AiPD: Autoinhibited Protein Database

Q9UQB8

Gene name	BAIAP2
Protein name	Brain-specific angiogenesis inhibitor 1-associated protein 2
Names	BAI-associated protein 2, BAI1-associated protein 2, Protein BAP2, Fas ligand-associated factor 3, FLAF3, Insulin receptor substrate p53/p58, IRS-58, IRSp53/58, Insulin receptor substrate protein of 53 kDa, IRSp53, Insulin receptor substrate p53
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10458
EC number
Protein Class	BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2 (PTHR14206)

Descriptions

BAIAP2 (IRSp53) is a SH3-containing protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. The N-terminal autoinhibitory region interacts intramolecularly with the central region containing CRIB motif and Cdc42 binding domain. When GTP-loaded Cdc42 binds to the CRIB motif, it abrogates the autoinhibitory, intramolecular interaction and allows the SH3 domain to interact with BAIAP2 effector proteins such as Mena. When the N-terminal autoinhibitory fragment is co-expressed with BAIAP2, the fragment inhibits the function of BAIAP2.

Autoinhibitory domains (AIDs)

Target domain	180-317 (Central region)
Relief mechanism	Partner binding
Assay	Deletion assay, Mutagenesis experiment, Structural analysis

AID

1-178 (N-terminal autoinhibitory region)

Target domain

180-317 (Central region)

Relief mechanism

Partner binding (Cdc42 binding to CRIB motif)

Assay

Deletion assay, Mutagenesis experiment, Structural analysis

Accessory elements

No accessory elements

References

Krugmann S et al. (2001) "Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex", Current biology : CB, 11, 1645-55

Miki H et al. (2002) "WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac", Biochemical and biophysical research communications, 293, 93-9

Kast DJ et al. (2014) "Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors", Nature structural & molecular biology, 21, 413-22

Autoinhibited structure

Activated structure

13 structures for Q9UQB8

Entry ID	Method	Resolution	Chain	Position	Source
1WDZ	X-ray	263 A	A/B	1-228	PDB
1Y2O	X-ray	220 A	A/B	1-250	PDB
2YKT	X-ray	211 A	A	1-250	PDB
3RNJ	X-ray	150 A	A	375-436	PDB
4JS0	X-ray	190 A	B	260-291	PDB
6BCR	X-ray	199 A	C/D/G/H	333-346	PDB
6BCY	X-ray	230 A	C/D/G/H	354-366	PDB
6BD1	X-ray	235 A	C/D/G/H	360-373	PDB
6BD2	X-ray	290 A	C	335-372	PDB
6BQT	X-ray	280 A	C/F/I/L	335-366	PDB
6ZEG	X-ray	109 A	A/B	448-464	PDB
6ZEI	X-ray	139 A	A/B	448-464	PDB
AF-Q9UQB8-F1	Predicted				AlphaFoldDB

