Q9VQN8
Gene name |
CG3326 |
Protein name |
Fidgetin-like protein 1 |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG3326 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9VQN8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9VQN8-F1 | Predicted | AlphaFoldDB |
No variants for Q9VQN8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9VQN8 | |||||
No associated diseases with Q9VQN8
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| microtubule severing ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| ATP metabolic process | The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. |
| microtubule severing | The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends. |
| mitotic sister chromatid segregation | The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. |
| regulation of microtubule depolymerization | Any process that modulates the frequency, rate or extent of microtubule depolymerization. |
| response to wounding | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UBP0 | SPAST | Spastin | Homo sapiens (Human) | PR |
| A6NCM1 | IQCA1L | IQ and AAA domain-containing protein 1-like | Homo sapiens (Human) | PR |
| Q6PIW4 | FIGNL1 | Fidgetin-like protein 1 | Homo sapiens (Human) | PR |
| A6H690 | Iqca1l | IQ and AAA domain-containing protein 1-like | Mus musculus (Mouse) | PR |
| Q6AXQ7 | Iqca1l | IQ and AAA domain-containing protein 1-like | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDEQSSWRS | KLLLICQQTR | SSSESIHFAA | LKDHHARLQA | CESMEKAMKE | RCQKKITMSR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RTKRGITHAG | YLFEMPHNSV | FEPECRGFYE | SCQQTEMASS | DLQAPALEVS | STYPVQQAVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SRPEGQFPES | RNNSTKKIDA | QQYSSESSSQ | SGFGFRTARE | QLIMDELKKK | NRQATSEVDA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VPTGMMNFRK | KTLGGKRTVS | SNFVSPVAQN | DNSTSSRSSS | IPPALAHLDS | KMVDHILGES |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MHDFKPVAWE | DIAGLESAKS | TFLEAIIMPL | RRPDLFTGVR | CPPRGVLLFG | PPGTGKTLIA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KSIASQAKAK | FFSINPSSLT | SKWVGDAEKL | VKTLFAVAAA | HQPAIIFIDE | VDSLLSKRSA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NENESTLRLK | NEFLIHLDGA | ASNEEIRVLV | IGATNRPQEL | DEAVRRRFVR | RLYVPLPTRE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ARQKIIEKLI | HQVKHNLDVR | QVIELAELTD | GYSGADVDTL | CRYASMAPLR | SLTPDQMEVI |
| 490 | 500 | 510 | 520 | ||
| ETHQLPAVTM | DDFKQALRVI | SKSVSSEDCK | QFEAWNEIYG | VRH |