Descriptions
Autoinhibitory domains (AIDs)
Target domain |
1-61 (Transcription factor, MADS-box) |
Relief mechanism |
PTM |
Assay |
|
Target domain |
1-61 (Transcription factor, MADS-box) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9W6U8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9W6U8-F1 | Predicted | AlphaFoldDB |
No variants for Q9W6U8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9W6U8 | |||||
No associated diseases with Q9W6U8
5 regional properties for Q9W6U8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 90 - 383 | IPR000719 |
| domain | AGC-kinase, C-terminal | 384 - 453 | IPR000961 |
| active_site | Serine/threonine-protein kinase, active site | 209 - 221 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 96 - 119 | IPR017441 |
| domain | Protein kinase, C-terminal | 402 - 443 | IPR017892 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cell differentiation | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A2VDZ3 | MEF2A | Myocyte-specific enhancer factor 2A | Bos taurus (Bovine) | SS |
| Q06413 | MEF2C | Myocyte-specific enhancer factor 2C | Homo sapiens (Human) | EV |
| Q02078 | MEF2A | Myocyte-specific enhancer factor 2A | Homo sapiens (Human) | SS |
| Q8CFN5 | Mef2c | Myocyte-specific enhancer factor 2C | Mus musculus (Mouse) | SS |
| Q60929 | Mef2a | Myocyte-specific enhancer factor 2A | Mus musculus (Mouse) | SS |
| A4UTP7 | MEF2C | Myocyte-specific enhancer factor 2C | Sus scrofa (Pig) | SS |
| A2ICN5 | MEF2A | Myocyte-specific enhancer factor 2A | Sus scrofa (Pig) | SS |
| A0A096MJY4 | Mef2c | Myocyte-specific enhancer factor 2C | Rattus norvegicus (Rat) | SS |
| Q2MJT0 | Mef2a | Myocyte-specific enhancer factor 2A | Rattus norvegicus (Rat) | SS |
| Q40702 | MADS2 | MADS-box transcription factor 2 | Oryza sativa subsp japonica (Rice) | PR |
| Q5K4R0 | MADS47 | MADS-box transcription factor 47 | Oryza sativa subsp japonica (Rice) | PR |
| Q655V4 | MADS30 | MADS-box transcription factor 30 | Oryza sativa subsp japonica (Rice) | PR |
| Q1PFA4 | AGL30 | Agamous-like MADS-box protein AGL30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P29383 | AGL3 | Agamous-like MADS-box protein AGL3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P35632 | AP3 | Floral homeotic protein APETALA 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q683D7 | MAF5 | Protein MADS AFFECTING FLOWERING 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FUY6 | J | MADS-box protein JOINTLESS | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGRKKIQITR | IMDERNRQVT | FTKRKFGLMK | KAYELSVLCD | CEIALIIFNS | SNKLFQYAST |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DMDKVLLKYT | EYNEPHESRT | NSDIVETLRK | KGLNGCESPD | ADDYFEHSPL | SEDRFSKLNE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DSDFIFKRGP | PGLPAQNFSM | SVTVPVSNPN | TLTYSNPGSS | LVSPSLAASS | SLTSTTMLSP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PQTTLHRNVS | PGAPQRPPST | GNAGGILGTT | DLTVPNGAGT | SPVGNGVWNS | RASPSLLGTA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GGGNGLGKVM | PTKSPPPPGG | GGLGMNNRKP | DLRVVIPPSS | KGMMPPLTEE | DELELNTQRI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SSSQSTQPLA | TPVVSVTTPS | FPPAGLVYSA | MPTAYNTDYS | LTSADLSAFE | GFNSPGMLSL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GQVSPWQQHH | LGPATLSSLV | SGSQLSQGSN | LSINTNQNIN | IKSEPISPPR | DRVNSSGFPQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QQPPQQPQPP | QPPQQPPQRQ | EMGRSPVDSL | SSSSSSYDGS | DREDPRSDFH | SPVVLGRPPN |
| 490 | |||||
| SEDRESPSVK | RMRMDTWVT |