404 variants for Q9UQB8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA401412633 rs1171086981	2	S>F		No	ClinGen gnomAD
CA294983703 rs11539639	4	S>P		No	ClinGen Ensembl
CA8826425 rs753024709	5	R>P		No	ClinGen ExAC gnomAD
CA8826426 rs115451635	6	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1475121022 CA401412668	8	E>D		No	ClinGen TOPMed
CA8826429 rs370763028	9	M>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs370763028 CA8826428	9	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA294983709 rs974729629	10	H>P		No	ClinGen TOPMed
rs1230578623 CA401412683	10	H>Q		No	ClinGen gnomAD
CA8826431 rs578230889	11	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1407224910 CA401412699	13	T>M		No	ClinGen TOPMed gnomAD
rs564046878 CA8826434	15	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs776230594 CA8826436	17	Y>C		No	ClinGen ExAC gnomAD
rs900913360 CA294999364	20	I>V		No	ClinGen Ensembl
CA8826484 rs374230803	24	F>Y		No	ClinGen ESP ExAC gnomAD
rs1598542596 CA401417000	25	N>T		No	ClinGen Ensembl
rs1404726554 CA401417067	29	R>Q		No	ClinGen gnomAD
rs377401222 CA294999380	29	R>W		No	ClinGen ESP TOPMed
rs1028076093 CA294999381	33	A>T		No	ClinGen TOPMed gnomAD
rs770013190 CA8826487	33	A>V		No	ClinGen ExAC TOPMed gnomAD
CA401417152 rs1459613705	34	M>T		No	ClinGen gnomAD
CA8826489 rs762949363	39	E>*		No	ClinGen ExAC TOPMed gnomAD
CA401417242 rs762949363	39	E>K		No	ClinGen ExAC TOPMed gnomAD
rs762949363 CA401417245	39	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA8826521 rs749901447	46	T>K		No	ClinGen ExAC gnomAD
rs749901447 CA8826522	46	T>M		No	ClinGen ExAC gnomAD
rs1319275232 CA401418379	50	K>Q		No	ClinGen gnomAD
rs1460415838 CA401418390	51	G>D		No	ClinGen TOPMed
COSM1750397 rs1436822616 CA401418397 COSM1750399 COSM1750398	52	Y>C	urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
CA8826527 rs749548807	54	D>A		No	ClinGen ExAC gnomAD
CA401418418 rs1217192954	55	A>T		No	ClinGen TOPMed gnomAD
CA295003420 rs970877727	57	V>A		No	ClinGen TOPMed gnomAD
rs745919667 CA8826530	57	V>M		No	ClinGen ExAC TOPMed gnomAD
rs981270696 CA401418445	59	M>I		No	ClinGen TOPMed
rs981270696 CA295003421	59	M>I		No	ClinGen TOPMed
rs1598565901 CA401418458	61	E>G		No	ClinGen Ensembl
CA401418453 rs1463652930	61	E>K		No	ClinGen gnomAD
rs1268866258 CA401418464	62	L>R		No	ClinGen gnomAD
CA8826531 rs771907623	62	L>V		No	ClinGen ExAC gnomAD
rs775556041 CA401418469	63	A>G		No	ClinGen ExAC TOPMed gnomAD
rs775556041 CA8826532	63	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1427755770 CA401418478	65	E>K		No	ClinGen gnomAD
CA401418500 rs1159158244	67	Q>H		No	ClinGen gnomAD
rs1598566033 CA401418510	69	S>P		No	ClinGen Ensembl
CA8826537 rs764946894	70	K>Q		No	ClinGen ExAC gnomAD
rs984006379 CA295003477	70	K>R		No	ClinGen TOPMed gnomAD
rs1433873364 CA401418521	71	E>K		No	ClinGen gnomAD
CA401418533 rs1227709698	72	L>P		No	ClinGen gnomAD
CA401418534 rs1227709698	72	L>R		No	ClinGen gnomAD
CA401418531 rs1345960849	72	L>V		No	ClinGen gnomAD
rs1331156207 CA401418535	73	G>R		No	ClinGen gnomAD
CA401423922 rs1186024143	74	D>V		No	ClinGen gnomAD
rs1333493352 CA401423931	75	V>I		No	ClinGen gnomAD
rs546067385 CA8826625	79	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8826626 rs769593965	81	E>K		No	ClinGen ExAC gnomAD
CA401424095 rs1473164792	87	Q>E		No	ClinGen gnomAD
CA401424103 rs1417487832	87	Q>R		No	ClinGen TOPMed
CA295029835 rs958763714	88	N>Y		No	ClinGen TOPMed
rs777643110 CA8826627	93	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1324688047 CA401424252	94	L>M		No	ClinGen gnomAD
rs948958629 CA295030779	95	K>R		No	ClinGen TOPMed
CA8826716 rs755745937	96	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs1402797058 CA401424298	100	E>V		No	ClinGen gnomAD
rs899161358 CA295030786	101	L>M		No	ClinGen TOPMed
CA8826718 rs371193130	103	T>M		No	ClinGen ExAC TOPMed gnomAD
CA8826722 rs373474550	110	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs762016795 CA8826724	114	R>T		No	ClinGen ExAC TOPMed gnomAD
CA401424445 rs1182175064	117	S>G		No	ClinGen gnomAD
CA8826725 rs769899566	117	S>T		No	ClinGen ExAC TOPMed gnomAD
