Q9W1I9

PR
Gene name
shu (CG4735)
Protein name
Inactive peptidyl-prolyl cis-trans isomerase shutdown
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG4735
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-172 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9W1I9

Entry ID Method Resolution Chain Position Source
AF-Q9W1I9-F1 Predicted AlphaFoldDB

No variants for Q9W1I9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9W1I9

No associated diseases with Q9W1I9

1 regional properties for Q9W1I9

Type Name Position InterPro Accession
domain FKBP-type peptidyl-prolyl cis-trans isomerase domain 101 - 192 IPR001179

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Present in the cytoplasm of germ cells
  • Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis
  • Also present in Yb bodies
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
P granule A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes.
Yb body A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell.

2 GO annotations of molecular function

Name Definition
Hsp90 protein binding Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

5 GO annotations of biological process

Name Definition
gene silencing by RNA A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
piRNA metabolic process The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QQ71 FKBP6 Inactive peptidyl-prolyl cis-trans isomerase FKBP6 Bos taurus (Bovine) PR
F6PHZ6 FKBP6 Inactive peptidyl-prolyl cis-trans isomerase FKBP6 Equus caballus (Horse) PR
Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4 Homo sapiens (Human) PR
Q14318 FKBP8 Peptidyl-prolyl cis-trans isomerase FKBP8 Homo sapiens (Human) EV
O35465 Fkbp8 Peptidyl-prolyl cis-trans isomerase FKBP8 Mus musculus (Mouse) SS
Q3B7U9 Fkbp8 Peptidyl-prolyl cis-trans isomerase FKBP8 Rattus norvegicus (Rat) SS
Q7DMA9 PAS1 Peptidyl-prolyl cis-trans isomerase PASTICCINO1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEENFEPYTP QLLKNPLSYS DLVKKGVEFE VDNSQQNHAR DLGLDSDSDS DYEDALDVDG
70 80 90 100 110 120
EELRSPWTYS FDELRALMSE IDENIYKRIT RTGHVDREAV PNKARVSVRY SGYWEGETAP
130 140 150 160 170 180
FDSSLLRGSK FVFETGQGTV VEGLEVAVRS MRPYEQAEFI ISYKLLFGEL GCPPRIKPKA
190 200 210 220 230 240
DALFKVEVID YSLIGDAKGI DAIPQEDRDK FCVVYPKAVD LHLHGKDSVK LGRYQSAATA
250 260 270 280 290 300
FERAVSSLNY CRMANDEEER KQTELLTTLN QNLMIVYNKM NKPKRACIMM KALRHLTMGN
310 320 330 340 350 360
PSCKALFQEG RALAALGEYN LARNAYLQAQ AKQPANKEIS DEIISMNKRI SKYEEASRDI
370 380 390 400 410 420
WARAFSLKNS KSDVRKTPAQ LEKEAKEQDF NDKMEDLIRR FKNTSDQQVS FSRKSYSNAQ
430 440 450
FDATCKLAKE HNLKLTLSPI QEDVLTLSKP DVKFA