Q9W1B0

SS
Gene name
gek (CG4012)
Protein name
Serine/threonine-protein kinase Genghis Khan
Names
EC 2.7.11.1
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG4012
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

CDC42BPA(MRCK) is a Cdc42-binding serine/threonine kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. A region containing the two distal CC domains (CC2 and CC3; residues 658-930) interacts intramolecularly with the kinase domain and negatively regulates its activity.

Autoinhibitory domains (AIDs)

606-871 (Coiled-coil domains) SS

Target domain

100-369 (Protein kinase domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

241-265 (Activation loop from InterPro)

Target domain

100-369 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9W1B0

Entry ID Method Resolution Chain Position Source
AF-Q9W1B0-F1 Predicted AlphaFoldDB

No variants for Q9W1B0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9W1B0

No associated diseases with Q9W1B0

10 regional properties for Q9W1B0

Type Name Position InterPro Accession
domain CRIB domain 1546 - 1583 IPR000095
domain Protein kinase domain 100 - 369 IPR000719
domain AGC-kinase, C-terminal 370 - 440 IPR000961
domain Citron homology (CNH) domain 1203 - 1504 IPR001180
domain Pleckstrin homology domain 1059 - 1179 IPR001849
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 989 - 1040 IPR002219
active_site Serine/threonine-protein kinase, active site 220 - 232 IPR008271
binding_site Protein kinase, ATP binding site 106 - 129 IPR017441
domain Protein kinase, C-terminal 388 - 430 IPR017892
domain KELK-motif containing domain 477 - 556 IPR031597