rs146668397 CA8826753	119	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1320899885 CA401424600	121	K>R		No	ClinGen TOPMed
rs1459638650 CA401424651	124	Q>H		No	ClinGen gnomAD
CA8826756 rs752146377	125	T>A		No	ClinGen ExAC gnomAD
rs1436993263 CA401424660	125	T>I		No	ClinGen TOPMed
rs1436993263 CA401424659	125	T>S		No	ClinGen TOPMed
rs1243301746 CA401424672	126	E>D		No	ClinGen gnomAD
CA401424680 rs1448534524	127	Q>*		No	ClinGen gnomAD
CA401424709 rs1190728401	129	S>N		No	ClinGen gnomAD
rs561571272 CA8826757	130	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8826759 rs748476838 COSM3937650 COSM3937649 COSM3937651	132	D>N	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs777916497 CA8826761	133	A>T		No	ClinGen ExAC TOPMed gnomAD
CA401424783 rs1261293190	135	D>V		No	ClinGen TOPMed
rs1339516863 CA401424808	137	C>Y		No	ClinGen gnomAD
rs749461725 CA8826762	138	Q>H		No	ClinGen ExAC gnomAD
CA8826765 rs745868193	145	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA401424922 rs1283140959	146	K>R		No	ClinGen gnomAD
rs767999334 CA295031716	148	S>N		No	ClinGen Ensembl
CA295031720 rs367841125	149	Q>E		No	ClinGen ESP TOPMed
rs991970933 CA295031725	151	S>N		No	ClinGen TOPMed
rs1322042328 CA401425004	152	K>R		No	ClinGen gnomAD
rs200297110 CA295031732	153	N>T		No	ClinGen Ensembl
rs1485321863 CA401425092	158	S>W		No	ClinGen gnomAD
CA401425143 rs1447305591	160	K>R		No	ClinGen gnomAD
CA401425176 rs1297851873	161	E>D		No	ClinGen TOPMed
rs761337520 CA8826771	162	L>R		No	ClinGen ExAC gnomAD
rs1234391673 CA401419860	165	I>V		No	ClinGen TOPMed
rs761195252 CA8826812	166	D>N		No	ClinGen ExAC
rs374731577 CA8826813	167	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1256907331 CA401419880	168	I>V		No	ClinGen TOPMed
rs765629866 CA8826816	171	K>R		No	ClinGen ExAC TOPMed gnomAD
rs368976984 CA8826817	173	G>V		No	ClinGen ESP ExAC TOPMed
rs149055618 CA8826820	175	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA401419966 rs563318276	178	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8826826 rs748990232	179	V>A		No	ClinGen ExAC TOPMed gnomAD
rs372635764 CA401419969	179	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8826824 rs372635764	179	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8826825 rs372635764	179	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1343074500 CA401419989	180	S>F		No	ClinGen gnomAD
rs1161177363 CA401419997	181	D>N		No	ClinGen TOPMed
CA8826830 rs771597263	182	G>S		No	ClinGen ExAC TOPMed gnomAD
CA8826834 rs773659690	187	L>V		No	ClinGen ExAC gnomAD
COSM985776 rs1283746976 CA401420953	191	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs766637531 CA401420957	191	R>H		No	ClinGen ExAC TOPMed gnomAD
rs766637531 CA8826836	191	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1490321848 CA401421050	195	C>Y		No	ClinGen gnomAD
rs767634545 CA8826839	202	C>F		No	ClinGen ExAC gnomAD
CA294989899 rs767634545	202	C>Y		No	ClinGen ExAC gnomAD
rs756060126 CA8826841 COSM1726737 COSM1726735 COSM1726736	203	A>T	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA401421254 rs1402134415	204	V>M		No	ClinGen gnomAD
CA401421289 rs1403009948	206	K>N		No	ClinGen gnomAD
rs528044923 CA8826844	206	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs745515587 CA8826846	209	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8826847 rs771522958	209	A>V		No	ClinGen ExAC gnomAD
rs748624549 CA8826849	210	A>G		No	ClinGen ExAC gnomAD
rs770293073 CA8826850	211	Y>C		No	ClinGen ExAC gnomAD
CA401421385 rs1460775535	213	S>C		No	ClinGen TOPMed
rs1316005015 CA401422909	215	G>V		No	ClinGen gnomAD
CA294993451 rs992770877	218	L>V		No	ClinGen TOPMed
CA294993460 rs767042934	220	A>T		No	ClinGen Ensembl
rs745320058 CA8826882	220	A>V		No	ClinGen ExAC gnomAD
CA8826884 rs779694736	222	K>R		No	ClinGen ExAC TOPMed gnomAD
CA8826886 rs369167632	224	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA294993470 rs369167632	224	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8826888 rs749861902	228	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1190766858 CA401422994	229	A>S		No	ClinGen gnomAD
