Q9VEN1

SS
Gene name
cher (cheerio, sko, CG3937)
Protein name
Filamin-A
Names
FLN-A , Actin-binding protein 280 , ABP-280 , Filamin-1 , Filamin1
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG3937
EC number
Protein Class

Descriptions

Filamins are actin-crosslinking proteins including an N terminal actin-binding domain and 24 Ig-like domain (IgFLNs). The N-terminus of IgFLNa20 forms a β-strand that associates with the integrin binding surface of IgFLNa21 and occupies the binding site for integrin adhesion receptors. Disruption of this IgFLNa20-IgFLNa21 interaction enhances filamin binding to integrin β-tails. In addition, IgFLNa18 negatively regulates the integrin binding to IgFLNa19.

Autoinhibitory domains (AIDs)

1564-1654 (IgFLNa18 domain) SS

Target domain

1655-1752 (IgFLNa19 domain)

Relief mechanism

PTM, Others

Assay

1700-1796 (IgFLNa20 domain) SS

Target domain

1847-1940 (IgFLNa21 domain)

Relief mechanism

PTM, Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VEN1

Entry ID Method Resolution Chain Position Source
AF-Q9VEN1-F1 Predicted AlphaFoldDB

No variants for Q9VEN1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VEN1

No associated diseases with Q9VEN1

14 regional properties for Q9VEN1

Type Name Position InterPro Accession
domain Protein kinase domain 467 - 755 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 468 - 743 IPR001245
domain Immunoglobulin subtype 2 48 - 108 IPR003598-1
domain Immunoglobulin subtype 2 163 - 231 IPR003598-2
domain Immunoglobulin subtype 2 262 - 340 IPR003598-3
domain Immunoglobulin subtype 42 - 116 IPR003599-1
domain Immunoglobulin subtype 157 - 242 IPR003599-2
domain Immunoglobulin subtype 256 - 351 IPR003599-3
domain Immunoglobulin-like domain 152 - 240 IPR007110-1
domain Immunoglobulin-like domain 249 - 349 IPR007110-2
active_site Tyrosine-protein kinase, active site 608 - 620 IPR008266
domain Immunoglobulin I-set 161 - 236 IPR013098
binding_site Protein kinase, ATP binding site 473 - 503 IPR017441
domain Tyrosine-protein kinase, catalytic domain 467 - 743 IPR020635

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cell membrane
  • Localizes to intercellular bridges corresponding to ring canals that connect cytoplasm of nurse cells to the developing oocyte
  • Localizes to nurse cell plasma membranes
  • Detected in both the inner and outer rims of the ring canal
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
apical cortex The region that lies just beneath the plasma membrane on the apical edge of a cell.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
female germline ring canal An intercellular bridge that connects the germline cells of a female cyst.
female germline ring canal inner rim A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins.
female germline ring canal outer rim An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
Z disc Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

