Q9VTU3

PR
Gene name
RhoGAP68F (CG6811)
Protein name
Rho GTPase-activating protein 68F
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG6811
EC number
Protein Class

Descriptions

(Annotation based on sequence homology with Q07960)
Rho GTPase-activating protein 1 (p50RhoGAP) comprises an N-terminal BCH domain and a C-terminal GAP domain separated by a proline-rich region. p50RhoGAP contains a non-canonical RhoA-binding motif in its BCH domain and is associated with GAP-mediated cell rounding. In the autoinhibited state, the GAP catalytic residue is being occluded and incapable of RhoA inactivation, and it only becomes accessible upon the release of autoinhibition of GAP from the BCH domain. The lipid binding to BCH domain may initiate the transition for the release of GAP domain from the inactive state to the active state of p50RhoGAP. This leads to the activation of the GAP domain of p50RhoGAP, resulting in the GAP-mediated GTPase inactivation of RhoA.

Autoinhibitory domains (AIDs)

1-119 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VTU3

Entry ID Method Resolution Chain Position Source
AF-Q9VTU3-F1 Predicted AlphaFoldDB

No variants for Q9VTU3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VTU3

No associated diseases with Q9VTU3

3 regional properties for Q9VTU3

Type Name Position InterPro Accession
domain Death domain 15 - 93 IPR000488
domain Protein kinase domain 210 - 475 IPR000719
domain IRAK2, death domain 3 - 91 IPR042151

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
small GTPase binding Binding to a small monomeric GTPase.

7 GO annotations of biological process

Name Definition
imaginal disc-derived leg morphogenesis The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster.
negative regulation of endocytic recycling Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling.
negative regulation of stress fiber assembly Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
positive regulation of synaptic assembly at neuromuscular junction Any process that activates or increases the frequency, rate or extent of synaptic assembly at neuromuscular junction.
Rho protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.
ventral furrow formation Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q07960 ARHGAP1 Rho GTPase-activating protein 1 Homo sapiens (Human) EV
P85298 ARHGAP8 Rho GTPase-activating protein 8 Homo sapiens (Human) SS
Q5FWK3 Arhgap1 Rho GTPase-activating protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MDAHSRFAPR LPGPAINPIV DNSDEPQPSL SDLHDFEPKL EFDDTELLAP SPLEKDVMVG
70 80 90 100 110 120
DFVLAEDPEL EPEEDVNPLE DDFEDQLREQ SENFQTPRNK CDFLGTDKQG RHIFGIYASR
130 140 150 160 170 180
FPEKSQLEGF VREIIKEIEP FVENDYILVY FHQGLKEDNK PSAQFLWNSY KELDRNFRKN
190 200 210 220 230 240
LKTLYVVHPT WFIRVIWNFF SPFISDKFRK KLVYISSLDE LRQALGLNKL KLPDNICDLD
250 260 270 280 290 300
DKLNPSRKPS TPPPSSNINA SRQQQHKMAT THQFGVPLKF IVMNSPCLNS IPPIVRKCVD
310 320 330 340 350 360
SLSITGVIDT EGIFRRSGNH SEIMALKERV NRGEDVDLKS VNVHVIAGLL KSFLRDLAEP
370 380 390 400 410 420
LLTFELYEDV TGFLDWPKEE RSRNVTQLIR EKLPEENYEL FKYIVEFLVR VMDCEDLNKM
430 440 450 460 470
TSSNLAIVFG PNFLWSRSTS TSLEEIAPIN AFVDFVLQNH KDIYLIDVNQ RTVSVD