CA401422999 rs1421282377	230	C>R		No	ClinGen TOPMed
rs779452421 CA8826890	230	C>W		No	ClinGen ExAC gnomAD
CA294993491 rs866376390	231	A>V		No	ClinGen gnomAD
rs772199606 CA401423010	232	D>H		No	ClinGen ExAC TOPMed gnomAD
CA8826892 rs772199606	232	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1403184984 CA401423018	233	P>A		No	ClinGen TOPMed gnomAD
CA401423019 rs1403184984	233	P>S		No	ClinGen TOPMed gnomAD
rs1183638797 CA401423039	236	I>L		No	ClinGen TOPMed
CA401423044 rs1485042595	236	I>N		No	ClinGen TOPMed
COSM301743 CA401423051 rs1342914435	237	P>L	central_nervous_system [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1316714271 CA401423048	237	P>S		No	ClinGen gnomAD
rs1244641725 CA401423061	239	R>C		No	ClinGen TOPMed
rs375070592 CA8826896	239	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs375070592 CA401423064	239	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs201786144 CA8826898	240	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8826899 rs772891818	240	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1401629705 CA401423071	241	V>L		No	ClinGen TOPMed
CA8826902 rs751267807	244	M>L		No	ClinGen ExAC TOPMed gnomAD
rs751267807 CA401423089	244	M>V		No	ClinGen ExAC TOPMed gnomAD
rs754657609 CA8826903	245	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA401423110 rs1351520450	246	Q>H		No	ClinGen TOPMed
CA8826905 rs752217288	246	Q>L		No	ClinGen ExAC gnomAD
rs757844412 CA8826906	248	A>P		No	ClinGen ExAC gnomAD
rs757844412 CA8826907	248	A>T		No	ClinGen ExAC gnomAD
rs1453382219 CA401423139	251	G>D		No	ClinGen gnomAD
rs758866130 CA8826909	251	G>S		No	ClinGen ExAC TOPMed gnomAD
rs141395686 CA8826911	252	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8826912 rs768826195	253	T>I		No	ClinGen ExAC gnomAD
CA8826913 rs776695608	254	L>F		No	ClinGen ExAC gnomAD
rs748164415 CA8826914	255	P>S		No	ClinGen ExAC gnomAD
CA401423168 rs150398192	256	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8826917 rs762765620	257	A>T		No	ClinGen ExAC TOPMed gnomAD
CA294993620 rs1031453012	259	S>L		No	ClinGen Ensembl
rs992100996 CA294993623	261	S>T		No	ClinGen Ensembl
rs1192971477 CA401423204	263	S>T		No	ClinGen gnomAD
rs1268196210 CA401423214	264	N>S		No	ClinGen gnomAD
rs752268332 CA8826922	266	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1440633271 CA401423241	269	D>N		No	ClinGen gnomAD
rs1220044907 CA401423250	270	P>A		No	ClinGen TOPMed
rs750986627 CA8826925	272	P>L		No	ClinGen ExAC TOPMed gnomAD
rs755203182 CA8826929	276	P>S		No	ClinGen ExAC TOPMed gnomAD
CA8826930 rs781447173	277	L>P		No	ClinGen ExAC gnomAD
rs1244910019 CA401423296	278	P>S		No	ClinGen gnomAD
rs1460543016 CA401423304	279	V>L		No	ClinGen TOPMed
CA401423312 rs1222303162	280	P>H		No	ClinGen TOPMed gnomAD
CA401423311 rs1222303162	280	P>L		No	ClinGen TOPMed gnomAD
rs1323400886 CA401423310	280	P>S		No	ClinGen gnomAD
CA8826936 rs774203588	284	A>T		No	ClinGen ExAC gnomAD
rs759347952 CA8826937	285	P>A		No	ClinGen ExAC gnomAD
CA401423341 rs1262958859	285	P>L		No	ClinGen gnomAD
CA8826938 rs759347952	285	P>S		No	ClinGen ExAC gnomAD
CA401423338 rs759347952	285	P>T		No	ClinGen ExAC gnomAD
rs760374560 CA8826940	286	F>L		No	ClinGen ExAC gnomAD
CA294993707 rs943691615	287	V>M		No	ClinGen gnomAD
CA294993983 rs768607123	289	R>Q		No	ClinGen gnomAD
rs745852347 CA8826976	290	M>T		No	ClinGen ExAC gnomAD
CA8826977 rs577903416	291	S>P		No	ClinGen 1000Genomes ExAC gnomAD
rs1358447063 CA401423393	292	A>V		No	ClinGen gnomAD
rs779998520 CA8826978	295	S>N		No	ClinGen ExAC TOPMed gnomAD
rs746723636 CA401423419	296	T>A		No	ClinGen ExAC gnomAD
rs746723636 CA8826979	296	T>P		No	ClinGen ExAC gnomAD
CA8826981 rs776209043	297	P>T		No	ClinGen ExAC gnomAD
rs544940030 CA8826982	298	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1361521420 CA401423440	299	M>I		No	ClinGen TOPMed
rs757535912 CA294994024	299	M>V		No	ClinGen Ensembl
rs141436998 CA8826986	302	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8826988 rs761006511	303	T>A		No	ClinGen ExAC gnomAD
rs754048103 CA401423469	304	G>D		No	ClinGen ExAC gnomAD
