Q9VRJ0

PR
Gene name
Gen (CG10670)
Protein name
Flap endonuclease GEN
Names
Flap structure-specific endonuclease GEN, Xpg-like endonuclease, DmGEN
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG10670
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

59-142 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VRJ0

Entry ID Method Resolution Chain Position Source
AF-Q9VRJ0-F1 Predicted AlphaFoldDB

No variants for Q9VRJ0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VRJ0

No associated diseases with Q9VRJ0

4 regional properties for Q9VRJ0

Type Name Position InterPro Accession
domain XPG, N-terminal 1 - 95 IPR006085
domain XPG-I domain 131 - 223 IPR006086
conserved_site Helix-hairpin-helix motif, class 2 210 - 244 IPR008918
domain Flap endonuclease GEN, chromatin organization modifier domain 400 - 472 IPR041012

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

9 GO annotations of molecular function

Name Definition
5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule.
5'-flap endonuclease activity Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
crossover junction endodeoxyribonuclease activity Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
double-stranded DNA 3'-5' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule.
endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
four-way junction DNA binding Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
metal ion binding Binding to a metal ion.
single-stranded DNA 3'-5' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule.

4 GO annotations of biological process

Name Definition
DNA catabolic process, endonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
DNA catabolic process, exonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q58DH8 FEN1 Flap endonuclease 1 Bos taurus (Bovine) PR
Q5ZLN4 FEN1 Flap endonuclease 1 Gallus gallus (Chicken) PR
P39748 FEN1 Flap endonuclease 1 Homo sapiens (Human) PR
Q5XIP6 Fen1 Flap endonuclease 1 Rattus norvegicus (Rat) PR
Q75LI2 FEN1B Flap endonuclease 1-B Oryza sativa subsp japonica (Rice) PR
Q9SXQ6 FEN1A Flap endonuclease 1-A Oryza sativa subsp japonica (Rice) PR
C5YUK3 FEN1-A Flap endonuclease 1-A Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
Q9M2Z3 SEND1 Single-strand DNA endonuclease 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGVKELWGVL TPHCERKPIN ELRGKKVAID LAGWVCESLN VVDYFVHPRH HLKNLFFRTC
70 80 90 100 110 120
YLIWEQVTPV FVLEGVAPKL KSQVIAKRNE LQFRGVKPKN SPECTQSQPS KGDKGRSRFN
130 140 150 160 170 180
HVLKQCETLL LSMGIQCVQG PGEAEAYCAF LNKHGLVDGV ISQDSDCFAY GAVRVYRNFS
190 200 210 220 230 240
VSTQGAQAAA GGAVDIYDMR EITSRMDFGQ QKIIVMALLC GCDYCPDGIG GIGKDGVLKL
250 260 270 280 290 300
FNKYKETEIL DRMRSWRGET DKYNALEIRV DDKSICSNCG HIGKTQSHTK SGCSVCRTHK
310 320 330 340 350 360
GCDESLWKEQ RLSIKSELTL RRKALLSPDF PNEEIIAEFL SEPDTIPNLN LNWRQPNLVK
370 380 390 400 410 420
FIKQIGHLLQ WPEIYCFQKF FPILTRWQVQ QSKQEKILIQ PHEIIKKRTV KGVPSLELRW
430 440 450 460 470 480
HDPSGIFKGL IPDKQIAEYE AEHPKGIEEL YYTIEPLDML ETAYPDLVAA FLKSKEKPAK
490 500 510 520 530 540
KTTRKKKTAS EEENKENEPN SKPKRVVRKI KAQPEENQPL LHQFLGRKKE GTPVKAPAPQ
550 560 570 580 590 600
RQQCSTPITK FLPSDLESDC DAEEFDMSDI VKGIISNPNA KPALTNHDGH QLHYEPMAED
610 620 630 640 650 660
LSLRLAQMSL GNVNESPKVE TKRDLSQVDQ LPQSKRFSLE DSFDLLVKGD LQKLARTPVE
670 680 690 700 710 720
RFKMQHRISE KIPTPVKPLD NISYFFNQSS DNADVFEELM NSSLVPQDQE DNAEDEEEDD
LVVISD