Q9VL72

PR
Gene name
Etl1 (CG5899)
Protein name
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog
Names
Enhancer trap locus homolog 1, Etl-1
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG5899
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-68 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VL72

Entry ID Method Resolution Chain Position Source
AF-Q9VL72-F1 Predicted AlphaFoldDB

No variants for Q9VL72

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VL72

No associated diseases with Q9VL72

3 regional properties for Q9VL72

Type Name Position InterPro Accession
domain SNF2, N-terminal 305 - 585 IPR000330
domain Helicase, C-terminal 653 - 818 IPR001650
domain Helicase superfamily 1/2, ATP-binding domain 285 - 480 IPR014001

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent activity, acting on DNA Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.
ATP-dependent chromatin remodeler activity An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
positive regulation of innate immune response Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P31380 FUN30 ATP-dependent helicase FUN30 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q24368 Iswi Chromatin-remodeling complex ATPase chain Iswi Drosophila melanogaster (Fruit fly) SS
Q9H4L7 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MSDSTVAASA SASASSSAKS SLSDLRQFRI NKNASSVVAS PSRTERVPGK KRIQVMADSD
70 80 90 100 110 120
SDGNDSQTPK KTKLELTVKE KEERYMAAAK ISPHFDTMAI QESLSRTNWD VAASVRYLRE
130 140 150 160 170 180
NCKPKGHNGP LAKSKLKPRS NGISGGNFSD NDHSDDDDVK QSKDQVYDSD DSDSEMSTKM
190 200 210 220 230 240
TGQRKKVFQF MNEASLIELQ SVKTLSEKKA LAIIDVRPFS DWSDLRQKLE SIRMSGDLLN
250 260 270 280 290 300
YAQELINKQN TVAAILSKCN NMVSRLEKAI SNGAGIVEQP KLLSSGLQLA DYQIIGLNWL
310 320 330 340 350 360
TVMHKQEMNG ILADEMGLGK TIQVIAFLAY LKENGLSQAA HLIVVPSSTL DNWEAEISRW
370 380 390 400 410 420
CPELVVEKYH GSQDERRRMR GRFAKDGFTG FDVLLTTYHI VGSTPEERKM FRVCKLDYVI
430 440 450 460 470 480
FDEAHMLKNM TTQRYANLIT INARMRILLT GTPLQNNLLE LISLLCFVMP KFFAKSIEDI
490 500 510 520 530 540
KSLFAKKGKS DGDQDEVSQF QETQIQRAKR IMKPFVLRRL KKDVLKNLPK KLSLVEKVPM
550 560 570 580 590 600
SSQQKIYYHE LVDYYSNNKG EVCSSSERAG IAIMMEMRRI ANHPLLMRHY FTDANLRGFS
610 620 630 640 650 660
KRLANASSFK KTNEQYIFEE LAVMSDFQVY QMMNKHEFYD VKIPDNLICD SGKFLYLDTL
670 680 690 700 710 720
LPKLKAEGHR VLLFSQFTMM LDIVEEYLRI RKFGFCRLDG ATAVNVRQDL ITDFNGDDSI
730 740 750 760 770 780
FVFLLSTKAG GVGINLTAAD TCVIHDIDFN PYNDKQAEDR CHRMGQQRPV TIYRLISEST
790 800 810 820 830 840
IEEGILMAAE EKLKLEKDIT SNEKGEVHEQ RCVVKLLTTA LGLDKDQEEQ LNNSLNNSIA
SPAK