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions

5 GO annotations of biological process

Name Definition
actin polymerization or depolymerization Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
actomyosin structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
synaptic target recognition The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q28021 ROCK2 Rho-associated protein kinase 2 Bos taurus (Bovine) SS
O75116 ROCK2 Rho-associated protein kinase 2 Homo sapiens (Human) SS
Q13464 ROCK1 Rho-associated protein kinase 1 Homo sapiens (Human) SS
Q9Y5S2 CDC42BPB Serine/threonine-protein kinase MRCK beta Homo sapiens (Human) SS
Q5VT25 CDC42BPA Serine/threonine-protein kinase MRCK alpha Homo sapiens (Human) EV
P70336 Rock2 Rho-associated protein kinase 2 Mus musculus (Mouse) SS
P70335 Rock1 Rho-associated protein kinase 1 Mus musculus (Mouse) SS
Q7TT50 Cdc42bpb Serine/threonine-protein kinase MRCK beta Mus musculus (Mouse) SS
Q80UW5 Cdc42bpg Serine/threonine-protein kinase MRCK gamma Mus musculus (Mouse) PR
Q3UU96 Cdc42bpa Serine/threonine-protein kinase MRCK alpha Mus musculus (Mouse) SS
M3TYT0 ROCK2 Rho-associated protein kinase 2 Sus scrofa (Pig) SS
Q62868 Rock2 Rho-associated protein kinase 2 Rattus norvegicus (Rat) EV
Q63644 Rock1 Rho-associated protein kinase 1 Rattus norvegicus (Rat) SS
Q7TT49 Cdc42bpb Serine/threonine-protein kinase MRCK beta Rattus norvegicus (Rat) SS
O54874 Cdc42bpa Serine/threonine-protein kinase MRCK alpha Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MEYESSEISD ITTGSCKKRL TFLKCILSDT TSDQKWAAEF GEDTEGHQFS LDYLLDTFIV
70 80 90 100 110 120
LYDECSNSSL RREKGVSDFL KLSKPFVHIV RKLRLSRDDF DILKIIGRGA FGEVCVVQMI
130 140 150 160 170 180
STEKVYAMKI LNKWEMLKRA ETACFREERD VLVFGDRQWI TNLHYAFQDN INLYLVMDYY
190 200 210 220 230 240
CGGDLLTLLS KFEDKLPEDM AKFYITEMIL AINSIHQIRY VHRDIKPDNV LLDKRGHVRL
250 260 270 280 290 300
ADFGSCLRLD KDGTVQSNVA VGTPDYISPE ILRAMEDGKG RYGTECDWWS LGVCMYEMLY
310 320 330 340 350 360
GETPFYAESL VETYGKIMNH QNCFNLPSQE TLNYKVSETS QDLLCKLICI PENRLGQNGI
370 380 390 400 410 420
QDFMDHPWFV GIDWKNIRQG PAPYVPEVSS PTDTSNFDVD DNDVRLTDSI PPSANPAFSG
430 440 450 460 470 480
FHLPFIGFTF SLTSSSTLDS KKNQSSGFGD DTLDTISSPQ LAILPSNNSE TPVDSVQLKA
490 500 510 520 530 540
LNDQLAALKQ EKAELSKQHN EVFERLKTQD SELQDAISQR NIAMMEYSEV TEKLSELRNQ
550 560 570 580 590 600
KQKLSRQVRD KEEELDGAMQ KNDSLRNELR KSDKTRRELE LHIEDAVIEA AKEKKLREHA
610 620 630 640 650 660
EDCCRQLQME LRKGSSSVET TMPLSISSEM SSYEIERLEL QFSEKLSHQQ TRHNMELEAL
670 680 690 700 710 720
REQFSELENA NLALTKELQQ TQERLKYTQM ESITDSAETL LELKKQHDLE KSSWFEEKQR
730 740 750 760 770 780
LSSEVNLKSK SLKELQAEDD EIFKELRMKR EAITLWERQM AEIIQWVSDE KDARGYLQAL
790 800 810 820 830 840
ATKMTEELEY LKHVGTFNNN GVDNKNWRNR RSQKLDKMEL LNLQSALQRE IQAKNMISDE
850 860 870 880 890 900
LSQTRSDLIS TQKEVRDYKK RYDSILHDFQ KKETELRDLQ KGGLEYSESF LNKSTHHGLS
910 920 930 940 950 960
SAFFRDMSKN SEIIDSAESF GNESGDNFTP NFFQSGNSGM LFNYEPKYAG KNNKDHSSMK
970 980 990 1000 1010 1020
EASVSDLSRE ESDQLVKESQ KKVPGNTAIH QFLVRTFSSP TKCNHCTSLM VGLTRQGVVC
1030 1040 1050 1060 1070 1080
EICGFACHTI CCQKVPTTCP VPMDQTKRPL GIDPTRGIGT AYEGYVKVPK SGVIKRGWIR
1090 1100 1110 1120 1130 1140
QFVVVCDFKL FLYDISPDRC ALPSVSVSQV LDMRDPEFSV GSVRESDVIH AAKKDVPCIF
1150 1160 1170 1180 1190 1200
KIKTALIDGG LSLNTLMLAD NESEKSKWVI ALGELHRILK RNSLPNTAIF KVNEILDNTL
1210 1220 1230 1240 1250 1260
SLIRNALCSV IIYPNQILLG TEDGLFYINL DQYEIARIGE SKKILQLWYI EEEQILVILC
1270 1280 1290 1300 1310 1320
GKQRNLRLLP IRALEASDVE WIKVVESKNC ISACTGIIRR FPNIVYSFII ALKRPNNHTQ
1330 1340 1350 1360 1370 1380
IVVYEINRTR TRHQKTCEFT IGYMAQHLQI LSDMRLVVAH QSGFTAYFLR GEATAMSLVH
1390 1400 1410 1420 1430 1440
PENQLCAFLN YSGVDAVRVI EILCPSGGNF GEYLLVFQTL AIYVDLQGRK SRDREIMYPA
1450 1460 1470 1480 1490 1500
FPTYITFCDG HLLVFSDTHL DIFNTQTAEW VQSIGLKQSL PLNNLGNVVL SSVNDTPLIV
1510 1520 1530 1540 1550 1560
YLSNIHTKGL LQYRDGNRKG LPSIKRRFSI REINKTIKSD RRSKMISAPT NFNHISHMGP
1570 1580 1590 1600 1610 1620
GDGIQNQRLL DLPTTLETAD QACSPIIHSL SCIPQSRKSN FLEQVDANSD DYGNDNIISR
1630
TPSPMASSFM DGLSNND