rs944066804 CA294994057	304	G>S		No	ClinGen TOPMed gnomAD
CA8826990 rs754048103	304	G>V		No	ClinGen ExAC gnomAD
CA8826991 rs751490909	305	P>L		No	ClinGen ExAC TOPMed gnomAD
CA294994064 rs1041492778	305	P>S		No	ClinGen TOPMed
CA401423479 rs1478142334	306	D>G		No	ClinGen gnomAD
rs750460687 CA8826993	308	E>K		No	ClinGen ExAC TOPMed gnomAD
CA8826997 rs754765663	312	P>L		No	ClinGen ExAC TOPMed gnomAD
CA294994110 rs754765663	312	P>R		No	ClinGen ExAC TOPMed gnomAD
rs746958217 CA8826996	312	P>S		No	ClinGen ExAC gnomAD
CA401423549 rs1351746625	316	R>C		No	ClinGen TOPMed gnomAD
rs747775919 CA8826999	316	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8827000 rs747775919	316	R>L		No	ClinGen ExAC TOPMed gnomAD
rs747775919 CA401423550	316	R>P		No	ClinGen ExAC TOPMed gnomAD
CA8827001 rs772717162	317	K>R		No	ClinGen ExAC TOPMed gnomAD
rs866018129 CA294994136	318	A>P		No	ClinGen gnomAD
CA401423574 rs1310518534	320	Q>R		No	ClinGen gnomAD
rs748742558 CA8827002	321	P>L		No	ClinGen ExAC gnomAD
CA8827006 rs561013874	324	L>P		No	ClinGen 1000Genomes ExAC gnomAD
rs371249844 CA8827007	325	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs371249844 CA401423604	325	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA401423610 rs1384450987	326	P>L		No	ClinGen gnomAD
rs528172800 CA8827009	327	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs528172800 CA8827010	327	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1406617262 CA401423626	329	S>C		No	ClinGen TOPMed
CA401423625 rs1414453756	329	S>P		No	ClinGen gnomAD
CA8827013 rs751497094	331	S>G		No	ClinGen ExAC
rs142524547 CA8827014	331	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA294994234 rs201778887	334	S>T		No	ClinGen TOPMed
rs1023609159 CA294994240	335	D>N		No	ClinGen TOPMed gnomAD
rs1023609159 CA401423664	335	D>Y		No	ClinGen TOPMed gnomAD
rs1425310031 CA401423676	336	S>F		No	ClinGen TOPMed
rs1189316987 CA401423680	337	Y>F		No	ClinGen TOPMed
CA294994250 rs1013923287	341	L>F		No	ClinGen TOPMed
CA8827021 rs778465491	343	V>M		No	ClinGen ExAC gnomAD
rs766633674 CA8827022	344	R>C		No	ClinGen ExAC gnomAD
CA401423725 rs1382858567	344	R>H		No	ClinGen gnomAD
rs1242160322 CA401423746	347	V>A		No	ClinGen gnomAD
rs1568178905 CA401423744	347	V>M		No	ClinGen Ensembl
CA401423772 rs1189402365	351	N>S		No	ClinGen gnomAD
rs1237939311 CA401423787	353	Y>S		No	ClinGen gnomAD
rs762325161 CA8827025	354	A>V		No	ClinGen ExAC gnomAD
CA401424386 rs1205755840	357	E>K		No	ClinGen TOPMed gnomAD
CA8827062 rs377734827	359	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1598804153 CA401424433	360	T>P		No	ClinGen Ensembl
CA401424454 rs1395924854	361	L>R		No	ClinGen gnomAD
rs1420880639 CA401424492	366	S>F		No	ClinGen gnomAD
rs144299493 CA8827070	373	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs771187979 CA401424535	373	R>H		No	ClinGen ExAC TOPMed gnomAD
rs771187979 CA8827071	373	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8827073 rs370295048	374	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs370295048 CA401424540	374	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA401424551 rs1311232269	376	R>C		No	ClinGen TOPMed gnomAD
rs772247244 CA8827074	376	R>H		No	ClinGen ExAC gnomAD
CA8827075 rs775502491	378	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA294994878 rs868516212	378	R>W		No	ClinGen TOPMed gnomAD
rs1598804386 CA401424595	379	V>G		No	ClinGen Ensembl
CA294994907 rs971652824	384	S>F		No	ClinGen TOPMed
rs761731419 CA8827079	386	A>T		No	ClinGen ExAC TOPMed gnomAD
COSM1680142 CA8827080 rs764906606 COSM1680143	388	G>E	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1391580828 CA401424735	389	D>A		No	ClinGen TOPMed gnomAD
CA8827082 rs757938751	390	N>K		No	ClinGen ExAC gnomAD
rs750134441 CA8827081	390	N>S		No	ClinGen ExAC TOPMed gnomAD
CA401424845 rs1293653505	397	K>E		No	ClinGen gnomAD
rs930294105 CA294994966	397	K>R		No	ClinGen TOPMed gnomAD
rs1444210178 CA401424884	399	G>A		No	ClinGen gnomAD
rs751045704 CA401424905	400	D>E		No	ClinGen ExAC TOPMed gnomAD
CA8827085 rs756700120	401	L>F		No	ClinGen ExAC gnomAD
rs367941559 CA8827086	402	I>V		No	ClinGen ESP ExAC gnomAD
