Q9V6K3
Gene name |
Nrk (ROR2, CG4007) |
Protein name |
Tyrosine-protein kinase transmembrane receptor Ror2 |
Names |
dRor2 , EC 2.7.10.1 , Neurospecific receptor tyrosine kinase |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG4007 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
441-711 (Protein kinase domain) |
Relief mechanism |
Others |
Assay |
|
Accessory elements
597-622 (Activation loop from InterPro)
Target domain |
441-711 (Tyrosine-protein kinase, catalytic domain) |
Relief mechanism |
|
Assay |
|
References
- Artim SC et al. (2012) "Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family", The Biochemical journal, 448, 213-20
- Uchikawa E et al. (2019) "Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex", eLife, 8,
- Nielsen J et al. (2022) "Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling", Journal of molecular biology, 434, 167458
- Chen YS et al. (2021) "Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation", Proceedings of the National Academy of Sciences of the United States of America, 118,
- Craddock BP et al. (2007) "Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region", FEBS letters, 581, 3235-40
Autoinhibited structure
Activated structure
2 structures for Q9V6K3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7ME4 | X-ray | 175 A | A | 42-321 | PDB |
| AF-Q9V6K3-F1 | Predicted | AlphaFoldDB |
No variants for Q9V6K3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9V6K3 | |||||
No associated diseases with Q9V6K3
4 regional properties for Q9V6K3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Homeodomain | 223 - 287 | IPR001356 |
| conserved_site | Homeobox, conserved site | 258 - 281 | IPR017970 |
| domain | Homeodomain, metazoa | 247 - 258 | IPR020479-1 |
| domain | Homeodomain, metazoa | 262 - 281 | IPR020479-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
| Wnt-protein binding | Binding to a Wnt-protein, a secreted growth factor involved in signaling. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| muscle cell cellular homeostasis | The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. |
| photoreceptor cell axon guidance | The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| rhabdomere development | The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
32 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q91044 | NTRK3 | NT-3 growth factor receptor | Gallus gallus (Chicken) | SS |
| Q91987 | NTRK2 | BDNF/NT-3 growth factors receptor | Gallus gallus (Chicken) | SS |
| Q91009 | NTRK1 | High affinity nerve growth factor receptor | Gallus gallus (Chicken) | SS |
| Q8AXY6 | MUSK | Muscle, skeletal receptor tyrosine protein kinase | Gallus gallus (Chicken) | SS |
| Q5IS37 | NTRK3 | NT-3 growth factor receptor | Pan troglodytes (Chimpanzee) | SS |
| Q24488 | Ror | Tyrosine-protein kinase transmembrane receptor Ror | Drosophila melanogaster (Fruit fly) | SS |
| P09208 | InR | Insulin-like receptor | Drosophila melanogaster (Fruit fly) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| P04629 | NTRK1 | High affinity nerve growth factor receptor | Homo sapiens (Human) | EV |
| Q01973 | ROR1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Homo sapiens (Human) | PR |
| Q16288 | NTRK3 | NT-3 growth factor receptor | Homo sapiens (Human) | SS |
| Q16620 | NTRK2 | BDNF/NT-3 growth factors receptor | Homo sapiens (Human) | EV |
| Q01974 | ROR2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Homo sapiens (Human) | EV |
| O15146 | MUSK | Muscle, skeletal receptor tyrosine-protein kinase | Homo sapiens (Human) | EV |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| P24786 | NTRK3 | NT-3 growth factor receptor | Sus scrofa (Pig) | SS |
| P35739 | Ntrk1 | High affinity nerve growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q03351 | Ntrk3 | NT-3 growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q63604 | Ntrk2 | BDNF/NT-3 growth factors receptor | Rattus norvegicus (Rat) | SS |
| Q62838 | Musk | Muscle, skeletal receptor tyrosine protein kinase | Rattus norvegicus (Rat) | SS |
| G5EGK5 | cam-1 | Tyrosine-protein kinase receptor cam-1 | Caenorhabditis elegans | SS |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1G4 | LECRK15 | Probable L-type lectin-domain containing receptor kinase I.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M345 | LECRK42 | L-type lectin-domain containing receptor kinase IV.2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96285 | LECRK55 | L-type lectin-domain containing receptor kinase V.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FNE1 | CRK42 | Cysteine-rich receptor-like protein kinase 42 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDQ3 | CRK34 | Cysteine-rich receptor-like protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAGQWVGVV | ERVLRGMVLK | WGANLAVLGL | CVFLFASATH | ANSLNAIEEP | VTRRHHQRHH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EREREENGYC | APYSGKVCKE | YLTGQVWYSL | EDPTGGWKNE | QVTTALWDEL | ISDLTGLCRE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AAEKMLCAYA | FPNCHMEGGR | AVKAPLCFED | CQATHLQFCY | NDWVLIEEKK | ERNMFIKSRG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HFRLPNCSSL | PHYNASMRRP | NCSYIGLTEL | KESEVSYDCR | NGNGRFYMGT | MNVSKSGIPC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QRWDTQYPHK | HFQPPLVFHQ | LLEGENYCRN | AGGEEPHPWC | YTVDESVRWQ | HCDIPMCPDY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VDPNAVDLNT | PIKMEKFFTP | SMIFLLAGIG | FVAIVTLHLM | ILLVYKLSKH | KDYSQPAGAA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TAECSVSMRG | GGDCGGNLNT | SRETLGGNGN | TNTLAKWGTI | RSTATIHSNC | VALTTVTNVS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DAKGTKPNAR | LEKLEYPRGD | IVYVRSLGQG | AFGRVFQARA | PGLVPDQEDL | LVAVKMLKDD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ASDQMQMDFE | REACLLAEFD | HPNIVRLLGV | CALGRPMCLL | FEYMAPGDLS | EFLRACSPYA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| THQAPTQDRL | QLNELHLLQM | AANIAAGMLY | LSERKFVHRD | LATRNCLINE | HMAVKIADFG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LSHKIYLQDY | YKGDENDFIP | IRWMPLESIL | YNKFSLESDV | WAYGICLWEV | FSFALQPYFG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LTHEEVIKYI | KEGNVLGCPD | NTPLSVYALM | RRCWNRKPSE | RPGFAEINHC | IQHSIAESEC |
| KAML |