Q9VUI3

PR
Gene name
DCX-EMAP (CG42247)
Protein name
Echinoderm microtubule-associated protein-like CG42247
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG42247
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

363-439 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VUI3

Entry ID Method Resolution Chain Position Source
AF-Q9VUI3-F1 Predicted AlphaFoldDB

No variants for Q9VUI3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VUI3

No associated diseases with Q9VUI3

12 regional properties for Q9VUI3

Type Name Position InterPro Accession
repeat WD40 repeat 516 - 562 IPR001680-1
repeat WD40 repeat 565 - 610 IPR001680-2
repeat WD40 repeat 660 - 697 IPR001680-3
repeat WD40 repeat 703 - 742 IPR001680-4
repeat WD40 repeat 792 - 831 IPR001680-5
repeat WD40 repeat 832 - 869 IPR001680-6
repeat WD40 repeat 872 - 911 IPR001680-7
repeat WD40 repeat 918 - 956 IPR001680-8
repeat WD40 repeat 1032 - 1072 IPR001680-9
domain Doublecortin domain 166 - 253 IPR003533-1
domain Doublecortin domain 295 - 380 IPR003533-2
domain HELP 449 - 515 IPR005108

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
sensory dendrite A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron.

1 GO annotations of molecular function

Name Definition
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.

5 GO annotations of biological process

Name Definition
adult locomotory behavior Locomotory behavior in a fully developed and mature organism.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
melanotic encapsulation of foreign target Formation of a multilayered, melanized sheath of cells around a foreign invader.
microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
sensory perception of sound The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96MT7 CFAP44 Cilia- and flagella-associated protein 44 Homo sapiens (Human) PR
O15075 DCLK1 Serine/threonine-protein kinase DCLK1 Homo sapiens (Human) EV
Q9UHG0 DCDC2 Doublecortin domain-containing protein 2 Homo sapiens (Human) PR
O00423 EML1 Echinoderm microtubule-associated protein-like 1 Homo sapiens (Human) PR
Q9JLM8 Dclk1 Serine/threonine-protein kinase DCLK1 Mus musculus (Mouse) SS
Q5DU00 Dcdc2 Doublecortin domain-containing protein 2 Mus musculus (Mouse) PR
Q95QC4 zyg-8 Serine/threonine-protein kinase zyg-8 Caenorhabditis elegans PR
10 20 30 40 50 60
MPQISPNAPL EGNVSPPPTQ PHLDDNLHNG NGNGNGIHSS SSNINKHGSN INGNNDSNRS
70 80 90 100 110 120
SPAKSPKRPV SSSFRIQNTS RYDNDEEDLA ASEQVAGGDR QVPDYWQQRN GATTGATSGR
130 140 150 160 170 180
QSRAISPGYL DNMSENSEQP PVVPLVRSKS RPEISSAAAS RYNNLSYWKA RRVVFYRNGD
190 200 210 220 230 240
PFFPGVELRY RPGRDVTSLD NLLDKISPKM DLPRGARYVF SMDGDRKYHL DELEDGAFYV
250 260 270 280 290 300
VSSFKAFKPA SYGKKNGMWY ASPGNQGWGS KPASRKPSIM EADLGTLSTT SGSIKRSAGR
310 320 330 340 350 360
VIRIINNLDH SVQCRVLLNL RTSQPFEEVL EDLGQVLKIN GAKKMYTGTG QEVRSFSQLR
370 380 390 400 410 420
NEFADVDTFY LATGTALIAG SPIRRSRSRP SVVAAAPILP TDELPKVPLR GARPRSKSRP
430 440 450 460 470 480
RILYAPESEI LRPNGEYTML DIMKEEPTKV TIRGLRRTFY PPVHHAPADN SPPDKKLQLQ
490 500 510 520 530 540
WVHGYRGIDA RRNLWVLPSG ELLYYVAAVA VLFDRDEDAQ RHYTGHTEDI MCMDVHPSRE
550 560 570 580 590 600
LVASGQKAGR DRKSQAHVRI WSTESLQTLY VFGMGELDSG VTAVAFSQLN GGSYILAVDS
610 620 630 640 650 660
GRESILSVWQ WQWGHLLGKV ATLQEGLSGA AFHPLDDNLI ITHGRGHLAF WHRRKDGFFE
670 680 690 700 710 720
RTDIVKQPSR SHVTSVQFEP DGDVITADSD GFITIYSVDS DGAYFVRTEF EAHNKGIGCL
730 740 750 760 770 780
IMLGEGTLLS GGEKDRKIAA WDSLQNYKKI ADTKLPEAAG GVRTIYPQRP GRNDGNIYVG
790 800 810 820 830 840
TTRNNILEGS LQRRFTQVVF GHGRQLWGLA AHPDDELYAT AGHDKHVALW RKNKLIWTIQ
850 860 870 880 890 900
TGYECVALAF HPFGTLAAGS TEGHLLVINC ENGAVMLTLR VCGSPLNCVA YNQVGDMIAM
910 920 930 940 950 960
GSQNGSIYLF RVSRDGFSYK KVNKIRGSQP LTHLDWSMDG NFVQTVTIDF DLLFWDAKSL
970 980 990 1000 1010 1020
SPERSPIAMK DVKWLTNNCT VGFLVAGQWS NRYYSTTNTI VATCSRSAAH DMLASGDAEG
1030 1040 1050 1060 1070
YLRLFRYPCI SPRAEFHESK VYSGMLACVR FLCGDHTLIT VGGTDASLMV WDIVEE