CA401424938 rs1310438757	403	T>I		No	ClinGen gnomAD
rs1197054885 CA401425021	410	R>C		No	ClinGen gnomAD
COSM1387187 COSM1387188 CA294994981 rs1048795319	410	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1181674630 CA401425035	411	D>Y		No	ClinGen gnomAD
rs1426129405 CA401425104	416	G>R		No	ClinGen gnomAD
rs1389339672 CA401425148	418	S>C		No	ClinGen TOPMed
rs1164975179 CA401425241	422	K>N		No	ClinGen TOPMed
rs1242252565 CA401425993	424	R>Q		No	ClinGen gnomAD
CA8827117 rs769551128	430	S>Y		No	ClinGen ExAC
rs1157873873 CA401426136	433	R>Q		No	ClinGen gnomAD
rs1378384366 CA401426169	436	D>N		No	ClinGen TOPMed gnomAD
CA8827119 rs762712608	438	D>N		No	ClinGen ExAC gnomAD
rs868482164 CA401426268	441	D>E		No	ClinGen gnomAD
rs868482164 CA294997053	441	D>E		No	ClinGen gnomAD
rs1345796272 CA401426254	441	D>N		No	ClinGen gnomAD
rs1291953702 CA401426287	442	R>S		No	ClinGen gnomAD
rs1373507555 CA401426293	443	L>V		No	ClinGen gnomAD
rs551077903 CA294997059	445	M>V		No	ClinGen TOPMed gnomAD
rs147016372 CA401426345	447	L>V		No	ClinGen ESP TOPMed gnomAD
rs1217508325 CA401426350	448	Q>E		No	ClinGen gnomAD
rs1255719699 CA401426354	448	Q>R		No	ClinGen gnomAD
CA401426359 rs1168863967	449	Q>*		No	ClinGen TOPMed
CA401426386 rs1190402415	452	S>R		No	ClinGen TOPMed
rs990703324 CA294997723	453	S>N		No	ClinGen TOPMed
rs1440624781 CA401426406	455	T>M		No	ClinGen gnomAD
rs1193077669 CA401426424	458	L>F		No	ClinGen gnomAD
CA294997779 rs556837209	460	D>A		No	ClinGen Ensembl
CA8827147 rs199703361	460	D>E		No	ClinGen ExAC TOPMed gnomAD
CA401426443 rs1568185960	461	K>R		No	ClinGen Ensembl
CA401426451 rs1401863588	462	D>G		No	ClinGen gnomAD
CA294997830 rs929249306	463	D>N		No	ClinGen TOPMed gnomAD
CA8827150 rs143678625	464	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs756189976 CA8827152	468	P>L		No	ClinGen ExAC gnomAD
rs756189976 CA8827153	468	P>R		No	ClinGen ExAC gnomAD
rs148086211 CA8827154	469	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA8827158 rs745605178	469	P>H		No	ClinGen ExAC gnomAD
CA8827157 rs745605178	469	P>L		No	ClinGen ExAC gnomAD
rs148086211 CA8827155	469	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA8827156 rs148086211	469	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs768070859 CA8827161 COSM1387191 COSM1387192	470	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA294997868 rs763454584	472	G>C		No	ClinGen ExAC TOPMed gnomAD
rs763454584 CA8827163	472	G>S		No	ClinGen ExAC TOPMed gnomAD
rs766813794 CA8827164	473	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8827167 rs767894444	474	A>T		No	ClinGen ExAC TOPMed gnomAD
CA294997917 rs922220997 COSM1522819 COSM1522820	476	R>Q	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
rs756312025 CA8827169	476	R>W		No	ClinGen ExAC TOPMed gnomAD
CA294997929 rs960239758	479	P>L		No	ClinGen gnomAD
CA8827171 rs753906511	479	P>S		No	ClinGen ExAC TOPMed gnomAD
rs779054777 CA8827174	480	A>S		No	ClinGen ExAC TOPMed gnomAD
rs779054777 CA8827173	480	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8827175 rs758173810	480	A>V		No	ClinGen ExAC gnomAD
CA8827177 rs746668540	483	A>T		No	ClinGen ExAC gnomAD
rs768284859 CA8827178	484	S>G		No	ClinGen ExAC gnomAD
CA8827179 rs780693390	484	S>R		No	ClinGen ExAC TOPMed gnomAD
rs199655276 CA8827182	485	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199655276 CA8827181	485	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA401426576 rs1467348606	485	G>V		No	ClinGen gnomAD
CA401426585 rs1555681992	486	F>L		No	ClinGen Ensembl
CA294997987 rs919299852	487	K>E		No	ClinGen gnomAD
CA401426589 rs1254092875	487	K>R		No	ClinGen gnomAD
CA401426607 rs377234248	489	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA8827184 rs370082792	491	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA8827186 rs760813385	495	V>L		No	ClinGen ExAC TOPMed gnomAD
rs760813385 CA8827187	495	V>M		No	ClinGen ExAC TOPMed gnomAD
CA401426652 rs765380311	497	A>P		No	ClinGen ExAC TOPMed gnomAD
rs765380311 CA8827190	497	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1326178487 CA401426657	498	F>L		No	ClinGen gnomAD
