Q9V461

PR
Gene name
Mcm6
Protein name
DNA replication licensing factor Mcm6
Names
DmMCM6
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG4039
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

225-352 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q9V461

Entry ID Method Resolution Chain Position Source
6RAW EM 370 A 6 1-817 PDB
6RAX EM 399 A 6 1-817 PDB
6RAY EM 428 A 6 1-817 PDB
6RAZ EM 446 A 6 1-817 PDB
AF-Q9V461-F1 Predicted AlphaFoldDB

No variants for Q9V461

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9V461

No associated diseases with Q9V461

6 regional properties for Q9V461

Type Name Position InterPro Accession
domain MCM domain 326 - 548 IPR001208
conserved_site Mini-chromosome maintenance, conserved site 447 - 455 IPR018525
domain MCM N-terminal domain 22 - 95 IPR027925
domain MCM OB domain 116 - 245 IPR033762
domain Mcm6, C-terminal winged-helix domain 702 - 816 IPR041024
domain MCM, AAA-lid domain 564 - 648 IPR041562

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
  • Associated with chromatin during cell cycles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
CMG complex A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication.
MCM complex A hexameric protein complex required for the initiation and regulation of DNA replication.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
metal ion binding Binding to a metal ion.
single-stranded DNA binding Binding to single-stranded DNA.

8 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
DNA replication initiation The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
DNA unwinding involved in DNA replication The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
double-strand break repair via break-induced replication The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.
eggshell chorion gene amplification Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster.
mitotic DNA replication Any nuclear DNA replication that is involved in a mitotic cell cycle.
regulation of DNA-templated DNA replication initiation Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KIZ8 MCM6 DNA replication licensing factor MCM6 Bos taurus (Bovine) PR
Q9XYU0 Mcm7 DNA replication licensing factor Mcm7 Drosophila melanogaster (Fruit fly) PR
Q14566 MCM6 DNA replication licensing factor MCM6 Homo sapiens (Human) PR
P97311 Mcm6 DNA replication licensing factor MCM6 Mus musculus (Mouse) PR
Q62724 Mcm6 DNA replication licensing factor MCM6 Rattus norvegicus (Rat) PR
Q6F353 Os05g0235800 DNA replication licensing factor MCM6 Oryza sativa subsp japonica (Rice) PR
P34647 mcm-6 DNA replication licensing factor mcm-6 Caenorhabditis elegans PR
Q9SF37 MCM8 Probable DNA helicase MCM8 Arabidopsis thaliana (Mouse-ear cress) PR
Q28CM3 mmcm6 Maternal DNA replication licensing factor mcm6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6P1V8 zmcm6 Zygotic DNA replication licensing factor mcm6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MDVADAQVGQ LRVKDEVGIR AQKLFQDFLE EFKEDGEIKY TRPAASLESP DRCTLEVSFE
70 80 90 100 110 120
DVEKYDQNLA TAIIEEYYHI YPFLCQSVSN YVKDRIGLKT QKDCYVAFTE VPTRHKVRDL
130 140 150 160 170 180
TTSKIGTLIR ISGQVVRTHP VHPELVSGVF MCLDCQTEIR NVEQQFKFTN PTICRNPVCS
190 200 210 220 230 240
NRKRFMLDVE KSLFLDFQKI RIQETQAELP RGCIPRAVEI ILRSELVETV QAGDRYDFTG
250 260 270 280 290 300
TLIVVPDVSV LAGVGTRAEN SSRHKPGEGM DGVTGLKALG MRELNYRMAF LACSVQATTA
310 320 330 340 350 360
RFGGTDLPMS EVTAEDMKKQ MTDAEWHKIY EMSKDRNLYQ NLISSLFPSI YGNDEVKRGI
370 380 390 400 410 420
LLQQFGGVAK TTTEKTSLRG DINVCIVGDP STAKSQFLKQ VSDFSPRAIY TSGKASSAAG
430 440 450 460 470 480
LTAAVVRDEE SFDFVIEAGA LMLADNGICC IDEFDKMDQR DQVAIHEAME QQTISIARAG
490 500 510 520 530 540
VRATLNARTS ILAAANPING RYDRSKSLQQ NIQLSAPIMS RFDLFFILVD ECNEVVDYAI
550 560 570 580 590 600
ARKIVDLHSN IEESVERAYT REEVLRYVTF ARQFKPVISQ EAGHMLVENY GHLRQRDTGT
610 620 630 640 650 660
SGRSTWRITV RQLESMIRLS EAMAKLECSN RVLERHVKEA FRLLNKSIIR VEQPDIHLDD
670 680 690 700 710 720
DEGLDMDDGI QHDIDMENNG AAANVDENNG MDTSASGAVQ KKKFTLSFED YKNLSTMLVL
730 740 750 760 770 780
HMRAEEARCE VEGNDTGIKR SNVVTWYLEQ VADQIESEDE LISRKNLIEK LIDRLIYHDQ
790 800 810
VIIPLKTSTL KPRIQVQKDF VEEDDPLLVV HPNYVVE