Q9UR24
Gene name |
rhp26 (SPCP25A2.02c) |
Protein name |
DNA repair protein rhp26 |
Names |
RAD26 homolog |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCP25A2.02c |
EC number |
|
Protein Class |
SNF2/RAD54 FAMILY MEMBER (PTHR45629) |
Descriptions
Rhp26 is a model protein related to CSB/ERCC6 (Cockayne syndrome B protein/excision repair cross complementation group 6) proteins with key roles in gene expression and DNA repair system. The leucine latch motif at the N-terminus of Rhp26 is responsible for the autoinhibition of the ATPase and chromatin-remodeling activity through its interactions with lobe 2 of the core ATPase domain. The disruption of the leucine latch motif or deletion of the N terminus eliminates the autoinhibition of ATPase and remarkably enhances the chromatin remodeling activity resulting in a hyperactive Rhp26.
Autoinhibitory domains (AIDs)
Target domain |
273-498 (ATPase domain) |
Relief mechanism |
Others |
Assay |
Deletion assay, Mutagenesis experiment |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9UR24
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9UR24-F1 | Predicted | AlphaFoldDB |
No variants for Q9UR24
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9UR24 | |||||
No associated diseases with Q9UR24
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR45629 | SNF2/RAD54 FAMILY MEMBER |
| PANTHER Subfamily | PTHR45629:SF7 | DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED |
| PANTHER Protein Class |
damaged DNA-binding protein
DNA metabolism protein |
|
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent activity, acting on DNA | Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. |
| ATP-dependent chromatin remodeler activity | An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. |
| helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| transcription-coupled nucleotide-excision repair | The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVNEDLSHL | GVFSVDQENL | ERDVTNTASE | YIAHESREIE | KKRLQKVRKE | ISSVKEKIRR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDERIDSRLT | KISVKENFRK | QLSKFRDTLQ | SLQSDENDIK | RRLNNEDSAN | APGIGAFSTE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ELERQELIRT | GKVTPFRNLS | GLQKEVDFDD | ESSIREAVIK | SEGTYYETAP | HLSSEPSNID |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HGIIPRDEKD | EYVTVDAVTE | KVVTAAIDDG | DDLVYRQRLN | AWCANRKELR | DQASASENNK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DRGEFEGKDE | WLLPHPSKKG | QTFEGGFTIP | GDIRPHLFRY | QVTCVQWLWE | LYCQEAGGII |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GDEMGLGKTI | QIVSFLSSLH | HSGKFQKPAL | IVCPATLMKQ | WVNEFHTWWA | PLRVVVLHAT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GSGQRASREK | RQYESDASES | EAEESKTSIK | LRGASSSFHR | YAKNLVESVF | TRGHILITTY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AGLRIYGDLI | LPREWGYCVL | DEGHKIRNPD | SEISISCKQI | RTVNRIILSG | TPIQNNLTEL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WNLFDFVFPG | RLGTLPVFQN | QFALPINIGG | YANASNVQVQ | TAYKCACMLR | DLISPYLLRR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MKLDVAADLP | KKSEQVLFCK | LTPLQRKAYQ | DFLQGSDMQK | ILNGKRQMLY | GIDILRKICN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HPDLVTREYL | LHKEDYNYGD | PEKSGKLKVI | RALLTLWKKQ | GHRTLLFSQT | RQMLDILEIG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LKDLPDVHYC | RMDGSTSIAL | RQDLVDNFNK | NEYFDVFLLT | TRVGGLGVNL | TGADRVILFD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PDWNPSTDAQ | ARERAWRLGQ | KKDVVVYRLM | TAGTIEEKIY | HRQIFKQFLT | NKILKDPKQR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RFFKMTDLHD | LFTLGDNKTE | GTETGSMFLG | SERVLRKDNS | SRNGNEAEDI | PARDRKKHKI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| HDKGKKVNSS | KVFEKMGIAS | MEKYKPPQES | NVTKTNSDST | LGDDSVLDDI | FASAGIQSTL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KHDDIMEASQ | TESILVEKEA | TRVANEALRA | VSSFRRPPRQ | LIPPQQSTNV | PGTSKPSGPI |
| 970 | |||||
| TSSTLLARLK | QRR |