2 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

15 GO annotations of biological process

Name Definition
actin crosslink formation The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.
behavioral response to ethanol Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
female germline ring canal formation Assembly of the intercellular bridges that connect the germ-line cells of a female cyst.
female germline ring canal formation, actin assembly Recruitment and organization of actin filaments in female germline ring canals.
germarium-derived female germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster.
germline ring canal formation Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts.
long-term memory The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
motor neuron axon guidance The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
negative regulation of lamellocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes.
positive regulation of cytoskeleton organization Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
sarcomere organization The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
syncytial embryo cellularization The separation of a syncytial embryo into individual cells.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O75369 FLNB Filamin-B Homo sapiens (Human) EV
P21333 FLNA Filamin-A Homo sapiens (Human) SS
Q80X90 Flnb Filamin-B Mus musculus (Mouse) SS
Q8BTM8 Flna Filamin-A Mus musculus (Mouse) SS
10 20 30 40 50 60
MEAERDLAED AQWKKIQQNT FTRWANEHLK TIDRSINNLE TDLSDGLRLI ALIEVLSQKR
70 80 90 100 110 120
MPKYNKRPTF RSQKLENVSV ALKFLQDEGI KIVNIDSSDI VDCKLKLILG LIWTLILHYS
130 140 150 160 170 180
ISMPMWDGED DKQLNGSGHT PKQRLLNWIH AKIPDLPINN FTNDWTTGKA VGALVDACAP
190 200 210 220 230 240
GLCPDWELWD PKDAVQNASE AMGLADDWLN VRQLIKPEEL VNPNVDEQSM MTYLSQYPNS
250 260 270 280 290 300
KLKTGAPLRP KTNPNRVRAY GPGIEPIGPV VGAPANFTVE TFSAGKGSVD VDIQGPNGEI
310 320 330 340 350 360
EKADVRFNND KNLTYTVSYI PKSEGSHKVA VKFSGRDIPK SPFPVKVEGH AGDASKVKVT
370 380 390 400 410 420
GPGIQPNGVT IKKPTFFDIL AKDAGRGVPE VIIIDPANHK TSVAAKVRQL ENDTWRCEYV
430 440 450 460 470 480
TALQGLHSVN VFYAGTPIPN SPFPVKVAPL SDARKVRASG RGLQATGVRV GDDADFKIYT
490 500 510 520 530 540
EGAGEGEPEV RVIGPGGMNQ NVMQSKVDGN TYECHYYPTK EGRYVIMVTF AGQEVAKSPF
550 560 570 580 590 600
EVKVGPKKES SIVAYGPGLS SGVIGYPAAF VVETNGETGA LGFTVAGPSQ AEIECHDNGD
610 620 630 640 650 660
GSALVKYHPT AVGEYAVHIL CDNEDIPKSP FIAQILPRTD FHPELVKASG PGLEKNGVTI
670 680 690 700 710 720
NQPTSFTVDP SKAGNAPLDV VVQDVFGTKL PVELKNNPDG TKKVTYTPTS GVPHTVEVNY
730 740 750 760 770 780
GGVSTPNSPH RVYVGVPVDA AKVQAFGPWL QPGVRPNAAT HFNVDAREAG DAELKVKIIH
790 800 810 820 830 840
EETKIEVPCR IIDNEDNTYS VEVIPPSKGA YTTTMTYGGQ RVPLGEKVVV EQTVDVSKIK
850 860 870 880 890 900
VDGLEPSVIM NAATDFMVDM SKVGSNIDSG KLSCAIFDPM GHVLPSKIVQ GPTDDIFRIM
910 920 930 940 950 960
YTPFEAGRHT IELMYDNIPV PGSPFVVNVK SGCDPARCKA YGPGLEKGLT NQKNKFTVET
970 980 990 1000 1010 1020
KGAGNGGLSL AIEGPSEAKM TCTDNRDGSC DVDYLATDPG EYDITIRFAD KHIPGSPFRV
1030 1040 1050 1060 1070 1080
LVEETVDPSK VKVYGPGIEH GQVRESVPTF FNVDVGEAGP GRIAVKLTNS EGIPVDNLRV
1090 1100 1110 1120 1130 1140
EDKGNCIYAV HYVPPKAGSV LTCQVKFSEV EVPCSPFVMT VFPKSEPTKV KVKGVNEKKK
1150 1160 1170 1180 1190 1200
TPASLPAEFE IDTKQAGQAD INVAIKNPKG KAMQPRLEEV STGTYVVSFV PDECGTYQCS
1210 1220 1230 1240 1250 1260
IKYGDKEIEG SPFKLEAFPT GEAKKCKLVE QAPKIQTSGS QSHLKVDARE AGDGAVTCKI
1270 1280 1290 1300 1310 1320
TNKAGSEIVD IDVIEKDGFF DILYALNDPG DYDINVKFGG KDIPNGSFSI KAVESIEQYS
1330 1340 1350 1360 1370 1380
HSEYIEEHTT KVVQQTTQSE LVNGKSEITY RSVAFEKLPL PTTGGNVTAE VRMPSGKVDK
1390 1400 1410 1420 1430 1440
PVIQDNRDGT VSVKYDPREE GSHELVVKYN GEPVQGSPFK FHVDSITSGY VTAYGPGLTH
1450 1460 1470 1480 1490 1500
GVTGEPANFT ISTKGASAGG LTMAVEGPSK ADINYHDNKD GTVSVQYLPT APGEYQVSVR
1510 1520 1530 1540 1550 1560
FGDKHIKGSP YFAKITGEGR KRNQISVGSC SEVTMPGDIT DDDLRALNAS IQAPSGLEEP
1570 1580 1590 1600 1610 1620
CFLKRMPTGN IGISFTPREI GEHLVSVKRL GKHINNSPFK VTVCEREVGD AKKVKVSGTG
1630 1640 1650 1660 1670 1680
LKEGQTHADN IFSVDTRNAG FGGLSVSIEG PSKAEIQCTD KDDGTLNISY KPTEPGYYIV
1690 1700 1710 1720 1730 1740
NLKFADHHVE GSPFTVKVAG EGSNRKREKI QRERDAVPIT EIGSQCKLTF KMPGITSFDL
1750 1760 1770 1780 1790 1800
AACVTSPSNV TEDAEIQEVE DGLYAVHFVP KELGVHTVSV RYSEMHIPGS PFQFTVGPLR
1810 1820 1830 1840 1850 1860
DSGSHLVKAG GSGLERGVVG EAAEFNVWTR EAGGGSLAIS VEGPSKADIE FKDRKDGSCD
1870 1880 1890 1900 1910 1920
VSYKVTEPGE YRVGLKFNDR HIPDSPFKVY VSPDAGDAHK LEVQQFPQGN IQADAPYQFM
1930 1940 1950 1960 1970 1980
VRKNGAKGEL DAKIVAPSGT DDDCFIQVID GEMYSVRFYP RENGIHAIHV KFNGVHIPDS
1990 2000 2010 2020 2030 2040
PFRIKVGKDV ADPAAVHASG NGLDEVKTGH KADFIINTCN AGVGTLAVSI DGPSKVAMDC
2050 2060 2070 2080 2090 2100
TEVEEGYKVR YTPLLPGEHY ITVKYNNMHI VGSPFKVNAT GDKLADEGAQ ETSTVIVETV
2110 2120 2130 2140 2150 2160
QKVAKGGKNT GVHLPTFKSD ASKVVSKGMG LKKAYIGKQN QFSISATDAG NNILYVGMYG
2170 2180 2190 2200
PKGPCEEFHV KHAGHNNYNV QYLVRDRGQY VLLIKWGEEH IPGSPFQIDV