Q9W4T4

SS
Gene name
dnc (CG32498)
Protein name
3',5'-cyclic-AMP phosphodiesterase, isoform I
Names
EC 3.1.4.53 , Learning/memory process protein , Protein dunce , cAMP-specific phosphodiesterase, isoform I
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
EC number
3.1.4.53: Phosphoric diester hydrolases
Protein Class

Descriptions

PDE4D encodes a cAMP-specific 3',5'-cyclic phosphodiesterase 4D involved in the hydrolysis of cAMP and cGMP, which play important roles in many physiological processes. The autoinhibitory domain of PDE4D is located in the upstream conserved region 2 (UCR2) that inhibits PDE4D activity. Specifically, the α-helical NQVSE[F/Y]ISXTFLD sequence within UCR2 can fold across the catalytic pocket and thus control access to it. In addition, UCR1 can interact with UCR2 to regulate the activity of PDE4.

Autoinhibitory domains (AIDs)

554-625 (Upstream conserved region 1) SS

Target domain

795-1124 (3'5'-cyclic nucleotide phosphodiesterase, catalytic domain)

Relief mechanism

PTM

Assay

656-734 (Upstream conserved region 2) SS

Target domain

795-1124 (3'5'-cyclic nucleotide phosphodiesterase, catalytic domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9W4T4

Entry ID Method Resolution Chain Position Source
AF-Q9W4T4-F1 Predicted AlphaFoldDB

No variants for Q9W4T4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9W4T4

No associated diseases with Q9W4T4

4 regional properties for Q9W4T4

Type Name Position InterPro Accession
domain 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 795 - 1124 IPR002073
domain HD/PDEase domain 871 - 1052 IPR003607
conserved_site 3'5'-cyclic nucleotide phosphodiesterase, conserved site 911 - 922 IPR023174
domain Phosphodiesterase 4 upstream conserved regions (UCR) 603 - 725 IPR040844

Functions

Description
EC Number 3.1.4.53 Phosphoric diester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

3 GO annotations of molecular function

Name Definition
3',5'-cyclic-AMP phosphodiesterase activity Catalysis of the reaction
3',5'-cyclic-GMP phosphodiesterase activity Catalysis of the reaction
metal ion binding Binding to a metal ion.

20 GO annotations of biological process

Name Definition
anesthesia-resistant memory The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.
associative learning Learning by associating a stimulus (the cause) with a particular outcome (the effect).
axon extension Long distance growth of a single axon process involved in cellular development.
behavioral response to ethanol Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
cAMP catabolic process The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
cAMP-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
circadian rhythm Any biological process in an organism that recurs with a regularity of approximately 24 hours.
conditioned taste aversion A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus.
courtship behavior The behavior of an organism for the purpose of attracting sexual partners.
learning Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
mating behavior The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.
medium-term memory The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).
memory The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.
nonassociative learning A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment.
olfactory learning Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
regulation of protein kinase A signaling Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
short-term memory The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.
thermosensory behavior Behavior that is dependent upon the sensation of temperature.

