Q9VDS5
PR
Gene name |
RhoGAP92B (CG4755) |
Protein name |
Rho GTPase-activating protein 92B |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG4755 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9VDS5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9VDS5-F1 | Predicted | AlphaFoldDB |
No variants for Q9VDS5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9VDS5 | |||||
No associated diseases with Q9VDS5
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. |
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| imaginal disc-derived leg morphogenesis | The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster. |
| negative regulation of actin filament polymerization | Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization. |
| neuromuscular synaptic transmission | The process of synaptic transmission from a neuron to a muscle, across a synapse. |
| positive regulation of BMP secretion | Any process that activates or increases the frequency, rate or extent of BMP secretion. |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| positive regulation of synaptic assembly at neuromuscular junction | Any process that activates or increases the frequency, rate or extent of synaptic assembly at neuromuscular junction. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| regulation of actin cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| regulation of Rac protein signal transduction | Any process that modulates the frequency, rate or extent of Rac protein signal transduction. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| subsynaptic reticulum organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a subsynaptic reticulum. A subsynaptic reticulum is an elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32019 | INPP5B | Type II inositol 1,4,5-trisphosphate 5-phosphatase | Homo sapiens (Human) | PR |
| Q9Y3L3 | SH3BP1 | SH3 domain-binding protein 1 | Homo sapiens (Human) | PR |
| Q8K2H3 | Fam13b | Protein FAM13B | Mus musculus (Mouse) | PR |
| Q8K337 | Inpp5b | Type II inositol 1,4,5-trisphosphate 5-phosphatase | Mus musculus (Mouse) | PR |
| Q8BYW1 | Arhgap25 | Rho GTPase-activating protein 25 | Mus musculus (Mouse) | PR |
| P55194 | Sh3bp1 | SH3 domain-binding protein 1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRQFAKIKI | AAENLSRSSK | SDSKDSELEA | IERQVDRYRD | TIEKIVRKLP | ALSGGGGSGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GSSEEQDKRT | KKNSHYKIAQ | ALDESAKELP | KDMPLQKVLA | NCGELEKTMA | ECIIESELET |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EAKVVRRLKN | ILDKEIQEIS | TLKRNVSRTL | QEYTSLKRSH | EAAIRLEEPA | AKVNHIKSQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EECELKLEKE | RDAWAAQMLE | LIAKEDEIVS | CIRDYVLNQR | NYHERALQHV | NASLARIQDT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IQGTEKSRFG | TSLKEHLTST | NREISYIVEL | CCCCLLEHGL | EEEGLLRVGC | ASTKLRRMKH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ALEAQHVKTP | LPLDYQDPHV | IGSILKLYLR | ELPEPLLTYN | LYKDFIRIAE | RHSEAERKTE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IKAILTKLPK | ENYANLRYLT | RFLSIVQQRS | ALNKMSSQNL | AIVMSPNMLW | PRIDKSSNAP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ADYIGQVNSS | SAANIIVELL | ISQWDYFFIG | EVEFYLTLQK | QKLFVEGKSK | SNSSNENLDR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NDSEVMESPR | YGTLRRQKAN | APSPPTTNGN | GIIMTTSQTS | HRPHAKELFP | QQTPEKQEKP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AKPPLPNLPQ | FQSPAASQPT | QTQLEPLPPP | PVTPAKPVPM | TRTQFFGLDN | LPSPTADRKS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TDSIGSFKLK | PDVPQKPLLP | KRPTVLGVGV | PKADGKSDDE | GGTTPTQATI | DNGNGSVRFK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TEHFLDKLRQ | ENGETNGTRE | VSSTTKENNH | NHDPPATAAD | QNQQQAQPQV | TTPISPNSFQ |
| 730 | |||||
| TPKRPTVPAP | PPPTNWKSSD |