CA401427301 rs1465369089	506	G>E		No	ClinGen gnomAD
rs767277559 CA8827215	506	G>R		No	ClinGen ExAC gnomAD
rs1468694528 CA401427322	507	A>E		No	ClinGen TOPMed
rs752370057 CA8827216	507	A>P		No	ClinGen ExAC gnomAD
rs1468694528 CA401427329	507	A>V		No	ClinGen TOPMed
CA8827220 rs746358890	508	R>P		No	ClinGen ExAC TOPMed gnomAD
rs746358890 CA8827219	508	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA401427341 rs777270344	508	R>W		No	ClinGen ExAC gnomAD
CA8827221 rs780682682	510	M>V		No	ClinGen ExAC TOPMed gnomAD
CA401427406 rs1213098350	511	S>I		No	ClinGen gnomAD
CA8827222 rs747445370	512	R>G		No	ClinGen ExAC gnomAD
CA295011792 rs940925293	514	P>L		No	ClinGen Ensembl
CA8827337 rs748064943	514	P>S		No	ClinGen ExAC TOPMed gnomAD
rs760359913 CA401430854	518	V>F		No	ClinGen ExAC TOPMed gnomAD
rs760359913 CA8827339 COSM1387193	518	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs773917475 CA8827342	519	Q>H		No	ClinGen ExAC gnomAD
CA8827341 VAR_050686 rs4969391	519	Q>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA8827343 rs369284270	520	L>P		No	ClinGen ESP ExAC gnomAD
rs1228892520 CA401430887	521	K>M		No	ClinGen TOPMed
CA8827345 rs775029947	522	P>A		No	ClinGen ExAC TOPMed gnomAD
rs762234702 CA8827347	522	P>L		No	ClinGen ExAC gnomAD
CA8827346 rs762234702	522	P>Q		No	ClinGen ExAC gnomAD
rs146357701 CA295011822	523	T>K		No	ClinGen ESP TOPMed gnomAD
CA401430902 rs1568208253	523	T>P		No	ClinGen Ensembl
CA401430947 rs766705468	526	N>K		No	ClinGen ExAC TOPMed gnomAD
CA8827353 rs766705468	526	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1182035051 CA401430944	526	N>S		No	ClinGen TOPMed gnomAD
CA8827354 rs546736073	527	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs746311826 CA8827397	531	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs772293989 CA8827398	532	S>F		No	ClinGen ExAC TOPMed gnomAD
rs772293989 CA8827399	532	S>Y		No	ClinGen ExAC TOPMed gnomAD
COSM562841 rs764303213 CA8827401	533	A>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA401431186 rs1196022329	534	Q>*		No	ClinGen TOPMed
CA401431184 rs1196022329	534	Q>E		No	ClinGen TOPMed
rs1231136990 CA401431198	535	G>R		No	ClinGen gnomAD
CA8827404 rs373541595	536	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1005411209 CA295012197	537	E>Q		No	ClinGen Ensembl
rs1475043194 CA401431243	538	G>D		No	ClinGen gnomAD
CA8827405 rs765281627	538	G>S		No	ClinGen ExAC TOPMed gnomAD
CA401431247 rs149637388	539	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758259928 CA8827407	539	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8827406 rs149637388	539	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA401431259 rs1387437133	540	E>*		No	ClinGen TOPMed
CA401431278 rs1306432116	541	H>R		No	ClinGen TOPMed
CA8827409 rs751240760	541	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA8827413 rs755574488	542	G>E		No	ClinGen ExAC TOPMed gnomAD
rs780691783 CA8827411	542	G>R		No	ClinGen ExAC TOPMed gnomAD
rs780691783 CA8827412	542	G>W		No	ClinGen ExAC TOPMed gnomAD
CA401431290 rs1285619464	543	D>A		No	ClinGen TOPMed gnomAD
CA401431291 rs1285619464	543	D>G		No	ClinGen TOPMed gnomAD
CA8827415 rs746339592	543	D>H		No	ClinGen ExAC gnomAD
rs1213816233 CA401431304	545	S>N		No	ClinGen gnomAD
CA401431305 rs1213816233	545	S>T		No	ClinGen gnomAD
rs1248924876 CA401431311	546	A>G		No	ClinGen TOPMed
rs544323535 CA8827419	546	A>S		No	ClinGen ExAC gnomAD
rs544323535 CA8827418	546	A>T		No	ClinGen ExAC gnomAD
rs776985011 CA8827423	547	R>C		No	ClinGen ExAC TOPMed gnomAD
rs776985011 CA8827422	547	R>G		No	ClinGen ExAC TOPMed gnomAD
rs765205664 CA8827424	547	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8827425 rs201102086	548	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1343954452 CA401431323	549	L>Q		No	ClinGen TOPMed
rs1417976985 CA401431330	550	A>D		No	ClinGen TOPMed gnomAD
rs555748569 CA295012271	550	A>P		No	ClinGen 1000Genomes gnomAD
rs1417976985 CA401431329	550	A>V		No	ClinGen TOPMed gnomAD
rs143905176 CA8827427	551	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8827428 rs751295798	552	R>K		No	ClinGen ExAC gnomAD

