKAF | EKAPCPSCSH | LTLKVEFSST | VVEYEYIVAF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NGYFTAKARN | SFISSALKSS | EVDNWRIIPR | NNPSSDYPSD | FEVIQIKEKQ | KAGLLTLEDH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PNIKRVTPQR | KVFRSLKFAE | SDPIVPCNET | RWSQKWQSSR | PLKRASLSLG | SGFWHATGRH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSRRLLRAIP | RQVAQTLQAD | VLWQMGYTGA | NVRVAVFDTG | LSEKHPHFKN | VKERTNWTNE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RTLDDGLGHG | TFVAGVIASM | RECQGFAPDA | ELHIFRVFTN | NQVSYTSWFL | DAFNYAILKK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IDVLNLSIGG | PDFMDHPFVD | KVWELTANNV | IMVSAIGNDG | PLYGTLNNPA | DQMDVIGVGG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IDFEDNIARF | SSRGMTTWEL | PGGYGRVKPD | IVTYGAGVRG | SGVKGGCRAL | SGTSVASPVV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AGAVTLLVST | VQKRELVNPA | SVKQALIASA | RRLPGVNMFE | QGHGKLDLLR | AYQILSSYKP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QASLSPSYID | LTECPYMWPY | CSQPIYYGGM | PTIVNVTILN | GMGVTGRIVD | KPEWRPYLPQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NGDNIEVAFS | YSSVLWPWSG | YLAISISVTK | KAASWEGIAQ | GHIMITVASP | AETELKNGAE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HTSTVKLPIK | VKIIPTPPRS | KRVLWDQYHN | LRYPPGYFPR | DNLRMKNDPL | DWNGDHVHTN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FRDMYQHLRS | MGYFVEVLGA | PFTCFDATQY | GTLLMVDSEE | EYFPEEIAKL | RRDVDNGLSL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VVFSDWYNTS | VMRKVKFYDE | NTRQWWMPDT | GGANVPALNE | LLSVWNMGFS | DGLYEGEFAL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ANHDMYYASG | CSIARFPEDG | VVITQTFKDQ | GLEVLKQETA | VVDNVPILGL | YQIPAEGGGR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IVLYGDSNCL | DDSHRQKDCF | WLLDALLQYT | SYGVTPPSLS | HSGNRQRPPS | GAGLAPPERM |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EGNHLHRYSK | VLEAHLGDPK | PRPLPACPHL | SWAKPQPLNE | TAPSNLWKHQ | KLLSIDLDKV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| VLPNFRSNRP | QVRPLSPGES | GAWDIPGGIM | PGRYNQEVGQ | TIPVFAFLGA | MVALAFFVVQ |
| 1030 | 1040 | 1050 | |||
| ISKAKSRPKR | RRPRAKRPQL | AQQAHPARTP | SV |