32 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q28156 PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase Bos taurus (Bovine) SS
P23439 PDE6B Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Bos taurus (Bovine) PR
P52731 PDE6C Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Gallus gallus (Chicken) PR
H2QL32 PDE9A High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Pan troglodytes (Chimpanzee) PR
Q9VJ79 Pde11 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 Drosophila melanogaster (Fruit fly) SS
Q9HCR9 PDE11A Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Homo sapiens (Human) SS
O76083 PDE9A High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens (Human) PR
O76074 PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase Homo sapiens (Human) EV
P51160 PDE6C Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Homo sapiens (Human) PR
P35913 PDE6B Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Homo sapiens (Human) PR
Q9Y233 PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Homo sapiens (Human) PR
P27815 PDE4A cAMP-specific 3',5'-cyclic phosphodiesterase 4A Homo sapiens (Human) EV SS
Q08493 PDE4C cAMP-specific 3',5'-cyclic phosphodiesterase 4C Homo sapiens (Human) EV SS
Q08499 PDE4D cAMP-specific 3',5'-cyclic phosphodiesterase 4D Homo sapiens (Human) EV
Q07343 PDE4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B Homo sapiens (Human) EV SS
P23440 Pde6b Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Mus musculus (Mouse) PR
O70628 Pde9a High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Mus musculus (Mouse) PR
Q8CG03 Pde5a cGMP-specific 3',5'-cyclic phosphodiesterase Mus musculus (Mouse) SS
Q8CA95 Pde10a cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Mus musculus (Mouse) PR
P0C1Q2 Pde11a Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Mus musculus (Mouse) SS
O89084 Pde4a 3',5'-cyclic-AMP phosphodiesterase 4A Mus musculus (Mouse) SS
Q3UEI1 Pde4c cAMP-specific 3',5'-cyclic phosphodiesterase 4C Mus musculus (Mouse) PR
Q01063 Pde4d 3',5'-cyclic-AMP phosphodiesterase 4D Mus musculus (Mouse) SS
Q8QZV1 Pde9a High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Rattus norvegicus (Rat) PR
Q8VID6 Pde11a Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Rattus norvegicus (Rat) SS
O54735 Pde5a cGMP-specific 3',5'-cyclic phosphodiesterase Rattus norvegicus (Rat) SS
Q9QYJ6 Pde10a cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Rattus norvegicus (Rat) PR
P54748 Pde4a 3',5'-cyclic-AMP phosphodiesterase 4A Rattus norvegicus (Rat) SS
P14270 Pde4d cAMP-specific 3',5'-cyclic phosphodiesterase 4D Rattus norvegicus (Rat) PR
P14646 Pde4b cAMP-specific 3',5'-cyclic phosphodiesterase 4B Rattus norvegicus (Rat) SS
P14644 Pde4c cAMP-specific 3',5'-cyclic phosphodiesterase 4C Rattus norvegicus (Rat) PR
Q22000 pde-4 Probable 3',5'-cyclic phosphodiesterase pde-4 Caenorhabditis elegans PR
10 20 30 40 50 60
MMRLARFTQG FSFNKNVAKH RGSGSSNGTG NGSGTGNGQG LGGSCSANGL AATGGVGGGG
70 80 90 100 110 120
GSGSGGGGCG SGSGSGSGKR KSKARTKCFG GTVFRCCLPC RGGGSAAPAT SPPQTPAQTP
130 140 150 160 170 180
DELKVIPEDC NLEKSAEQKR DLLERNNKED DLLNRTVSGS ELDLYGGAGG GTKKHSLADT
190 200 210 220 230 240
IDTSVTTPIS LKTLINDVDE ELDQQLSAAD IAAASLASGL VARRAEPETL SDASVSPTAV
250 260 270 280 290 300
VQQQQQQQQQ LQQPLLQSQP HFVPSSGNIL SQVTLYSGSN PSTNPCQSAV QNQGQNSNPN
310 320 330 340 350 360
PNQNPNTNPN QNQQRCSCQP QTSPLPHIKE EEESDQANFK HQTSLKEHQP LPPPITIATG
370 380 390 400 410 420
YCGSCESVHH SSATSSSAGT VPPGGQQTQE YIAGTSSTPS PRIKLKFRKP HKSCWSRIVL
430 440 450 460 470 480
APIGSAGGSS SATTVIGSNS NETLASSSTT GGTATTTQNS SSVSVAAHHR LTSSSASALA
490 500 510 520 530 540
TSHPSNSQLL PTSKMQAEQG SIGDLQKYHS RYLKNRRHTL ANVRFDVENG QGARSPLEGG
550 560 570 580 590 600
SPSAGLVLQN LPQRRESFLY RSDSDFEMSP KSMSRNSSIA SERFKEQEAS ILVDRSHGED
610 620 630 640 650 660
LIVTPFAQIL ASLRSVRNNL LSLTNVPASN KSRRPNQSSS ASRSGNPPGA PLSQGEEAYT
670 680 690 700 710 720
RLATDTIEEL DWCLDQLETI QTHRSVSDMA SLKFKRMLNK ELSHFSESSR SGNQISEYIC
730 740 750 760 770 780
STFLDKQQEF DLPSLRVEDN PELVAANAAA GQQSAGQYAR SRSPRGPPMS QISGVKRPLS
790 800 810 820 830 840
HTNSFTGERL PTFGVETPRE NELGTLLGEL DTWGIQIFSI GEFSVNRPLT CVAYTIFQSR
850 860 870 880 890 900
ELLTSLMIPP KTFLNFMSTL EDHYVKDNPF HNSLHAADVT QSTNVLLNTP ALEGVFTPLE
910 920 930 940 950 960
VGGALFAACI HDVDHPGLTN QFLVNSSSEL ALMYNDESVL ENHHLAVAFK LLQNQGCDIF
970 980 990 1000 1010 1020
CNMQKKQRQT LRKMVIDIVL STDMSKHMSL LADLKTMVET KKVAGSGVLL LDNYTDRIQV
1030 1040 1050 1060 1070 1080
LENLVHCADL SNPTKPLPLY KRWVALLMEE FFLQGDKERE SGMDISPMCD RHNATIEKSQ
1090 1100 1110 1120 1130 1140
VGFIDYIVHP LWETWADLVH PDAQDILDTL EENRDYYQSM IPPSPPPSGV DENPQEDRIR
1150 1160 1170 1180 1190 1200
FQVTLEESDQ ENLAELEEGD ESGGESTTTG TTGTTAASAL SGAGGGGGGG GGMAPRTGGC
QNQPQHGGM