No associated diseases with Q9UQB8

4 regional properties for Q9UQB8

Type	Name	Position	InterPro Accession
domain	SH3 domain	374 - 437	IPR001452
domain	IMD/I-BAR domain	1 - 250	IPR013606
domain	I-BAR domain containing protein IRSp53, Inverse-Bin/Amphiphysin/Rvs domain	5 - 236	IPR030128
domain	IRSp53, SH3 domain	377 - 435	IPR035594

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Membrane; Peripheral membrane protein Cell projection, filopodium Cell projection, ruffle Cytoplasm, cytoskeleton	Detected throughout the cytoplasm in the absence of specific binding partners Detected in filopodia and close to membrane ruffles Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites
PANTHER Family	PTHR14206	BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2
PANTHER Subfamily	PTHR14206:SF3	BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2
PANTHER Protein Class	scaffold/adaptor protein
PANTHER Pathway Category	No pathway information available

25 GO annotations of cellular component

Name	Definition
adherens junction	A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic shaft	Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
dendritic spine cytoplasm	The region of the neuronal cytoplasm located in dendritic spines.
excitatory synapse	A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
filopodium	Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
neuron projection branch point	The location where a secondary projection arises from a neuron projection.
neuron projection terminus	The specialized, terminal region of a neuron projection such as an axon or a dendrite.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic cytosol	The region of the cytosol consisting of all cytosol that is part of the postsynapse.
postsynaptic density, intracellular component	A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
presynaptic cytosol	The region of the cytosol consisting of all cytosol that is part of the presynapse.
rough endoplasmic reticulum	The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
ruffle	Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
Schaffer collateral - CA1 synapse	A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
secretory granule	A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
synaptic membrane	A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

8 GO annotations of molecular function

Name	Definition
cadherin binding involved in cell-cell adhesion	Any cadherin binding that occurs as part of the process of cell-cell adhesion.
cytoskeletal anchor activity	The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way.
identical protein binding	Binding to an identical protein or proteins.
PDZ domain binding	Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
proline-rich region binding	Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.
protein C-terminus binding	Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
scaffold protein binding	Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
transcription coregulator binding	Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.

20 GO annotations of biological process

Name	Definition
actin crosslink formation	The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.
actin filament bundle assembly	The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
axonogenesis	De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
brain development	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
cellular response to epidermal growth factor stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
cellular response to L-glutamate	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus.
dendrite development	The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
insulin receptor signaling pathway	The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
modification of synaptic structure, modulating synaptic transmission	Any process that modulates synaptic transmission via modification of the structure of the synapse.
plasma membrane organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
positive regulation of actin cytoskeleton reorganization	Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization.
positive regulation of actin filament polymerization	Any process that activates or increases the frequency, rate or extent of actin polymerization.
positive regulation of dendritic spine morphogenesis	Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
positive regulation of excitatory postsynaptic potential	Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
protein localization to synapse	Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
regulation of actin cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of cell shape	Any process that modulates the surface configuration of a cell.
regulation of modification of postsynaptic actin cytoskeleton	Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton.
regulation of synaptic plasticity	A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
response to bacterium	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5EAD0	BAIAP2	Brain-specific angiogenesis inhibitor 1-associated protein 2	Bos taurus (Bovine)	PR
Q9UHR4	BAIAP2L1	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	Homo sapiens (Human)	PR
Q6UXY1	BAIAP2L2	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2	Homo sapiens (Human)	PR
Q80Y61	Baiap2l2	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2	Mus musculus (Mouse)	PR
Q8BKX1	Baiap2	BAR/IMD domain-containing adapter protein 2	Mus musculus (Mouse)	SS
Q6GMN2	Baiap2	BAR/IMD domain-containing adapter protein 2	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MSLSRSEEMH	RLTENVYKTI	MEQFNPSLRN	FIAMGKNYEK	ALAGVTYAAK	GYFDALVKMG
70	80	90	100	110	120
ELASESQGSK	ELGDVLFQMA	EVHRQIQNQL	EEMLKSFHNE	LLTQLEQKVE	LDSRYLSAAL
130	140	150	160	170	180
KKYQTEQRSK	GDALDKCQAE	LKKLRKKSQG	SKNPQKYSDK	ELQYIDAISN	KQGELENYVS
190	200	210	220	230	240
DGYKTALTEE	RRRFCFLVEK	QCAVAKNSAA	YHSKGKELLA	QKLPLWQQAC	ADPSKIPERA
250	260	270	280	290	300
VQLMQQVASN	GATLPSALSA	SKSNLVISDP	IPGAKPLPVP	PELAPFVGRM	SAQESTPIMN
310	320	330	340	350	360
GVTGPDGEDY	SPWADRKAAQ	PKSLSPPQSQ	SKLSDSYSNT	LPVRKSVTPK	NSYATTENKT
370	380	390	400	410	420
LPRSSSMAAG	LERNGRMRVK	AIFSHAAGDN	STLLSFKEGD	LITLLVPEAR	DGWHYGESEK
430	440	450	460	470	480
TKMRGWFPFS	YTRVLDSDGS	DRLHMSLQQG	KSSSTGNLLD	KDDLAIPPPD	YGAASRAFPA
490	500	510	520	530	540
QTASGFKQRP	YSVAVPAFSQ	GLDDYGARSM	SRNPFAHVQL	KPTVTNDRCD	LSAQGPEGRE
550
HGDGSARTLA	GR