Q9VT57
Gene name |
Cdk8 (CG10572) |
Protein name |
Cyclin-dependent kinase 8 |
Names |
Cell division protein kinase 8, DmCdk8, Mediator complex subunit Cdk8, Mediator of RNA polymerase II transcription subunit Cdk8 |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG10572 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|

Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
172-198 (Activation loop from InterPro)
Target domain |
21-335 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure

Activated structure

1 structures for Q9VT57
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-Q9VT57-F1 | Predicted | AlphaFoldDB |
No variants for Q9VT57
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
No variants for Q9VT57 |
No associated diseases with Q9VT57
Functions
Description | ||
---|---|---|
EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
Subcellular Localization |
|
|
PANTHER Family | ||
PANTHER Subfamily | ||
PANTHER Protein Class | ||
PANTHER Pathway Category | No pathway information available |
2 GO annotations of cellular component
Name | Definition |
---|---|
mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
Name | Definition |
---|---|
ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
RNA polymerase II CTD heptapeptide repeat kinase activity | Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II. |
7 GO annotations of biological process
Name | Definition |
---|---|
chaeta development | The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell. |
G1/S transition of mitotic cell cycle | The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. |
imaginal disc-derived leg segmentation | Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint. |
positive regulation of autophagy | Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
protein phosphorylation | The process of introducing a phosphate group on to a protein. |
sex comb development | The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg. |
snRNA 3'-end processing | Any process involved in forming the mature 3' end of an snRNA molecule. |
7 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
P39073 | SSN3 | Meiotic mRNA stability protein kinase SSN3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
Q9BWU1 | CDK19 | Cyclin-dependent kinase 19 | Homo sapiens (Human) | PR |
P49336 | CDK8 | Cyclin-dependent kinase 8 | Homo sapiens (Human) | PR |
Q8BWD8 | Cdk19 | Cyclin-dependent kinase 19 | Mus musculus (Mouse) | PR |
Q8R3L8 | Cdk8 | Cyclin-dependent kinase 8 | Mus musculus (Mouse) | PR |
Q6P3N6 | cdk8 | Cyclin-dependent kinase 8 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
Q8JH47 | cdk8 | Cyclin-dependent kinase 8 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MDYDFKMKTQ | IERTKVEDLF | NYEGCKVGRG | TYGHVYKAKW | KETSDGKEYA | LKQIDGTGLS |
70 | 80 | 90 | 100 | 110 | 120 |
MSACREIALL | RELKHQNVIT | LIRVFLSHND | RKVFLLIDYA | EHDLWHIIKF | HRAAKATKKQ |
130 | 140 | 150 | 160 | 170 | 180 |
VVVPRGMVKS | LLYQILDGIH | YLHSNWVLHR | DLKPANILVM | GDGNERGRVK | IADMGFARLF |
190 | 200 | 210 | 220 | 230 | 240 |
NAPLKPLADL | DPVVVTFWYR | APELLLGARH | YTKAIDIWAI | GCIFAELLTS | EPIFHCRQED |
250 | 260 | 270 | 280 | 290 | 300 |
IKTSNPYHHD | QLDRIFNVMG | FPQDKDWEDI | KKMPEHHTLT | KDFKRSTYST | CSLAKYMERH |
310 | 320 | 330 | 340 | 350 | 360 |
KIKPDSKAFH | LLQKLLLMDP | NKRITSEQAM | QDQYFQEEPQ | PTQDVFAGCP | IPYPKREFLT |
370 | 380 | 390 | 400 | 410 | 420 |
DDDQEDKSDN | KRQQQQQQQQ | QQQQQQQQQQ | QQQQQQQQQQ | MNAEPNAKRV | RLSGAGNQQD |
430 | 440 | 450 | |||
FHHQQQQQQQ | QQQQQQQQQQ | QMMFNQQQNF | QRFN |